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Protein

Zinc finger matrin-type protein 3

Gene

ZMAT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri70 – 100Matrin-type 1Sequence analysisAdd BLAST31
Zinc fingeri147 – 177Matrin-type 2Sequence analysisAdd BLAST31
Zinc fingeri246 – 276Matrin-type 3Sequence analysisAdd BLAST31

GO - Molecular functioni

  • p53 binding Source: GO_Central
  • RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processApoptosis, DNA damage, Growth regulation, Protein transport, Translocation, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger matrin-type protein 3
Alternative name(s):
Zinc finger protein WIG-1
p53-activated gene 608 protein
Gene namesi
Name:ZMAT3Imported
Synonyms:PAG608Imported, WIG1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000172667.10.
HGNCiHGNC:29983. ZMAT3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64393.
OpenTargetsiENSG00000172667.
PharmGKBiPA145147560.

Polymorphism and mutation databases

BioMutaiZMAT3.
DMDMi74734128.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003107791 – 289Zinc finger matrin-type protein 3Add BLAST289

Proteomic databases

EPDiQ9HA38.
MaxQBiQ9HA38.
PaxDbiQ9HA38.
PeptideAtlasiQ9HA38.
PRIDEiQ9HA38.

PTM databases

iPTMnetiQ9HA38.
PhosphoSitePlusiQ9HA38.

Expressioni

Tissue specificityi

Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine.1 Publication

Inductioni

By DNA damage in a p53/TP53-dependent manner. Up-regulated following ionizing radiation in primary squamous cell carcinoma of the lung and in various colon cancer cell lines.2 Publications

Gene expression databases

BgeeiENSG00000172667.
CleanExiHS_ZMAT3.
ExpressionAtlasiQ9HA38. baseline and differential.
GenevisibleiQ9HA38. HS.

Organism-specific databases

HPAiHPA028671.
HPA054356.

Interactioni

Subunit structurei

Interacts with dsRNA.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122151. 28 interactors.
IntActiQ9HA38. 17 interactors.
MINTiMINT-6542853.
STRINGi9606.ENSP00000311221.

Structurei

3D structure databases

ProteinModelPortaliQ9HA38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri70 – 100Matrin-type 1Sequence analysisAdd BLAST31
Zinc fingeri147 – 177Matrin-type 2Sequence analysisAdd BLAST31
Zinc fingeri246 – 276Matrin-type 3Sequence analysisAdd BLAST31

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHBJ. Eukaryota.
ENOG4110YZS. LUCA.
GeneTreeiENSGT00730000111202.
HOGENOMiHOG000065751.
HOVERGENiHBG052765.
InParanoidiQ9HA38.
KOiK10137.
OMAiQGKNHSK.
OrthoDBiEOG091G07L6.
PhylomeDBiQ9HA38.
TreeFamiTF350019.

Family and domain databases

InterProiView protein in InterPro
IPR003604. Matrin/U1-like-C_Znf_C2H2.
IPR022755. Znf_C2H2_jaz.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF12171. zf-C2H2_jaz. 1 hit.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 3 hits.
SM00451. ZnF_U1. 3 hits.
SUPFAMiSSF57667. SSF57667. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HA38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MILLQHAVLP PPKQPSPSPP MSVATRSTGT LQLPPQKPFG QEASLPLAGE
60 70 80 90 100
EELSKGGEQD CALEELCKPL YCKLCNVTLN SAQQAQAHYQ GKNHGKKLRN
110 120 130 140 150
YYAANSCPPP ARMSNVVEPA ATPVVPVPPQ MGSFKPGGRV ILATENDYCK
160 170 180 190 200
LCDASFSSPA VAQAHYQGKN HAKRLRLAEA QSNSFSESSE LGQRRARKEG
210 220 230 240 250
NEFKMMPNRR NMYTVQNNSA GPYFNPRSRQ RIPRDLAMCV TPSGQFYCSM
260 270 280
CNVGAGEEME FRQHLESKQH KSKVSEQRYR NEMENLGYV
Length:289
Mass (Da):32,059
Last modified:March 1, 2001 - v1
Checksum:iCF3CAB0AA51DDD29
GO
Isoform 2 (identifier: Q9HA38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-220: Missing.

Show »
Length:288
Mass (Da):31,988
Checksum:i3699244082C0DE11
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040093220Missing in isoform 2. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF355465 mRNA. Translation: AAK83287.1.
AY037945 mRNA. Translation: AAK71491.1.
AK022358 mRNA. Translation: BAB14020.1.
AK122768 mRNA. Translation: BAG53718.1.
AC117456 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78424.1.
CH471052 Genomic DNA. Translation: EAW78426.1.
CH471052 Genomic DNA. Translation: EAW78425.1.
BC002896 mRNA. Translation: AAH02896.1.
CCDSiCCDS3224.1. [Q9HA38-1]
CCDS46962.1. [Q9HA38-2]
RefSeqiNP_071915.1. NM_022470.3. [Q9HA38-1]
NP_689426.1. NM_152240.2. [Q9HA38-2]
XP_005247763.1. XM_005247706.2. [Q9HA38-2]
XP_011511375.1. XM_011513073.1. [Q9HA38-1]
UniGeneiHs.371609.

Genome annotation databases

EnsembliENST00000311417; ENSP00000311221; ENSG00000172667. [Q9HA38-1]
ENST00000432729; ENSP00000396506; ENSG00000172667. [Q9HA38-2]
GeneIDi64393.
KEGGihsa:64393.
UCSCiuc003fjg.5. human. [Q9HA38-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZMAT3_HUMAN
AccessioniPrimary (citable) accession number: Q9HA38
Secondary accession number(s): B3KVA6, D3DNR1, Q96A21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2001
Last modified: September 27, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot