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Protein

Zinc finger matrin-type protein 3

Gene

ZMAT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri70 – 10031Matrin-type 1Sequence AnalysisAdd
BLAST
Zinc fingeri147 – 17731Matrin-type 2Sequence AnalysisAdd
BLAST
Zinc fingeri246 – 27631Matrin-type 3Sequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cellular response to DNA damage stimulus Source: UniProtKB-KW
  3. positive regulation of apoptotic process Source: Ensembl
  4. protein transport Source: UniProtKB-KW
  5. regulation of growth Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, DNA damage, Growth regulation, Protein transport, Translocation, Transport

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger matrin-type protein 3
Alternative name(s):
Zinc finger protein WIG-1
p53-activated gene 608 protein
Gene namesi
Name:ZMAT3Imported
Synonyms:PAG608Imported, WIG1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:29983. ZMAT3.

Subcellular locationi

Nucleus 1 Publication. Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145147560.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Zinc finger matrin-type protein 3PRO_0000310779Add
BLAST

Proteomic databases

MaxQBiQ9HA38.
PaxDbiQ9HA38.
PRIDEiQ9HA38.

PTM databases

PhosphoSiteiQ9HA38.

Expressioni

Tissue specificityi

Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine.1 Publication

Inductioni

By DNA damage in a p53/TP53-dependent manner. Up-regulated following ionizing radiation in primary squamous cell carcinoma of the lung and in various colon cancer cell lines.2 Publications

Gene expression databases

BgeeiQ9HA38.
CleanExiHS_ZMAT3.
ExpressionAtlasiQ9HA38. baseline and differential.
GenevestigatoriQ9HA38.

Interactioni

Subunit structurei

Interacts with dsRNA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AGO2Q9UKV85EBI-2548480,EBI-528269
DHX9Q082113EBI-2548480,EBI-352022
HNRNPA2B1P226263EBI-2548480,EBI-299649

Protein-protein interaction databases

BioGridi122151. 19 interactions.
IntActiQ9HA38. 5 interactions.
MINTiMINT-6542853.
STRINGi9606.ENSP00000311221.

Structurei

3D structure databases

ProteinModelPortaliQ9HA38.
SMRiQ9HA38. Positions 72-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 matrin-type zinc fingers.Sequence Analysis

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri70 – 10031Matrin-type 1Sequence AnalysisAdd
BLAST
Zinc fingeri147 – 17731Matrin-type 2Sequence AnalysisAdd
BLAST
Zinc fingeri246 – 27631Matrin-type 3Sequence AnalysisAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG77347.
GeneTreeiENSGT00730000111202.
HOGENOMiHOG000065751.
HOVERGENiHBG052765.
InParanoidiQ9HA38.
KOiK10137.
OMAiNNTGPYF.
OrthoDBiEOG7DJSMX.
PhylomeDBiQ9HA38.
TreeFamiTF350019.

Family and domain databases

InterProiIPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
SM00451. ZnF_U1. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9HA38-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MILLQHAVLP PPKQPSPSPP MSVATRSTGT LQLPPQKPFG QEASLPLAGE
60 70 80 90 100
EELSKGGEQD CALEELCKPL YCKLCNVTLN SAQQAQAHYQ GKNHGKKLRN
110 120 130 140 150
YYAANSCPPP ARMSNVVEPA ATPVVPVPPQ MGSFKPGGRV ILATENDYCK
160 170 180 190 200
LCDASFSSPA VAQAHYQGKN HAKRLRLAEA QSNSFSESSE LGQRRARKEG
210 220 230 240 250
NEFKMMPNRR NMYTVQNNSA GPYFNPRSRQ RIPRDLAMCV TPSGQFYCSM
260 270 280
CNVGAGEEME FRQHLESKQH KSKVSEQRYR NEMENLGYV
Length:289
Mass (Da):32,059
Last modified:March 1, 2001 - v1
Checksum:iCF3CAB0AA51DDD29
GO
Isoform 2 (identifier: Q9HA38-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-220: Missing.

Show »
Length:288
Mass (Da):31,988
Checksum:i3699244082C0DE11
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei220 – 2201Missing in isoform 2. 3 PublicationsVSP_040093

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF355465 mRNA. Translation: AAK83287.1.
AY037945 mRNA. Translation: AAK71491.1.
AK022358 mRNA. Translation: BAB14020.1.
AK122768 mRNA. Translation: BAG53718.1.
AC117456 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78424.1.
CH471052 Genomic DNA. Translation: EAW78426.1.
CH471052 Genomic DNA. Translation: EAW78425.1.
BC002896 mRNA. Translation: AAH02896.1.
CCDSiCCDS3224.1. [Q9HA38-1]
CCDS46962.1. [Q9HA38-2]
RefSeqiNP_071915.1. NM_022470.3. [Q9HA38-1]
NP_689426.1. NM_152240.2. [Q9HA38-2]
XP_005247763.1. XM_005247706.1. [Q9HA38-2]
XP_006713788.1. XM_006713725.1. [Q9HA38-1]
XP_006713789.1. XM_006713726.1. [Q9HA38-2]
UniGeneiHs.371609.

Genome annotation databases

EnsembliENST00000311417; ENSP00000311221; ENSG00000172667. [Q9HA38-1]
ENST00000432729; ENSP00000396506; ENSG00000172667. [Q9HA38-2]
GeneIDi64393.
KEGGihsa:64393.
UCSCiuc003fjg.3. human. [Q9HA38-1]
uc003fji.3. human. [Q9HA38-2]

Polymorphism databases

DMDMi74734128.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF355465 mRNA. Translation: AAK83287.1.
AY037945 mRNA. Translation: AAK71491.1.
AK022358 mRNA. Translation: BAB14020.1.
AK122768 mRNA. Translation: BAG53718.1.
AC117456 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78424.1.
CH471052 Genomic DNA. Translation: EAW78426.1.
CH471052 Genomic DNA. Translation: EAW78425.1.
BC002896 mRNA. Translation: AAH02896.1.
CCDSiCCDS3224.1. [Q9HA38-1]
CCDS46962.1. [Q9HA38-2]
RefSeqiNP_071915.1. NM_022470.3. [Q9HA38-1]
NP_689426.1. NM_152240.2. [Q9HA38-2]
XP_005247763.1. XM_005247706.1. [Q9HA38-2]
XP_006713788.1. XM_006713725.1. [Q9HA38-1]
XP_006713789.1. XM_006713726.1. [Q9HA38-2]
UniGeneiHs.371609.

3D structure databases

ProteinModelPortaliQ9HA38.
SMRiQ9HA38. Positions 72-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122151. 19 interactions.
IntActiQ9HA38. 5 interactions.
MINTiMINT-6542853.
STRINGi9606.ENSP00000311221.

PTM databases

PhosphoSiteiQ9HA38.

Polymorphism databases

DMDMi74734128.

Proteomic databases

MaxQBiQ9HA38.
PaxDbiQ9HA38.
PRIDEiQ9HA38.

Protocols and materials databases

DNASUi64393.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311417; ENSP00000311221; ENSG00000172667. [Q9HA38-1]
ENST00000432729; ENSP00000396506; ENSG00000172667. [Q9HA38-2]
GeneIDi64393.
KEGGihsa:64393.
UCSCiuc003fjg.3. human. [Q9HA38-1]
uc003fji.3. human. [Q9HA38-2]

Organism-specific databases

CTDi64393.
GeneCardsiGC03M178735.
HGNCiHGNC:29983. ZMAT3.
MIMi606452. gene.
neXtProtiNX_Q9HA38.
PharmGKBiPA145147560.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG77347.
GeneTreeiENSGT00730000111202.
HOGENOMiHOG000065751.
HOVERGENiHBG052765.
InParanoidiQ9HA38.
KOiK10137.
OMAiNNTGPYF.
OrthoDBiEOG7DJSMX.
PhylomeDBiQ9HA38.
TreeFamiTF350019.

Miscellaneous databases

ChiTaRSiZMAT3. human.
GenomeRNAii64393.
NextBioi66321.
PROiQ9HA38.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HA38.
CleanExiHS_ZMAT3.
ExpressionAtlasiQ9HA38. baseline and differential.
GenevestigatoriQ9HA38.

Family and domain databases

InterProiIPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
SM00451. ZnF_U1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosomal localization of human WIG-1/PAG608 and demonstration of amplification with increased expression in primary squamous cell carcinoma of the lung."
    Varmeh-Ziaie S., Ichimura K., Yang F., Rabbits P., Collins V.P.
    Cancer Lett. 174:179-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INDUCTION.
  2. "Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein."
    Hellborg F., Qian W., Mendez-Vidal C., Asker C., Kost-Alimova M., Wilhelm M., Imreh S., Wiman K.G.
    Oncogene 20:5466-5474(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
    Tissue: TestisImported.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Mammary glandImported.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung carcinomaImported.
  7. "The p53-induced Wig-1 protein binds double-stranded RNAs with structural characteristics of siRNAs and miRNAs."
    Mendez Vidal C., Prahl M., Wiman K.G.
    FEBS Lett. 580:4401-4408(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.

Entry informationi

Entry nameiZMAT3_HUMAN
AccessioniPrimary (citable) accession number: Q9HA38
Secondary accession number(s): B3KVA6, D3DNR1, Q96A21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2001
Last modified: February 4, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.