Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9HA38

- ZMAT3_HUMAN

UniProt

Q9HA38 - ZMAT3_HUMAN

Protein

Zinc finger matrin-type protein 3

Gene

ZMAT3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri70 – 10031Matrin-type 1Sequence AnalysisAdd
    BLAST
    Zinc fingeri147 – 17731Matrin-type 2Sequence AnalysisAdd
    BLAST
    Zinc fingeri246 – 27631Matrin-type 3Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. cellular response to DNA damage stimulus Source: UniProtKB-KW
    3. positive regulation of apoptotic process Source: Ensembl
    4. protein transport Source: UniProtKB-KW
    5. regulation of growth Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis, DNA damage, Growth regulation, Protein transport, Translocation, Transport

    Keywords - Ligandi

    Metal-binding, RNA-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger matrin-type protein 3
    Alternative name(s):
    Zinc finger protein WIG-1
    p53-activated gene 608 protein
    Gene namesi
    Name:ZMAT3Imported
    Synonyms:PAG608Imported, WIG1Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:29983. ZMAT3.

    Subcellular locationi

    Nucleus 1 Publication. Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145147560.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Zinc finger matrin-type protein 3PRO_0000310779Add
    BLAST

    Proteomic databases

    MaxQBiQ9HA38.
    PaxDbiQ9HA38.
    PRIDEiQ9HA38.

    PTM databases

    PhosphoSiteiQ9HA38.

    Expressioni

    Tissue specificityi

    Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine.1 Publication

    Inductioni

    By DNA damage in a p53/TP53-dependent manner. Up-regulated following ionizing radiation in primary squamous cell carcinoma of the lung and in various colon cancer cell lines.2 Publications

    Gene expression databases

    ArrayExpressiQ9HA38.
    BgeeiQ9HA38.
    CleanExiHS_ZMAT3.
    GenevestigatoriQ9HA38.

    Interactioni

    Subunit structurei

    Interacts with dsRNA.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AGO2Q9UKV85EBI-2548480,EBI-528269
    DHX9Q082113EBI-2548480,EBI-352022
    HNRNPA2B1P226263EBI-2548480,EBI-299649

    Protein-protein interaction databases

    BioGridi122151. 9 interactions.
    IntActiQ9HA38. 5 interactions.
    MINTiMINT-6542853.
    STRINGi9606.ENSP00000311221.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HA38.
    SMRiQ9HA38. Positions 69-179, 247-279.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 matrin-type zinc fingers.Sequence Analysis

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri70 – 10031Matrin-type 1Sequence AnalysisAdd
    BLAST
    Zinc fingeri147 – 17731Matrin-type 2Sequence AnalysisAdd
    BLAST
    Zinc fingeri246 – 27631Matrin-type 3Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG77347.
    HOGENOMiHOG000065751.
    HOVERGENiHBG052765.
    InParanoidiQ9HA38.
    KOiK10137.
    OMAiNNTGPYF.
    OrthoDBiEOG7DJSMX.
    PhylomeDBiQ9HA38.
    TreeFamiTF350019.

    Family and domain databases

    InterProiIPR015880. Znf_C2H2-like.
    IPR022755. Znf_C2H2_jaz.
    IPR003604. Znf_U1.
    [Graphical view]
    PfamiPF12171. zf-C2H2_jaz. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    SM00451. ZnF_U1. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HA38-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MILLQHAVLP PPKQPSPSPP MSVATRSTGT LQLPPQKPFG QEASLPLAGE    50
    EELSKGGEQD CALEELCKPL YCKLCNVTLN SAQQAQAHYQ GKNHGKKLRN 100
    YYAANSCPPP ARMSNVVEPA ATPVVPVPPQ MGSFKPGGRV ILATENDYCK 150
    LCDASFSSPA VAQAHYQGKN HAKRLRLAEA QSNSFSESSE LGQRRARKEG 200
    NEFKMMPNRR NMYTVQNNSA GPYFNPRSRQ RIPRDLAMCV TPSGQFYCSM 250
    CNVGAGEEME FRQHLESKQH KSKVSEQRYR NEMENLGYV 289
    Length:289
    Mass (Da):32,059
    Last modified:March 1, 2001 - v1
    Checksum:iCF3CAB0AA51DDD29
    GO
    Isoform 2 (identifier: Q9HA38-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         220-220: Missing.

    Show »
    Length:288
    Mass (Da):31,988
    Checksum:i3699244082C0DE11
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei220 – 2201Missing in isoform 2. 3 PublicationsVSP_040093

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF355465 mRNA. Translation: AAK83287.1.
    AY037945 mRNA. Translation: AAK71491.1.
    AK022358 mRNA. Translation: BAB14020.1.
    AK122768 mRNA. Translation: BAG53718.1.
    AC117456 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78424.1.
    CH471052 Genomic DNA. Translation: EAW78426.1.
    CH471052 Genomic DNA. Translation: EAW78425.1.
    BC002896 mRNA. Translation: AAH02896.1.
    CCDSiCCDS3224.1. [Q9HA38-1]
    CCDS46962.1. [Q9HA38-2]
    RefSeqiNP_071915.1. NM_022470.3. [Q9HA38-1]
    NP_689426.1. NM_152240.2. [Q9HA38-2]
    XP_005247763.1. XM_005247706.1. [Q9HA38-2]
    XP_006713788.1. XM_006713725.1. [Q9HA38-1]
    XP_006713789.1. XM_006713726.1. [Q9HA38-2]
    UniGeneiHs.371609.

    Genome annotation databases

    EnsembliENST00000311417; ENSP00000311221; ENSG00000172667. [Q9HA38-1]
    ENST00000432729; ENSP00000396506; ENSG00000172667. [Q9HA38-2]
    GeneIDi64393.
    KEGGihsa:64393.
    UCSCiuc003fjg.3. human. [Q9HA38-1]
    uc003fji.3. human. [Q9HA38-2]

    Polymorphism databases

    DMDMi74734128.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF355465 mRNA. Translation: AAK83287.1 .
    AY037945 mRNA. Translation: AAK71491.1 .
    AK022358 mRNA. Translation: BAB14020.1 .
    AK122768 mRNA. Translation: BAG53718.1 .
    AC117456 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78424.1 .
    CH471052 Genomic DNA. Translation: EAW78426.1 .
    CH471052 Genomic DNA. Translation: EAW78425.1 .
    BC002896 mRNA. Translation: AAH02896.1 .
    CCDSi CCDS3224.1. [Q9HA38-1 ]
    CCDS46962.1. [Q9HA38-2 ]
    RefSeqi NP_071915.1. NM_022470.3. [Q9HA38-1 ]
    NP_689426.1. NM_152240.2. [Q9HA38-2 ]
    XP_005247763.1. XM_005247706.1. [Q9HA38-2 ]
    XP_006713788.1. XM_006713725.1. [Q9HA38-1 ]
    XP_006713789.1. XM_006713726.1. [Q9HA38-2 ]
    UniGenei Hs.371609.

    3D structure databases

    ProteinModelPortali Q9HA38.
    SMRi Q9HA38. Positions 69-179, 247-279.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122151. 9 interactions.
    IntActi Q9HA38. 5 interactions.
    MINTi MINT-6542853.
    STRINGi 9606.ENSP00000311221.

    PTM databases

    PhosphoSitei Q9HA38.

    Polymorphism databases

    DMDMi 74734128.

    Proteomic databases

    MaxQBi Q9HA38.
    PaxDbi Q9HA38.
    PRIDEi Q9HA38.

    Protocols and materials databases

    DNASUi 64393.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311417 ; ENSP00000311221 ; ENSG00000172667 . [Q9HA38-1 ]
    ENST00000432729 ; ENSP00000396506 ; ENSG00000172667 . [Q9HA38-2 ]
    GeneIDi 64393.
    KEGGi hsa:64393.
    UCSCi uc003fjg.3. human. [Q9HA38-1 ]
    uc003fji.3. human. [Q9HA38-2 ]

    Organism-specific databases

    CTDi 64393.
    GeneCardsi GC03M178735.
    HGNCi HGNC:29983. ZMAT3.
    MIMi 606452. gene.
    neXtProti NX_Q9HA38.
    PharmGKBi PA145147560.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG77347.
    HOGENOMi HOG000065751.
    HOVERGENi HBG052765.
    InParanoidi Q9HA38.
    KOi K10137.
    OMAi NNTGPYF.
    OrthoDBi EOG7DJSMX.
    PhylomeDBi Q9HA38.
    TreeFami TF350019.

    Miscellaneous databases

    GenomeRNAii 64393.
    NextBioi 66321.
    PROi Q9HA38.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HA38.
    Bgeei Q9HA38.
    CleanExi HS_ZMAT3.
    Genevestigatori Q9HA38.

    Family and domain databases

    InterProi IPR015880. Znf_C2H2-like.
    IPR022755. Znf_C2H2_jaz.
    IPR003604. Znf_U1.
    [Graphical view ]
    Pfami PF12171. zf-C2H2_jaz. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    SM00451. ZnF_U1. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and chromosomal localization of human WIG-1/PAG608 and demonstration of amplification with increased expression in primary squamous cell carcinoma of the lung."
      Varmeh-Ziaie S., Ichimura K., Yang F., Rabbits P., Collins V.P.
      Cancer Lett. 174:179-187(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INDUCTION.
    2. "Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein."
      Hellborg F., Qian W., Mendez-Vidal C., Asker C., Kost-Alimova M., Wilhelm M., Imreh S., Wiman K.G.
      Oncogene 20:5466-5474(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
      Tissue: TestisImported.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Mammary glandImported.
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung carcinomaImported.
    7. "The p53-induced Wig-1 protein binds double-stranded RNAs with structural characteristics of siRNAs and miRNAs."
      Mendez Vidal C., Prahl M., Wiman K.G.
      FEBS Lett. 580:4401-4408(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.

    Entry informationi

    Entry nameiZMAT3_HUMAN
    AccessioniPrimary (citable) accession number: Q9HA38
    Secondary accession number(s): B3KVA6, D3DNR1, Q96A21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3