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Q9HA38 (ZMAT3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger matrin-type protein 3
Alternative name(s):
Zinc finger protein WIG-1
p53-activated gene 608 protein
Gene names
Name:ZMAT3
Synonyms:PAG608, WIG1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus. Ref.2

Subunit structure

Interacts with dsRNA. Ref.7

Subcellular location

Nucleus. Nucleusnucleolus Ref.2 UniProtKB O08781.

Tissue specificity

Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine. Ref.1

Induction

By DNA damage in a p53/TP53-dependent manner. Up-regulated following ionizing radiation in primary squamous cell carcinoma of the lung and in various colon cancer cell lines. Ref.1 Ref.2

Sequence similarities

Contains 3 matrin-type zinc fingers.

Binary interactions

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9HA38-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9HA38-2)

The sequence of this isoform differs from the canonical sequence as follows:
     220-220: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Zinc finger matrin-type protein 3
PRO_0000310779

Regions

Zinc finger70 – 10031Matrin-type 1
Zinc finger147 – 17731Matrin-type 2
Zinc finger246 – 27631Matrin-type 3

Natural variations

Alternative sequence2201Missing in isoform 2.
VSP_040093

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: CF3CAB0AA51DDD29

FASTA28932,059
        10         20         30         40         50         60 
MILLQHAVLP PPKQPSPSPP MSVATRSTGT LQLPPQKPFG QEASLPLAGE EELSKGGEQD 

        70         80         90        100        110        120 
CALEELCKPL YCKLCNVTLN SAQQAQAHYQ GKNHGKKLRN YYAANSCPPP ARMSNVVEPA 

       130        140        150        160        170        180 
ATPVVPVPPQ MGSFKPGGRV ILATENDYCK LCDASFSSPA VAQAHYQGKN HAKRLRLAEA 

       190        200        210        220        230        240 
QSNSFSESSE LGQRRARKEG NEFKMMPNRR NMYTVQNNSA GPYFNPRSRQ RIPRDLAMCV 

       250        260        270        280 
TPSGQFYCSM CNVGAGEEME FRQHLESKQH KSKVSEQRYR NEMENLGYV 

« Hide

Isoform 2 [UniParc].

Checksum: 3699244082C0DE11
Show »

FASTA28831,988

References

« Hide 'large scale' references
[1]"Cloning and chromosomal localization of human WIG-1/PAG608 and demonstration of amplification with increased expression in primary squamous cell carcinoma of the lung."
Varmeh-Ziaie S., Ichimura K., Yang F., Rabbits P., Collins V.P.
Cancer Lett. 174:179-187(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INDUCTION.
[2]"Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein."
Hellborg F., Qian W., Mendez-Vidal C., Asker C., Kost-Alimova M., Wilhelm M., Imreh S., Wiman K.G.
Oncogene 20:5466-5474(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
Tissue: Testis.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Mammary gland.
[4]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung carcinoma.
[7]"The p53-induced Wig-1 protein binds double-stranded RNAs with structural characteristics of siRNAs and miRNAs."
Mendez Vidal C., Prahl M., Wiman K.G.
FEBS Lett. 580:4401-4408(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF355465 mRNA. Translation: AAK83287.1.
AY037945 mRNA. Translation: AAK71491.1.
AK022358 mRNA. Translation: BAB14020.1.
AK122768 mRNA. Translation: BAG53718.1.
AC117456 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78424.1.
CH471052 Genomic DNA. Translation: EAW78426.1.
CH471052 Genomic DNA. Translation: EAW78425.1.
BC002896 mRNA. Translation: AAH02896.1.
RefSeqNP_071915.1. NM_022470.3.
NP_689426.1. NM_152240.2.
XP_005247763.1. XM_005247706.1.
UniGeneHs.371609.

3D structure databases

ProteinModelPortalQ9HA38.
SMRQ9HA38. Positions 39-179, 244-285.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122151. 9 interactions.
IntActQ9HA38. 5 interactions.
MINTMINT-6542853.
STRING9606.ENSP00000311221.

PTM databases

PhosphoSiteQ9HA38.

Polymorphism databases

DMDM74734128.

Proteomic databases

PaxDbQ9HA38.
PRIDEQ9HA38.

Protocols and materials databases

DNASU64393.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000311417; ENSP00000311221; ENSG00000172667. [Q9HA38-1]
ENST00000432729; ENSP00000396506; ENSG00000172667. [Q9HA38-2]
GeneID64393.
KEGGhsa:64393.
UCSCuc003fjg.3. human. [Q9HA38-1]
uc003fji.3. human. [Q9HA38-2]

Organism-specific databases

CTD64393.
GeneCardsGC03M178735.
HGNCHGNC:29983. ZMAT3.
MIM606452. gene.
neXtProtNX_Q9HA38.
PharmGKBPA145147560.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG77347.
HOGENOMHOG000065751.
HOVERGENHBG052765.
InParanoidQ9HA38.
KOK10137.
OMAMILLQHT.
OrthoDBEOG7DJSMX.
PhylomeDBQ9HA38.
TreeFamTF350019.

Gene expression databases

ArrayExpressQ9HA38.
BgeeQ9HA38.
CleanExHS_ZMAT3.
GenevestigatorQ9HA38.

Family and domain databases

InterProIPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
IPR003604. Znf_U1.
[Graphical view]
PfamPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 3 hits.
SM00451. ZnF_U1. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi64393.
NextBio66321.
PROQ9HA38.
SOURCESearch...

Entry information

Entry nameZMAT3_HUMAN
AccessionPrimary (citable) accession number: Q9HA38
Secondary accession number(s): B3KVA6, D3DNR1, Q96A21
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM