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Q9H9Z2

- LN28A_HUMAN

UniProt

Q9H9Z2 - LN28A_HUMAN

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Protein

Protein lin-28 homolog A

Gene

LIN28A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.By similarity2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri137 – 15418CCHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri159 – 17618CCHC-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. miRNA binding Source: Ensembl
  3. mRNA binding Source: Ensembl
  4. RNA binding Source: UniProtKB
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. germ cell development Source: Ensembl
  2. miRNA catabolic process Source: UniProtKB
  3. negative regulation of glial cell differentiation Source: Ensembl
  4. positive regulation of neuron differentiation Source: Ensembl
  5. positive regulation of translation Source: Ensembl
  6. pre-miRNA processing Source: UniProtKB
  7. regulation of gene silencing by miRNA Source: Ensembl
  8. regulation of transcription, DNA-templated Source: InterPro
  9. RNA 3'-end processing Source: UniProtKB
  10. stem cell maintenance Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

RNA-mediated gene silencing

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_200812. Transcriptional regulation of pluripotent stem cells.
SignaLinkiQ9H9Z2.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-28 homolog A
Short name:
Lin-28A
Alternative name(s):
Zinc finger CCHC domain-containing protein 1
Gene namesi
Name:LIN28A
Synonyms:CSDD1, LIN28, ZCCHC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:15986. LIN28A.

Subcellular locationi

Cytoplasm. Nucleusnucleolus
Note: Nucleolar localization observed in 10-15% of the nuclei in differentiated myotubes (By similarity). Shuttles between the cytoplasm and the nucleus. Localizes to cytoplasmic processing bodies and stress granules.By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytoplasmic mRNA processing body Source: UniProtKB
  3. cytoplasmic stress granule Source: UniProtKB
  4. nucleolus Source: Ensembl
  5. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi46 – 461W → A: Does not affect localization to cytoplasmic processing bodies; when associated with A-55 and A-73. 1 Publication
Mutagenesisi55 – 551F → A: Does not affect localization to cytoplasmic processing bodies; when associated with A-46 and A-73. 1 Publication
Mutagenesisi73 – 731F → A: Does not affect localization to cytoplasmic processing bodies; when associated with A-46 and A-55. 1 Publication
Mutagenesisi147 – 1471H → A: Abolishes ability to suppress pre-let-7 biogenesis and localization to cytoplasmic processing bodies without affecting pre-let-7 binding; when associated with A-169. 2 Publications
Mutagenesisi169 – 1691H → A: Abolishes ability to suppress pre-let-7 biogenesis and localization to cytoplasmic processing bodies without affecting pre-let-7 binding; when associated with A-147. 2 Publications

Organism-specific databases

PharmGKBiPA165751523.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 209208Protein lin-28 homolog APRO_0000253787Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine2 Publications
Modified residuei3 – 31Phosphoserine1 Publication
Modified residuei120 – 1201Phosphoserine1 Publication
Modified residuei200 – 2001Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9H9Z2.
PRIDEiQ9H9Z2.

PTM databases

PhosphoSiteiQ9H9Z2.

Expressioni

Tissue specificityi

Expressed in embryonic stem cells (ES cells), placenta and testis.3 Publications

Developmental stagei

Expressed in fetal liver. Expression decreases during differentiation of ES cells or upon induction of neuronal differentiation by retinoic acid.3 Publications

Inductioni

Can be negatively regulated by the interaction of microRNAs miR-125a and miR-125b with at least two miRNA responsive elements (miREs) in the 3'-UTR of this gene. These interactions may reduce both translation efficiency and mRNA abundance. Negatively regulated by retinoic acid.2 Publications

Gene expression databases

BgeeiQ9H9Z2.
CleanExiHS_LIN28.
GenevestigatoriQ9H9Z2.

Organism-specific databases

HPAiCAB020785.

Interactioni

Subunit structurei

Monomer. During skeletal muscle differentiation, associated with translation initiation complexes in the polysomal compartment. Directly interacts with EIF3S2. Interaction with NCL is RNA-dependent (By similarity). Interacts with ZCCHC11/TUT4.By similarity2 Publications

Protein-protein interaction databases

BioGridi122842. 84 interactions.
IntActiQ9H9Z2. 2 interactions.
STRINGi9606.ENSP00000254231.

Structurei

Secondary structure

1
209
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi140 – 1423
Beta strandi145 – 1473
Turni149 – 1513
Turni162 – 1643
Beta strandi167 – 1693
Turni171 – 1733
Helixi176 – 1783

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CQFNMR-A137-186[»]
2LI8NMR-A124-186[»]
ProteinModelPortaliQ9H9Z2.
SMRiQ9H9Z2. Positions 34-186.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H9Z2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 11274CSDAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni113 – 13624Flexible linkerAdd
BLAST

Domaini

The CSD domain is required for function in muscle differentiation.By similarity
The CCHC zinc fingers interact with the GGAG motif at the 3' end of let-7 miRNAs precursors, more generally they bind the 5'-NGNNG-3' consensus motif with micromolar affinity. The CSD domain recognizes the loop at the 5' end. The flexible linker allows accommodating variable sequences and lengths among let-7 family members.

Sequence similaritiesi

Belongs to the lin-28 family.Curated
Contains 2 CCHC-type zinc fingers.PROSITE-ProRule annotation
Contains 1 CSD (cold-shock) domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri137 – 15418CCHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri159 – 17618CCHC-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG244191.
GeneTreeiENSGT00390000001177.
HOGENOMiHOG000047091.
HOVERGENiHBG081922.
InParanoidiQ9H9Z2.
OMAiSGICKWF.
OrthoDBiEOG72JWJ8.
PhylomeDBiQ9H9Z2.
TreeFamiTF316240.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
PRINTSiPR00050. COLDSHOCK.
SMARTiSM00357. CSP. 1 hit.
SM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H9Z2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSVSNQQFA GGCAKAAEEA PEEAPEDAAR AADEPQLLHG AGICKWFNVR
60 70 80 90 100
MGFGFLSMTA RAGVALDPPV DVFVHQSKLH MEGFRSLKEG EAVEFTFKKS
110 120 130 140 150
AKGLESIRVT GPGGVFCIGS ERRPKGKSMQ KRRSKGDRCY NCGGLDHHAK
160 170 180 190 200
ECKLPPQPKK CHFCQSISHM VASCPLKAQQ GPSAQGKPTY FREEEEEIHS

PTLLPEAQN
Length:209
Mass (Da):22,743
Last modified:March 1, 2001 - v1
Checksum:iFA5EF6DD33FABF54
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF521099 mRNA. Translation: AAM77751.1.
AK022519 mRNA. Translation: BAB14075.1.
AL513365 Genomic DNA. Translation: CAI21500.1.
BC028566 mRNA. Translation: AAH28566.1.
CCDSiCCDS280.1.
RefSeqiNP_078950.1. NM_024674.4.
XP_006710962.1. XM_006710899.1.
XP_006710963.1. XM_006710900.1.
UniGeneiHs.86154.

Genome annotation databases

EnsembliENST00000254231; ENSP00000254231; ENSG00000131914.
ENST00000326279; ENSP00000363314; ENSG00000131914.
GeneIDi79727.
KEGGihsa:79727.
UCSCiuc001bmj.3. human.

Polymorphism databases

DMDMi74752750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF521099 mRNA. Translation: AAM77751.1 .
AK022519 mRNA. Translation: BAB14075.1 .
AL513365 Genomic DNA. Translation: CAI21500.1 .
BC028566 mRNA. Translation: AAH28566.1 .
CCDSi CCDS280.1.
RefSeqi NP_078950.1. NM_024674.4.
XP_006710962.1. XM_006710899.1.
XP_006710963.1. XM_006710900.1.
UniGenei Hs.86154.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CQF NMR - A 137-186 [» ]
2LI8 NMR - A 124-186 [» ]
ProteinModelPortali Q9H9Z2.
SMRi Q9H9Z2. Positions 34-186.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122842. 84 interactions.
IntActi Q9H9Z2. 2 interactions.
STRINGi 9606.ENSP00000254231.

PTM databases

PhosphoSitei Q9H9Z2.

Polymorphism databases

DMDMi 74752750.

Proteomic databases

PaxDbi Q9H9Z2.
PRIDEi Q9H9Z2.

Protocols and materials databases

DNASUi 79727.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000254231 ; ENSP00000254231 ; ENSG00000131914 .
ENST00000326279 ; ENSP00000363314 ; ENSG00000131914 .
GeneIDi 79727.
KEGGi hsa:79727.
UCSCi uc001bmj.3. human.

Organism-specific databases

CTDi 79727.
GeneCardsi GC01P026737.
HGNCi HGNC:15986. LIN28A.
HPAi CAB020785.
MIMi 611043. gene.
neXtProti NX_Q9H9Z2.
PharmGKBi PA165751523.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG244191.
GeneTreei ENSGT00390000001177.
HOGENOMi HOG000047091.
HOVERGENi HBG081922.
InParanoidi Q9H9Z2.
OMAi SGICKWF.
OrthoDBi EOG72JWJ8.
PhylomeDBi Q9H9Z2.
TreeFami TF316240.

Enzyme and pathway databases

Reactomei REACT_200812. Transcriptional regulation of pluripotent stem cells.
SignaLinki Q9H9Z2.

Miscellaneous databases

EvolutionaryTracei Q9H9Z2.
GeneWikii LIN28.
GenomeRNAii 79727.
NextBioi 69098.
PROi Q9H9Z2.
SOURCEi Search...

Gene expression databases

Bgeei Q9H9Z2.
CleanExi HS_LIN28.
Genevestigatori Q9H9Z2.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
4.10.60.10. 1 hit.
InterProi IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
IPR001878. Znf_CCHC.
[Graphical view ]
Pfami PF00313. CSD. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view ]
PRINTSi PR00050. COLDSHOCK.
SMARTi SM00357. CSP. 1 hit.
SM00343. ZnF_C2HC. 2 hits.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEi PS50158. ZF_CCHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites."
    Moss E.G., Tang L.
    Dev. Biol. 258:432-442(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Erratum
    Moss E.G., Tang L.
    Dev. Biol. 262:361-361(2003)
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  6. "Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation."
    Sempere L.F., Freemantle S., Pitha-Rowe I., Moss E.G., Dmitrovsky E., Ambros V.
    Genome Biol. 5:R13.1-R13.11(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  7. "The transcriptome profile of human embryonic stem cells as defined by SAGE."
    Richards M., Tan S.-P., Tan J.-H., Chan W.-K., Bongso A.
    Stem Cells 22:51-64(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  8. "Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells."
    Gerecht-Nir S., Dazard J.-E., Golan-Mashiach M., Osenberg S., Botvinnik A., Amariglio N., Domany E., Rechavi G., Givol D., Itskovitz-Eldor J.
    Dev. Dyn. 232:487-497(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  9. "Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation."
    Lee Y.S., Kim H.K., Chung S., Kim K.-S., Dutta A.
    J. Biol. Chem. 280:16635-16641(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  10. "Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells."
    Wu L., Belasco J.G.
    Mol. Cell. Biol. 25:9198-9208(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  11. "Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules."
    Balzer E., Moss E.G.
    RNA Biol. 4:16-25(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF TRP-46; PHE-55; PHE-73; HIS-147 AND HIS-169.
  12. "Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA."
    Heo I., Joo C., Cho J., Ha M., Han J., Kim V.N.
    Mol. Cell 32:276-284(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, RNA-BINDING, MUTAGENESIS OF HIS-147 AND HIS-169.
  13. "TUT4 in concert with Lin28 suppresses MicroRNA biogenesis through pre-microRNA uridylation."
    Heo I., Joo C., Kim Y.-K., Ha M., Yoon M.-J., Cho J., Yeom K.-H., Han J., Kim V.N.
    Cell 138:696-708(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, RNA-BINDING, INTERACTION WITH ZCCHC11.
  14. Cited for: POSSIBLE INVOLVEMENT IN CANCERS.
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3; SER-120 AND SER-200, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  16. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Solution structure of the zinc-finger domain in LIN-28."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 134-186.
  18. "Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28."
    Loughlin F.E., Gebert L.F., Towbin H., Brunschweiger A., Hall J., Allain F.H.
    Nat. Struct. Mol. Biol. 19:84-89(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 124-186 IN COMPLEX WITH SHORT RNA, CONSENSUS MOTIF.

Entry informationi

Entry nameiLN28A_HUMAN
AccessioniPrimary (citable) accession number: Q9H9Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Overexpressed in primary tumors (overall frequency approximately 15%), overexpression being linked to repression of let-7 family miRNAs and derepression of let-7 targets. Facilitates cellular transformation in vitro, and overexpression is associated with advanced disease across multiple tumor types.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3