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Q9H9Y4

- GPN2_HUMAN

UniProt

Q9H9Y4 - GPN2_HUMAN

Protein

GPN-loop GTPase 2

Gene

GPN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi16 – 238GTPSequence Analysis

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GPN-loop GTPase 2
    Alternative name(s):
    ATP-binding domain 1 family member B
    Gene namesi
    Name:GPN2
    Synonyms:ATPBD1B
    ORF Names:UNQ5828/PRO19647
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25513. GPN2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162390149.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 310309GPN-loop GTPase 2PRO_0000247829Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9H9Y4.
    PaxDbiQ9H9Y4.
    PRIDEiQ9H9Y4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H9Y4.
    BgeeiQ9H9Y4.
    CleanExiHS_GPN2.
    GenevestigatoriQ9H9Y4.

    Organism-specific databases

    HPAiHPA028059.

    Interactioni

    Protein-protein interaction databases

    BioGridi120104. 1 interaction.
    STRINGi9606.ENSP00000363250.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H9Y4.
    SMRiQ9H9Y4. Positions 10-202.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPN-loop GTPase family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000207661.
    HOVERGENiHBG054729.
    InParanoidiQ9H9Y4.
    KOiK06883.
    OMAiVELFTHH.
    OrthoDBiEOG72VH6M.
    PhylomeDBiQ9H9Y4.
    TreeFamiTF300828.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR004130. Uncharacterised_ATP-bd.
    [Graphical view]
    PfamiPF03029. ATP_bind_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9H9Y4-1 [UniParc]FASTAAdd to Basket

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    MAGAAPTTAF GQAVIGPPGS GKTTYCLGMS EFLRALGRRV AVVNLDPANE    50
    GLPYECAVDV GELVGLGDVM DALRLGPNGG LLYCMEYLEA NLDWLRAKLD 100
    PLRGHYFLFD CPGQVELCTH HGALRSIFSQ MAQWDLRLTA VHLVDSHYCT 150
    DPAKFISVLC TSLATMLHVE LPHINLLSKM DLIEHYGKLA FNLDYYTEVL 200
    DLSYLLDHLA SDPFFRHYRQ LNEKLVQLIE DYSLVSFIPL NIQDKESIQR 250
    VLQAVDKANG YCFRAQEQRS LEAMMSAAMG ADFHFSSTLG IQEKYLAPSN 300
    QSVEQEAMQL 310
    Length:310
    Mass (Da):34,561
    Last modified:July 25, 2006 - v2
    Checksum:iF73EAF808DA692CA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151I → T in AAQ76820. (PubMed:16533400)Curated
    Sequence conflicti15 – 151I → T in BAA91556. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti227 – 2271Q → R.1 Publication
    Corresponds to variant rs17856257 [ dbSNP | Ensembl ].
    VAR_027153
    Natural varianti264 – 2641R → G.3 Publications
    Corresponds to variant rs3170660 [ dbSNP | Ensembl ].
    VAR_027154

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY364261 mRNA. Translation: AAQ76820.1.
    AY358864 mRNA. Translation: AAQ89223.1.
    AK001211 mRNA. Translation: BAA91556.1.
    AK022535 mRNA. Translation: BAB14084.1.
    AL034380 Genomic DNA. Translation: CAB92117.1.
    BC007815 mRNA. Translation: AAH07815.1.
    BC008634 mRNA. Translation: AAH08634.1.
    CCDSiCCDS289.1.
    RefSeqiNP_060536.3. NM_018066.3.
    UniGeneiHs.14333.

    Genome annotation databases

    EnsembliENST00000374135; ENSP00000363250; ENSG00000142751.
    GeneIDi54707.
    KEGGihsa:54707.
    UCSCiuc001bnd.1. human.

    Polymorphism databases

    DMDMi110832767.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY364261 mRNA. Translation: AAQ76820.1 .
    AY358864 mRNA. Translation: AAQ89223.1 .
    AK001211 mRNA. Translation: BAA91556.1 .
    AK022535 mRNA. Translation: BAB14084.1 .
    AL034380 Genomic DNA. Translation: CAB92117.1 .
    BC007815 mRNA. Translation: AAH07815.1 .
    BC008634 mRNA. Translation: AAH08634.1 .
    CCDSi CCDS289.1.
    RefSeqi NP_060536.3. NM_018066.3.
    UniGenei Hs.14333.

    3D structure databases

    ProteinModelPortali Q9H9Y4.
    SMRi Q9H9Y4. Positions 10-202.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120104. 1 interaction.
    STRINGi 9606.ENSP00000363250.

    Polymorphism databases

    DMDMi 110832767.

    Proteomic databases

    MaxQBi Q9H9Y4.
    PaxDbi Q9H9Y4.
    PRIDEi Q9H9Y4.

    Protocols and materials databases

    DNASUi 54707.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374135 ; ENSP00000363250 ; ENSG00000142751 .
    GeneIDi 54707.
    KEGGi hsa:54707.
    UCSCi uc001bnd.1. human.

    Organism-specific databases

    CTDi 54707.
    GeneCardsi GC01M027205.
    HGNCi HGNC:25513. GPN2.
    HPAi HPA028059.
    neXtProti NX_Q9H9Y4.
    PharmGKBi PA162390149.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000207661.
    HOVERGENi HBG054729.
    InParanoidi Q9H9Y4.
    KOi K06883.
    OMAi VELFTHH.
    OrthoDBi EOG72VH6M.
    PhylomeDBi Q9H9Y4.
    TreeFami TF300828.

    Miscellaneous databases

    GenomeRNAii 54707.
    NextBioi 57265.
    PROi Q9H9Y4.

    Gene expression databases

    ArrayExpressi Q9H9Y4.
    Bgeei Q9H9Y4.
    CleanExi HS_GPN2.
    Genevestigatori Q9H9Y4.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR004130. Uncharacterised_ATP-bd.
    [Graphical view ]
    Pfami PF03029. ATP_bind_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "NovelFam3000 -- uncharacterized human protein domains conserved across model organisms."
      Kemmer D., Podowski R.M., Arenillas D., Lim J., Hodges E., Roth P., Sonnhammer E.L.L., Hoeoeg C., Wasserman W.W.
      BMC Genomics 7:48-48(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-264.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-264.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-227 AND GLY-264.
      Tissue: Cervix and Eye.
    6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGPN2_HUMAN
    AccessioniPrimary (citable) accession number: Q9H9Y4
    Secondary accession number(s): Q96HG4, Q9NUE1, Q9NW30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3