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Q9H9Y4

- GPN2_HUMAN

UniProt

Q9H9Y4 - GPN2_HUMAN

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Protein

GPN-loop GTPase 2

Gene

GPN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei78 – 781Stabilizes the phosphate intermediate; shared with dimeric partnerBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 246GTPBy similarity
Nucleotide bindingi178 – 1814GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GPN-loop GTPase 2Curated
Alternative name(s):
ATP-binding domain 1 family member B
Gene namesi
Name:GPN2Imported1 Publication
Synonyms:ATPBD1B
ORF Names:UNQ5828/PRO19647
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:25513. GPN2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162390149.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 310309GPN-loop GTPase 2PRO_0000247829Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9H9Y4.
PaxDbiQ9H9Y4.
PRIDEiQ9H9Y4.

Expressioni

Gene expression databases

BgeeiQ9H9Y4.
CleanExiHS_GPN2.
ExpressionAtlasiQ9H9Y4. baseline and differential.
GenevestigatoriQ9H9Y4.

Organism-specific databases

HPAiHPA028059.

Interactioni

Subunit structurei

Heterodimers with GPN1 or GPN3 (By similarity). Binds to RNA polymerase II (RNAPII) (PubMed:20864038).By similarity1 Publication

Protein-protein interaction databases

BioGridi120104. 8 interactions.
STRINGi9606.ENSP00000363250.

Structurei

3D structure databases

ProteinModelPortaliQ9H9Y4.
SMRiQ9H9Y4. Positions 12-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi76 – 783Gly-Pro-Asn (GPN)-loop; involved in dimer interfaceBy similarity

Sequence similaritiesi

Belongs to the GPN-loop GTPase family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00550000075096.
HOGENOMiHOG000207661.
HOVERGENiHBG054729.
InParanoidiQ9H9Y4.
KOiK06883.
OMAiVELFTHH.
OrthoDBiEOG72VH6M.
PhylomeDBiQ9H9Y4.
TreeFamiTF300828.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004130. Uncharacterised_ATP-bd.
[Graphical view]
PfamiPF03029. ATP_bind_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H9Y4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGAAPTTAF GQAVIGPPGS GKTTYCLGMS EFLRALGRRV AVVNLDPANE
60 70 80 90 100
GLPYECAVDV GELVGLGDVM DALRLGPNGG LLYCMEYLEA NLDWLRAKLD
110 120 130 140 150
PLRGHYFLFD CPGQVELCTH HGALRSIFSQ MAQWDLRLTA VHLVDSHYCT
160 170 180 190 200
DPAKFISVLC TSLATMLHVE LPHINLLSKM DLIEHYGKLA FNLDYYTEVL
210 220 230 240 250
DLSYLLDHLA SDPFFRHYRQ LNEKLVQLIE DYSLVSFIPL NIQDKESIQR
260 270 280 290 300
VLQAVDKANG YCFRAQEQRS LEAMMSAAMG ADFHFSSTLG IQEKYLAPSN
310
QSVEQEAMQL
Length:310
Mass (Da):34,561
Last modified:July 25, 2006 - v2
Checksum:iF73EAF808DA692CA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151I → T in AAQ76820. (PubMed:16533400)Curated
Sequence conflicti15 – 151I → T in BAA91556. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti227 – 2271Q → R.1 Publication
Corresponds to variant rs17856257 [ dbSNP | Ensembl ].
VAR_027153
Natural varianti264 – 2641R → G.3 Publications
Corresponds to variant rs3170660 [ dbSNP | Ensembl ].
VAR_027154

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY364261 mRNA. Translation: AAQ76820.1.
AY358864 mRNA. Translation: AAQ89223.1.
AK001211 mRNA. Translation: BAA91556.1.
AK022535 mRNA. Translation: BAB14084.1.
AL034380 Genomic DNA. Translation: CAB92117.1.
BC007815 mRNA. Translation: AAH07815.1.
BC008634 mRNA. Translation: AAH08634.1.
CCDSiCCDS289.1.
RefSeqiNP_060536.3. NM_018066.3.
UniGeneiHs.14333.

Genome annotation databases

EnsembliENST00000374135; ENSP00000363250; ENSG00000142751.
GeneIDi54707.
KEGGihsa:54707.
UCSCiuc001bnd.1. human.

Polymorphism databases

DMDMi110832767.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY364261 mRNA. Translation: AAQ76820.1 .
AY358864 mRNA. Translation: AAQ89223.1 .
AK001211 mRNA. Translation: BAA91556.1 .
AK022535 mRNA. Translation: BAB14084.1 .
AL034380 Genomic DNA. Translation: CAB92117.1 .
BC007815 mRNA. Translation: AAH07815.1 .
BC008634 mRNA. Translation: AAH08634.1 .
CCDSi CCDS289.1.
RefSeqi NP_060536.3. NM_018066.3.
UniGenei Hs.14333.

3D structure databases

ProteinModelPortali Q9H9Y4.
SMRi Q9H9Y4. Positions 12-202.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120104. 8 interactions.
STRINGi 9606.ENSP00000363250.

Polymorphism databases

DMDMi 110832767.

Proteomic databases

MaxQBi Q9H9Y4.
PaxDbi Q9H9Y4.
PRIDEi Q9H9Y4.

Protocols and materials databases

DNASUi 54707.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374135 ; ENSP00000363250 ; ENSG00000142751 .
GeneIDi 54707.
KEGGi hsa:54707.
UCSCi uc001bnd.1. human.

Organism-specific databases

CTDi 54707.
GeneCardsi GC01M027205.
HGNCi HGNC:25513. GPN2.
HPAi HPA028059.
neXtProti NX_Q9H9Y4.
PharmGKBi PA162390149.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00550000075096.
HOGENOMi HOG000207661.
HOVERGENi HBG054729.
InParanoidi Q9H9Y4.
KOi K06883.
OMAi VELFTHH.
OrthoDBi EOG72VH6M.
PhylomeDBi Q9H9Y4.
TreeFami TF300828.

Miscellaneous databases

GenomeRNAii 54707.
NextBioi 57265.
PROi Q9H9Y4.

Gene expression databases

Bgeei Q9H9Y4.
CleanExi HS_GPN2.
ExpressionAtlasi Q9H9Y4. baseline and differential.
Genevestigatori Q9H9Y4.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR004130. Uncharacterised_ATP-bd.
[Graphical view ]
Pfami PF03029. ATP_bind_1. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NovelFam3000 -- uncharacterized human protein domains conserved across model organisms."
    Kemmer D., Podowski R.M., Arenillas D., Lim J., Hodges E., Roth P., Sonnhammer E.L.L., Hoeoeg C., Wasserman W.W.
    BMC Genomics 7:48-48(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-264.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-264.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-227 AND GLY-264.
    Tissue: Cervix and Eye.
  6. "HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II."
    Boulon S., Pradet-Balade B., Verheggen C., Molle D., Boireau S., Georgieva M., Azzag K., Robert M.C., Ahmad Y., Neel H., Lamond A.I., Bertrand E.
    Mol. Cell 39:912-924(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: BINDING TO RNA POYMERASE II.
  7. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGPN2_HUMAN
AccessioniPrimary (citable) accession number: Q9H9Y4
Secondary accession number(s): Q96HG4, Q9NUE1, Q9NW30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 26, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3