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Protein

Ribosome production factor 1

Gene

RPF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be required for ribosome biogenesis.1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • rRNA primary transcript binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome production factor 1
Alternative name(s):
Brix domain-containing protein 5
Ribosome biogenesis protein RPF1
Gene namesi
Name:RPF1
Synonyms:BXDC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30350. RPF1.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: UniProtKB
  • preribosome, large subunit precursor Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165752348.

Polymorphism and mutation databases

BioMutaiRPF1.
DMDMi71153718.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Ribosome production factor 1PRO_0000120248Add
BLAST

Proteomic databases

EPDiQ9H9Y2.
MaxQBiQ9H9Y2.
PaxDbiQ9H9Y2.
PeptideAtlasiQ9H9Y2.
PRIDEiQ9H9Y2.

2D gel databases

SWISS-2DPAGEQ9H9Y2.

PTM databases

iPTMnetiQ9H9Y2.
PhosphoSiteiQ9H9Y2.

Expressioni

Gene expression databases

BgeeiENSG00000117133.
CleanExiHS_BXDC5.
ExpressionAtlasiQ9H9Y2. baseline and differential.
GenevisibleiQ9H9Y2. HS.

Organism-specific databases

HPAiHPA024642.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-9996007,EBI-10172290

Protein-protein interaction databases

BioGridi123133. 39 interactions.
IntActiQ9H9Y2. 6 interactions.
MINTiMINT-3047947.
STRINGi9606.ENSP00000359688.

Structurei

3D structure databases

ProteinModelPortaliQ9H9Y2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini142 – 325184BrixPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni303 – 32018RNA-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 Brix domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2780. Eukaryota.
COG2136. LUCA.
GeneTreeiENSGT00550000074691.
HOGENOMiHOG000172062.
HOVERGENiHBG083559.
InParanoidiQ9H9Y2.
KOiK14846.
OMAiTDEFAPY.
OrthoDBiEOG091G0CQ2.
PhylomeDBiQ9H9Y2.
TreeFamiTF105897.

Family and domain databases

Gene3Di3.40.50.10480. 1 hit.
InterProiIPR004154. Anticodon-bd.
IPR007109. Brix.
[Graphical view]
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H9Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKAGDKSSS SGKKSLKRKA AAEELQEAAG AGDGATENGV QPPKAAAFPP
60 70 80 90 100
GFSISEIKNK QRRHLMFTRW KQQQRKEKLA AKKKLKKERE ALGDKAPPKP
110 120 130 140 150
VPKTIDNQRV YDETTVDPND EEVAYDEATD EFASYFNKQT SPKILITTSD
160 170 180 190 200
RPHGRTVRLC EQLSTVIPNS HVYYRRGLAL KKIIPQCIAR DFTDLIVINE
210 220 230 240 250
DRKTPNGLIL SHLPNGPTAH FKMSSVRLRK EIKRRGKDPT EHIPEIILNN
260 270 280 290 300
FTTRLGHSIG RMFASLFPHN PQFIGRQVAT FHNQRDYIFF RFHRYIFRSE
310 320 330 340
KKVGIQELGP RFTLKLRSLQ KGTFDSKYGE YEWVHKPREM DTSRRKFHL
Length:349
Mass (Da):40,111
Last modified:July 19, 2005 - v2
Checksum:iF939904B3AB79890
GO

Sequence cautioni

The sequence CAH71915 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91S → G.2 Publications
Corresponds to variant rs2292191 [ dbSNP | Ensembl ].
VAR_022871
Natural varianti223 – 2231M → I.
Corresponds to variant rs7528067 [ dbSNP | Ensembl ].
VAR_048421

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322053 mRNA. Translation: AAL37236.1.
AK022537 mRNA. Translation: BAB14086.1.
AL359762, AL844170 Genomic DNA. Translation: CAH70204.1.
AL844170, AL359762 Genomic DNA. Translation: CAH71914.1.
AL844170 Genomic DNA. Translation: CAH71915.1. Sequence problems.
BC016051 mRNA. Translation: AAH16051.1.
CR627468 mRNA. Translation: CAH10670.1.
AL359584 mRNA. Translation: CAH10671.1.
CCDSiCCDS695.1.
PIRiT50616.
RefSeqiNP_079341.2. NM_025065.6.
UniGeneiHs.481202.

Genome annotation databases

EnsembliENST00000370654; ENSP00000359688; ENSG00000117133.
GeneIDi80135.
KEGGihsa:80135.
UCSCiuc001djv.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322053 mRNA. Translation: AAL37236.1.
AK022537 mRNA. Translation: BAB14086.1.
AL359762, AL844170 Genomic DNA. Translation: CAH70204.1.
AL844170, AL359762 Genomic DNA. Translation: CAH71914.1.
AL844170 Genomic DNA. Translation: CAH71915.1. Sequence problems.
BC016051 mRNA. Translation: AAH16051.1.
CR627468 mRNA. Translation: CAH10670.1.
AL359584 mRNA. Translation: CAH10671.1.
CCDSiCCDS695.1.
PIRiT50616.
RefSeqiNP_079341.2. NM_025065.6.
UniGeneiHs.481202.

3D structure databases

ProteinModelPortaliQ9H9Y2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123133. 39 interactions.
IntActiQ9H9Y2. 6 interactions.
MINTiMINT-3047947.
STRINGi9606.ENSP00000359688.

PTM databases

iPTMnetiQ9H9Y2.
PhosphoSiteiQ9H9Y2.

Polymorphism and mutation databases

BioMutaiRPF1.
DMDMi71153718.

2D gel databases

SWISS-2DPAGEQ9H9Y2.

Proteomic databases

EPDiQ9H9Y2.
MaxQBiQ9H9Y2.
PaxDbiQ9H9Y2.
PeptideAtlasiQ9H9Y2.
PRIDEiQ9H9Y2.

Protocols and materials databases

DNASUi80135.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370654; ENSP00000359688; ENSG00000117133.
GeneIDi80135.
KEGGihsa:80135.
UCSCiuc001djv.5. human.

Organism-specific databases

CTDi80135.
GeneCardsiRPF1.
HGNCiHGNC:30350. RPF1.
HPAiHPA024642.
neXtProtiNX_Q9H9Y2.
PharmGKBiPA165752348.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2780. Eukaryota.
COG2136. LUCA.
GeneTreeiENSGT00550000074691.
HOGENOMiHOG000172062.
HOVERGENiHBG083559.
InParanoidiQ9H9Y2.
KOiK14846.
OMAiTDEFAPY.
OrthoDBiEOG091G0CQ2.
PhylomeDBiQ9H9Y2.
TreeFamiTF105897.

Miscellaneous databases

ChiTaRSiRPF1. human.
GenomeRNAii80135.
PROiQ9H9Y2.

Gene expression databases

BgeeiENSG00000117133.
CleanExiHS_BXDC5.
ExpressionAtlasiQ9H9Y2. baseline and differential.
GenevisibleiQ9H9Y2. HS.

Family and domain databases

Gene3Di3.40.50.10480. 1 hit.
InterProiIPR004154. Anticodon-bd.
IPR007109. Brix.
[Graphical view]
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPF1_HUMAN
AccessioniPrimary (citable) accession number: Q9H9Y2
Secondary accession number(s): Q5VSK7, Q6AHX1, Q8WXZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: September 7, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.