ID   JMJD4_HUMAN             Reviewed;         463 AA.
AC   Q9H9V9; Q5TBZ1; Q5TBZ6; Q9H970;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 2.
DT   25-JAN-2012, entry version 62.
DE   RecName: Full=JmjC domain-containing protein 4;
DE   AltName: Full=Jumonji domain-containing protein 4;
GN   Name=JMJD4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP   VAL-11.
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA   Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA   Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA   Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA   Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA   Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA   Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA   Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA   Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA   Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA   Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA   Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA   Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA   Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9H9V9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9H9V9-2; Sequence=VSP_026324;
CC   -!- SIMILARITY: Contains 1 JmjC domain.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-47 is the initiator.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB14366.1; Type=Erroneous initiation;
CC       Sequence=CAI23067.1; Type=Erroneous initiation;
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DR   EMBL; AK022579; BAB14109.1; -; mRNA.
DR   EMBL; AK023030; BAB14366.1; ALT_INIT; mRNA.
DR   EMBL; AL136378; CAI23067.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL136378; CAI23068.1; -; Genomic_DNA.
DR   IPI; IPI00011132; -.
DR   IPI; IPI00549346; -.
DR   RefSeq; NP_001154937.1; NM_001161465.1.
DR   RefSeq; NP_075383.2; NM_023007.2.
DR   UniGene; Hs.555974; -.
DR   UniGene; Hs.729813; -.
DR   ProteinModelPortal; Q9H9V9; -.
DR   SMR; Q9H9V9; 24-346.
DR   IntAct; Q9H9V9; 1.
DR   PhosphoSite; Q9H9V9; -.
DR   DMDM; 150383500; -.
DR   PRIDE; Q9H9V9; -.
DR   Ensembl; ENST00000366758; ENSP00000355720; ENSG00000081692.
DR   GeneID; 65094; -.
DR   KEGG; hsa:65094; -.
DR   NMPDR; fig|9606.3.peg.3183; -.
DR   UCSC; uc001hrb.1; human.
DR   UCSC; uc001hrc.1; human.
DR   CTD; 65094; -.
DR   GeneCards; GC01M227918; -.
DR   HGNC; HGNC:25724; JMJD4.
DR   HPA; HPA027260; -.
DR   neXtProt; NX_Q9H9V9; -.
DR   PharmGKB; PA142671643; -.
DR   eggNOG; prNOG14147; -.
DR   GeneTree; ENSGT00530000063579; -.
DR   HOGENOM; HBG713878; -.
DR   HOVERGEN; HBG097429; -.
DR   InParanoid; Q9H9V9; -.
DR   OMA; WVNGCNL; -.
DR   OrthoDB; EOG47SSDS; -.
DR   PhylomeDB; Q9H9V9; -.
DR   NextBio; 67290; -.
DR   ArrayExpress; Q9H9V9; -.
DR   Bgee; Q9H9V9; -.
DR   CleanEx; HS_JMJD4; -.
DR   Genevestigator; Q9H9V9; -.
DR   InterPro; IPR013129; TF_JmjC.
DR   InterPro; IPR003347; TF_JmjC_AAH.
DR   Pfam; PF02373; JmjC; 1.
DR   SMART; SM00558; JmjC; 1.
DR   PROSITE; PS51184; JMJC; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Polymorphism;
KW   Reference proteome.
FT   CHAIN         1    463       JmjC domain-containing protein 4.
FT                                /FTId=PRO_0000291959.
FT   DOMAIN      188    347       JmjC.
FT   VAR_SEQ     354    369       Missing (in isoform 2).
FT                                /FTId=VSP_026324.
FT   VARIANT      11     11       A -> V (in dbSNP:rs7419238).
FT                                /FTId=VAR_032898.
FT   VARIANT      16     16       G -> C (in dbSNP:rs34560898).
FT                                /FTId=VAR_032899.
FT   VARIANT      65     65       D -> E (in dbSNP:rs2295994).
FT                                /FTId=VAR_032900.
FT   VARIANT     461    461       A -> V (in dbSNP:rs3087908).
FT                                /FTId=VAR_032901.
FT   CONFLICT    244    244       W -> R (in Ref. 1; BAB14366).
FT   CONFLICT    445    445       Q -> R (in Ref. 1; BAB14366).
SQ   SEQUENCE   463 AA;  52493 MW;  CD79490AB06E8652 CRC64;
     MRAGPEPQAL AGQKRGALRL LVPRLVLTVS APAEVRRRVL RPVLSWMDRE TRALADSHFR
     GLGVDVPGVG QAPGRVAFVS EPGAFSYADF VRGFLLPNLP CVFSSAFTQG WGSRRRWVTP
     AGRPDFDHLL RTYGDVVVPV ANCGVQEYNS NPKEHMTLRD YITYWKEYIQ AGYSSPRGCL
     YLKDWHLCRD FPVEDVFTLP VYFSSDWLNE FWDALDVDDY RFVYAGPAGS WSPFHADIFR
     SFSWSVNVCG RKKWLLFPPG QEEALRDRHG NLPYDVTSPA LCDTHLHPRN QLAGPPLEIT
     QEAGEMVFVP SGWHHQVHNL DDTISINHNW VNGFNLANMW RFLQQELCAV QEEVSEWRDS
     MPDWHHHCQV IMRSCSGINF EEFYHFLKVI AEKRLLVLRE AAAEDGAGLG FEQAAFDVGR
     ITEVLASLVA HPDFQRVDTS AFSPQPKELL QQLREAVDAA AAP
//