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Q9H9V9

- JMJD4_HUMAN

UniProt

Q9H9V9 - JMJD4_HUMAN

Protein

JmjC domain-containing protein 4

Gene

JMJD4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    JmjC domain-containing protein 4
    Alternative name(s):
    Jumonji domain-containing protein 4
    Gene namesi
    Name:JMJD4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25724. JMJD4.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671643.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 463463JmjC domain-containing protein 4PRO_0000291959Add
    BLAST

    Proteomic databases

    MaxQBiQ9H9V9.
    PaxDbiQ9H9V9.
    PRIDEiQ9H9V9.

    PTM databases

    PhosphoSiteiQ9H9V9.

    Expressioni

    Gene expression databases

    BgeeiQ9H9V9.
    CleanExiHS_JMJD4.
    GenevestigatoriQ9H9V9.

    Organism-specific databases

    HPAiHPA027260.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HIST2H4BP628053EBI-2866290,EBI-302023

    Protein-protein interaction databases

    BioGridi122393. 3 interactions.
    IntActiQ9H9V9. 3 interactions.
    MINTiMINT-6781888.
    STRINGi9606.ENSP00000355720.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H9V9.
    SMRiQ9H9V9. Positions 226-330.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini188 – 347160JmjCPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 JmjC domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG291944.
    HOGENOMiHOG000039078.
    HOVERGENiHBG097429.
    InParanoidiQ9H9V9.
    OMAiKKWLLYP.
    OrthoDBiEOG7992Q8.
    PhylomeDBiQ9H9V9.
    TreeFamiTF105936.

    Family and domain databases

    InterProiIPR003347. JmjC_dom.
    [Graphical view]
    SMARTiSM00558. JmjC. 1 hit.
    [Graphical view]
    PROSITEiPS51184. JMJC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H9V9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRAGPEPQAL AGQKRGALRL LVPRLVLTVS APAEVRRRVL RPVLSWMDRE    50
    TRALADSHFR GLGVDVPGVG QAPGRVAFVS EPGAFSYADF VRGFLLPNLP 100
    CVFSSAFTQG WGSRRRWVTP AGRPDFDHLL RTYGDVVVPV ANCGVQEYNS 150
    NPKEHMTLRD YITYWKEYIQ AGYSSPRGCL YLKDWHLCRD FPVEDVFTLP 200
    VYFSSDWLNE FWDALDVDDY RFVYAGPAGS WSPFHADIFR SFSWSVNVCG 250
    RKKWLLFPPG QEEALRDRHG NLPYDVTSPA LCDTHLHPRN QLAGPPLEIT 300
    QEAGEMVFVP SGWHHQVHNL DDTISINHNW VNGFNLANMW RFLQQELCAV 350
    QEEVSEWRDS MPDWHHHCQV IMRSCSGINF EEFYHFLKVI AEKRLLVLRE 400
    AAAEDGAGLG FEQAAFDVGR ITEVLASLVA HPDFQRVDTS AFSPQPKELL 450
    QQLREAVDAA AAP 463
    Length:463
    Mass (Da):52,493
    Last modified:June 26, 2007 - v2
    Checksum:iCD79490AB06E8652
    GO
    Isoform 2 (identifier: Q9H9V9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         354-369: Missing.

    Show »
    Length:447
    Mass (Da):50,461
    Checksum:i22F00AC7D86D1A0E
    GO

    Sequence cautioni

    The sequence BAB14366.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAI23067.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti244 – 2441W → R in BAB14366. (PubMed:14702039)Curated
    Sequence conflicti445 – 4451Q → R in BAB14366. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111A → V.1 Publication
    Corresponds to variant rs7419238 [ dbSNP | Ensembl ].
    VAR_032898
    Natural varianti16 – 161G → C.
    Corresponds to variant rs34560898 [ dbSNP | Ensembl ].
    VAR_032899
    Natural varianti65 – 651D → E.
    Corresponds to variant rs2295994 [ dbSNP | Ensembl ].
    VAR_032900
    Natural varianti461 – 4611A → V.
    Corresponds to variant rs3087908 [ dbSNP | Ensembl ].
    VAR_032901

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei354 – 36916Missing in isoform 2. 1 PublicationVSP_026324Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022579 mRNA. Translation: BAB14109.1.
    AK023030 mRNA. Translation: BAB14366.1. Different initiation.
    AL136378 Genomic DNA. Translation: CAI23067.1. Different initiation.
    AL136378 Genomic DNA. Translation: CAI23068.1.
    CCDSiCCDS1561.1. [Q9H9V9-1]
    CCDS59203.1. [Q9H9V9-2]
    RefSeqiNP_001154937.1. NM_001161465.1. [Q9H9V9-2]
    NP_075383.2. NM_023007.2. [Q9H9V9-1]
    UniGeneiHs.555974.
    Hs.745334.

    Genome annotation databases

    EnsembliENST00000366758; ENSP00000355720; ENSG00000081692. [Q9H9V9-1]
    ENST00000438896; ENSP00000387830; ENSG00000081692. [Q9H9V9-2]
    GeneIDi65094.
    KEGGihsa:65094.
    UCSCiuc001hrb.3. human. [Q9H9V9-1]
    uc001hrc.3. human. [Q9H9V9-2]

    Polymorphism databases

    DMDMi150383500.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022579 mRNA. Translation: BAB14109.1 .
    AK023030 mRNA. Translation: BAB14366.1 . Different initiation.
    AL136378 Genomic DNA. Translation: CAI23067.1 . Different initiation.
    AL136378 Genomic DNA. Translation: CAI23068.1 .
    CCDSi CCDS1561.1. [Q9H9V9-1 ]
    CCDS59203.1. [Q9H9V9-2 ]
    RefSeqi NP_001154937.1. NM_001161465.1. [Q9H9V9-2 ]
    NP_075383.2. NM_023007.2. [Q9H9V9-1 ]
    UniGenei Hs.555974.
    Hs.745334.

    3D structure databases

    ProteinModelPortali Q9H9V9.
    SMRi Q9H9V9. Positions 226-330.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122393. 3 interactions.
    IntActi Q9H9V9. 3 interactions.
    MINTi MINT-6781888.
    STRINGi 9606.ENSP00000355720.

    PTM databases

    PhosphoSitei Q9H9V9.

    Polymorphism databases

    DMDMi 150383500.

    Proteomic databases

    MaxQBi Q9H9V9.
    PaxDbi Q9H9V9.
    PRIDEi Q9H9V9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366758 ; ENSP00000355720 ; ENSG00000081692 . [Q9H9V9-1 ]
    ENST00000438896 ; ENSP00000387830 ; ENSG00000081692 . [Q9H9V9-2 ]
    GeneIDi 65094.
    KEGGi hsa:65094.
    UCSCi uc001hrb.3. human. [Q9H9V9-1 ]
    uc001hrc.3. human. [Q9H9V9-2 ]

    Organism-specific databases

    CTDi 65094.
    GeneCardsi GC01M227918.
    HGNCi HGNC:25724. JMJD4.
    HPAi HPA027260.
    neXtProti NX_Q9H9V9.
    PharmGKBi PA142671643.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG291944.
    HOGENOMi HOG000039078.
    HOVERGENi HBG097429.
    InParanoidi Q9H9V9.
    OMAi KKWLLYP.
    OrthoDBi EOG7992Q8.
    PhylomeDBi Q9H9V9.
    TreeFami TF105936.

    Miscellaneous databases

    GenomeRNAii 65094.
    NextBioi 67290.
    PROi Q9H9V9.

    Gene expression databases

    Bgeei Q9H9V9.
    CleanExi HS_JMJD4.
    Genevestigatori Q9H9V9.

    Family and domain databases

    InterProi IPR003347. JmjC_dom.
    [Graphical view ]
    SMARTi SM00558. JmjC. 1 hit.
    [Graphical view ]
    PROSITEi PS51184. JMJC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-11.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiJMJD4_HUMAN
    AccessioniPrimary (citable) accession number: Q9H9V9
    Secondary accession number(s): Q5TBZ1, Q5TBZ6, Q9H970
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-47 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3