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Q9H9V9 (JMJD4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
JmjC domain-containing protein 4
Alternative name(s):
Jumonji domain-containing protein 4
Gene names
Name:JMJD4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 JmjC domain.

Caution

It is uncertain whether Met-1 or Met-47 is the initiator.

Sequence caution

The sequence BAB14366.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAI23067.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionprotein binding

Inferred from physical interaction PubMed 24360279. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

HIST2H4BP628053EBI-2866290,EBI-302023

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H9V9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H9V9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     354-369: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 463463JmjC domain-containing protein 4
PRO_0000291959

Regions

Domain188 – 347160JmjC

Natural variations

Alternative sequence354 – 36916Missing in isoform 2.
VSP_026324
Natural variant111A → V. Ref.1
Corresponds to variant rs7419238 [ dbSNP | Ensembl ].
VAR_032898
Natural variant161G → C.
Corresponds to variant rs34560898 [ dbSNP | Ensembl ].
VAR_032899
Natural variant651D → E.
Corresponds to variant rs2295994 [ dbSNP | Ensembl ].
VAR_032900
Natural variant4611A → V.
Corresponds to variant rs3087908 [ dbSNP | Ensembl ].
VAR_032901

Experimental info

Sequence conflict2441W → R in BAB14366. Ref.1
Sequence conflict4451Q → R in BAB14366. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 26, 2007. Version 2.
Checksum: CD79490AB06E8652

FASTA46352,493
        10         20         30         40         50         60 
MRAGPEPQAL AGQKRGALRL LVPRLVLTVS APAEVRRRVL RPVLSWMDRE TRALADSHFR 

        70         80         90        100        110        120 
GLGVDVPGVG QAPGRVAFVS EPGAFSYADF VRGFLLPNLP CVFSSAFTQG WGSRRRWVTP 

       130        140        150        160        170        180 
AGRPDFDHLL RTYGDVVVPV ANCGVQEYNS NPKEHMTLRD YITYWKEYIQ AGYSSPRGCL 

       190        200        210        220        230        240 
YLKDWHLCRD FPVEDVFTLP VYFSSDWLNE FWDALDVDDY RFVYAGPAGS WSPFHADIFR 

       250        260        270        280        290        300 
SFSWSVNVCG RKKWLLFPPG QEEALRDRHG NLPYDVTSPA LCDTHLHPRN QLAGPPLEIT 

       310        320        330        340        350        360 
QEAGEMVFVP SGWHHQVHNL DDTISINHNW VNGFNLANMW RFLQQELCAV QEEVSEWRDS 

       370        380        390        400        410        420 
MPDWHHHCQV IMRSCSGINF EEFYHFLKVI AEKRLLVLRE AAAEDGAGLG FEQAAFDVGR 

       430        440        450        460 
ITEVLASLVA HPDFQRVDTS AFSPQPKELL QQLREAVDAA AAP 

« Hide

Isoform 2 [UniParc].

Checksum: 22F00AC7D86D1A0E
Show »

FASTA44750,461

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-11.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK022579 mRNA. Translation: BAB14109.1.
AK023030 mRNA. Translation: BAB14366.1. Different initiation.
AL136378 Genomic DNA. Translation: CAI23067.1. Different initiation.
AL136378 Genomic DNA. Translation: CAI23068.1.
CCDSCCDS1561.1. [Q9H9V9-1]
CCDS59203.1. [Q9H9V9-2]
RefSeqNP_001154937.1. NM_001161465.1. [Q9H9V9-2]
NP_075383.2. NM_023007.2. [Q9H9V9-1]
UniGeneHs.555974.
Hs.745334.

3D structure databases

ProteinModelPortalQ9H9V9.
SMRQ9H9V9. Positions 226-330.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122393. 3 interactions.
IntActQ9H9V9. 3 interactions.
MINTMINT-6781888.
STRING9606.ENSP00000355720.

PTM databases

PhosphoSiteQ9H9V9.

Polymorphism databases

DMDM150383500.

Proteomic databases

MaxQBQ9H9V9.
PaxDbQ9H9V9.
PRIDEQ9H9V9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000366758; ENSP00000355720; ENSG00000081692. [Q9H9V9-1]
ENST00000438896; ENSP00000387830; ENSG00000081692. [Q9H9V9-2]
GeneID65094.
KEGGhsa:65094.
UCSCuc001hrb.3. human. [Q9H9V9-1]
uc001hrc.3. human. [Q9H9V9-2]

Organism-specific databases

CTD65094.
GeneCardsGC01M227918.
HGNCHGNC:25724. JMJD4.
HPAHPA027260.
neXtProtNX_Q9H9V9.
PharmGKBPA142671643.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG291944.
HOGENOMHOG000039078.
HOVERGENHBG097429.
InParanoidQ9H9V9.
OMAKKWLLYP.
OrthoDBEOG7992Q8.
PhylomeDBQ9H9V9.
TreeFamTF105936.

Gene expression databases

BgeeQ9H9V9.
CleanExHS_JMJD4.
GenevestigatorQ9H9V9.

Family and domain databases

InterProIPR003347. JmjC_dom.
[Graphical view]
SMARTSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEPS51184. JMJC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi65094.
NextBio67290.
PROQ9H9V9.

Entry information

Entry nameJMJD4_HUMAN
AccessionPrimary (citable) accession number: Q9H9V9
Secondary accession number(s): Q5TBZ1, Q5TBZ6, Q9H970
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: July 9, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM