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Protein

RING finger protein 122

Gene

RNF122

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May induce necrosis and apoptosis. May play a role in cell viability.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri93 – 134RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133874-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 122
Gene namesi
Name:RNF122
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:21147. RNF122.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133874.
PharmGKBiPA134892945.

Polymorphism and mutation databases

DMDMi110816410.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002478521 – 155RING finger protein 122Add BLAST155

Proteomic databases

MaxQBiQ9H9V4.
PaxDbiQ9H9V4.
PeptideAtlasiQ9H9V4.
PRIDEiQ9H9V4.

PTM databases

iPTMnetiQ9H9V4.
PhosphoSitePlusiQ9H9V4.

Expressioni

Tissue specificityi

Widely expressed in several tissues and cell lines.1 Publication

Gene expression databases

BgeeiENSG00000133874.
CleanExiHS_RNF122.
GenevisibleiQ9H9V4. HS.

Organism-specific databases

HPAiHPA003888.

Interactioni

Protein-protein interaction databases

BioGridi122936. 9 interactors.
IntActiQ9H9V4. 5 interactors.
STRINGi9606.ENSP00000256257.

Structurei

3D structure databases

ProteinModelPortaliQ9H9V4.
SMRiQ9H9V4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri93 – 134RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00710000106755.
HOGENOMiHOG000004806.
HOVERGENiHBG058899.
InParanoidiQ9H9V4.
KOiK15699.
OMAiQLYGTCA.
OrthoDBiEOG091G0PFG.
PhylomeDBiQ9H9V4.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H9V4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPFQWCNGC FCGLGLVSTN KSCSMPPISF QDLPLNIYMV IFGTGIFVFM
60 70 80 90 100
LSLIFCCYFI SKLRNQAQSE RYGYKEVVLK GDAKKLQLYG QTCAVCLEDF
110 120 130 140 150
KGKDELGVLP CQHAFHRKCL VKWLEVRCVC PMCNKPIASP SEATQNIGIL

LDELV
Length:155
Mass (Da):17,475
Last modified:July 25, 2006 - v2
Checksum:iE86B8E6F4954457B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70E → D in BAB14115 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022588 mRNA. Translation: BAB14115.1.
BC093884 mRNA. Translation: AAH93884.1.
BC101573 mRNA. Translation: AAI01574.1.
CCDSiCCDS6091.1.
RefSeqiNP_079063.2. NM_024787.3.
UniGeneiHs.151237.

Genome annotation databases

EnsembliENST00000256257; ENSP00000256257; ENSG00000133874.
GeneIDi79845.
KEGGihsa:79845.
UCSCiuc003xjo.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022588 mRNA. Translation: BAB14115.1.
BC093884 mRNA. Translation: AAH93884.1.
BC101573 mRNA. Translation: AAI01574.1.
CCDSiCCDS6091.1.
RefSeqiNP_079063.2. NM_024787.3.
UniGeneiHs.151237.

3D structure databases

ProteinModelPortaliQ9H9V4.
SMRiQ9H9V4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122936. 9 interactors.
IntActiQ9H9V4. 5 interactors.
STRINGi9606.ENSP00000256257.

PTM databases

iPTMnetiQ9H9V4.
PhosphoSitePlusiQ9H9V4.

Polymorphism and mutation databases

DMDMi110816410.

Proteomic databases

MaxQBiQ9H9V4.
PaxDbiQ9H9V4.
PeptideAtlasiQ9H9V4.
PRIDEiQ9H9V4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256257; ENSP00000256257; ENSG00000133874.
GeneIDi79845.
KEGGihsa:79845.
UCSCiuc003xjo.3. human.

Organism-specific databases

CTDi79845.
GeneCardsiRNF122.
HGNCiHGNC:21147. RNF122.
HPAiHPA003888.
neXtProtiNX_Q9H9V4.
OpenTargetsiENSG00000133874.
PharmGKBiPA134892945.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00710000106755.
HOGENOMiHOG000004806.
HOVERGENiHBG058899.
InParanoidiQ9H9V4.
KOiK15699.
OMAiQLYGTCA.
OrthoDBiEOG091G0PFG.
PhylomeDBiQ9H9V4.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133874-MONOMER.

Miscellaneous databases

ChiTaRSiRNF122. human.
GeneWikiiRNF122.
GenomeRNAii79845.
PROiQ9H9V4.

Gene expression databases

BgeeiENSG00000133874.
CleanExiHS_RNF122.
GenevisibleiQ9H9V4. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRN122_HUMAN
AccessioniPrimary (citable) accession number: Q9H9V4
Secondary accession number(s): Q52LK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.