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Protein

Calcium-binding protein 39-like

Gene

CAB39L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102547-MONOMER.
ReactomeiR-HSA-380972. Energy dependent regulation of mTOR by LKB1-AMPK.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 39-like
Alternative name(s):
Antigen MLAA-34
MO25beta
Mo25-like protein
Gene namesi
Name:CAB39L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20290. CAB39L.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi81617.
OpenTargetsiENSG00000102547.
PharmGKBiPA134913801.

Polymorphism and mutation databases

DMDMi51338824.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002098261 – 337Calcium-binding protein 39-likeAdd BLAST337

Proteomic databases

EPDiQ9H9S4.
MaxQBiQ9H9S4.
PaxDbiQ9H9S4.
PeptideAtlasiQ9H9S4.
PRIDEiQ9H9S4.

PTM databases

iPTMnetiQ9H9S4.
PhosphoSitePlusiQ9H9S4.
SwissPalmiQ9H9S4.

Expressioni

Gene expression databases

BgeeiENSG00000102547.
CleanExiHS_CAB39L.
ExpressionAtlasiQ9H9S4. baseline and differential.
GenevisibleiQ9H9S4. HS.

Organism-specific databases

HPAiCAB003686.
HPA045954.

Interactioni

Subunit structurei

Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MX1P205913EBI-1047244,EBI-929476

Protein-protein interaction databases

BioGridi123552. 8 interactors.
IntActiQ9H9S4. 5 interactors.
STRINGi9606.ENSP00000261669.

Structurei

Secondary structure

1337
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi16 – 29Combined sources14
Helixi33 – 36Combined sources4
Helixi38 – 53Combined sources16
Helixi66 – 76Combined sources11
Helixi78 – 84Combined sources7
Helixi91 – 105Combined sources15
Helixi114 – 121Combined sources8
Helixi124 – 131Combined sources8
Helixi132 – 134Combined sources3
Turni136 – 138Combined sources3
Helixi139 – 149Combined sources11
Helixi153 – 160Combined sources8
Helixi163 – 167Combined sources5
Helixi168 – 171Combined sources4
Helixi177 – 192Combined sources16
Helixi195 – 204Combined sources10
Helixi206 – 217Combined sources12
Helixi222 – 237Combined sources16
Helixi239 – 241Combined sources3
Helixi242 – 248Combined sources7
Helixi252 – 261Combined sources10
Helixi267 – 282Combined sources16
Helixi288 – 296Combined sources9
Helixi298 – 307Combined sources10
Turni308 – 311Combined sources4
Helixi316 – 330Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZHPX-ray2.90A/B5-337[»]
ProteinModelPortaliQ9H9S4.
SMRiQ9H9S4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mo25 family.Curated

Phylogenomic databases

eggNOGiKOG1566. Eukaryota.
ENOG410XP4S. LUCA.
GeneTreeiENSGT00390000004360.
HOGENOMiHOG000234711.
HOVERGENiHBG050757.
InParanoidiQ9H9S4.
KOiK08272.
OMAiEQFRDFF.
OrthoDBiEOG091G0DTL.
PhylomeDBiQ9H9S4.
TreeFamiTF314910.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013878. Mo25.
[Graphical view]
PANTHERiPTHR10182. PTHR10182. 1 hit.
PfamiPF08569. Mo25. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H9S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKMPLFSKS HKNPAEIVKI LKDNLAILEK QDKKTDKASE EVSKSLQAMK
60 70 80 90 100
EILCGTNEKE PPTEAVAQLA QELYSSGLLV TLIADLQLID FEGKKDVTQI
110 120 130 140 150
FNNILRRQIG TRSPTVEYIS AHPHILFMLL KGYEAPQIAL RCGIMLRECI
160 170 180 190 200
RHEPLAKIIL FSNQFRDFFK YVELSTFDIA SDAFATFKDL LTRHKVLVAD
210 220 230 240 250
FLEQNYDTIF EDYEKLLQSE NYVTKRQSLK LLGELILDRH NFAIMTKYIS
260 270 280 290 300
KPENLKLMMN LLRDKSPNIQ FEAFHVFKVF VASPHKTQPI VEILLKNQPK
310 320 330
LIEFLSSFQK ERTDDEQFAD EKNYLIKQIR DLKKTAP
Length:337
Mass (Da):39,088
Last modified:August 16, 2004 - v3
Checksum:i5C6C7A83B9B4CA2D
GO

Sequence cautioni

The sequence BAB14147 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93G → E in AAH10993 (PubMed:15489334).Curated1
Sequence conflicti156A → V in BAB14147 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288977 mRNA. Translation: AAQ93064.2.
AL136218, AL138875 Genomic DNA. Translation: CAI10816.1.
AL138875, AL136218 Genomic DNA. Translation: CAI10893.1.
BC010993 mRNA. Translation: AAH10993.2.
AK022639 mRNA. Translation: BAB14147.1. Different initiation.
CCDSiCCDS9416.2.
RefSeqiNP_001073138.1. NM_001079670.2.
NP_001274266.1. NM_001287337.1.
NP_001274267.1. NM_001287338.1.
NP_001274268.1. NM_001287339.1.
NP_112187.2. NM_030925.3.
XP_011533556.1. XM_011535254.2.
XP_011533557.1. XM_011535255.2.
XP_011533558.1. XM_011535256.2.
XP_016876274.1. XM_017020785.1.
XP_016876275.1. XM_017020786.1.
XP_016876276.1. XM_017020787.1.
XP_016876277.1. XM_017020788.1.
UniGeneiHs.742971.
Hs.87159.

Genome annotation databases

EnsembliENST00000347776; ENSP00000261669; ENSG00000102547.
ENST00000355854; ENSP00000348113; ENSG00000102547.
ENST00000409308; ENSP00000386375; ENSG00000102547.
ENST00000410043; ENSP00000386328; ENSG00000102547.
ENST00000610540; ENSP00000479669; ENSG00000102547.
GeneIDi81617.
KEGGihsa:81617.
UCSCiuc001vcw.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288977 mRNA. Translation: AAQ93064.2.
AL136218, AL138875 Genomic DNA. Translation: CAI10816.1.
AL138875, AL136218 Genomic DNA. Translation: CAI10893.1.
BC010993 mRNA. Translation: AAH10993.2.
AK022639 mRNA. Translation: BAB14147.1. Different initiation.
CCDSiCCDS9416.2.
RefSeqiNP_001073138.1. NM_001079670.2.
NP_001274266.1. NM_001287337.1.
NP_001274267.1. NM_001287338.1.
NP_001274268.1. NM_001287339.1.
NP_112187.2. NM_030925.3.
XP_011533556.1. XM_011535254.2.
XP_011533557.1. XM_011535255.2.
XP_011533558.1. XM_011535256.2.
XP_016876274.1. XM_017020785.1.
XP_016876275.1. XM_017020786.1.
XP_016876276.1. XM_017020787.1.
XP_016876277.1. XM_017020788.1.
UniGeneiHs.742971.
Hs.87159.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZHPX-ray2.90A/B5-337[»]
ProteinModelPortaliQ9H9S4.
SMRiQ9H9S4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123552. 8 interactors.
IntActiQ9H9S4. 5 interactors.
STRINGi9606.ENSP00000261669.

PTM databases

iPTMnetiQ9H9S4.
PhosphoSitePlusiQ9H9S4.
SwissPalmiQ9H9S4.

Polymorphism and mutation databases

DMDMi51338824.

Proteomic databases

EPDiQ9H9S4.
MaxQBiQ9H9S4.
PaxDbiQ9H9S4.
PeptideAtlasiQ9H9S4.
PRIDEiQ9H9S4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347776; ENSP00000261669; ENSG00000102547.
ENST00000355854; ENSP00000348113; ENSG00000102547.
ENST00000409308; ENSP00000386375; ENSG00000102547.
ENST00000410043; ENSP00000386328; ENSG00000102547.
ENST00000610540; ENSP00000479669; ENSG00000102547.
GeneIDi81617.
KEGGihsa:81617.
UCSCiuc001vcw.5. human.

Organism-specific databases

CTDi81617.
DisGeNETi81617.
GeneCardsiCAB39L.
H-InvDBHIX0011314.
HGNCiHGNC:20290. CAB39L.
HPAiCAB003686.
HPA045954.
MIMi612175. gene.
neXtProtiNX_Q9H9S4.
OpenTargetsiENSG00000102547.
PharmGKBiPA134913801.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1566. Eukaryota.
ENOG410XP4S. LUCA.
GeneTreeiENSGT00390000004360.
HOGENOMiHOG000234711.
HOVERGENiHBG050757.
InParanoidiQ9H9S4.
KOiK08272.
OMAiEQFRDFF.
OrthoDBiEOG091G0DTL.
PhylomeDBiQ9H9S4.
TreeFamiTF314910.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102547-MONOMER.
ReactomeiR-HSA-380972. Energy dependent regulation of mTOR by LKB1-AMPK.

Miscellaneous databases

GeneWikiiCAB39L.
GenomeRNAii81617.
PROiQ9H9S4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102547.
CleanExiHS_CAB39L.
ExpressionAtlasiQ9H9S4. baseline and differential.
GenevisibleiQ9H9S4. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013878. Mo25.
[Graphical view]
PANTHERiPTHR10182. PTHR10182. 1 hit.
PfamiPF08569. Mo25. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCB39L_HUMAN
AccessioniPrimary (citable) accession number: Q9H9S4
Secondary accession number(s): Q5TAW6
, Q6WG71, Q96FG1, Q9BZ33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Found in serum of 50% of patients with acute monocytic leukemia.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.