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Q9H9S4

- CB39L_HUMAN

UniProt

Q9H9S4 - CB39L_HUMAN

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Protein
Calcium-binding protein 39-like
Gene
CAB39L
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 By similarity.

GO - Biological processi

  1. cell cycle arrest Source: Reactome
  2. insulin receptor signaling pathway Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_21285. Regulation of AMPK activity via LKB1.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 39-like
Alternative name(s):
Antigen MLAA-34
MO25beta
Mo25-like protein
Gene namesi
Name:CAB39L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:20290. CAB39L.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134913801.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Calcium-binding protein 39-like
PRO_0000209826Add
BLAST

Proteomic databases

MaxQBiQ9H9S4.
PaxDbiQ9H9S4.
PRIDEiQ9H9S4.

PTM databases

PhosphoSiteiQ9H9S4.

Expressioni

Gene expression databases

ArrayExpressiQ9H9S4.
BgeeiQ9H9S4.
CleanExiHS_CAB39L.
GenevestigatoriQ9H9S4.

Organism-specific databases

HPAiCAB003686.
HPA045954.

Interactioni

Subunit structurei

Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity By similarity.

Protein-protein interaction databases

BioGridi123552. 3 interactions.
IntActiQ9H9S4. 3 interactions.
STRINGi9606.ENSP00000261669.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 2914
Helixi33 – 364
Helixi38 – 5316
Helixi66 – 7611
Helixi78 – 847
Helixi91 – 10515
Helixi114 – 1218
Helixi124 – 1318
Helixi132 – 1343
Turni136 – 1383
Helixi139 – 14911
Helixi153 – 1608
Helixi163 – 1675
Helixi168 – 1714
Helixi177 – 19216
Helixi195 – 20410
Helixi206 – 21712
Helixi222 – 23716
Helixi239 – 2413
Helixi242 – 2487
Helixi252 – 26110
Helixi267 – 28216
Helixi288 – 2969
Helixi298 – 30710
Turni308 – 3114
Helixi316 – 33015

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZHPX-ray2.90A/B5-337[»]
ProteinModelPortaliQ9H9S4.
SMRiQ9H9S4. Positions 15-334.

Family & Domainsi

Sequence similaritiesi

Belongs to the Mo25 family.

Phylogenomic databases

eggNOGiNOG307443.
HOGENOMiHOG000234711.
HOVERGENiHBG050757.
InParanoidiQ9H9S4.
KOiK08272.
OMAiNFQKERT.
OrthoDBiEOG7CK371.
PhylomeDBiQ9H9S4.
TreeFamiTF314910.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013878. Mo25.
[Graphical view]
PANTHERiPTHR10182. PTHR10182. 1 hit.
PfamiPF08569. Mo25. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H9S4-1 [UniParc]FASTAAdd to Basket

« Hide

MKKMPLFSKS HKNPAEIVKI LKDNLAILEK QDKKTDKASE EVSKSLQAMK    50
EILCGTNEKE PPTEAVAQLA QELYSSGLLV TLIADLQLID FEGKKDVTQI 100
FNNILRRQIG TRSPTVEYIS AHPHILFMLL KGYEAPQIAL RCGIMLRECI 150
RHEPLAKIIL FSNQFRDFFK YVELSTFDIA SDAFATFKDL LTRHKVLVAD 200
FLEQNYDTIF EDYEKLLQSE NYVTKRQSLK LLGELILDRH NFAIMTKYIS 250
KPENLKLMMN LLRDKSPNIQ FEAFHVFKVF VASPHKTQPI VEILLKNQPK 300
LIEFLSSFQK ERTDDEQFAD EKNYLIKQIR DLKKTAP 337
Length:337
Mass (Da):39,088
Last modified:August 16, 2004 - v3
Checksum:i5C6C7A83B9B4CA2D
GO

Sequence cautioni

The sequence BAB14147.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931G → E in AAH10993. 1 Publication
Sequence conflicti156 – 1561A → V in BAB14147. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY288977 mRNA. Translation: AAQ93064.2.
AL136218, AL138875 Genomic DNA. Translation: CAI10816.1.
AL138875, AL136218 Genomic DNA. Translation: CAI10893.1.
BC010993 mRNA. Translation: AAH10993.2.
AK022639 mRNA. Translation: BAB14147.1. Different initiation.
CCDSiCCDS9416.2.
RefSeqiNP_001073138.1. NM_001079670.2.
NP_001274266.1. NM_001287337.1.
NP_001274267.1. NM_001287338.1.
NP_001274268.1. NM_001287339.1.
NP_112187.2. NM_030925.3.
UniGeneiHs.742971.
Hs.87159.

Genome annotation databases

EnsembliENST00000347776; ENSP00000261669; ENSG00000102547.
ENST00000355854; ENSP00000348113; ENSG00000102547.
ENST00000409308; ENSP00000386375; ENSG00000102547.
ENST00000410043; ENSP00000386328; ENSG00000102547.
GeneIDi81617.
KEGGihsa:81617.
UCSCiuc001vcw.3. human.

Polymorphism databases

DMDMi51338824.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY288977 mRNA. Translation: AAQ93064.2 .
AL136218 , AL138875 Genomic DNA. Translation: CAI10816.1 .
AL138875 , AL136218 Genomic DNA. Translation: CAI10893.1 .
BC010993 mRNA. Translation: AAH10993.2 .
AK022639 mRNA. Translation: BAB14147.1 . Different initiation.
CCDSi CCDS9416.2.
RefSeqi NP_001073138.1. NM_001079670.2.
NP_001274266.1. NM_001287337.1.
NP_001274267.1. NM_001287338.1.
NP_001274268.1. NM_001287339.1.
NP_112187.2. NM_030925.3.
UniGenei Hs.742971.
Hs.87159.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZHP X-ray 2.90 A/B 5-337 [» ]
ProteinModelPortali Q9H9S4.
SMRi Q9H9S4. Positions 15-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123552. 3 interactions.
IntActi Q9H9S4. 3 interactions.
STRINGi 9606.ENSP00000261669.

PTM databases

PhosphoSitei Q9H9S4.

Polymorphism databases

DMDMi 51338824.

Proteomic databases

MaxQBi Q9H9S4.
PaxDbi Q9H9S4.
PRIDEi Q9H9S4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000347776 ; ENSP00000261669 ; ENSG00000102547 .
ENST00000355854 ; ENSP00000348113 ; ENSG00000102547 .
ENST00000409308 ; ENSP00000386375 ; ENSG00000102547 .
ENST00000410043 ; ENSP00000386328 ; ENSG00000102547 .
GeneIDi 81617.
KEGGi hsa:81617.
UCSCi uc001vcw.3. human.

Organism-specific databases

CTDi 81617.
GeneCardsi GC13M049882.
H-InvDB HIX0011314.
HGNCi HGNC:20290. CAB39L.
HPAi CAB003686.
HPA045954.
MIMi 612175. gene.
neXtProti NX_Q9H9S4.
PharmGKBi PA134913801.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307443.
HOGENOMi HOG000234711.
HOVERGENi HBG050757.
InParanoidi Q9H9S4.
KOi K08272.
OMAi NFQKERT.
OrthoDBi EOG7CK371.
PhylomeDBi Q9H9S4.
TreeFami TF314910.

Enzyme and pathway databases

Reactomei REACT_21285. Regulation of AMPK activity via LKB1.

Miscellaneous databases

GeneWikii CAB39L.
GenomeRNAii 81617.
NextBioi 71962.
PROi Q9H9S4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9H9S4.
Bgeei Q9H9S4.
CleanExi HS_CAB39L.
Genevestigatori Q9H9S4.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013878. Mo25.
[Graphical view ]
PANTHERi PTHR10182. PTHR10182. 1 hit.
Pfami PF08569. Mo25. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Serological identification of immunogenic antigens in acute monocytic leukemia."
    Chen G., Zhang W.G., Cao X.M., Li F.Y., Liu X.P., Yao L.B.
    Leuk. Res. 29:503-509(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Monocytic leukemia.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-337.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCB39L_HUMAN
AccessioniPrimary (citable) accession number: Q9H9S4
Secondary accession number(s): Q5TAW6
, Q6WG71, Q96FG1, Q9BZ33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Found in serum of 50% of patients with acute monocytic leukemia.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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