Q9H9S4 (CB39L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calcium-binding protein 39-like

Alternative name(s):
Antigen MLAA-34
MO25beta
Mo25-like protein

Gene names

Name:

CAB39L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 By similarity.
Subunit structure	Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity By similarity.
Miscellaneous	Found in serum of 50% of patients with acute monocytic leukemia.
Sequence similarities	Belongs to the Mo25 family.
Sequence caution	The sequence BAB14147.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle arrest Traceable author statement. Source: Reactome insulin receptor signaling pathway Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 337

337

Calcium-binding protein 39-like

PRO_0000209826

Amino acid modifications

Modified residue

162

1

Phosphoserine By similarity

Experimental info

Sequence conflict

93

1

G → E in AAH10993. Ref.3

Sequence conflict

156

1

A → V in BAB14147. Ref.4

Secondary structure

1

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337

Helix Strand Turn

Details...

Helix

16 – 29

14

Helix

33 – 36

4

Helix

38 – 53

16

Helix

66 – 76

11

Helix

78 – 84

7

Helix

91 – 105

15

Helix

114 – 121

8

Helix

124 – 131

8

Helix

132 – 134

3

Turn

136 – 138

3

Helix

139 – 149

11

Helix

153 – 160

8

Helix

163 – 167

5

Helix

168 – 171

4

Helix

177 – 192

16

Helix

195 – 204

10

Helix

206 – 217

12

Helix

222 – 237

16

Helix

239 – 241

3

Helix

242 – 248

7

Helix

252 – 261

10

Helix

267 – 282

16

Helix

288 – 296

9

Helix

298 – 307

10

Turn

308 – 311

4

Helix

316 – 330

15

Sequences

	Sequence		Length	Mass (Da)
	Q9H9S4 [UniParc]. Last modified August 16, 2004. Version 3. Checksum: 5C6C7A83B9B4CA2D	FASTA	337	39,088
	10 20 30 40 50 60 MKKMPLFSKS HKNPAEIVKI LKDNLAILEK QDKKTDKASE EVSKSLQAMK EILCGTNEKE 70 80 90 100 110 120 PPTEAVAQLA QELYSSGLLV TLIADLQLID FEGKKDVTQI FNNILRRQIG TRSPTVEYIS 130 140 150 160 170 180 AHPHILFMLL KGYEAPQIAL RCGIMLRECI RHEPLAKIIL FSNQFRDFFK YVELSTFDIA 190 200 210 220 230 240 SDAFATFKDL LTRHKVLVAD FLEQNYDTIF EDYEKLLQSE NYVTKRQSLK LLGELILDRH 250 260 270 280 290 300 NFAIMTKYIS KPENLKLMMN LLRDKSPNIQ FEAFHVFKVF VASPHKTQPI VEILLKNQPK 310 320 330 LIEFLSSFQK ERTDDEQFAD EKNYLIKQIR DLKKTAP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Serological identification of immunogenic antigens in acute monocytic leukemia." Chen G., Zhang W.G., Cao X.M., Li F.Y., Liu X.P., Yao L.B. Leuk. Res. 29:503-509(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Monocytic leukemia.
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-337.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY288977 mRNA. Translation: AAQ93064.2.
AL136218, AL138875 Genomic DNA. Translation: CAI10816.1.
AL138875, AL136218 Genomic DNA. Translation: CAI10893.1.
BC010993 mRNA. Translation: AAH10993.2.
AK022639 mRNA. Translation: BAB14147.1. Different initiation.

IPI

IPI00026359.

RefSeq

NP_001073138.1. NM_001079670.1.
NP_112187.2. NM_030925.2.

UniGene

Hs.87159.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3ZHP	X-ray	2.90	A/B	5-337	[»]

ProteinModelPortal

Q9H9S4.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9H9S4. 2 interactions.

STRING

9606.ENSP00000261669.

PTM databases

PhosphoSite

Q9H9S4.

Polymorphism databases

DMDM

51338824.

Proteomic databases

PaxDb

Q9H9S4.

PRIDE

Q9H9S4.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000347776; ENSP00000261669; ENSG00000102547.
ENST00000355854; ENSP00000348113; ENSG00000102547.
ENST00000409308; ENSP00000386375; ENSG00000102547.
ENST00000410043; ENSP00000386328; ENSG00000102547.

GeneID

81617.

KEGG

hsa:81617.

UCSC

uc001vcw.3. human.

Organism-specific databases

CTD

81617.

GeneCards

GC13M049882.

H-InvDB

HIX0011314.

HGNC

HGNC:20290. CAB39L.

HPA

CAB003686.

MIM

612175. gene.

neXtProt

NX_Q9H9S4.

PharmGKB

PA134913801.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG307443.

HOGENOM

HOG000234711.

HOVERGEN

HBG050757.

InParanoid

Q9H9S4.

KO

K08272.

OMA

SDKEPPT.

OrthoDB

EOG4JDH72.

PhylomeDB

Q9H9S4.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.
REACT_11163. Activated AMPK stimulates fatty-acid oxidation in muscle.

Gene expression databases

ArrayExpress

Q9H9S4.

Bgee

Q9H9S4.

CleanEx

HS_CAB39L.

Genevestigator

Q9H9S4.

GermOnline

ENSG00000102547. Homo sapiens.

Family and domain databases

Gene3D

1.25.10.10. 1 hit.

InterPro

IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013878. Mo25.
[Graphical view]

PANTHER

PTHR10182. PTHR10182. 1 hit.

Pfam

PF08569. Mo25. 1 hit.
[Graphical view]

SUPFAM

SSF48371. ARM-type_fold. 1 hit.

ProtoNet

Search...

Other

GenomeRNAi

81617.

NextBio

71962.

SOURCE

Search...

Entry information

Entry name

CB39L_HUMAN

Accession

Primary (citable) accession number: Q9H9S4
Secondary accession number(s): Q5TAW6 , Q6WG71, Q96FG1, Q9BZ33

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	August 16, 2004
Last modified:	May 29, 2013
This is version 98 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.