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Protein

Calcium-binding protein 39-like

Gene

CAB39L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_21285. Regulation of AMPK activity via LKB1.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 39-like
Alternative name(s):
Antigen MLAA-34
MO25beta
Mo25-like protein
Gene namesi
Name:CAB39L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20290. CAB39L.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134913801.

Polymorphism and mutation databases

DMDMi51338824.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Calcium-binding protein 39-likePRO_0000209826Add
BLAST

Proteomic databases

MaxQBiQ9H9S4.
PaxDbiQ9H9S4.
PRIDEiQ9H9S4.

PTM databases

PhosphoSiteiQ9H9S4.

Expressioni

Gene expression databases

BgeeiQ9H9S4.
CleanExiHS_CAB39L.
ExpressionAtlasiQ9H9S4. baseline and differential.
GenevisibleiQ9H9S4. HS.

Organism-specific databases

HPAiCAB003686.
HPA045954.

Interactioni

Subunit structurei

Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MX1P205913EBI-1047244,EBI-929476

Protein-protein interaction databases

BioGridi123552. 7 interactions.
IntActiQ9H9S4. 4 interactions.
STRINGi9606.ENSP00000261669.

Structurei

Secondary structure

1
337
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 2914Combined sources
Helixi33 – 364Combined sources
Helixi38 – 5316Combined sources
Helixi66 – 7611Combined sources
Helixi78 – 847Combined sources
Helixi91 – 10515Combined sources
Helixi114 – 1218Combined sources
Helixi124 – 1318Combined sources
Helixi132 – 1343Combined sources
Turni136 – 1383Combined sources
Helixi139 – 14911Combined sources
Helixi153 – 1608Combined sources
Helixi163 – 1675Combined sources
Helixi168 – 1714Combined sources
Helixi177 – 19216Combined sources
Helixi195 – 20410Combined sources
Helixi206 – 21712Combined sources
Helixi222 – 23716Combined sources
Helixi239 – 2413Combined sources
Helixi242 – 2487Combined sources
Helixi252 – 26110Combined sources
Helixi267 – 28216Combined sources
Helixi288 – 2969Combined sources
Helixi298 – 30710Combined sources
Turni308 – 3114Combined sources
Helixi316 – 33015Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZHPX-ray2.90A/B5-337[»]
ProteinModelPortaliQ9H9S4.
SMRiQ9H9S4. Positions 15-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mo25 family.Curated

Phylogenomic databases

eggNOGiNOG307443.
GeneTreeiENSGT00390000004360.
HOGENOMiHOG000234711.
HOVERGENiHBG050757.
InParanoidiQ9H9S4.
KOiK08272.
OMAiILCGTSD.
OrthoDBiEOG7CK371.
PhylomeDBiQ9H9S4.
TreeFamiTF314910.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013878. Mo25.
[Graphical view]
PANTHERiPTHR10182. PTHR10182. 1 hit.
PfamiPF08569. Mo25. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H9S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKMPLFSKS HKNPAEIVKI LKDNLAILEK QDKKTDKASE EVSKSLQAMK
60 70 80 90 100
EILCGTNEKE PPTEAVAQLA QELYSSGLLV TLIADLQLID FEGKKDVTQI
110 120 130 140 150
FNNILRRQIG TRSPTVEYIS AHPHILFMLL KGYEAPQIAL RCGIMLRECI
160 170 180 190 200
RHEPLAKIIL FSNQFRDFFK YVELSTFDIA SDAFATFKDL LTRHKVLVAD
210 220 230 240 250
FLEQNYDTIF EDYEKLLQSE NYVTKRQSLK LLGELILDRH NFAIMTKYIS
260 270 280 290 300
KPENLKLMMN LLRDKSPNIQ FEAFHVFKVF VASPHKTQPI VEILLKNQPK
310 320 330
LIEFLSSFQK ERTDDEQFAD EKNYLIKQIR DLKKTAP
Length:337
Mass (Da):39,088
Last modified:August 16, 2004 - v3
Checksum:i5C6C7A83B9B4CA2D
GO

Sequence cautioni

The sequence BAB14147.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931G → E in AAH10993 (PubMed:15489334).Curated
Sequence conflicti156 – 1561A → V in BAB14147 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288977 mRNA. Translation: AAQ93064.2.
AL136218, AL138875 Genomic DNA. Translation: CAI10816.1.
AL138875, AL136218 Genomic DNA. Translation: CAI10893.1.
BC010993 mRNA. Translation: AAH10993.2.
AK022639 mRNA. Translation: BAB14147.1. Different initiation.
CCDSiCCDS9416.2.
RefSeqiNP_001073138.1. NM_001079670.2.
NP_001274266.1. NM_001287337.1.
NP_001274267.1. NM_001287338.1.
NP_001274268.1. NM_001287339.1.
NP_112187.2. NM_030925.3.
XP_011533556.1. XM_011535254.1.
XP_011533557.1. XM_011535255.1.
XP_011533558.1. XM_011535256.1.
XP_011533559.1. XM_011535257.1.
UniGeneiHs.742971.
Hs.87159.

Genome annotation databases

EnsembliENST00000347776; ENSP00000261669; ENSG00000102547.
ENST00000355854; ENSP00000348113; ENSG00000102547.
ENST00000409308; ENSP00000386375; ENSG00000102547.
ENST00000410043; ENSP00000386328; ENSG00000102547.
ENST00000610540; ENSP00000479669; ENSG00000102547.
GeneIDi81617.
KEGGihsa:81617.
UCSCiuc001vcw.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288977 mRNA. Translation: AAQ93064.2.
AL136218, AL138875 Genomic DNA. Translation: CAI10816.1.
AL138875, AL136218 Genomic DNA. Translation: CAI10893.1.
BC010993 mRNA. Translation: AAH10993.2.
AK022639 mRNA. Translation: BAB14147.1. Different initiation.
CCDSiCCDS9416.2.
RefSeqiNP_001073138.1. NM_001079670.2.
NP_001274266.1. NM_001287337.1.
NP_001274267.1. NM_001287338.1.
NP_001274268.1. NM_001287339.1.
NP_112187.2. NM_030925.3.
XP_011533556.1. XM_011535254.1.
XP_011533557.1. XM_011535255.1.
XP_011533558.1. XM_011535256.1.
XP_011533559.1. XM_011535257.1.
UniGeneiHs.742971.
Hs.87159.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZHPX-ray2.90A/B5-337[»]
ProteinModelPortaliQ9H9S4.
SMRiQ9H9S4. Positions 15-334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123552. 7 interactions.
IntActiQ9H9S4. 4 interactions.
STRINGi9606.ENSP00000261669.

PTM databases

PhosphoSiteiQ9H9S4.

Polymorphism and mutation databases

DMDMi51338824.

Proteomic databases

MaxQBiQ9H9S4.
PaxDbiQ9H9S4.
PRIDEiQ9H9S4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347776; ENSP00000261669; ENSG00000102547.
ENST00000355854; ENSP00000348113; ENSG00000102547.
ENST00000409308; ENSP00000386375; ENSG00000102547.
ENST00000410043; ENSP00000386328; ENSG00000102547.
ENST00000610540; ENSP00000479669; ENSG00000102547.
GeneIDi81617.
KEGGihsa:81617.
UCSCiuc001vcw.3. human.

Organism-specific databases

CTDi81617.
GeneCardsiGC13M049882.
H-InvDBHIX0011314.
HGNCiHGNC:20290. CAB39L.
HPAiCAB003686.
HPA045954.
MIMi612175. gene.
neXtProtiNX_Q9H9S4.
PharmGKBiPA134913801.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG307443.
GeneTreeiENSGT00390000004360.
HOGENOMiHOG000234711.
HOVERGENiHBG050757.
InParanoidiQ9H9S4.
KOiK08272.
OMAiILCGTSD.
OrthoDBiEOG7CK371.
PhylomeDBiQ9H9S4.
TreeFamiTF314910.

Enzyme and pathway databases

ReactomeiREACT_21285. Regulation of AMPK activity via LKB1.

Miscellaneous databases

GeneWikiiCAB39L.
GenomeRNAii81617.
NextBioi71962.
PROiQ9H9S4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H9S4.
CleanExiHS_CAB39L.
ExpressionAtlasiQ9H9S4. baseline and differential.
GenevisibleiQ9H9S4. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013878. Mo25.
[Graphical view]
PANTHERiPTHR10182. PTHR10182. 1 hit.
PfamiPF08569. Mo25. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Serological identification of immunogenic antigens in acute monocytic leukemia."
    Chen G., Zhang W.G., Cao X.M., Li F.Y., Liu X.P., Yao L.B.
    Leuk. Res. 29:503-509(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Monocytic leukemia.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-337.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCB39L_HUMAN
AccessioniPrimary (citable) accession number: Q9H9S4
Secondary accession number(s): Q5TAW6
, Q6WG71, Q96FG1, Q9BZ33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 16, 2004
Last modified: July 22, 2015
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Found in serum of 50% of patients with acute monocytic leukemia.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.