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Q9H9S4

- CB39L_HUMAN

UniProt

Q9H9S4 - CB39L_HUMAN

Protein

Calcium-binding protein 39-like

Gene

CAB39L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 3 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 By similarity.By similarity

    GO - Biological processi

    1. cell cycle arrest Source: Reactome
    2. insulin receptor signaling pathway Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_21285. Regulation of AMPK activity via LKB1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-binding protein 39-like
    Alternative name(s):
    Antigen MLAA-34
    MO25beta
    Mo25-like protein
    Gene namesi
    Name:CAB39L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:20290. CAB39L.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. extracellular vesicular exosome Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134913801.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337Calcium-binding protein 39-likePRO_0000209826Add
    BLAST

    Proteomic databases

    MaxQBiQ9H9S4.
    PaxDbiQ9H9S4.
    PRIDEiQ9H9S4.

    PTM databases

    PhosphoSiteiQ9H9S4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H9S4.
    BgeeiQ9H9S4.
    CleanExiHS_CAB39L.
    GenevestigatoriQ9H9S4.

    Organism-specific databases

    HPAiCAB003686.
    HPA045954.

    Interactioni

    Subunit structurei

    Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.By similarity

    Protein-protein interaction databases

    BioGridi123552. 3 interactions.
    IntActiQ9H9S4. 3 interactions.
    STRINGi9606.ENSP00000261669.

    Structurei

    Secondary structure

    1
    337
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi16 – 2914
    Helixi33 – 364
    Helixi38 – 5316
    Helixi66 – 7611
    Helixi78 – 847
    Helixi91 – 10515
    Helixi114 – 1218
    Helixi124 – 1318
    Helixi132 – 1343
    Turni136 – 1383
    Helixi139 – 14911
    Helixi153 – 1608
    Helixi163 – 1675
    Helixi168 – 1714
    Helixi177 – 19216
    Helixi195 – 20410
    Helixi206 – 21712
    Helixi222 – 23716
    Helixi239 – 2413
    Helixi242 – 2487
    Helixi252 – 26110
    Helixi267 – 28216
    Helixi288 – 2969
    Helixi298 – 30710
    Turni308 – 3114
    Helixi316 – 33015

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZHPX-ray2.90A/B5-337[»]
    ProteinModelPortaliQ9H9S4.
    SMRiQ9H9S4. Positions 15-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Mo25 family.Curated

    Phylogenomic databases

    eggNOGiNOG307443.
    HOGENOMiHOG000234711.
    HOVERGENiHBG050757.
    InParanoidiQ9H9S4.
    KOiK08272.
    OMAiNFQKERT.
    OrthoDBiEOG7CK371.
    PhylomeDBiQ9H9S4.
    TreeFamiTF314910.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR013878. Mo25.
    [Graphical view]
    PANTHERiPTHR10182. PTHR10182. 1 hit.
    PfamiPF08569. Mo25. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9H9S4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKMPLFSKS HKNPAEIVKI LKDNLAILEK QDKKTDKASE EVSKSLQAMK    50
    EILCGTNEKE PPTEAVAQLA QELYSSGLLV TLIADLQLID FEGKKDVTQI 100
    FNNILRRQIG TRSPTVEYIS AHPHILFMLL KGYEAPQIAL RCGIMLRECI 150
    RHEPLAKIIL FSNQFRDFFK YVELSTFDIA SDAFATFKDL LTRHKVLVAD 200
    FLEQNYDTIF EDYEKLLQSE NYVTKRQSLK LLGELILDRH NFAIMTKYIS 250
    KPENLKLMMN LLRDKSPNIQ FEAFHVFKVF VASPHKTQPI VEILLKNQPK 300
    LIEFLSSFQK ERTDDEQFAD EKNYLIKQIR DLKKTAP 337
    Length:337
    Mass (Da):39,088
    Last modified:August 16, 2004 - v3
    Checksum:i5C6C7A83B9B4CA2D
    GO

    Sequence cautioni

    The sequence BAB14147.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti93 – 931G → E in AAH10993. (PubMed:15489334)Curated
    Sequence conflicti156 – 1561A → V in BAB14147. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY288977 mRNA. Translation: AAQ93064.2.
    AL136218, AL138875 Genomic DNA. Translation: CAI10816.1.
    AL138875, AL136218 Genomic DNA. Translation: CAI10893.1.
    BC010993 mRNA. Translation: AAH10993.2.
    AK022639 mRNA. Translation: BAB14147.1. Different initiation.
    CCDSiCCDS9416.2.
    RefSeqiNP_001073138.1. NM_001079670.2.
    NP_001274266.1. NM_001287337.1.
    NP_001274267.1. NM_001287338.1.
    NP_001274268.1. NM_001287339.1.
    NP_112187.2. NM_030925.3.
    UniGeneiHs.742971.
    Hs.87159.

    Genome annotation databases

    EnsembliENST00000347776; ENSP00000261669; ENSG00000102547.
    ENST00000355854; ENSP00000348113; ENSG00000102547.
    ENST00000409308; ENSP00000386375; ENSG00000102547.
    ENST00000410043; ENSP00000386328; ENSG00000102547.
    GeneIDi81617.
    KEGGihsa:81617.
    UCSCiuc001vcw.3. human.

    Polymorphism databases

    DMDMi51338824.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY288977 mRNA. Translation: AAQ93064.2 .
    AL136218 , AL138875 Genomic DNA. Translation: CAI10816.1 .
    AL138875 , AL136218 Genomic DNA. Translation: CAI10893.1 .
    BC010993 mRNA. Translation: AAH10993.2 .
    AK022639 mRNA. Translation: BAB14147.1 . Different initiation.
    CCDSi CCDS9416.2.
    RefSeqi NP_001073138.1. NM_001079670.2.
    NP_001274266.1. NM_001287337.1.
    NP_001274267.1. NM_001287338.1.
    NP_001274268.1. NM_001287339.1.
    NP_112187.2. NM_030925.3.
    UniGenei Hs.742971.
    Hs.87159.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZHP X-ray 2.90 A/B 5-337 [» ]
    ProteinModelPortali Q9H9S4.
    SMRi Q9H9S4. Positions 15-334.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123552. 3 interactions.
    IntActi Q9H9S4. 3 interactions.
    STRINGi 9606.ENSP00000261669.

    PTM databases

    PhosphoSitei Q9H9S4.

    Polymorphism databases

    DMDMi 51338824.

    Proteomic databases

    MaxQBi Q9H9S4.
    PaxDbi Q9H9S4.
    PRIDEi Q9H9S4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000347776 ; ENSP00000261669 ; ENSG00000102547 .
    ENST00000355854 ; ENSP00000348113 ; ENSG00000102547 .
    ENST00000409308 ; ENSP00000386375 ; ENSG00000102547 .
    ENST00000410043 ; ENSP00000386328 ; ENSG00000102547 .
    GeneIDi 81617.
    KEGGi hsa:81617.
    UCSCi uc001vcw.3. human.

    Organism-specific databases

    CTDi 81617.
    GeneCardsi GC13M049882.
    H-InvDB HIX0011314.
    HGNCi HGNC:20290. CAB39L.
    HPAi CAB003686.
    HPA045954.
    MIMi 612175. gene.
    neXtProti NX_Q9H9S4.
    PharmGKBi PA134913801.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307443.
    HOGENOMi HOG000234711.
    HOVERGENi HBG050757.
    InParanoidi Q9H9S4.
    KOi K08272.
    OMAi NFQKERT.
    OrthoDBi EOG7CK371.
    PhylomeDBi Q9H9S4.
    TreeFami TF314910.

    Enzyme and pathway databases

    Reactomei REACT_21285. Regulation of AMPK activity via LKB1.

    Miscellaneous databases

    GeneWikii CAB39L.
    GenomeRNAii 81617.
    NextBioi 71962.
    PROi Q9H9S4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H9S4.
    Bgeei Q9H9S4.
    CleanExi HS_CAB39L.
    Genevestigatori Q9H9S4.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR013878. Mo25.
    [Graphical view ]
    PANTHERi PTHR10182. PTHR10182. 1 hit.
    Pfami PF08569. Mo25. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Serological identification of immunogenic antigens in acute monocytic leukemia."
      Chen G., Zhang W.G., Cao X.M., Li F.Y., Liu X.P., Yao L.B.
      Leuk. Res. 29:503-509(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Monocytic leukemia.
    2. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-337.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCB39L_HUMAN
    AccessioniPrimary (citable) accession number: Q9H9S4
    Secondary accession number(s): Q5TAW6
    , Q6WG71, Q96FG1, Q9BZ33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 110 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Found in serum of 50% of patients with acute monocytic leukemia.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3