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Q9H9S0

- NANOG_HUMAN

UniProt

Q9H9S0 - NANOG_HUMAN

Protein

Homeobox protein NANOG

Gene

NANOG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi95 – 15460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. DNA binding Source: UniProtKB
    3. enhancer sequence-specific DNA binding Source: Ensembl
    4. sequence-specific DNA binding transcription factor activity Source: HGNC
    5. transcription corepressor activity Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: HGNC
    2. cell proliferation Source: HGNC
    3. embryo development Source: HGNC
    4. embryonic pattern specification Source: Ensembl
    5. endodermal cell fate specification Source: MGI
    6. gonad development Source: Ensembl
    7. mesodermal cell fate commitment Source: Ensembl
    8. negative regulation of BMP signaling pathway Source: Ensembl
    9. negative regulation of cell fate commitment Source: Ensembl
    10. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    11. positive regulation of cell proliferation Source: Ensembl
    12. positive regulation of mitotic cell cycle Source: Ensembl
    13. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    14. regulation of cell differentiation Source: HGNC
    15. regulation of gene expression Source: UniProtKB
    16. regulation of transcription, DNA-templated Source: HGNC
    17. response to retinoic acid Source: Ensembl
    18. somatic stem cell maintenance Source: UniProtKB
    19. stem cell division Source: Ensembl
    20. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_200670. POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation.
    REACT_200759. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.
    REACT_200812. Transcriptional regulation of pluripotent stem cells.
    SignaLinkiQ9H9S0.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein NANOG
    Alternative name(s):
    Homeobox transcription factor Nanog
    Short name:
    hNanog
    Gene namesi
    Name:NANOG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:20857. NANOG.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleolus Source: BHF-UCL
    2. nucleoplasm Source: Ensembl
    3. nucleus Source: BHF-UCL

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134864904.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Homeobox protein NANOGPRO_0000261418Add
    BLAST

    Proteomic databases

    PaxDbiQ9H9S0.
    PRIDEiQ9H9S0.

    PTM databases

    PhosphoSiteiQ9H9S0.

    Expressioni

    Tissue specificityi

    Expressed in testicular carcinoma and derived germ cell tumors (at protein level). Expressed in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell line and testicular embryonic carcinoma. Not expressed in many somatic organs and oocytes.5 Publications

    Developmental stagei

    Expressed in embryonic stem (ES) and carcinoma (EC) cells. Expressed in inner cell mass (ICM) of the blastocyst and gonocytes between 14 and 19 weeks of gestation (at protein level). Not expressed in oocytes, unfertilized oocytes, 2-16 cell embryos and early morula (at protein level). Expressed in embryonic stem cells (ES). Expression decreases with ES differentiation.5 Publications

    Gene expression databases

    BgeeiQ9H9S0.
    CleanExiHS_NANOG.
    GenevestigatoriQ9H9S0.

    Organism-specific databases

    HPAiCAB019380.

    Interactioni

    Subunit structurei

    Interacts with SMAD1 and SALL4. Interacts with ZNF281/ZFP281 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi123000. 6 interactions.
    STRINGi9606.ENSP00000229307.

    Structurei

    Secondary structure

    1
    305
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi104 – 11613
    Beta strandi117 – 1193
    Helixi122 – 13110
    Helixi136 – 14813
    Turni149 – 1513

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2KT0NMR-A75-157[»]
    ProteinModelPortaliQ9H9S0.
    SMRiQ9H9S0. Positions 75-157.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9H9S0.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati196 – 20051
    Repeati201 – 20552
    Repeati206 – 21053
    Repeati216 – 22054
    Repeati221 – 22555
    Repeati226 – 23056
    Repeati231 – 23557
    Repeati236 – 24058

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni196 – 240458 X repeats starting with a Trp in each unitAdd
    BLAST
    Regioni196 – 24045Sufficient for transactivation activityBy similarityAdd
    BLAST
    Regioni241 – 30565Sufficient for strong transactivation activityBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Nanog homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox, Repeat

    Phylogenomic databases

    eggNOGiNOG297592.
    HOGENOMiHOG000236291.
    HOVERGENiHBG058783.
    InParanoidiQ9H9S0.
    KOiK10164.
    OMAiTWTNPTW.
    PhylomeDBiQ9H9S0.
    TreeFamiTF337402.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H9S0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSVDPACPQS LPCFEASDCK ESSPMPVICG PEENYPSLQM SSAEMPHTET    50
    VSPLPSSMDL LIQDSPDSST SPKGKQPTSA EKSVAKKEDK VPVKKQKTRT 100
    VFSSTQLCVL NDRFQRQKYL SLQQMQELSN ILNLSYKQVK TWFQNQRMKS 150
    KRWQKNNWPK NSNGVTQKAS APTYPSLYSS YHQGCLVNPT GNLPMWSNQT 200
    WNNSTWSNQT QNIQSWSNHS WNTQTWCTQS WNNQAWNSPF YNCGEESLQS 250
    CMQFQPNSPA SDLEAALEAA GEGLNVIQQT TRYFSTPQTM DLFLNYSMNM 300
    QPEDV 305
    Length:305
    Mass (Da):34,620
    Last modified:November 28, 2006 - v2
    Checksum:iAC3B2E067C591773
    GO
    Isoform 2 (identifier: Q9H9S0-2) [UniParc]FASTAAdd to Basket

    Also known as: Nanog-delta 48

    The sequence of this isoform differs from the canonical sequence as follows:
         168-183: Missing.

    Show »
    Length:289
    Mass (Da):32,838
    Checksum:i65FB4489711E7742
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti82 – 821K → N.4 Publications
    Corresponds to variant rs2889551 [ dbSNP | Ensembl ].
    VAR_029384

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei168 – 18316Missing in isoform 2. 1 PublicationVSP_021688Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB093576 mRNA. Translation: BAC76999.1.
    AY230262 mRNA. Translation: AAP49529.1.
    AY578089 mRNA. Translation: AAT81526.1.
    AK022643 mRNA. Translation: BAB14151.1.
    CH471116 Genomic DNA. Translation: EAW88649.1.
    CH471116 Genomic DNA. Translation: EAW88651.1.
    CCDSiCCDS31736.1. [Q9H9S0-1]
    RefSeqiNP_079141.2. NM_024865.2. [Q9H9S0-1]
    XP_005253541.1. XM_005253484.2. [Q9H9S0-2]
    UniGeneiHs.635882.

    Genome annotation databases

    EnsembliENST00000229307; ENSP00000229307; ENSG00000111704. [Q9H9S0-1]
    ENST00000526286; ENSP00000435288; ENSG00000111704. [Q9H9S0-2]
    GeneIDi79923.
    KEGGihsa:79923.
    UCSCiuc009zfy.1. human. [Q9H9S0-1]

    Polymorphism databases

    DMDMi118573073.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Nanog entry

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB093576 mRNA. Translation: BAC76999.1 .
    AY230262 mRNA. Translation: AAP49529.1 .
    AY578089 mRNA. Translation: AAT81526.1 .
    AK022643 mRNA. Translation: BAB14151.1 .
    CH471116 Genomic DNA. Translation: EAW88649.1 .
    CH471116 Genomic DNA. Translation: EAW88651.1 .
    CCDSi CCDS31736.1. [Q9H9S0-1 ]
    RefSeqi NP_079141.2. NM_024865.2. [Q9H9S0-1 ]
    XP_005253541.1. XM_005253484.2. [Q9H9S0-2 ]
    UniGenei Hs.635882.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2KT0 NMR - A 75-157 [» ]
    ProteinModelPortali Q9H9S0.
    SMRi Q9H9S0. Positions 75-157.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123000. 6 interactions.
    STRINGi 9606.ENSP00000229307.

    PTM databases

    PhosphoSitei Q9H9S0.

    Polymorphism databases

    DMDMi 118573073.

    Proteomic databases

    PaxDbi Q9H9S0.
    PRIDEi Q9H9S0.

    Protocols and materials databases

    DNASUi 79923.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000229307 ; ENSP00000229307 ; ENSG00000111704 . [Q9H9S0-1 ]
    ENST00000526286 ; ENSP00000435288 ; ENSG00000111704 . [Q9H9S0-2 ]
    GeneIDi 79923.
    KEGGi hsa:79923.
    UCSCi uc009zfy.1. human. [Q9H9S0-1 ]

    Organism-specific databases

    CTDi 79923.
    GeneCardsi GC12P007940.
    H-InvDB HIX0010400.
    HIX0038147.
    HGNCi HGNC:20857. NANOG.
    HPAi CAB019380.
    MIMi 607937. gene.
    neXtProti NX_Q9H9S0.
    PharmGKBi PA134864904.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG297592.
    HOGENOMi HOG000236291.
    HOVERGENi HBG058783.
    InParanoidi Q9H9S0.
    KOi K10164.
    OMAi TWTNPTW.
    PhylomeDBi Q9H9S0.
    TreeFami TF337402.

    Enzyme and pathway databases

    Reactomei REACT_200670. POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation.
    REACT_200759. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.
    REACT_200812. Transcriptional regulation of pluripotent stem cells.
    SignaLinki Q9H9S0.

    Miscellaneous databases

    EvolutionaryTracei Q9H9S0.
    GeneWikii Homeobox_protein_NANOG.
    GenomeRNAii 79923.
    NextBioi 69830.
    PROi Q9H9S0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H9S0.
    CleanExi HS_NANOG.
    Genevestigatori Q9H9S0.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells."
      Mitsui K., Tokuzawa Y., Itoh H., Segawa K., Murakami M., Takahashi K., Maruyama M., Maeda M., Yamanaka S.
      Cell 113:631-642(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASN-82, TISSUE SPECIFICITY.
      Tissue: Embryonic stem cell.
    2. "Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma."
      Clark A.T., Rodriguez R.T., Bodnar M.S., Abeyta M.J., Cedars M.I., Turek P.J., Firpo M.T., Reijo Pera R.A.
      Stem Cells 22:169-179(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Embryonic stem cell.
    3. "Identification and functional characterization of an alternative splice variant within the fourth exon of human nanog."
      Kim J.S., Kim J., Kim B.S., Chung H.Y., Lee Y.Y., Park C.-S., Lee Y.S., Lee Y.H., Chung I.Y.
      Exp. Mol. Med. 37:601-607(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, DNA-BINDING, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Embryonic stem cell.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-82.
      Tissue: Teratocarcinoma.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-82.
    6. "Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells."
      Chambers I., Colby D., Robertson M., Nichols J., Lee S., Tweedie S., Smith A.
      Cell 113:643-655(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human."
      Hart A.H., Hartley L., Ibrahim M., Robb L.
      Dev. Dyn. 230:187-198(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    8. "Identification of a putative transactivation domain in human Nanog."
      Oh J.-H., Do H.-J., Yang H.-M., Moon S.-Y., Cha K.-Y., Chung H.-M., Kim J.-H.
      Exp. Mol. Med. 37:250-254(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours."
      Hoei-Hansen C.E., Almstrup K., Nielsen J.E., Brask Sonne S., Graem N., Skakkebaek N.E., Leffers H., Rajpert-De Meyts E.
      Histopathology 47:48-56(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    10. "Pluripotential competence of cells associated with Nanog activity."
      Hatano S.Y., Tada M., Kimura H., Yamaguchi S., Kono T., Nakano T., Suemori H., Nakatsuji N., Tada T.
      Mech. Dev. 122:67-79(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    11. "Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages."
      Hyslop L.A., Stojkovic M., Armstrong L., Walter T., Stojkovic P., Przyborski S., Herbert M., Murdoch A., Strachan T., Lako M.
      Stem Cells 23:1035-1043(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    12. "Solution structure of human stem cell transcription factor NANOG."
      Center for eukaryotic structural genomics (CESG)
      Submitted (MAR-2010) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 75-157.
    13. Cited for: VARIANT ASN-82.

    Entry informationi

    Entry nameiNANOG_HUMAN
    AccessioniPrimary (citable) accession number: Q9H9S0
    Secondary accession number(s): D3DUU4, Q2TTG0, Q6JZS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Exists an other tandem duplicated non-processed pseudogene (NANOGP1) and 10 other NANOG-related nucleotide sequences located on different chromosomes, all of which are processed pseudogenes lacking introns (NANOGP2 to NANOGP11); except NANOGP8 which is a retrogene.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3