Q9H9R9 (DBND1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dysbindin domain-containing protein 1

Gene names

Name:

DBNDD1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the dysbindin family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H9R9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H9R9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MEPPEGAGTG → MGETWKNICSTVRHGWWLRDHRMAGLPIPP

Isoform 3 (identifier: Q9H9R9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MEPPEGAGTGE → MTQQWREVNE...RGRQRARPPK

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 158	158	Dysbindin domain-containing protein 1		PRO_0000292438
Natural variations
	Alternative sequence	1 – 11	11	MEPPEGAGTGE → MTQQWREVNEDREAVAQARS WQSLNLGDRDMGVSFIETAL ALSAARARRPLLTSHPPSRP FQPPKHTPSPPPAPRVNSRH PGRSVSLSLPSASQAPPVPL ASPEGRPHTVGAPHASTWKR TRGRQRARPPK in isoform 3.		VSP_037541
	Alternative sequence	1 – 10	10	MEPPEGAGTG → MGETWKNICSTVRHGWWLRD HRMAGLPIPP in isoform 2.		VSP_026214
Experimental info
	Sequence conflict	26	1	P → S in BAB14152. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 16, 2009. Version 2. Checksum: 498F80B5002A2C33	FASTA	158	17,042
	10 20 30 40 50 60 MEPPEGAGTG EIVKEAEVPQ AALGVPAQGT GDNGHTPVEE EVGGIPVPAP GLLQVTERRQ 70 80 90 100 110 120 PLSSVSSLEV HFDLLDLTEL TDMSDQELAE VFADSDDENL NTESPAGLHP LPRAGYLRSP 130 140 150 SWTRTRAEQS HEKQPLGDPE RQATVLDTFL TVERPQED
	Isoform 2 [UniParc]. Checksum: FB6433859E619A48	FASTA	178	19,643
	10 20 30 40 50 60 MGETWKNICS TVRHGWWLRD HRMAGLPIPP EIVKEAEVPQ AALGVPAQGT GDNGHTPVEE 70 80 90 100 110 120 EVGGIPVPAP GLLQVTERRQ PLSSVSSLEV HFDLLDLTEL TDMSDQELAE VFADSDDENL 130 140 150 160 170 NTESPAGLHP LPRAGYLRSP SWTRTRAEQS HEKQPLGDPE RQATVLDTFL TVERPQED
	Isoform 3 [UniParc]. Checksum: 8C506340A84A02D8	FASTA	278	30,344
	10 20 30 40 50 60 MTQQWREVNE DREAVAQARS WQSLNLGDRD MGVSFIETAL ALSAARARRP LLTSHPPSRP 70 80 90 100 110 120 FQPPKHTPSP PPAPRVNSRH PGRSVSLSLP SASQAPPVPL ASPEGRPHTV GAPHASTWKR 130 140 150 160 170 180 TRGRQRARPP KIVKEAEVPQ AALGVPAQGT GDNGHTPVEE EVGGIPVPAP GLLQVTERRQ 190 200 210 220 230 240 PLSSVSSLEV HFDLLDLTEL TDMSDQELAE VFADSDDENL NTESPAGLHP LPRAGYLRSP 250 260 270 SWTRTRAEQS HEKQPLGDPE RQATVLDTFL TVERPQED

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Eye.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 122-158. Tissue: Amygdala.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK022644 mRNA. Translation: BAB14152.1. AK298932 mRNA. Translation: BAG61035.1. AC092143 Genomic DNA. No translation available. BC000700 mRNA. Translation: AAH00700.2. AL713678 mRNA. Translation: CAH10640.1.
IPI	IPI00031533. IPI00304285. IPI00872543.
RefSeq	NP_001036075.1. NM_001042610.1. NP_076948.2. NM_024043.2.
UniGene	Hs.301394.
3D structure databases
ProteinModelPortal	Q9H9R9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9H9R9.
Polymorphism databases
DMDM	239938618.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000002501; ENSP00000002501; ENSG00000003249.
GeneID	79007.
KEGG	hsa:79007.
UCSC	uc002fqe.1. human. uc002fqf.1. human.
Organism-specific databases
CTD	79007.
GeneCards	GC16M090071.
HGNC	HGNC:28455. DBNDD1.
HPA	HPA043018.
neXtProt	NX_Q9H9R9.
PharmGKB	PA144596443.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18885.
GeneTree	ENSGT00390000018903.
HOVERGEN	HBG056558.
OMA	PAIVDTF.
OrthoDB	EOG4GB77R.
Gene expression databases
ArrayExpress	Q9H9R9.
Bgee	Q9H9R9.
CleanEx	HS_DBNDD1.
Genevestigator	Q9H9R9.
Family and domain databases
InterPro	IPR007531. Dysbindin. [Graphical view]
PANTHER	PTHR16294. Dysbindin. 1 hit.
Pfam	PF04440. Dysbindin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	67641.

Entry information

Entry name

DBND1_HUMAN

Accession

Primary (citable) accession number: Q9H9R9
Secondary accession number(s): B4DQS3, Q69YT2, Q9BW25

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	June 16, 2009
Last modified:	January 25, 2012
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.