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Protein

COP9 signalosome complex subunit 7b

Gene

COPS7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.4 Publications

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-5696394. DNA Damage Recognition in GG-NER.
R-HSA-6781823. Formation of TC-NER Pre-Incision Complex.

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 7b
Short name:
SGN7b
Short name:
Signalosome subunit 7b
Alternative name(s):
JAB1-containing signalosome subunit 7b
Gene namesi
Name:COPS7B
Synonyms:CSN7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:16760. COPS7B.

Subcellular locationi

GO - Cellular componenti

  • COP9 signalosome Source: UniProtKB
  • cytoplasm Source: UniProtKB-SubCell
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26759.

Chemistry

ChEMBLiCHEMBL5706.

Polymorphism and mutation databases

DMDMi55976598.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources1 Publication
Chaini2 – 264263COP9 signalosome complex subunit 7bPRO_0000120999Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources1 Publication
Isoform 3 (identifier: Q9H9Q2-3)
Modified residuei261 – 2611PhosphothreonineCombined sources
Modified residuei263 – 2631PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H9Q2.
MaxQBiQ9H9Q2.
PaxDbiQ9H9Q2.
PeptideAtlasiQ9H9Q2.
PRIDEiQ9H9Q2.

PTM databases

iPTMnetiQ9H9Q2.
PhosphoSiteiQ9H9Q2.

Expressioni

Gene expression databases

BgeeiENSG00000144524.
CleanExiHS_COPS7B.
ExpressionAtlasiQ9H9Q2. baseline and differential.
GenevisibleiQ9H9Q2. HS.

Organism-specific databases

HPAiHPA034675.
HPA034676.

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NMIQ132873EBI-2510162,EBI-372942
NMIQ8WTW23EBI-2510162,EBI-10174268

Protein-protein interaction databases

BioGridi122237. 70 interactions.
DIPiDIP-53525N.
IntActiQ9H9Q2. 17 interactions.
STRINGi9606.ENSP00000272995.

Structurei

3D structure databases

ProteinModelPortaliQ9H9Q2.
SMRiQ9H9Q2. Positions 13-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 156105PCIAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili188 – 23750Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the CSN7/EIF3M family. CSN7 subfamily.Curated
Contains 1 PCI domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3250. Eukaryota.
ENOG410XP7W. LUCA.
GeneTreeiENSGT00390000013069.
HOGENOMiHOG000006003.
HOVERGENiHBG051138.
InParanoidiQ9H9Q2.
KOiK12180.
PhylomeDBiQ9H9Q2.
TreeFamiTF101149.

Family and domain databases

InterProiIPR027530. Csn7b.
IPR000717. PCI_dom.
[Graphical view]
PANTHERiPTHR15350:SF8. PTHR15350:SF8. 1 hit.
PfamiPF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H9Q2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGEQKPSSN LLEQFILLAK GTSGSALTAL ISQVLEAPGV YVFGELLELA
60 70 80 90 100
NVQELAEGAN AAYLQLLNLF AYGTYPDYIA NKESLPELST AQQNKLKHLT
110 120 130 140 150
IVSLASRMKC IPYSVLLKDL EMRNLRELED LIIEAVYTDI IQGKLDQRNQ
160 170 180 190 200
LLEVDFCIGR DIRKKDINNI VKTLHEWCDG CEAVLLGIEQ QVLRANQYKE
210 220 230 240 250
NHNRTQQQVE AEVTNIKKTL KATASSSAQE MEQQLAEREC PPHAEQRQPT
260
KKMSKVKGLV SSRH
Length:264
Mass (Da):29,622
Last modified:March 1, 2001 - v1
Checksum:iFF9279CEA6CB7707
GO
Isoform 2 (identifier: Q9H9Q2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.

Note: No experimental confirmation available.
Show »
Length:157
Mass (Da):18,157
Checksum:i14EF8FC4F2AAB95E
GO
Isoform 3 (identifier: Q9H9Q2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-264: VTNIKKTLKA...KVKGLVSSRH → REKRDVPLLN...RGSPPRRCPK

Show »
Length:273
Mass (Da):30,959
Checksum:i5CC118D3000C1A92
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 107107Missing in isoform 2. 1 PublicationVSP_011913Add
BLAST
Alternative sequencei213 – 26452VTNIK…VSSRH → REKRDVPLLNLITTAFFWLP TSRRHSKPPHPPRLRRWSSS WLNGSVPLTLSRGSPPRRCP K in isoform 3. 1 PublicationVSP_040266Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022674 mRNA. Translation: BAB14170.1.
AK024273 mRNA. Translation: BAB14868.1.
AC073476 Genomic DNA. Translation: AAY24152.1.
CH471063 Genomic DNA. Translation: EAW70980.1.
BC010739 mRNA. Translation: AAH10739.2.
BC091493 mRNA. Translation: AAH91493.1.
CCDSiCCDS2488.1. [Q9H9Q2-1]
CCDS63153.1. [Q9H9Q2-3]
CCDS63154.1. [Q9H9Q2-2]
RefSeqiNP_001269879.1. NM_001282950.2. [Q9H9Q2-3]
NP_001269881.1. NM_001282952.2. [Q9H9Q2-2]
NP_073567.1. NM_022730.3. [Q9H9Q2-1]
UniGeneiHs.335061.
Hs.611663.

Genome annotation databases

EnsembliENST00000350033; ENSP00000272995; ENSG00000144524. [Q9H9Q2-1]
ENST00000373608; ENSP00000362710; ENSG00000144524. [Q9H9Q2-3]
ENST00000409091; ENSP00000386527; ENSG00000144524. [Q9H9Q2-2]
ENST00000410024; ENSP00000386567; ENSG00000144524. [Q9H9Q2-1]
ENST00000620578; ENSP00000484579; ENSG00000144524. [Q9H9Q2-2]
GeneIDi64708.
KEGGihsa:64708.
UCSCiuc002vsg.3. human. [Q9H9Q2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022674 mRNA. Translation: BAB14170.1.
AK024273 mRNA. Translation: BAB14868.1.
AC073476 Genomic DNA. Translation: AAY24152.1.
CH471063 Genomic DNA. Translation: EAW70980.1.
BC010739 mRNA. Translation: AAH10739.2.
BC091493 mRNA. Translation: AAH91493.1.
CCDSiCCDS2488.1. [Q9H9Q2-1]
CCDS63153.1. [Q9H9Q2-3]
CCDS63154.1. [Q9H9Q2-2]
RefSeqiNP_001269879.1. NM_001282950.2. [Q9H9Q2-3]
NP_001269881.1. NM_001282952.2. [Q9H9Q2-2]
NP_073567.1. NM_022730.3. [Q9H9Q2-1]
UniGeneiHs.335061.
Hs.611663.

3D structure databases

ProteinModelPortaliQ9H9Q2.
SMRiQ9H9Q2. Positions 13-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122237. 70 interactions.
DIPiDIP-53525N.
IntActiQ9H9Q2. 17 interactions.
STRINGi9606.ENSP00000272995.

Chemistry

ChEMBLiCHEMBL5706.

PTM databases

iPTMnetiQ9H9Q2.
PhosphoSiteiQ9H9Q2.

Polymorphism and mutation databases

DMDMi55976598.

Proteomic databases

EPDiQ9H9Q2.
MaxQBiQ9H9Q2.
PaxDbiQ9H9Q2.
PeptideAtlasiQ9H9Q2.
PRIDEiQ9H9Q2.

Protocols and materials databases

DNASUi64708.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350033; ENSP00000272995; ENSG00000144524. [Q9H9Q2-1]
ENST00000373608; ENSP00000362710; ENSG00000144524. [Q9H9Q2-3]
ENST00000409091; ENSP00000386527; ENSG00000144524. [Q9H9Q2-2]
ENST00000410024; ENSP00000386567; ENSG00000144524. [Q9H9Q2-1]
ENST00000620578; ENSP00000484579; ENSG00000144524. [Q9H9Q2-2]
GeneIDi64708.
KEGGihsa:64708.
UCSCiuc002vsg.3. human. [Q9H9Q2-1]

Organism-specific databases

CTDi64708.
GeneCardsiCOPS7B.
HGNCiHGNC:16760. COPS7B.
HPAiHPA034675.
HPA034676.
MIMi616010. gene.
neXtProtiNX_Q9H9Q2.
PharmGKBiPA26759.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3250. Eukaryota.
ENOG410XP7W. LUCA.
GeneTreeiENSGT00390000013069.
HOGENOMiHOG000006003.
HOVERGENiHBG051138.
InParanoidiQ9H9Q2.
KOiK12180.
PhylomeDBiQ9H9Q2.
TreeFamiTF101149.

Enzyme and pathway databases

ReactomeiR-HSA-5696394. DNA Damage Recognition in GG-NER.
R-HSA-6781823. Formation of TC-NER Pre-Incision Complex.

Miscellaneous databases

ChiTaRSiCOPS7B. human.
GeneWikiiCOPS7B.
GenomeRNAii64708.
PROiQ9H9Q2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144524.
CleanExiHS_COPS7B.
ExpressionAtlasiQ9H9Q2. baseline and differential.
GenevisibleiQ9H9Q2. HS.

Family and domain databases

InterProiIPR027530. Csn7b.
IPR000717. PCI_dom.
[Graphical view]
PANTHERiPTHR15350:SF8. PTHR15350:SF8. 1 hit.
PfamiPF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSN7B_HUMAN
AccessioniPrimary (citable) accession number: Q9H9Q2
Secondary accession number(s): Q53S22, Q5BJG3, Q9H7V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.