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Protein

Chondrolectin

Gene

CHODL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in the development of the nervous system such as in neurite outgrowth and elongation. May be involved in motor axon growth and guidance.By similarity

Miscellaneous

A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells.1 Publication

GO - Molecular functioni

GO - Biological processi

  • muscle organ development Source: HGNC
  • regulation of neuron projection development Source: Ensembl

Keywordsi

Biological processNeurogenesis
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Chondrolectin
Alternative name(s):
Transmembrane protein MT75
Gene namesi
Name:CHODL
Synonyms:C21orf68
ORF Names:PRED12, UNQ872/PRO1890
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000154645.13
HGNCiHGNC:17807 CHODL
MIMi607247 gene
neXtProtiNX_Q9H9P2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 216ExtracellularSequence analysisAdd BLAST195
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 273CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi140578
OpenTargetsiENSG00000154645
PharmGKBiPA26475

Polymorphism and mutation databases

BioMutaiCHODL
DMDMi18202949

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001741522 – 273ChondrolectinAdd BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi61 ↔ 178PROSITE-ProRule annotation
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi144 ↔ 170PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H9P2
PeptideAtlasiQ9H9P2
PRIDEiQ9H9P2

PTM databases

iPTMnetiQ9H9P2
PhosphoSitePlusiQ9H9P2

Expressioni

Tissue specificityi

Found in spleen, testis, prostate and fetal liver. Expression limited to vascular muscle of testis, smooth muscle of prostate stroma, heart muscle, skeletal muscle, crypts of small intestine, and red pulp of spleen. B lymphocytes express isoform 2 only; peripheral blood T lymphocytes express isoform 3 only; granulocytes and monocytes express neither isoform 2 nor isoform 3. During development of T lymphocytes, bone marrow progenitor cells express isoform 2 only; thymocytes at different stages of maturation express predominantly isoform 2 and weakly isoform 3, and mature thymocytes express only isoform 2.3 Publications

Gene expression databases

BgeeiENSG00000154645
CleanExiHS_CHODL
ExpressionAtlasiQ9H9P2 baseline and differential
GenevisibleiQ9H9P2 HS

Organism-specific databases

HPAiHPA017282

Interactioni

Subunit structurei

Interacts with RABGGTB.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000299295

Structurei

3D structure databases

ProteinModelPortaliQ9H9P2
SMRiQ9H9P2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 179C-type lectinPROSITE-ProRule annotationAdd BLAST145

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00390000001844
HOGENOMiHOG000294068
HOVERGENiHBG050945
InParanoidiQ9H9P2
KOiK10078
OMAiSACPDLY
OrthoDBiEOG091G0FDX
PhylomeDBiQ9H9P2
TreeFamiTF330715

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H9P2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRVVSLLLG AALLCGHGAF CRRVVSGQKV CFADFKHPCY KMAYFHELSS
60 70 80 90 100
RVSFQEARLA CESEGGVLLS LENEAEQKLI ESMLQNLTKP GTGISDGDFW
110 120 130 140 150
IGLWRNGDGQ TSGACPDLYQ WSDGSNSQYR NWYTDEPSCG SEKCVVMYHQ
160 170 180 190 200
PTANPGLGGP YLYQWNDDRC NMKHNYICKY EPEINPTAPV EKPYLTNQPG
210 220 230 240 250
DTHQNVVVTE AGIIPNLIYV VIPTIPLLLL ILVAFGTCCF QMLHKSKGRT
260 270
KTSPNQSTLW ISKSTRKESG MEV
Note: Produced by alternative promoter usage.
Length:273
Mass (Da):30,431
Last modified:October 18, 2001 - v2
Checksum:iF4890AAFB572A311
GO
Isoform 2 (identifier: Q9H9P2-2) [UniParc]FASTAAdd to basket
Also known as: CHODLF

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Note: roduced by alternative promoter usage.
Show »
Length:232
Mass (Da):25,979
Checksum:i98B80BBDF7C7F439
GO
Isoform 3 (identifier: Q9H9P2-3) [UniParc]FASTAAdd to basket
Also known as: CHODLFdeltaE

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.
     212-273: GIIPNLIYVV...STRKESGMEV → VKEEQKLVQT...EITKDLQDEL

Note: Produced by alternative splicing of isoform 2.
Show »
Length:236
Mass (Da):27,157
Checksum:i5110DE6A86472CD9
GO
Isoform 4 (identifier: Q9H9P2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MSRVVSLLLGAALLCGHGAFCRRVVSG → MTAGSAHS

Note: Produced by alternative splicing of isoform 1. No experimental confirmation available.
Show »
Length:254
Mass (Da):28,418
Checksum:iCD50D9959326678D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56E → G in AAP43902 (PubMed:12621022).Curated1
Sequence conflicti159G → S in AAP43902 (PubMed:12621022).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0172751 – 41Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST41
Alternative sequenceiVSP_0433001 – 27MSRVV…RVVSG → MTAGSAHS in isoform 4. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_017276212 – 273GIIPN…SGMEV → VKEEQKLVQTSLHCGFQRVP EKKAAWKYNNSLTWFQNFVI LDLYKEWHQNNSLEWLEITK DLQDEL in isoform 3. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257472 mRNA Translation: AAL05981.1
AF523313 mRNA Translation: AAP43902.1
AF523314 mRNA Translation: AAP43903.1
AF523315 mRNA Translation: AAP43904.1
AY358608 mRNA Translation: AAQ88971.1
AK022689 mRNA Translation: BAB14181.1
AK296009 mRNA Translation: BAG58780.1
AK313725 mRNA Translation: BAG36467.1
AF130417 Genomic DNA No translation available.
AL078474 Genomic DNA No translation available.
AL109761 Genomic DNA No translation available.
AL163217 Genomic DNA Translation: CAB90388.1
AP000404 Genomic DNA No translation available.
AP000656 Genomic DNA No translation available.
AP000745 Genomic DNA No translation available.
AP000998 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX10018.1
BC009418 mRNA Translation: AAH09418.1
CCDSiCCDS13570.1 [Q9H9P2-1]
CCDS56208.1 [Q9H9P2-4]
CCDS56209.1 [Q9H9P2-2]
CCDS56210.1 [Q9H9P2-3]
RefSeqiNP_001191103.1, NM_001204174.1 [Q9H9P2-4]
NP_001191104.1, NM_001204175.1 [Q9H9P2-2]
NP_001191105.1, NM_001204176.1 [Q9H9P2-2]
NP_001191106.1, NM_001204177.1
NP_001191107.1, NM_001204178.1
NP_079220.2, NM_024944.2 [Q9H9P2-1]
XP_011527759.1, XM_011529457.2 [Q9H9P2-2]
UniGeneiHs.283725

Genome annotation databases

EnsembliENST00000299295; ENSP00000299295; ENSG00000154645 [Q9H9P2-1]
ENST00000400127; ENSP00000382992; ENSG00000154645 [Q9H9P2-2]
ENST00000400128; ENSP00000382993; ENSG00000154645 [Q9H9P2-2]
ENST00000543733; ENSP00000443566; ENSG00000154645 [Q9H9P2-4]
GeneIDi140578
KEGGihsa:140578
UCSCiuc002ykr.5 human [Q9H9P2-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCHODL_HUMAN
AccessioniPrimary (citable) accession number: Q9H9P2
Secondary accession number(s): B2R9C0
, B4DJB8, Q7Z798, Q7Z799, Q7Z7A0, Q9HCY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: February 28, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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