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Protein

Chondrolectin

Gene

CHODL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • muscle organ development Source: HGNC
  • regulation of neuron projection development Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Chondrolectin
Alternative name(s):
Transmembrane protein MT75
Gene namesi
Name:CHODL
Synonyms:C21orf68
ORF Names:PRED12, UNQ872/PRO1890
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:17807. CHODL.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 216195ExtracellularSequence analysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence analysisAdd
BLAST
Topological domaini238 – 27336CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • perinuclear region of cytoplasm Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26475.

Polymorphism and mutation databases

BioMutaiCHODL.
DMDMi18202949.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 273252ChondrolectinPRO_0000017415Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi61 ↔ 178PROSITE-ProRule annotation
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence analysis
Disulfide bondi144 ↔ 170PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9H9P2.
PaxDbiQ9H9P2.
PeptideAtlasiQ9H9P2.
PRIDEiQ9H9P2.

PTM databases

iPTMnetiQ9H9P2.

Expressioni

Tissue specificityi

Found in spleen, testis, prostate and fetal liver. Expression limited to vascular muscle of testis, smooth muscle of prostate stroma, heart muscle, skeletal muscle, crypts of small intestine, and red pulp of spleen.2 Publications

Gene expression databases

BgeeiQ9H9P2.
CleanExiHS_CHODL.
ExpressionAtlasiQ9H9P2. baseline and differential.
GenevisibleiQ9H9P2. HS.

Organism-specific databases

HPAiHPA017282.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000299295.

Structurei

3D structure databases

ProteinModelPortaliQ9H9P2.
SMRiQ9H9P2. Positions 34-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 179145C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00390000001844.
HOGENOMiHOG000294068.
HOVERGENiHBG050945.
InParanoidiQ9H9P2.
KOiK10078.
OMAiSACPDLY.
OrthoDBiEOG7FV3RQ.
PhylomeDBiQ9H9P2.
TreeFamiTF330715.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H9P2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRVVSLLLG AALLCGHGAF CRRVVSGQKV CFADFKHPCY KMAYFHELSS
60 70 80 90 100
RVSFQEARLA CESEGGVLLS LENEAEQKLI ESMLQNLTKP GTGISDGDFW
110 120 130 140 150
IGLWRNGDGQ TSGACPDLYQ WSDGSNSQYR NWYTDEPSCG SEKCVVMYHQ
160 170 180 190 200
PTANPGLGGP YLYQWNDDRC NMKHNYICKY EPEINPTAPV EKPYLTNQPG
210 220 230 240 250
DTHQNVVVTE AGIIPNLIYV VIPTIPLLLL ILVAFGTCCF QMLHKSKGRT
260 270
KTSPNQSTLW ISKSTRKESG MEV
Length:273
Mass (Da):30,431
Last modified:October 18, 2001 - v2
Checksum:iF4890AAFB572A311
GO
Isoform 2 (identifier: Q9H9P2-2) [UniParc]FASTAAdd to basket

Also known as: CHODLF

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Show »
Length:232
Mass (Da):25,979
Checksum:i98B80BBDF7C7F439
GO
Isoform 3 (identifier: Q9H9P2-3) [UniParc]FASTAAdd to basket

Also known as: CHODLFdeltaE

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.
     212-273: GIIPNLIYVV...STRKESGMEV → VKEEQKLVQT...EITKDLQDEL

Show »
Length:236
Mass (Da):27,157
Checksum:i5110DE6A86472CD9
GO
Isoform 4 (identifier: Q9H9P2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MSRVVSLLLGAALLCGHGAFCRRVVSG → MTAGSAHS

Note: No experimental confirmation available.
Show »
Length:254
Mass (Da):28,418
Checksum:iCD50D9959326678D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561E → G in AAP43902 (PubMed:12621022).Curated
Sequence conflicti159 – 1591G → S in AAP43902 (PubMed:12621022).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4141Missing in isoform 2 and isoform 3. 2 PublicationsVSP_017275Add
BLAST
Alternative sequencei1 – 2727MSRVV…RVVSG → MTAGSAHS in isoform 4. 1 PublicationVSP_043300Add
BLAST
Alternative sequencei212 – 27362GIIPN…SGMEV → VKEEQKLVQTSLHCGFQRVP EKKAAWKYNNSLTWFQNFVI LDLYKEWHQNNSLEWLEITK DLQDEL in isoform 3. 1 PublicationVSP_017276Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257472 mRNA. Translation: AAL05981.1.
AF523313 mRNA. Translation: AAP43902.1.
AF523314 mRNA. Translation: AAP43903.1.
AF523315 mRNA. Translation: AAP43904.1.
AY358608 mRNA. Translation: AAQ88971.1.
AK022689 mRNA. Translation: BAB14181.1.
AK296009 mRNA. Translation: BAG58780.1.
AK313725 mRNA. Translation: BAG36467.1.
AF130417 Genomic DNA. No translation available.
AL078474 Genomic DNA. No translation available.
AL109761 Genomic DNA. No translation available.
AL163217 Genomic DNA. Translation: CAB90388.1.
AP000404 Genomic DNA. No translation available.
AP000656 Genomic DNA. No translation available.
AP000745 Genomic DNA. No translation available.
AP000998 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX10018.1.
BC009418 mRNA. Translation: AAH09418.1.
CCDSiCCDS13570.1. [Q9H9P2-1]
CCDS56208.1. [Q9H9P2-4]
CCDS56209.1. [Q9H9P2-2]
CCDS56210.1. [Q9H9P2-3]
RefSeqiNP_001191103.1. NM_001204174.1. [Q9H9P2-4]
NP_001191104.1. NM_001204175.1. [Q9H9P2-2]
NP_001191105.1. NM_001204176.1. [Q9H9P2-2]
NP_001191106.1. NM_001204177.1.
NP_001191107.1. NM_001204178.1.
NP_079220.2. NM_024944.2. [Q9H9P2-1]
XP_011527757.1. XM_011529455.1.
XP_011527758.1. XM_011529456.1. [Q9H9P2-2]
XP_011527759.1. XM_011529457.1. [Q9H9P2-2]
UniGeneiHs.283725.

Genome annotation databases

EnsembliENST00000299295; ENSP00000299295; ENSG00000154645. [Q9H9P2-1]
ENST00000400127; ENSP00000382992; ENSG00000154645. [Q9H9P2-2]
ENST00000400128; ENSP00000382993; ENSG00000154645. [Q9H9P2-2]
ENST00000543733; ENSP00000443566; ENSG00000154645. [Q9H9P2-4]
GeneIDi140578.
KEGGihsa:140578.
UCSCiuc002ykr.5. human. [Q9H9P2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Chondrolectin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257472 mRNA. Translation: AAL05981.1.
AF523313 mRNA. Translation: AAP43902.1.
AF523314 mRNA. Translation: AAP43903.1.
AF523315 mRNA. Translation: AAP43904.1.
AY358608 mRNA. Translation: AAQ88971.1.
AK022689 mRNA. Translation: BAB14181.1.
AK296009 mRNA. Translation: BAG58780.1.
AK313725 mRNA. Translation: BAG36467.1.
AF130417 Genomic DNA. No translation available.
AL078474 Genomic DNA. No translation available.
AL109761 Genomic DNA. No translation available.
AL163217 Genomic DNA. Translation: CAB90388.1.
AP000404 Genomic DNA. No translation available.
AP000656 Genomic DNA. No translation available.
AP000745 Genomic DNA. No translation available.
AP000998 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX10018.1.
BC009418 mRNA. Translation: AAH09418.1.
CCDSiCCDS13570.1. [Q9H9P2-1]
CCDS56208.1. [Q9H9P2-4]
CCDS56209.1. [Q9H9P2-2]
CCDS56210.1. [Q9H9P2-3]
RefSeqiNP_001191103.1. NM_001204174.1. [Q9H9P2-4]
NP_001191104.1. NM_001204175.1. [Q9H9P2-2]
NP_001191105.1. NM_001204176.1. [Q9H9P2-2]
NP_001191106.1. NM_001204177.1.
NP_001191107.1. NM_001204178.1.
NP_079220.2. NM_024944.2. [Q9H9P2-1]
XP_011527757.1. XM_011529455.1.
XP_011527758.1. XM_011529456.1. [Q9H9P2-2]
XP_011527759.1. XM_011529457.1. [Q9H9P2-2]
UniGeneiHs.283725.

3D structure databases

ProteinModelPortaliQ9H9P2.
SMRiQ9H9P2. Positions 34-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000299295.

PTM databases

iPTMnetiQ9H9P2.

Polymorphism and mutation databases

BioMutaiCHODL.
DMDMi18202949.

Proteomic databases

EPDiQ9H9P2.
PaxDbiQ9H9P2.
PeptideAtlasiQ9H9P2.
PRIDEiQ9H9P2.

Protocols and materials databases

DNASUi140578.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299295; ENSP00000299295; ENSG00000154645. [Q9H9P2-1]
ENST00000400127; ENSP00000382992; ENSG00000154645. [Q9H9P2-2]
ENST00000400128; ENSP00000382993; ENSG00000154645. [Q9H9P2-2]
ENST00000543733; ENSP00000443566; ENSG00000154645. [Q9H9P2-4]
GeneIDi140578.
KEGGihsa:140578.
UCSCiuc002ykr.5. human. [Q9H9P2-1]

Organism-specific databases

CTDi140578.
GeneCardsiCHODL.
HGNCiHGNC:17807. CHODL.
HPAiHPA017282.
MIMi607247. gene.
neXtProtiNX_Q9H9P2.
PharmGKBiPA26475.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00390000001844.
HOGENOMiHOG000294068.
HOVERGENiHBG050945.
InParanoidiQ9H9P2.
KOiK10078.
OMAiSACPDLY.
OrthoDBiEOG7FV3RQ.
PhylomeDBiQ9H9P2.
TreeFamiTF330715.

Miscellaneous databases

ChiTaRSiCHODL. human.
GeneWikiiCHODL.
GenomeRNAii140578.
PROiQ9H9P2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H9P2.
CleanExiHS_CHODL.
ExpressionAtlasiQ9H9P2. baseline and differential.
GenevisibleiQ9H9P2. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of human chondrolectin, a novel type I transmembrane protein homologous to C-type lectins."
    Weng L., Smits P., Wauters J., Merregaert J.
    Genomics 80:62-70(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "A novel alternative spliced chondrolectin isoform lacking the transmembrane domain is expressed during T cell maturation."
    Weng L., Van Bockstaele D.R., Wauters J., Van Marck E., Plum J., Berneman Z.N., Merregaert J.
    J. Biol. Chem. 278:19164-19170(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
    Tissue: Brain.
  5. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  8. "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map."
    Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.
    Genomics 78:46-54(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. Cited for: SUBCELLULAR LOCATION, MISCELLANEOUS.

Entry informationi

Entry nameiCHODL_HUMAN
AccessioniPrimary (citable) accession number: Q9H9P2
Secondary accession number(s): B2R9C0
, B4DJB8, Q7Z798, Q7Z799, Q7Z7A0, Q9HCY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: July 6, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.