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Protein

Akirin-1

Gene

AKIRIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Akirin-1
Gene namesi
Name:AKIRIN1
Synonyms:C1orf108
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25744. AKIRIN1.

Subcellular locationi

GO - Cellular componenti

  • nuclear membrane Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162376180.

Polymorphism and mutation databases

BioMutaiAKIRIN1.
DMDMi74752744.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Akirin-1PRO_0000274318Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221PhosphoserineCombined sources
Modified residuei72 – 721PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H9L7.
MaxQBiQ9H9L7.
PaxDbiQ9H9L7.
PeptideAtlasiQ9H9L7.
PRIDEiQ9H9L7.

PTM databases

iPTMnetiQ9H9L7.
PhosphoSiteiQ9H9L7.

Expressioni

Tissue specificityi

Widely expressed with the highest expression in heart, liver, placenta and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000174574.
CleanExiHS_AKIRIN1.
ExpressionAtlasiQ9H9L7. baseline and differential.
GenevisibleiQ9H9L7. HS.

Organism-specific databases

HPAiHPA051871.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GOPCQ9HD263EBI-10309796,EBI-349832

Protein-protein interaction databases

BioGridi122775. 5 interactions.
IntActiQ9H9L7. 1 interaction.
STRINGi9606.ENSP00000392678.

Structurei

3D structure databases

ProteinModelPortaliQ9H9L7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi23 – 286Nuclear localization signal

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi20 – 7354Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the akirin family.Curated

Phylogenomic databases

eggNOGiKOG4330. Eukaryota.
ENOG4111J00. LUCA.
GeneTreeiENSGT00390000007905.
HOGENOMiHOG000231406.
HOVERGENiHBG055078.
InParanoidiQ9H9L7.
OMAiEYNRYQR.
OrthoDBiEOG091G0PVD.
PhylomeDBiQ9H9L7.
TreeFamiTF317123.

Family and domain databases

InterProiIPR024132. Akirin.
[Graphical view]
PANTHERiPTHR13293. PTHR13293. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H9L7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACGATLKRP MEFEAALLSP GSPKRRRCAP LPGPTPGLRP PDAEPPPPFQ
60 70 80 90 100
TQTPPQSLQQ PAPPGSERRL PTPEQIFQNI KQEYSRYQRW RHLEVVLNQS
110 120 130 140 150
EACASESQPH SSALTAPSSP GSSWMKKDQP TFTLRQVGII CERLLKDYED
160 170 180 190
KIREEYEQIL NTKLAEQYES FVKFTHDQIM RRYGTRPTSY VS
Length:192
Mass (Da):21,867
Last modified:March 1, 2001 - v1
Checksum:i21D7B2E6E026A802
GO
Isoform 2 (identifier: Q9H9L7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-165: Missing.

Note: No experimental confirmation available.
Show »
Length:147
Mass (Da):16,497
Checksum:i77B18170BBD8DEC2
GO

Sequence cautioni

The sequence AAI19747 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391R → G in BAD96996 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei121 – 16545Missing in isoform 2. 1 PublicationVSP_042769Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022728 mRNA. Translation: BAB14208.1.
AK223276 mRNA. Translation: BAD96996.1.
AK303098 mRNA. Translation: BAG64208.1.
AL606465 Genomic DNA. Translation: CAI16710.1.
BC119745 mRNA. Translation: AAI19746.1.
BC119746 mRNA. Translation: AAI19747.1. Different initiation.
CCDSiCCDS433.1. [Q9H9L7-1]
CCDS44113.1. [Q9H9L7-2]
RefSeqiNP_001129747.1. NM_001136275.1. [Q9H9L7-2]
NP_078871.1. NM_024595.2. [Q9H9L7-1]
UniGeneiHs.293563.

Genome annotation databases

EnsembliENST00000432648; ENSP00000392678; ENSG00000174574. [Q9H9L7-1]
ENST00000446189; ENSP00000389866; ENSG00000174574. [Q9H9L7-2]
GeneIDi79647.
KEGGihsa:79647.
UCSCiuc001ccw.4. human. [Q9H9L7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022728 mRNA. Translation: BAB14208.1.
AK223276 mRNA. Translation: BAD96996.1.
AK303098 mRNA. Translation: BAG64208.1.
AL606465 Genomic DNA. Translation: CAI16710.1.
BC119745 mRNA. Translation: AAI19746.1.
BC119746 mRNA. Translation: AAI19747.1. Different initiation.
CCDSiCCDS433.1. [Q9H9L7-1]
CCDS44113.1. [Q9H9L7-2]
RefSeqiNP_001129747.1. NM_001136275.1. [Q9H9L7-2]
NP_078871.1. NM_024595.2. [Q9H9L7-1]
UniGeneiHs.293563.

3D structure databases

ProteinModelPortaliQ9H9L7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122775. 5 interactions.
IntActiQ9H9L7. 1 interaction.
STRINGi9606.ENSP00000392678.

PTM databases

iPTMnetiQ9H9L7.
PhosphoSiteiQ9H9L7.

Polymorphism and mutation databases

BioMutaiAKIRIN1.
DMDMi74752744.

Proteomic databases

EPDiQ9H9L7.
MaxQBiQ9H9L7.
PaxDbiQ9H9L7.
PeptideAtlasiQ9H9L7.
PRIDEiQ9H9L7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000432648; ENSP00000392678; ENSG00000174574. [Q9H9L7-1]
ENST00000446189; ENSP00000389866; ENSG00000174574. [Q9H9L7-2]
GeneIDi79647.
KEGGihsa:79647.
UCSCiuc001ccw.4. human. [Q9H9L7-1]

Organism-specific databases

CTDi79647.
GeneCardsiAKIRIN1.
H-InvDBHIX0000452.
HGNCiHGNC:25744. AKIRIN1.
HPAiHPA051871.
MIMi615164. gene.
neXtProtiNX_Q9H9L7.
PharmGKBiPA162376180.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4330. Eukaryota.
ENOG4111J00. LUCA.
GeneTreeiENSGT00390000007905.
HOGENOMiHOG000231406.
HOVERGENiHBG055078.
InParanoidiQ9H9L7.
OMAiEYNRYQR.
OrthoDBiEOG091G0PVD.
PhylomeDBiQ9H9L7.
TreeFamiTF317123.

Miscellaneous databases

ChiTaRSiAKIRIN1. human.
GenomeRNAii79647.
PROiQ9H9L7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174574.
CleanExiHS_AKIRIN1.
ExpressionAtlasiQ9H9L7. baseline and differential.
GenevisibleiQ9H9L7. HS.

Family and domain databases

InterProiIPR024132. Akirin.
[Graphical view]
PANTHERiPTHR13293. PTHR13293. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAKIR1_HUMAN
AccessioniPrimary (citable) accession number: Q9H9L7
Secondary accession number(s): B4DZU6, Q0VDB3, Q53FK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

'Akiraka ni suru' means 'making things clear' in Japanese. The name is given based on the presence of the clear nuclear localization signal.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.