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Protein

Akirin-1

Gene

AKIRIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

'Akiraka ni suru' means 'making things clear' in Japanese. The name is given based on the presence of the clear nuclear localization signal.

Caution

Names & Taxonomyi

Protein namesi
Recommended name:
Akirin-1
Gene namesi
Name:AKIRIN1
Synonyms:C1orf108
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000174574.15
HGNCiHGNC:25744 AKIRIN1
MIMi615164 gene
neXtProtiNX_Q9H9L7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174574
PharmGKBiPA162376180

Polymorphism and mutation databases

BioMutaiAKIRIN1
DMDMi74752744

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743181 – 192Akirin-1Add BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineCombined sources1
Modified residuei72PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H9L7
MaxQBiQ9H9L7
PaxDbiQ9H9L7
PeptideAtlasiQ9H9L7
PRIDEiQ9H9L7

PTM databases

iPTMnetiQ9H9L7
PhosphoSitePlusiQ9H9L7

Expressioni

Tissue specificityi

Widely expressed with the highest expression in heart, liver, placenta and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000174574
CleanExiHS_AKIRIN1
ExpressionAtlasiQ9H9L7 baseline and differential
GenevisibleiQ9H9L7 HS

Organism-specific databases

HPAiHPA051871

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GOPCQ9HD263EBI-10309796,EBI-349832

Protein-protein interaction databases

BioGridi1227758 interactors.
IntActiQ9H9L7 1 interactor.
STRINGi9606.ENSP00000392678

Structurei

3D structure databases

ProteinModelPortaliQ9H9L7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi23 – 28Nuclear localization signal6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi20 – 73Pro-richAdd BLAST54

Sequence similaritiesi

Belongs to the akirin family.Curated

Phylogenomic databases

eggNOGiKOG4330 Eukaryota
ENOG4111J00 LUCA
GeneTreeiENSGT00390000007905
HOGENOMiHOG000231406
HOVERGENiHBG055078
InParanoidiQ9H9L7
OMAiEYNRYQR
OrthoDBiEOG091G0PVD
PhylomeDBiQ9H9L7
TreeFamiTF317123

Family and domain databases

InterProiView protein in InterPro
IPR024132 Akirin
PANTHERiPTHR13293 PTHR13293, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H9L7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACGATLKRP MEFEAALLSP GSPKRRRCAP LPGPTPGLRP PDAEPPPPFQ
60 70 80 90 100
TQTPPQSLQQ PAPPGSERRL PTPEQIFQNI KQEYSRYQRW RHLEVVLNQS
110 120 130 140 150
EACASESQPH SSALTAPSSP GSSWMKKDQP TFTLRQVGII CERLLKDYED
160 170 180 190
KIREEYEQIL NTKLAEQYES FVKFTHDQIM RRYGTRPTSY VS
Length:192
Mass (Da):21,867
Last modified:March 1, 2001 - v1
Checksum:i21D7B2E6E026A802
GO
Isoform 2 (identifier: Q9H9L7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-165: Missing.

Note: No experimental confirmation available.
Show »
Length:147
Mass (Da):16,497
Checksum:i77B18170BBD8DEC2
GO

Sequence cautioni

The sequence AAI19747 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39R → G in BAD96996 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042769121 – 165Missing in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022728 mRNA Translation: BAB14208.1
AK223276 mRNA Translation: BAD96996.1
AK303098 mRNA Translation: BAG64208.1
AL606465 Genomic DNA No translation available.
BC119745 mRNA Translation: AAI19746.1
BC119746 mRNA Translation: AAI19747.1 Different initiation.
CCDSiCCDS433.1 [Q9H9L7-1]
CCDS44113.1 [Q9H9L7-2]
RefSeqiNP_001129747.1, NM_001136275.1 [Q9H9L7-2]
NP_078871.1, NM_024595.2 [Q9H9L7-1]
UniGeneiHs.293563

Genome annotation databases

EnsembliENST00000432648; ENSP00000392678; ENSG00000174574 [Q9H9L7-1]
ENST00000446189; ENSP00000389866; ENSG00000174574 [Q9H9L7-2]
GeneIDi79647
KEGGihsa:79647
UCSCiuc001ccw.4 human [Q9H9L7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAKIR1_HUMAN
AccessioniPrimary (citable) accession number: Q9H9L7
Secondary accession number(s): B4DZU6, Q0VDB3, Q53FK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome