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Protein

Interferon-stimulated 20 kDa exonuclease-like 2

Gene

ISG20L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease
Biological processRibosome biogenesis

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-stimulated 20 kDa exonuclease-like 2 (EC:3.1.-.-)
Gene namesi
Name:ISG20L2
ORF Names:HSD-38, HSD38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143319.16
HGNCiHGNC:25745 ISG20L2
MIMi611930 gene
neXtProtiNX_Q9H9L3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143319
PharmGKBiPA142671650

Polymorphism and mutation databases

BioMutaiISG20L2
DMDMi42559527

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000841211 – 353Interferon-stimulated 20 kDa exonuclease-like 2Add BLAST353

Proteomic databases

EPDiQ9H9L3
MaxQBiQ9H9L3
PaxDbiQ9H9L3
PeptideAtlasiQ9H9L3
PRIDEiQ9H9L3

2D gel databases

SWISS-2DPAGEQ9H9L3

PTM databases

iPTMnetiQ9H9L3
PhosphoSitePlusiQ9H9L3

Expressioni

Gene expression databases

BgeeiENSG00000143319
CleanExiHS_ISG20L2
GenevisibleiQ9H9L3 HS

Organism-specific databases

HPAiHPA028005
HPA054285

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123618, 10 interactors
IntActiQ9H9L3, 15 interactors
MINTiQ9H9L3
STRINGi9606.ENSP00000323424

Structurei

3D structure databases

ProteinModelPortaliQ9H9L3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 353ExonucleaseAdd BLAST176

Phylogenomic databases

eggNOGiKOG2249 Eukaryota
COG0847 LUCA
GeneTreeiENSGT00520000055542
HOGENOMiHOG000182422
HOVERGENiHBG107986
InParanoidiQ9H9L3
KOiK18329
OMAiHMVNATP
OrthoDBiEOG091G0BHZ
PhylomeDBiQ9H9L3
TreeFamiTF354340

Family and domain databases

CDDicd06149 ISG20, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR037433 ISG20_DEDDh
IPR034933 ISG20L2
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR12801:SF78 PTHR12801:SF78, 1 hit
PfamiView protein in Pfam
PF00929 RNase_T, 1 hit
SMARTiView protein in SMART
SM00479 EXOIII, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H9L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLLLNLDF GEPPPKKALE GNAKHRNFVK KRRLLERRGF LSKKNQPPSK
60 70 80 90 100
APKLHSEPSK KGETPTVDGT WKTPSFPKKK TAASSNGSGQ PLDKKAAVSW
110 120 130 140 150
LTPAPSKKAD SVAAKVDLLG EFQSALPKIN SHPTRSQKKS SQKKSSKKNH
160 170 180 190 200
PQKNAPQNST QAHSENKCSG ASQKLPRKMV AIDCEMVGTG PKGHVSSLAR
210 220 230 240 250
CSIVNYNGDV LYDEYILPPC HIVDYRTRWS GIRKQHMVNA TPFKIARGQI
260 270 280 290 300
LKILTGKIVV GHAIHNDFKA LQYFHPKSLT RDTSHIPPLN RKADCPENAT
310 320 330 340 350
MSLKHLTKKL LNRDIQVGKS GHSSVEDAQA TMELYKLVEV EWEEHLARNP

PTD
Length:353
Mass (Da):39,154
Last modified:March 1, 2001 - v1
Checksum:i07558CDED402C195
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038171130N → S. Corresponds to variant dbSNP:rs3795737Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY391837 mRNA Translation: AAS55433.1
AK022733 mRNA Translation: BAB14212.1
AL590666 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52919.1
CH471121 Genomic DNA Translation: EAW52920.1
BC000575 mRNA Translation: AAH00575.1
CCDSiCCDS1153.1
RefSeqiNP_001290024.1, NM_001303095.1
XP_005245573.1, XM_005245516.4
XP_006711623.1, XM_006711560.3
XP_006711624.1, XM_006711561.3
UniGeneiHs.301904

Genome annotation databases

EnsembliENST00000313146; ENSP00000323424; ENSG00000143319
ENST00000368219; ENSP00000357202; ENSG00000143319
GeneIDi81875
KEGGihsa:81875
UCSCiuc001fps.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiI20L2_HUMAN
AccessioniPrimary (citable) accession number: Q9H9L3
Secondary accession number(s): D3DVC6, Q64KA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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