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Q9H9L3

- I20L2_HUMAN

UniProt

Q9H9L3 - I20L2_HUMAN

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Protein

Interferon-stimulated 20 kDa exonuclease-like 2

Gene

ISG20L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group.1 Publication

GO - Molecular functioni

  1. exonuclease activity Source: UniProtKB-KW
  2. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. ribosome biogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-stimulated 20 kDa exonuclease-like 2 (EC:3.1.-.-)
Gene namesi
Name:ISG20L2
ORF Names:HSD-38, HSD38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:25745. ISG20L2.

Subcellular locationi

Nucleusnucleolus 2 Publications

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671650.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Interferon-stimulated 20 kDa exonuclease-like 2PRO_0000084121Add
BLAST

Proteomic databases

MaxQBiQ9H9L3.
PaxDbiQ9H9L3.
PeptideAtlasiQ9H9L3.
PRIDEiQ9H9L3.

2D gel databases

SWISS-2DPAGEQ9H9L3.

PTM databases

PhosphoSiteiQ9H9L3.

Expressioni

Gene expression databases

BgeeiQ9H9L3.
CleanExiHS_ISG20L2.
GenevestigatoriQ9H9L3.

Organism-specific databases

HPAiHPA028005.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EML1O004233EBI-751335,EBI-751327
NCK1P163332EBI-751335,EBI-389883

Protein-protein interaction databases

BioGridi123618. 1 interaction.
IntActiQ9H9L3. 7 interactions.
MINTiMINT-1457372.
STRINGi9606.ENSP00000323424.

Structurei

3D structure databases

ProteinModelPortaliQ9H9L3.
SMRiQ9H9L3. Positions 178-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini178 – 353176ExonucleaseAdd
BLAST

Sequence similaritiesi

Contains 1 exonuclease domain.Curated

Phylogenomic databases

eggNOGiCOG0847.
GeneTreeiENSGT00520000055542.
HOGENOMiHOG000182422.
HOVERGENiHBG107986.
InParanoidiQ9H9L3.
KOiK18329.
OMAiHMVNATP.
OrthoDBiEOG7WHHB0.
PhylomeDBiQ9H9L3.
TreeFamiTF354340.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR006055. Exonuclease.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00929. RNase_T. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H9L3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTLLLNLDF GEPPPKKALE GNAKHRNFVK KRRLLERRGF LSKKNQPPSK
60 70 80 90 100
APKLHSEPSK KGETPTVDGT WKTPSFPKKK TAASSNGSGQ PLDKKAAVSW
110 120 130 140 150
LTPAPSKKAD SVAAKVDLLG EFQSALPKIN SHPTRSQKKS SQKKSSKKNH
160 170 180 190 200
PQKNAPQNST QAHSENKCSG ASQKLPRKMV AIDCEMVGTG PKGHVSSLAR
210 220 230 240 250
CSIVNYNGDV LYDEYILPPC HIVDYRTRWS GIRKQHMVNA TPFKIARGQI
260 270 280 290 300
LKILTGKIVV GHAIHNDFKA LQYFHPKSLT RDTSHIPPLN RKADCPENAT
310 320 330 340 350
MSLKHLTKKL LNRDIQVGKS GHSSVEDAQA TMELYKLVEV EWEEHLARNP

PTD
Length:353
Mass (Da):39,154
Last modified:March 1, 2001 - v1
Checksum:i07558CDED402C195
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti130 – 1301N → S.
Corresponds to variant rs3795737 [ dbSNP | Ensembl ].
VAR_038171

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY391837 mRNA. Translation: AAS55433.1.
AK022733 mRNA. Translation: BAB14212.1.
AL590666 Genomic DNA. Translation: CAI16341.1.
CH471121 Genomic DNA. Translation: EAW52919.1.
CH471121 Genomic DNA. Translation: EAW52920.1.
BC000575 mRNA. Translation: AAH00575.1.
CCDSiCCDS1153.1.
RefSeqiNP_112242.1. NM_030980.1.
XP_005245573.1. XM_005245516.2.
XP_005245574.1. XM_005245517.2.
XP_006711623.1. XM_006711560.1.
XP_006711624.1. XM_006711561.1.
UniGeneiHs.301904.

Genome annotation databases

EnsembliENST00000313146; ENSP00000323424; ENSG00000143319.
ENST00000368219; ENSP00000357202; ENSG00000143319.
GeneIDi81875.
KEGGihsa:81875.
UCSCiuc001fps.1. human.

Polymorphism databases

DMDMi42559527.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY391837 mRNA. Translation: AAS55433.1 .
AK022733 mRNA. Translation: BAB14212.1 .
AL590666 Genomic DNA. Translation: CAI16341.1 .
CH471121 Genomic DNA. Translation: EAW52919.1 .
CH471121 Genomic DNA. Translation: EAW52920.1 .
BC000575 mRNA. Translation: AAH00575.1 .
CCDSi CCDS1153.1.
RefSeqi NP_112242.1. NM_030980.1.
XP_005245573.1. XM_005245516.2.
XP_005245574.1. XM_005245517.2.
XP_006711623.1. XM_006711560.1.
XP_006711624.1. XM_006711561.1.
UniGenei Hs.301904.

3D structure databases

ProteinModelPortali Q9H9L3.
SMRi Q9H9L3. Positions 178-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123618. 1 interaction.
IntActi Q9H9L3. 7 interactions.
MINTi MINT-1457372.
STRINGi 9606.ENSP00000323424.

PTM databases

PhosphoSitei Q9H9L3.

Polymorphism databases

DMDMi 42559527.

2D gel databases

SWISS-2DPAGE Q9H9L3.

Proteomic databases

MaxQBi Q9H9L3.
PaxDbi Q9H9L3.
PeptideAtlasi Q9H9L3.
PRIDEi Q9H9L3.

Protocols and materials databases

DNASUi 81875.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000313146 ; ENSP00000323424 ; ENSG00000143319 .
ENST00000368219 ; ENSP00000357202 ; ENSG00000143319 .
GeneIDi 81875.
KEGGi hsa:81875.
UCSCi uc001fps.1. human.

Organism-specific databases

CTDi 81875.
GeneCardsi GC01M156691.
HGNCi HGNC:25745. ISG20L2.
HPAi HPA028005.
MIMi 611930. gene.
neXtProti NX_Q9H9L3.
PharmGKBi PA142671650.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0847.
GeneTreei ENSGT00520000055542.
HOGENOMi HOG000182422.
HOVERGENi HBG107986.
InParanoidi Q9H9L3.
KOi K18329.
OMAi HMVNATP.
OrthoDBi EOG7WHHB0.
PhylomeDBi Q9H9L3.
TreeFami TF354340.

Miscellaneous databases

ChiTaRSi ISG20L2. human.
GenomeRNAii 81875.
NextBioi 72218.
PROi Q9H9L3.
SOURCEi Search...

Gene expression databases

Bgeei Q9H9L3.
CleanExi HS_ISG20L2.
Genevestigatori Q9H9L3.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
InterProi IPR006055. Exonuclease.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view ]
Pfami PF00929. RNase_T. 1 hit.
[Graphical view ]
SMARTi SM00479. EXOIII. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new spermatogenesis-related gene."
    Yang C.B., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "ISG20L2, a novel vertebrate nucleolar exoribonuclease involved in ribosome biogenesis."
    Coute Y., Kindbeiter K., Belin S., Dieckmann R., Duret L., Bezin L., Sanchez J.-C., Diaz J.-J.
    Mol. Cell. Proteomics 7:546-559(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiI20L2_HUMAN
AccessioniPrimary (citable) accession number: Q9H9L3
Secondary accession number(s): D3DVC6, Q64KA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3