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Q9H9L3

- I20L2_HUMAN

UniProt

Q9H9L3 - I20L2_HUMAN

Protein

Interferon-stimulated 20 kDa exonuclease-like 2

Gene

ISG20L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group.1 Publication

    GO - Molecular functioni

    1. exonuclease activity Source: UniProtKB-KW
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. ribosome biogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Exonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    Ribosome biogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon-stimulated 20 kDa exonuclease-like 2 (EC:3.1.-.-)
    Gene namesi
    Name:ISG20L2
    ORF Names:HSD-38, HSD38
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25745. ISG20L2.

    Subcellular locationi

    Nucleusnucleolus 2 Publications

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671650.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 353353Interferon-stimulated 20 kDa exonuclease-like 2PRO_0000084121Add
    BLAST

    Proteomic databases

    MaxQBiQ9H9L3.
    PaxDbiQ9H9L3.
    PeptideAtlasiQ9H9L3.
    PRIDEiQ9H9L3.

    2D gel databases

    SWISS-2DPAGEQ9H9L3.

    PTM databases

    PhosphoSiteiQ9H9L3.

    Expressioni

    Gene expression databases

    BgeeiQ9H9L3.
    CleanExiHS_ISG20L2.
    GenevestigatoriQ9H9L3.

    Organism-specific databases

    HPAiHPA028005.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EML1O004233EBI-751335,EBI-751327
    NCK1P163332EBI-751335,EBI-389883

    Protein-protein interaction databases

    BioGridi123618. 1 interaction.
    IntActiQ9H9L3. 7 interactions.
    MINTiMINT-1457372.
    STRINGi9606.ENSP00000323424.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H9L3.
    SMRiQ9H9L3. Positions 178-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini178 – 353176ExonucleaseAdd
    BLAST

    Sequence similaritiesi

    Contains 1 exonuclease domain.Curated

    Phylogenomic databases

    eggNOGiCOG0847.
    HOGENOMiHOG000182422.
    HOVERGENiHBG107986.
    InParanoidiQ9H9L3.
    KOiK18329.
    OMAiHMVNATP.
    OrthoDBiEOG7WHHB0.
    PhylomeDBiQ9H9L3.
    TreeFamiTF354340.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    InterProiIPR006055. Exonuclease.
    IPR013520. Exonuclease_RNaseT/DNA_pol3.
    IPR012337. RNaseH-like_dom.
    [Graphical view]
    PfamiPF00929. RNase_T. 1 hit.
    [Graphical view]
    SMARTiSM00479. EXOIII. 1 hit.
    [Graphical view]
    SUPFAMiSSF53098. SSF53098. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9H9L3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTLLLNLDF GEPPPKKALE GNAKHRNFVK KRRLLERRGF LSKKNQPPSK    50
    APKLHSEPSK KGETPTVDGT WKTPSFPKKK TAASSNGSGQ PLDKKAAVSW 100
    LTPAPSKKAD SVAAKVDLLG EFQSALPKIN SHPTRSQKKS SQKKSSKKNH 150
    PQKNAPQNST QAHSENKCSG ASQKLPRKMV AIDCEMVGTG PKGHVSSLAR 200
    CSIVNYNGDV LYDEYILPPC HIVDYRTRWS GIRKQHMVNA TPFKIARGQI 250
    LKILTGKIVV GHAIHNDFKA LQYFHPKSLT RDTSHIPPLN RKADCPENAT 300
    MSLKHLTKKL LNRDIQVGKS GHSSVEDAQA TMELYKLVEV EWEEHLARNP 350
    PTD 353
    Length:353
    Mass (Da):39,154
    Last modified:March 1, 2001 - v1
    Checksum:i07558CDED402C195
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti130 – 1301N → S.
    Corresponds to variant rs3795737 [ dbSNP | Ensembl ].
    VAR_038171

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY391837 mRNA. Translation: AAS55433.1.
    AK022733 mRNA. Translation: BAB14212.1.
    AL590666 Genomic DNA. Translation: CAI16341.1.
    CH471121 Genomic DNA. Translation: EAW52919.1.
    CH471121 Genomic DNA. Translation: EAW52920.1.
    BC000575 mRNA. Translation: AAH00575.1.
    CCDSiCCDS1153.1.
    RefSeqiNP_112242.1. NM_030980.1.
    XP_005245573.1. XM_005245516.2.
    XP_005245574.1. XM_005245517.2.
    XP_006711623.1. XM_006711560.1.
    XP_006711624.1. XM_006711561.1.
    UniGeneiHs.301904.

    Genome annotation databases

    EnsembliENST00000313146; ENSP00000323424; ENSG00000143319.
    ENST00000368219; ENSP00000357202; ENSG00000143319.
    GeneIDi81875.
    KEGGihsa:81875.
    UCSCiuc001fps.1. human.

    Polymorphism databases

    DMDMi42559527.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY391837 mRNA. Translation: AAS55433.1 .
    AK022733 mRNA. Translation: BAB14212.1 .
    AL590666 Genomic DNA. Translation: CAI16341.1 .
    CH471121 Genomic DNA. Translation: EAW52919.1 .
    CH471121 Genomic DNA. Translation: EAW52920.1 .
    BC000575 mRNA. Translation: AAH00575.1 .
    CCDSi CCDS1153.1.
    RefSeqi NP_112242.1. NM_030980.1.
    XP_005245573.1. XM_005245516.2.
    XP_005245574.1. XM_005245517.2.
    XP_006711623.1. XM_006711560.1.
    XP_006711624.1. XM_006711561.1.
    UniGenei Hs.301904.

    3D structure databases

    ProteinModelPortali Q9H9L3.
    SMRi Q9H9L3. Positions 178-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123618. 1 interaction.
    IntActi Q9H9L3. 7 interactions.
    MINTi MINT-1457372.
    STRINGi 9606.ENSP00000323424.

    PTM databases

    PhosphoSitei Q9H9L3.

    Polymorphism databases

    DMDMi 42559527.

    2D gel databases

    SWISS-2DPAGE Q9H9L3.

    Proteomic databases

    MaxQBi Q9H9L3.
    PaxDbi Q9H9L3.
    PeptideAtlasi Q9H9L3.
    PRIDEi Q9H9L3.

    Protocols and materials databases

    DNASUi 81875.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313146 ; ENSP00000323424 ; ENSG00000143319 .
    ENST00000368219 ; ENSP00000357202 ; ENSG00000143319 .
    GeneIDi 81875.
    KEGGi hsa:81875.
    UCSCi uc001fps.1. human.

    Organism-specific databases

    CTDi 81875.
    GeneCardsi GC01M156691.
    HGNCi HGNC:25745. ISG20L2.
    HPAi HPA028005.
    MIMi 611930. gene.
    neXtProti NX_Q9H9L3.
    PharmGKBi PA142671650.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0847.
    HOGENOMi HOG000182422.
    HOVERGENi HBG107986.
    InParanoidi Q9H9L3.
    KOi K18329.
    OMAi HMVNATP.
    OrthoDBi EOG7WHHB0.
    PhylomeDBi Q9H9L3.
    TreeFami TF354340.

    Miscellaneous databases

    ChiTaRSi ISG20L2. human.
    GenomeRNAii 81875.
    NextBioi 72218.
    PROi Q9H9L3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H9L3.
    CleanExi HS_ISG20L2.
    Genevestigatori Q9H9L3.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    InterProi IPR006055. Exonuclease.
    IPR013520. Exonuclease_RNaseT/DNA_pol3.
    IPR012337. RNaseH-like_dom.
    [Graphical view ]
    Pfami PF00929. RNase_T. 1 hit.
    [Graphical view ]
    SMARTi SM00479. EXOIII. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53098. SSF53098. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A new spermatogenesis-related gene."
      Yang C.B., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "ISG20L2, a novel vertebrate nucleolar exoribonuclease involved in ribosome biogenesis."
      Coute Y., Kindbeiter K., Belin S., Dieckmann R., Duret L., Bezin L., Sanchez J.-C., Diaz J.-J.
      Mol. Cell. Proteomics 7:546-559(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiI20L2_HUMAN
    AccessioniPrimary (citable) accession number: Q9H9L3
    Secondary accession number(s): D3DVC6, Q64KA2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3