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Protein

Ubiquitin carboxyl-terminal hydrolase 42

Gene

USP42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Deubiquitinating enzyme which may play an important role during spermatogenesis.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei120NucleophilePROSITE-ProRule annotation1
Active sitei371Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processDifferentiation, Spermatogenesis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-5689880 Ub-specific processing proteases

Protein family/group databases

MEROPSiC19.048

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 42 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 42
Ubiquitin thioesterase 42
Ubiquitin-specific-processing protease 42
Gene namesi
Name:USP42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106346.11
HGNCiHGNC:20068 USP42
neXtProtiNX_Q9H9J4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi84132
OpenTargetsiENSG00000106346
PharmGKBiPA134902515

Polymorphism and mutation databases

BioMutaiUSP42
DMDMi322510098

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806721 – 1324Ubiquitin carboxyl-terminal hydrolase 42Add BLAST1324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75PhosphoserineCombined sources1
Modified residuei483PhosphoserineCombined sources1
Modified residuei754PhosphoserineCombined sources1
Modified residuei856PhosphoserineCombined sources1
Modified residuei1181PhosphoserineCombined sources1
Modified residuei1219PhosphoserineBy similarity1
Modified residuei1222PhosphoserineBy similarity1
Modified residuei1226PhosphoserineCombined sources1
Modified residuei1247PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H9J4
MaxQBiQ9H9J4
PaxDbiQ9H9J4
PeptideAtlasiQ9H9J4
PRIDEiQ9H9J4

PTM databases

iPTMnetiQ9H9J4
PhosphoSitePlusiQ9H9J4

Miscellaneous databases

PMAP-CutDBQ9H9J4

Expressioni

Tissue specificityi

Broadly expressed.1 Publication

Gene expression databases

BgeeiENSG00000106346
CleanExiHS_USP42
ExpressionAtlasiQ9H9J4 baseline and differential
GenevisibleiQ9H9J4 HS

Organism-specific databases

HPAiHPA006752
HPA064800

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TP53P046372EBI-9118105,EBI-366083

Protein-protein interaction databases

BioGridi123904, 39 interactors
IntActiQ9H9J4, 29 interactors
MINTiQ9H9J4
STRINGi9606.ENSP00000301962

Structurei

3D structure databases

ProteinModelPortaliQ9H9J4
SMRiQ9H9J4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 412USPAdd BLAST302

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi742 – 937Pro-richAdd BLAST196
Compositional biasi946 – 1118Arg-richAdd BLAST173
Compositional biasi1176 – 1246Lys-richAdd BLAST71

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

eggNOGiKOG1865 Eukaryota
ENOG410XQ92 LUCA
GeneTreeiENSGT00890000139343
HOGENOMiHOG000236355
HOVERGENiHBG080724
InParanoidiQ9H9J4
KOiK11855
OMAiLPSHMIK
OrthoDBiEOG091G02D8
PhylomeDBiQ9H9J4
TreeFamiTF315281

Family and domain databases

InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H9J4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTIVDKASES SDPSAYQNQP GSSEAVSPGD MDAGSASWGA VSSLNDVSNH
60 70 80 90 100
TLSLGPVPGA VVYSSSSVPD KSKPSPQKDQ ALGDGIAPPQ KVLFPSEKIC
110 120 130 140 150
LKWQQTHRVG AGLQNLGNTC FANAALQCLT YTPPLANYML SHEHSKTCHA
160 170 180 190 200
EGFCMMCTMQ AHITQALSNP GDVIKPMFVI NEMRRIARHF RFGNQEDAHE
210 220 230 240 250
FLQYTVDAMQ KACLNGSNKL DRHTQATTLV CQIFGGYLRS RVKCLNCKGV
260 270 280 290 300
SDTFDPYLDI TLEIKAAQSV NKALEQFVKP EQLDGENSYK CSKCKKMVPA
310 320 330 340 350
SKRFTIHRSS NVLTLSLKRF ANFTGGKIAK DVKYPEYLDI RPYMSQPNGE
360 370 380 390 400
PIVYVLYAVL VHTGFNCHAG HYFCYIKASN GLWYQMNDSI VSTSDIRSVL
410 420 430 440 450
SQQAYVLFYI RSHDVKNGGE LTHPTHSPGQ SSPRPVISQR VVTNKQAAPG
460 470 480 490 500
FIGPQLPSHM IKNPPHLNGT GPLKDTPSSS MSSPNGNSSV NRASPVNASA
510 520 530 540 550
SVQNWSVNRS SVIPEHPKKQ KITISIHNKL PVRQCQSQPN LHSNSLENPT
560 570 580 590 600
KPVPSSTITN SAVQSTSNAS TMSVSSKVTK PIPRSESCSQ PVMNGKSKLN
610 620 630 640 650
SSVLVPYGAE SSEDSDEESK GLGKENGIGT IVSSHSPGQD AEDEEATPHE
660 670 680 690 700
LQEPMTLNGA NSADSDSDPK ENGLAPDGAS CQGQPALHSE NPFAKANGLP
710 720 730 740 750
GKLMPAPLLS LPEDKILETF RLSNKLKGST DEMSAPGAER GPPEDRDAEP
760 770 780 790 800
QPGSPAAESL EEPDAAAGLS STKKAPPPRD PGTPATKEGA WEAMAVAPEE
810 820 830 840 850
PPPSAGEDIV GDTAPPDLCD PGSLTGDASP LSQDAKGMIA EGPRDSALAE
860 870 880 890 900
APEGLSPAPP ARSEEPCEQP LLVHPSGDHA RDAQDPSQSL GAPEAAERPP
910 920 930 940 950
APVLDMAPAG HPEGDAEPSP GERVEDAAAP KAPGPSPAKE KIGSLRKVDR
960 970 980 990 1000
GHYRSRRERS SSGEPARESR SKTEGHRHRR RRTCPRERDR QDRHAPEHHP
1010 1020 1030 1040 1050
GHGDRLSPGE RRSLGRCSHH HSRHRSGVEL DWVRHHYTEG ERGWGREKFY
1060 1070 1080 1090 1100
PDRPRWDRCR YYHDRYALYA ARDWKPFHGG REHERAGLHE RPHKDHNRGR
1110 1120 1130 1140 1150
RGCEPARERE RHRPSSPRAG APHALAPHPD RFSHDRTALV AGDNCNLSDR
1160 1170 1180 1190 1200
FHEHENGKSR KRRHDSVENS DSHVEKKARR SEQKDPLEEP KAKKHKKSKK
1210 1220 1230 1240 1250
KKKSKDKHRD RDSRHQQDSD LSAACSDADL HRHKKKKKKK KRHSRKSEDF
1260 1270 1280 1290 1300
VKDSELHLPR VTSLETVAQF RRAQGGFPLS GGPPLEGVGP FREKTKHLRM
1310 1320
ESRDDRCRLF EYGQGKRRYL ELGR
Length:1,324
Mass (Da):145,392
Last modified:February 8, 2011 - v3
Checksum:i6EB4975521ABF516
GO
Isoform 2 (identifier: Q9H9J4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1316-1324: KRRYLELGR → D

Show »
Length:1,316
Mass (Da):144,335
Checksum:i28998E673C8EFE3B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti655M → T in CAE53097 (PubMed:14715245).Curated1
Sequence conflicti655M → T in BAB14232 (PubMed:14702039).Curated1
Sequence conflicti1214R → RR in CAE53097 (PubMed:14715245).Curated1
Sequence conflicti1217Q → R in AAT67238 (PubMed:15489334).Curated1
Sequence conflicti1294K → E in AAT67238 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0597541030L → P. Corresponds to variant dbSNP:rs6463529Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0405291316 – 1324KRRYLELGR → D in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ601395 mRNA Translation: CAE53097.1
AY618868 mRNA Translation: AAT67238.1
AC004895 Genomic DNA No translation available.
BC060846 mRNA Translation: AAH60846.2
BC132862 mRNA Translation: AAI32863.1
AK022759 mRNA Translation: BAB14232.1
CCDSiCCDS47535.1 [Q9H9J4-2]
RefSeqiNP_115548.1, NM_032172.2 [Q9H9J4-2]
UniGeneiHs.31856

Genome annotation databases

EnsembliENST00000306177; ENSP00000301962; ENSG00000106346 [Q9H9J4-2]
GeneIDi84132
KEGGihsa:84132
UCSCiuc011jwp.3 human [Q9H9J4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUBP42_HUMAN
AccessioniPrimary (citable) accession number: Q9H9J4
Secondary accession number(s): A2RUE3
, B5MDA5, Q0VIN8, Q3C166, Q6P9B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 8, 2011
Last modified: May 23, 2018
This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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