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Protein

MAP6 domain-containing protein 1

Gene

MAP6D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have microtubule-stabilizing activity.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
MAP6 domain-containing protein 1
Alternative name(s):
21 kDa STOP-like protein
Short name:
SL21
Gene namesi
Name:MAP6D1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000180834.7
HGNCiHGNC:25753 MAP6D1
MIMi610593 gene
neXtProtiNX_Q9H9H5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi5C → G: Loss of Golgi colocalization and gain of microtubule colocalization; when associated with C-10 and C-11. 1 Publication1
Mutagenesisi10C → G: Loss of Golgi colocalization and gain of microtubule colocalization; when associated with C-5 and C-11. 1 Publication1
Mutagenesisi11C → G: Loss of Golgi colocalization and gain of microtubule colocalization; when associated with C-5 and C-10. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000180834
PharmGKBiPA142671480

Polymorphism and mutation databases

BioMutaiMAP6D1
DMDMi74734016

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002719151 – 199MAP6 domain-containing protein 1Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi5S-palmitoyl cysteine1 Publication1
Lipidationi10S-palmitoyl cysteine1 Publication1
Lipidationi11S-palmitoyl cysteine1 Publication1
Modified residuei38PhosphoserineBy similarity1
Modified residuei167PhosphoserineBy similarity1

Post-translational modificationi

Palmitoylated. Palmitoylation enhances association with microtubules.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ9H9H5
PeptideAtlasiQ9H9H5
PRIDEiQ9H9H5

PTM databases

PhosphoSitePlusiQ9H9H5

Expressioni

Gene expression databases

BgeeiENSG00000180834
CleanExiHS_MAP6D1
ExpressionAtlasiQ9H9H5 baseline and differential
GenevisibleiQ9H9H5 HS

Organism-specific databases

HPAiHPA037991

Interactioni

Subunit structurei

Interacts with calmodulin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000314560

Structurei

3D structure databases

ProteinModelPortaliQ9H9H5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STOP family.Curated

Phylogenomic databases

eggNOGiENOG410J5A6 Eukaryota
ENOG410YI0W LUCA
GeneTreeiENSGT00530000063947
HOGENOMiHOG000113451
HOVERGENiHBG081946
InParanoidiQ9H9H5
OMAiQRDFGVW
OrthoDBiEOG091G0A3G
PhylomeDBiQ9H9H5
TreeFamiTF338320

Family and domain databases

InterProiView protein in InterPro
IPR007882 MAP6
PANTHERiPTHR14759 PTHR14759, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H9H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWPCISRLC CLARRWNQLD RSDVAVPLTL HGYSDLDSEE PGTGGAASRR
60 70 80 90 100
GQPPAGARDS GRDVPLTQYQ RDFGLWTTPA GPKDPPPGRG PGAGGRRGKS
110 120 130 140 150
SAQSSAPPAP GARGVYVLPI GDADAAAAVT TSYRQEFQAW TGVKPSRSTK
160 170 180 190
TKPARVITTH TSGWDSSPGA GFQVPEVRKK FTPNPSAIFQ ASAPRILNV
Length:199
Mass (Da):21,005
Last modified:March 1, 2001 - v1
Checksum:i36AF2D2B9C60C5A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022810 mRNA Translation: BAB14254.1
BC006434 mRNA Translation: AAH06434.1
CCDSiCCDS3247.1
RefSeqiNP_079147.1, NM_024871.2
UniGeneiHs.478465

Genome annotation databases

EnsembliENST00000318631; ENSP00000314560; ENSG00000180834
GeneIDi79929
KEGGihsa:79929
UCSCiuc003fmc.3 human

Similar proteinsi

Entry informationi

Entry nameiMA6D1_HUMAN
AccessioniPrimary (citable) accession number: Q9H9H5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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