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Protein

MAP6 domain-containing protein 1

Gene

MAP6D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May have microtubule-stabilizing activity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
MAP6 domain-containing protein 1
Alternative name(s):
21 kDa STOP-like protein
Short name:
SL21
Gene namesi
Name:MAP6D1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25753. MAP6D1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi5 – 51C → G: Loss of Golgi colocalization and gain of microtubule colocalization; when associated with C-10 and C-11. 1 Publication
Mutagenesisi10 – 101C → G: Loss of Golgi colocalization and gain of microtubule colocalization; when associated with C-5 and C-11. 1 Publication
Mutagenesisi11 – 111C → G: Loss of Golgi colocalization and gain of microtubule colocalization; when associated with C-5 and C-10. 1 Publication

Organism-specific databases

PharmGKBiPA142671480.

Polymorphism and mutation databases

BioMutaiMAP6D1.
DMDMi74734016.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199MAP6 domain-containing protein 1PRO_0000271915Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi5 – 51S-palmitoyl cysteine1 Publication
Lipidationi10 – 101S-palmitoyl cysteine1 Publication
Lipidationi11 – 111S-palmitoyl cysteine1 Publication
Modified residuei38 – 381PhosphoserineBy similarity
Modified residuei167 – 1671PhosphoserineBy similarity

Post-translational modificationi

Palmitoylated. Palmitoylation enhances association with microtubules.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ9H9H5.
PaxDbiQ9H9H5.
PeptideAtlasiQ9H9H5.
PRIDEiQ9H9H5.

PTM databases

PhosphoSiteiQ9H9H5.

Expressioni

Gene expression databases

BgeeiQ9H9H5.
CleanExiHS_MAP6D1.
ExpressionAtlasiQ9H9H5. baseline and differential.
GenevisibleiQ9H9H5. HS.

Organism-specific databases

HPAiHPA037991.

Interactioni

Subunit structurei

Interacts with calmodulin.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9H9H5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STOP family.Curated

Phylogenomic databases

eggNOGiENOG410J5A6. Eukaryota.
ENOG410YI0W. LUCA.
GeneTreeiENSGT00530000063947.
HOGENOMiHOG000113451.
HOVERGENiHBG081946.
InParanoidiQ9H9H5.
OMAiQRDFGVW.
OrthoDBiEOG7ZWD1D.
PhylomeDBiQ9H9H5.
TreeFamiTF338320.

Family and domain databases

InterProiIPR007882. MAP6.
[Graphical view]
PANTHERiPTHR14759. PTHR14759. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H9H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWPCISRLC CLARRWNQLD RSDVAVPLTL HGYSDLDSEE PGTGGAASRR
60 70 80 90 100
GQPPAGARDS GRDVPLTQYQ RDFGLWTTPA GPKDPPPGRG PGAGGRRGKS
110 120 130 140 150
SAQSSAPPAP GARGVYVLPI GDADAAAAVT TSYRQEFQAW TGVKPSRSTK
160 170 180 190
TKPARVITTH TSGWDSSPGA GFQVPEVRKK FTPNPSAIFQ ASAPRILNV
Length:199
Mass (Da):21,005
Last modified:March 1, 2001 - v1
Checksum:i36AF2D2B9C60C5A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022810 mRNA. Translation: BAB14254.1.
BC006434 mRNA. Translation: AAH06434.1.
CCDSiCCDS3247.1.
RefSeqiNP_079147.1. NM_024871.2.
UniGeneiHs.478465.

Genome annotation databases

EnsembliENST00000318631; ENSP00000314560; ENSG00000180834.
GeneIDi79929.
KEGGihsa:79929.
UCSCiuc003fmc.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022810 mRNA. Translation: BAB14254.1.
BC006434 mRNA. Translation: AAH06434.1.
CCDSiCCDS3247.1.
RefSeqiNP_079147.1. NM_024871.2.
UniGeneiHs.478465.

3D structure databases

ProteinModelPortaliQ9H9H5.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9H9H5.

Polymorphism and mutation databases

BioMutaiMAP6D1.
DMDMi74734016.

Proteomic databases

EPDiQ9H9H5.
PaxDbiQ9H9H5.
PeptideAtlasiQ9H9H5.
PRIDEiQ9H9H5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318631; ENSP00000314560; ENSG00000180834.
GeneIDi79929.
KEGGihsa:79929.
UCSCiuc003fmc.3. human.

Organism-specific databases

CTDi79929.
GeneCardsiMAP6D1.
HGNCiHGNC:25753. MAP6D1.
HPAiHPA037991.
MIMi610593. gene.
neXtProtiNX_Q9H9H5.
PharmGKBiPA142671480.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J5A6. Eukaryota.
ENOG410YI0W. LUCA.
GeneTreeiENSGT00530000063947.
HOGENOMiHOG000113451.
HOVERGENiHBG081946.
InParanoidiQ9H9H5.
OMAiQRDFGVW.
OrthoDBiEOG7ZWD1D.
PhylomeDBiQ9H9H5.
TreeFamiTF338320.

Miscellaneous databases

ChiTaRSiMAP6D1. human.
GenomeRNAii79929.
PROiQ9H9H5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H9H5.
CleanExiHS_MAP6D1.
ExpressionAtlasiQ9H9H5. baseline and differential.
GenevisibleiQ9H9H5. HS.

Family and domain databases

InterProiIPR007882. MAP6.
[Graphical view]
PANTHERiPTHR14759. PTHR14759. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. "STOP-like protein 21 is a novel member of the STOP family, revealing a Golgi localization of STOP proteins."
    Gory-Faure S., Windscheid V., Bosc C., Peris L., Proietto D., Franck R., Denarier E., Job D., Andrieux A.
    J. Biol. Chem. 281:28387-28396(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-5; CYS-10 AND CYS-11, MUTAGENESIS OF CYS-5; CYS-10 AND CYS-11.

Entry informationi

Entry nameiMA6D1_HUMAN
AccessioniPrimary (citable) accession number: Q9H9H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.