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Protein

Vacuolar protein sorting-associated protein 37B

Gene

VPS37B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.1 Publication

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB

GO - Biological processi

  • endosomal transport Source: Reactome
  • endosome transport via multivesicular body sorting pathway Source: InterPro
  • macroautophagy Source: ParkinsonsUK-UCL
  • multivesicular body assembly Source: ParkinsonsUK-UCL
  • positive regulation of viral budding via host ESCRT complex Source: UniProtKB
  • positive regulation of viral release from host cell Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • viral budding via host ESCRT complex Source: ParkinsonsUK-UCL
  • viral life cycle Source: Reactome

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-162588 Budding and maturation of HIV virion
R-HSA-174490 Membrane binding and targetting of GAG proteins
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 37B
Short name:
hVps37B
Alternative name(s):
ESCRT-I complex subunit VPS37B
Gene namesi
Name:VPS37B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139722.6
HGNCiHGNC:25754 VPS37B
MIMi610037 gene
neXtProtiNX_Q9H9H4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79720
OpenTargetsiENSG00000139722
PharmGKBiPA142670616

Polymorphism and mutation databases

BioMutaiVPS37B
DMDMi74734015

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002872001 – 285Vacuolar protein sorting-associated protein 37BAdd BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei218Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ9H9H4
MaxQBiQ9H9H4
PaxDbiQ9H9H4
PeptideAtlasiQ9H9H4
PRIDEiQ9H9H4

PTM databases

iPTMnetiQ9H9H4
PhosphoSitePlusiQ9H9H4

Expressioni

Tissue specificityi

Widely expressed. Expressed in macrophages and lymphocytes.1 Publication

Gene expression databases

BgeeiENSG00000139722
CleanExiHS_VPS37B
ExpressionAtlasiQ9H9H4 baseline and differential
GenevisibleiQ9H9H4 HS

Organism-specific databases

HPAiHPA038217
HPA038218

Interactioni

Subunit structurei

Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with CEP55. Interacts with IST1.5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122836, 33 interactors
CORUMiQ9H9H4
ELMiQ9H9H4
IntActiQ9H9H4, 32 interactors
MINTiQ9H9H4
STRINGi9606.ENSP00000267202

Structurei

3D structure databases

ProteinModelPortaliQ9H9H4
SMRiQ9H9H4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 173VPS37 C-terminalPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 170Interaction with IST11 PublicationAdd BLAST121

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi170 – 280Pro-richAdd BLAST111

Sequence similaritiesi

Belongs to the VPS37 family.Curated

Phylogenomic databases

eggNOGiKOG3270 Eukaryota
ENOG4111UJN LUCA
GeneTreeiENSGT00530000063123
HOGENOMiHOG000234744
HOVERGENiHBG073355
InParanoidiQ9H9H4
KOiK12185
OMAiRTMHLRR
OrthoDBiEOG091G0GMF
PhylomeDBiQ9H9H4
TreeFamiTF321840

Family and domain databases

Gene3Di1.10.287.660, 1 hit
InterProiView protein in InterPro
IPR037202 ESCRT_assembly_dom
IPR029012 Helix_hairpin_bin_sf
IPR009851 Mod_r
IPR037859 Vps37
PANTHERiPTHR13678 PTHR13678, 1 hit
PfamiView protein in Pfam
PF07200 Mod_r, 1 hit
SUPFAMiSSF140111 SSF140111, 1 hit
PROSITEiView protein in PROSITE
PS51314 VPS37_C, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H9H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAGSEARF AGLSLVQLNE LLEDEGQLTE MVQKMEETQN VQLNKEMTLA
60 70 80 90 100
SNRSLAEGNL LYQPQLDTLK ARLTQKYQEL QVLFEAYQIK KTKLDRQSSS
110 120 130 140 150
ASLETLLALL QAEGAKIEED TENMAEKFLD GELPLDSFID VYQSKRKLAH
160 170 180 190 200
MRRVKIEKLQ EMVLKGQRLP QALAPLPPRL PELAPTAPLP YPAPEASGPP
210 220 230 240 250
AVAPRRIPPP PPPVPAGRLA TPFTAAMSSG QAVPYPGLQC PPLPPRVGLP
260 270 280
TQQGFSSQFV SPYPPPLPQR PPPRLPPHQP GFILQ
Length:285
Mass (Da):31,307
Last modified:March 1, 2001 - v1
Checksum:i43E70924AFA5DCE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022812 mRNA Translation: BAB14255.1
BC005882 mRNA Translation: AAH05882.1
CCDSiCCDS9239.1
RefSeqiNP_078943.1, NM_024667.2
UniGeneiHs.507162

Genome annotation databases

EnsembliENST00000267202; ENSP00000267202; ENSG00000139722
GeneIDi79720
KEGGihsa:79720
UCSCiuc001udl.4 human

Similar proteinsi

Entry informationi

Entry nameiVP37B_HUMAN
AccessioniPrimary (citable) accession number: Q9H9H4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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