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Protein

Vacuolar protein sorting-associated protein 37B

Gene

VPS37B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.1 Publication

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB

GO - Biological processi

  • autophagy Source: ParkinsonsUK-UCL
  • endosomal transport Source: Reactome
  • intracellular transport of virus Source: Reactome
  • multivesicular body assembly Source: ParkinsonsUK-UCL
  • positive regulation of viral budding via host ESCRT complex Source: UniProtKB
  • positive regulation of viral release from host cell Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • viral budding via host ESCRT complex Source: ParkinsonsUK-UCL
  • viral life cycle Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-162588. Budding and maturation of HIV virion.
R-HSA-174490. Membrane binding and targetting of GAG proteins.
R-HSA-917729. Endosomal Sorting Complex Required For Transport (ESCRT).

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 37B
Short name:
hVps37B
Alternative name(s):
ESCRT-I complex subunit VPS37B
Gene namesi
Name:VPS37B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25754. VPS37B.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • endosome Source: UniProtKB
  • endosome membrane Source: UniProtKB
  • ESCRT I complex Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • late endosome membrane Source: UniProtKB-SubCell
  • midbody Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670616.

Polymorphism and mutation databases

BioMutaiVPS37B.
DMDMi74734015.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Vacuolar protein sorting-associated protein 37BPRO_0000287200Add
BLAST

Proteomic databases

EPDiQ9H9H4.
MaxQBiQ9H9H4.
PaxDbiQ9H9H4.
PeptideAtlasiQ9H9H4.
PRIDEiQ9H9H4.

PTM databases

iPTMnetiQ9H9H4.
PhosphoSiteiQ9H9H4.

Expressioni

Tissue specificityi

Widely expressed. Expressed in macrophages and lymphocytes.1 Publication

Gene expression databases

BgeeiQ9H9H4.
CleanExiHS_VPS37B.
ExpressionAtlasiQ9H9H4. baseline and differential.
GenevisibleiQ9H9H4. HS.

Organism-specific databases

HPAiHPA038217.
HPA038218.

Interactioni

Subunit structurei

Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoechiometry. Interacts with CEP55. Interacts with IST1.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081173EBI-4400866,EBI-717810
BYSLQ138955EBI-4400866,EBI-358049
CDC73Q6P1J93EBI-4400866,EBI-930143
DCUN1D1Q96GG93EBI-4400866,EBI-740086
ERCC1P079923EBI-4400866,EBI-750962
FBF1Q8TES7-63EBI-4400866,EBI-10244131
NCK2O436393EBI-4400866,EBI-713635
PRKAA1Q131313EBI-4400866,EBI-1181405
QARSP47897-23EBI-4400866,EBI-10209725
SH3YL1Q96HL84EBI-4400866,EBI-722667
SMARCD1Q96GM54EBI-4400866,EBI-358489
SORBS3O605043EBI-4400866,EBI-741237
UBASH3BQ8TF423EBI-4400866,EBI-1380492
VPS28Q548N13EBI-4400866,EBI-10243107

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122836. 33 interactions.
IntActiQ9H9H4. 21 interactions.
MINTiMINT-6173622.
STRINGi9606.ENSP00000267202.

Structurei

3D structure databases

ProteinModelPortaliQ9H9H4.
SMRiQ9H9H4. Positions 108-156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 17390VPS37 C-terminalPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 170121Interaction with IST1Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi170 – 280111Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the VPS37 family.Curated
Contains 1 VPS37 C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3270. Eukaryota.
ENOG4111UJN. LUCA.
GeneTreeiENSGT00530000063123.
HOGENOMiHOG000234744.
HOVERGENiHBG073355.
InParanoidiQ9H9H4.
KOiK12185.
OMAiFESYQLR.
OrthoDBiEOG7KQ22B.
PhylomeDBiQ9H9H4.
TreeFamiTF321840.

Family and domain databases

InterProiIPR009851. Mod_r.
[Graphical view]
PfamiPF07200. Mod_r. 1 hit.
[Graphical view]
PROSITEiPS51314. VPS37_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H9H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAGSEARF AGLSLVQLNE LLEDEGQLTE MVQKMEETQN VQLNKEMTLA
60 70 80 90 100
SNRSLAEGNL LYQPQLDTLK ARLTQKYQEL QVLFEAYQIK KTKLDRQSSS
110 120 130 140 150
ASLETLLALL QAEGAKIEED TENMAEKFLD GELPLDSFID VYQSKRKLAH
160 170 180 190 200
MRRVKIEKLQ EMVLKGQRLP QALAPLPPRL PELAPTAPLP YPAPEASGPP
210 220 230 240 250
AVAPRRIPPP PPPVPAGRLA TPFTAAMSSG QAVPYPGLQC PPLPPRVGLP
260 270 280
TQQGFSSQFV SPYPPPLPQR PPPRLPPHQP GFILQ
Length:285
Mass (Da):31,307
Last modified:March 1, 2001 - v1
Checksum:i43E70924AFA5DCE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022812 mRNA. Translation: BAB14255.1.
BC005882 mRNA. Translation: AAH05882.1.
CCDSiCCDS9239.1.
RefSeqiNP_078943.1. NM_024667.2.
UniGeneiHs.507162.

Genome annotation databases

EnsembliENST00000267202; ENSP00000267202; ENSG00000139722.
GeneIDi79720.
KEGGihsa:79720.
UCSCiuc001udl.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022812 mRNA. Translation: BAB14255.1.
BC005882 mRNA. Translation: AAH05882.1.
CCDSiCCDS9239.1.
RefSeqiNP_078943.1. NM_024667.2.
UniGeneiHs.507162.

3D structure databases

ProteinModelPortaliQ9H9H4.
SMRiQ9H9H4. Positions 108-156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122836. 33 interactions.
IntActiQ9H9H4. 21 interactions.
MINTiMINT-6173622.
STRINGi9606.ENSP00000267202.

PTM databases

iPTMnetiQ9H9H4.
PhosphoSiteiQ9H9H4.

Polymorphism and mutation databases

BioMutaiVPS37B.
DMDMi74734015.

Proteomic databases

EPDiQ9H9H4.
MaxQBiQ9H9H4.
PaxDbiQ9H9H4.
PeptideAtlasiQ9H9H4.
PRIDEiQ9H9H4.

Protocols and materials databases

DNASUi79720.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267202; ENSP00000267202; ENSG00000139722.
GeneIDi79720.
KEGGihsa:79720.
UCSCiuc001udl.4. human.

Organism-specific databases

CTDi79720.
GeneCardsiVPS37B.
HGNCiHGNC:25754. VPS37B.
HPAiHPA038217.
HPA038218.
MIMi610037. gene.
neXtProtiNX_Q9H9H4.
PharmGKBiPA142670616.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3270. Eukaryota.
ENOG4111UJN. LUCA.
GeneTreeiENSGT00530000063123.
HOGENOMiHOG000234744.
HOVERGENiHBG073355.
InParanoidiQ9H9H4.
KOiK12185.
OMAiFESYQLR.
OrthoDBiEOG7KQ22B.
PhylomeDBiQ9H9H4.
TreeFamiTF321840.

Enzyme and pathway databases

ReactomeiR-HSA-162588. Budding and maturation of HIV virion.
R-HSA-174490. Membrane binding and targetting of GAG proteins.
R-HSA-917729. Endosomal Sorting Complex Required For Transport (ESCRT).

Miscellaneous databases

ChiTaRSiVPS37B. human.
GenomeRNAii79720.
PROiQ9H9H4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H9H4.
CleanExiHS_VPS37B.
ExpressionAtlasiQ9H9H4. baseline and differential.
GenevisibleiQ9H9H4. HS.

Family and domain databases

InterProiIPR009851. Mod_r.
[Graphical view]
PfamiPF07200. Mod_r. 1 hit.
[Graphical view]
PROSITEiPS51314. VPS37_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  3. "The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding."
    Stuchell M.D., Garrus J.E., Mueller B., Stray K.M., Ghaffarian S., McKinnon R., Kraeusslich H.-G., Morham S.G., Sundquist W.I.
    J. Biol. Chem. 279:36059-36071(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TSG101, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding."
    Morita E., Sandrin V., Alam S.L., Eckert D.M., Gygi S.P., Sundquist W.I.
    Cell Host Microbe 2:41-53(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TSG101; VPS28; MVB12A AND MVB12B, RECONSTITUTION OF THE ESCRT-I COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  5. "Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis."
    Morita E., Sandrin V., Chung H.Y., Morham S.G., Gygi S.P., Rodesch C.K., Sundquist W.I.
    EMBO J. 26:4215-4227(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CEP55.
  6. "Biochemical analyses of human IST1 and its function in cytokinesis."
    Bajorek M., Morita E., Skalicky J.J., Morham S.G., Babst M., Sundquist W.I.
    Mol. Biol. Cell 20:1360-1373(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IST1.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION IN AN ESCRT-I COMPLEX WITH UBAP1, SUBUNIT.

Entry informationi

Entry nameiVP37B_HUMAN
AccessioniPrimary (citable) accession number: Q9H9H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.