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Q9H9G7

- AGO3_HUMAN

UniProt

Q9H9G7 - AGO3_HUMAN

Protein

Protein argonaute-3

Gene

AGO3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4.2 PublicationsUniRule annotation

    GO - Molecular functioni

    1. miRNA binding Source: UniProtKB-HAMAP
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. epidermal growth factor receptor signaling pathway Source: Reactome
    2. Fc-epsilon receptor signaling pathway Source: Reactome
    3. fibroblast growth factor receptor signaling pathway Source: Reactome
    4. gene expression Source: Reactome
    5. innate immune response Source: Reactome
    6. mRNA catabolic process Source: UniProtKB
    7. negative regulation of translation involved in gene silencing by miRNA Source: UniProtKB
    8. neurotrophin TRK receptor signaling pathway Source: Reactome
    9. Notch signaling pathway Source: Reactome
    10. phosphatidylinositol-mediated signaling Source: Reactome
    11. regulation of stem cell proliferation Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    RNA-mediated gene silencing, Translation regulation

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_118560. Small interfering RNA (siRNA) biogenesis.
    REACT_118568. Pre-NOTCH Transcription and Translation.
    REACT_118699. Post-transcriptional silencing by small RNAs.
    REACT_12417. MicroRNA (miRNA) biogenesis.
    REACT_169325. Oncogene Induced Senescence.
    REACT_169436. Oxidative Stress Induced Senescence.
    REACT_172761. Ca2+ pathway.
    REACT_75829. PIP3 activates AKT signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein argonaute-3UniRule annotation
    Short name:
    Argonaute3UniRule annotation
    Short name:
    hAgo3
    Alternative name(s):
    Argonaute RISC catalytic component 3
    Eukaryotic translation initiation factor 2C 3UniRule annotation
    Short name:
    eIF-2C 3UniRule annotation
    Short name:
    eIF2C 3UniRule annotation
    Gene namesi
    Name:AGO3
    Synonyms:EIF2C3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:18421. AGO3.

    Subcellular locationi

    CytoplasmP-body 1 PublicationUniRule annotation

    GO - Cellular componenti

    1. cytoplasmic mRNA processing body Source: UniProtKB-SubCell
    2. cytosol Source: Reactome
    3. membrane Source: UniProtKB
    4. micro-ribonucleoprotein complex Source: UniProtKB-HAMAP
    5. RISC complex Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38329.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 860860Protein argonaute-3PRO_0000194061Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9H9G7.
    PaxDbiQ9H9G7.
    PRIDEiQ9H9G7.

    PTM databases

    PhosphoSiteiQ9H9G7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H9G7.
    BgeeiQ9H9G7.
    CleanExiHS_EIF2C3.
    GenevestigatoriQ9H9G7.

    Organism-specific databases

    HPAiHPA048342.

    Interactioni

    Subunit structurei

    Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H. Interacts with EDC4.3 PublicationsUniRule annotation

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    IPO8O153975EBI-2267883,EBI-358808
    TNRC6AQ8NDV73EBI-2267883,EBI-2269715

    Protein-protein interaction databases

    BioGridi128177. 55 interactions.
    DIPiDIP-54486N.
    IntActiQ9H9G7. 49 interactions.
    STRINGi9606.ENSP00000362287.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H9G7.
    SMRiQ9H9G7. Positions 12-860.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini236 – 349114PAZUniRule annotationAdd
    BLAST
    Domaini518 – 819302PiwiUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the argonaute family. Ago subfamily.UniRule annotation
    Contains 1 PAZ domain.UniRule annotation
    Contains 1 Piwi domain.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG279895.
    HOGENOMiHOG000116043.
    InParanoidiQ9H9G7.
    KOiK11593.
    OMAiGRSMPEP.
    OrthoDBiEOG7HHWRC.
    PhylomeDBiQ9H9G7.
    TreeFamiTF101510.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    HAMAPiMF_03032. AGO3.
    InterProiIPR028603. AGO3.
    IPR014811. DUF1785.
    IPR003100. PAZ_dom.
    IPR003165. Piwi.
    IPR012337. RNaseH-like_dom.
    [Graphical view]
    PfamiPF08699. DUF1785. 1 hit.
    PF02170. PAZ. 1 hit.
    PF02171. Piwi. 1 hit.
    [Graphical view]
    SMARTiSM00949. PAZ. 1 hit.
    SM00950. Piwi. 1 hit.
    [Graphical view]
    SUPFAMiSSF101690. SSF101690. 1 hit.
    SSF53098. SSF53098. 1 hit.
    PROSITEiPS50821. PAZ. 1 hit.
    PS50822. PIWI. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H9G7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEIGSAGPAG AQPLLMVPRR PGYGTMGKPI KLLANCFQVE IPKIDVYLYE    50
    VDIKPDKCPR RVNREVVDSM VQHFKVTIFG DRRPVYDGKR SLYTANPLPV 100
    ATTGVDLDVT LPGEGGKDRP FKVSIKFVSR VSWHLLHEVL TGRTLPEPLE 150
    LDKPISTNPV HAVDVVLRHL PSMKYTPVGR SFFSAPEGYD HPLGGGREVW 200
    FGFHQSVRPA MWKMMLNIDV SATAFYKAQP VIQFMCEVLD IHNIDEQPRP 250
    LTDSHRVKFT KEIKGLKVEV THCGTMRRKY RVCNVTRRPA SHQTFPLQLE 300
    NGQTVERTVA QYFREKYTLQ LKYPHLPCLQ VGQEQKHTYL PLEVCNIVAG 350
    QRCIKKLTDN QTSTMIKATA RSAPDRQEEI SRLVRSANYE TDPFVQEFQF 400
    KVRDEMAHVT GRVLPAPMLQ YGGRNRTVAT PSHGVWDMRG KQFHTGVEIK 450
    MWAIACFATQ RQCREEILKG FTDQLRKISK DAGMPIQGQP CFCKYAQGAD 500
    SVEPMFRHLK NTYSGLQLII VILPGKTPVY AEVKRVGDTL LGMATQCVQV 550
    KNVIKTSPQT LSNLCLKINV KLGGINNILV PHQRPSVFQQ PVIFLGADVT 600
    HPPAGDGKKP SIAAVVGSMD AHPSRYCATV RVQRPRQEII QDLASMVREL 650
    LIQFYKSTRF KPTRIIFYRD GVSEGQFRQV LYYELLAIRE ACISLEKDYQ 700
    PGITYIVVQK RHHTRLFCAD RTERVGRSGN IPAGTTVDTD ITHPYEFDFY 750
    LCSHAGIQGT SRPSHYHVLW DDNCFTADEL QLLTYQLCHT YVRCTRSVSI 800
    PAPAYYAHLV AFRARYHLVD KEHDSAEGSH VSGQSNGRDP QALAKAVQIH 850
    QDTLRTMYFA 860
    Length:860
    Mass (Da):97,360
    Last modified:September 27, 2005 - v2
    Checksum:i6FF1277995E5322E
    GO
    Isoform 2 (identifier: Q9H9G7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-234: Missing.

    Show »
    Length:626
    Mass (Da):71,211
    Checksum:i5475FD0337AAD9CE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251T → A in BAB14262. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 234234Missing in isoform 2. 1 PublicationVSP_041084Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022827 mRNA. Translation: BAB14262.1.
    AL139286, AL138787 Genomic DNA. Translation: CAI22802.1.
    AL138787, AL139286 Genomic DNA. Translation: CAI22268.1.
    AL138787 Genomic DNA. Translation: CAI22269.1.
    BC025769 mRNA. No translation available.
    CCDSiCCDS399.1. [Q9H9G7-1]
    CCDS400.1. [Q9H9G7-2]
    RefSeqiNP_079128.2. NM_024852.3. [Q9H9G7-1]
    NP_803171.1. NM_177422.2. [Q9H9G7-2]
    XP_005270632.1. XM_005270575.1. [Q9H9G7-1]
    XP_006710467.1. XM_006710404.1. [Q9H9G7-2]
    UniGeneiHs.657659.

    Genome annotation databases

    EnsembliENST00000246314; ENSP00000246314; ENSG00000126070. [Q9H9G7-2]
    ENST00000373191; ENSP00000362287; ENSG00000126070. [Q9H9G7-1]
    GeneIDi192669.
    KEGGihsa:192669.
    UCSCiuc001bzp.3. human. [Q9H9G7-1]

    Polymorphism databases

    DMDMi76803660.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022827 mRNA. Translation: BAB14262.1 .
    AL139286 , AL138787 Genomic DNA. Translation: CAI22802.1 .
    AL138787 , AL139286 Genomic DNA. Translation: CAI22268.1 .
    AL138787 Genomic DNA. Translation: CAI22269.1 .
    BC025769 mRNA. No translation available.
    CCDSi CCDS399.1. [Q9H9G7-1 ]
    CCDS400.1. [Q9H9G7-2 ]
    RefSeqi NP_079128.2. NM_024852.3. [Q9H9G7-1 ]
    NP_803171.1. NM_177422.2. [Q9H9G7-2 ]
    XP_005270632.1. XM_005270575.1. [Q9H9G7-1 ]
    XP_006710467.1. XM_006710404.1. [Q9H9G7-2 ]
    UniGenei Hs.657659.

    3D structure databases

    ProteinModelPortali Q9H9G7.
    SMRi Q9H9G7. Positions 12-860.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128177. 55 interactions.
    DIPi DIP-54486N.
    IntActi Q9H9G7. 49 interactions.
    STRINGi 9606.ENSP00000362287.

    PTM databases

    PhosphoSitei Q9H9G7.

    Polymorphism databases

    DMDMi 76803660.

    Proteomic databases

    MaxQBi Q9H9G7.
    PaxDbi Q9H9G7.
    PRIDEi Q9H9G7.

    Protocols and materials databases

    DNASUi 192669.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000246314 ; ENSP00000246314 ; ENSG00000126070 . [Q9H9G7-2 ]
    ENST00000373191 ; ENSP00000362287 ; ENSG00000126070 . [Q9H9G7-1 ]
    GeneIDi 192669.
    KEGGi hsa:192669.
    UCSCi uc001bzp.3. human. [Q9H9G7-1 ]

    Organism-specific databases

    CTDi 192669.
    GeneCardsi GC01P036399.
    HGNCi HGNC:18421. AGO3.
    HPAi HPA048342.
    MIMi 607355. gene.
    neXtProti NX_Q9H9G7.
    PharmGKBi PA38329.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279895.
    HOGENOMi HOG000116043.
    InParanoidi Q9H9G7.
    KOi K11593.
    OMAi GRSMPEP.
    OrthoDBi EOG7HHWRC.
    PhylomeDBi Q9H9G7.
    TreeFami TF101510.

    Enzyme and pathway databases

    Reactomei REACT_118560. Small interfering RNA (siRNA) biogenesis.
    REACT_118568. Pre-NOTCH Transcription and Translation.
    REACT_118699. Post-transcriptional silencing by small RNAs.
    REACT_12417. MicroRNA (miRNA) biogenesis.
    REACT_169325. Oncogene Induced Senescence.
    REACT_169436. Oxidative Stress Induced Senescence.
    REACT_172761. Ca2+ pathway.
    REACT_75829. PIP3 activates AKT signaling.

    Miscellaneous databases

    ChiTaRSi EIF2C3. human.
    GenomeRNAii 192669.
    NextBioi 89367.
    PROi Q9H9G7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H9G7.
    Bgeei Q9H9G7.
    CleanExi HS_EIF2C3.
    Genevestigatori Q9H9G7.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    HAMAPi MF_03032. AGO3.
    InterProi IPR028603. AGO3.
    IPR014811. DUF1785.
    IPR003100. PAZ_dom.
    IPR003165. Piwi.
    IPR012337. RNaseH-like_dom.
    [Graphical view ]
    Pfami PF08699. DUF1785. 1 hit.
    PF02170. PAZ. 1 hit.
    PF02171. Piwi. 1 hit.
    [Graphical view ]
    SMARTi SM00949. PAZ. 1 hit.
    SM00950. Piwi. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101690. SSF101690. 1 hit.
    SSF53098. SSF53098. 1 hit.
    PROSITEi PS50821. PAZ. 1 hit.
    PS50822. PIWI. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Leukocyte.
    4. "Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs."
      Meister G., Landthaler M., Patkaniowska A., Dorsett Y., Teng G., Tuschl T.
      Mol. Cell 15:185-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: ASSOCIATION WITH MIRNA.
    5. "Inhibition of translational initiation by Let-7 MicroRNA in human cells."
      Pillai R.S., Bhattacharyya S.N., Artus C.G., Zoller T., Cougot N., Basyuk E., Bertrand E., Filipowicz W.
      Science 309:1573-1576(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    6. "Importance of translation and nonnucleolytic ago proteins for on-target RNA interference."
      Wu L., Fan J., Belasco J.G.
      Curr. Biol. 18:1327-1332(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs."
      Weinmann L., Hoeck J., Ivacevic T., Ohrt T., Muetze J., Schwille P., Kremmer E., Benes V., Urlaub H., Meister G.
      Cell 136:496-507(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EIF4B; IMP8; PRMT5 AND TNRC6B.
    8. "HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."
      Phalora P.K., Sherer N.M., Wolinsky S.M., Swanson C.M., Malim M.H.
      J. Virol. 86:11712-11724(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH APOBEC3F; APOBEC3G AND APOBEC3H.
    9. "DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation."
      Hu Q., Tanasa B., Trabucchi M., Li W., Zhang J., Ohgi K.A., Rose D.W., Glass C.K., Rosenfeld M.G.
      Nat. Struct. Mol. Biol. 19:1168-1175(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH EDC4.
    10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAGO3_HUMAN
    AccessioniPrimary (citable) accession number: Q9H9G7
    Secondary accession number(s): B1ALI0, Q5TA55, Q9H1U6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2003
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Translation initiation factors
      List of translation initiation factor entries
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3