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Reviewed, UniProtKB/Swiss-Prot Q9H9F9 (ARP5_HUMAN)

Last modified November 24, 2009. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Actin-related protein 5
      Short name=hARP5
Alternative name(s):
    Sarcoma antigen NY-SAR-16
Gene names
Name: ACTR5
Synonyms: ARP5
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length607 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May be involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex By similarity.

Subunit structure

Component of the chromatin remodeling INO80 complex, at least composed of ACTL6A, ACTR5, ACTR8, RVBL1, RVBL2, INO80, INO80B, INO80C, INO80D and INO80E.

Sequence similarities

Belongs to the actin family. ARP5 subfamily.

Sequence caution

The sequence AAO65164.1 differs from that shown. Reason: Frameshift at positions 319, 343 and 347.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processregulation of transcription

Inferred from electronic annotation. Source: UniProtKB-KW

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 607607Actin-related protein 5
PRO_0000247842

Regions

Coiled coil288 – 32740 Potential
Coiled coil355 – 38430 Potential

Natural variations

Natural variant2981R → L: dbSNP rs17853829. Ref.3
VAR_027158
Natural variant4611I → L: dbSNP rs35805905.
VAR_048189
Natural variant4831I → V: dbSNP rs2245231. Ref.3
VAR_027159
Natural variant5801P → L: dbSNP rs3752289.
VAR_027160

Experimental info

Sequence conflict69 – 702RG → AR in AAO65164. Ref.4
Sequence conflict4811K → E in BAB14270. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9H9F9-1 [UniParc].

Last modified July 25, 2006. Version 2.
Checksum: DA3E50AE37BCC363

FASTA60768,297
        10         20         30         40         50         60 
MAANVFPFRD ARAAPDPVLE AGPVAHGPLP VPLVLDNGSF QVRAGWACPG QDPGPEPRLQ 

        70         80         90        100        110        120 
FRAVCARGRG GARGASGPQV GNALGSLEPL RWMLRSPFDR NVPVNLELQE LLLDYSFQHL 

       130        140        150        160        170        180 
GVSSQGCVDH PIVLTEAVCN PLYSRQMMSE LLFECYGIPK VAYGIDSLFS FYHNKPKNSM 

       190        200        210        220        230        240 
CSGLIISSGY QCTHVLPILE GRLDAKNCKR INLGGSQAAG YLQRLLQLKY PGHLAAITLS 

       250        260        270        280        290        300 
RMEEILHEHS YIAEDYVEEL HKWRCPDYYE NNVHKMQLPF SSKLLGSTLT SEEKQERRQQ 

       310        320        330        340        350        360 
QLRRLQELNA RRREEKLQLD QERLDRLLYV QELLEDGQMD QFHKALIELN MDSPEELQSY 

       370        380        390        400        410        420 
IQKLSIAVEQ AKQKILQAEV NLEVDVVDSK PETPDLEQLE PSLEDVESMN DFDPLFSEET 

       430        440        450        460        470        480 
PGVEKPVTTV QPVFNLAAYH QLFVGTERIR APEIIFQPSL IGEEQAGIAE TLQYILDRYP 

       490        500        510        520        530        540 
KDIQEMLVQN VFLTGGNTMY PGMKARMEKE LLEMRPFRSS FQVQLASNPV LDAWYGARDW 

       550        560        570        580        590        600 
ALNHLDDNEV WITRKEYEEK GGEYLKEHCA SNIYVPIRLP KQASRSSDAQ ASSKGSAAGG 


GGAGEQA 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed: 11780052] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-298 AND VAL-483.
Tissue: Brain, Cervix and Ovary.
[4]"Immunomic analysis of human sarcoma."
Lee S.-Y., Obata Y., Yoshida M., Stockert E., Williamson B., Jungbluth A.A., Chen Y.-T., Old L.J., Scanlan M.J.
Proc. Natl. Acad. Sci. U.S.A. 100:2651-2656(2003) [PubMed: 12601173] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 69-348.
[5]"A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex."
Jin J., Cai Y., Yao T., Gottschalk A.J., Florens L., Swanson S.K., Gutierrez J.L., Coleman M.K., Workman J.L., Mushegian A., Washburn M.P., Conaway R.C., Conaway J.W.
J. Biol. Chem. 280:41207-41212(2005) [PubMed: 16230350] [Abstract]
Cited for: MASS SPECTROMETRY, IDENTIFICATION IN THE INO80 COMPLEX.
+Additional computationally mapped references.

Cross-references

Sequence databases

AK022847 mRNA. Translation: BAB14270.1.
AL133519 Genomic DNA. Translation: CAD37358.1.
BC001324 mRNA. Translation: AAH01324.1.
BC006162 mRNA. Translation: AAH06162.1.
BC038402 mRNA. Translation: AAH38402.1.
AY211911 mRNA. Translation: AAO65164.1. Frameshift.
IPIIPI00292787.
RefSeqNP_079131.3.
UniGeneHs.371585

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ9H9F9.

Proteomic databases

PRIDEQ9H9F9.

Genome annotation databases

EnsemblENST00000243903; ENSP00000243903; ENSG00000101442; Homo sapiens. [Genome view]
GeneID79913.
KEGGhsa:79913.
UCSCuc002xjd.2. human.

Organism-specific databases

CTD79913.
GeneCardsGC20P036810.
HGNCHGNC:14671. ACTR5.
PharmGKBPA24490.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9H9F9.
HOVERGENQ9H9F9.
OMATTVQPVF
OrthoDBEOG9BZQMX

Gene expression databases

ArrayExpressQ9H9F9.
BgeeQ9H9F9.
CleanExHS_ACTR5.
GenevestigatorQ9H9F9.
GermOnlineENSG00000101442. Homo sapiens.

Family and domain databases

InterProIPR004000. Actin-like.
IPR004001. Actin_CS.
[Graphical view]
PANTHERPTHR11937. Actin_like. 1 hit.
PfamPF00022. Actin. 1 hit.
[Graphical view]
SMARTSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEPS00432. ACTINS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio69786.

Entry information

Entry nameARP5_HUMAN
AccessionPrimary (citable) accession number: Q9H9F9
Secondary accession number(s): Q86WF7 expand/collapse secondary AC list , Q8IUY5, Q8N724, Q9BRN0, Q9BVB7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 24, 2009
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents