Q9H9F9 (ARP5_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 80.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Actin-related protein 5 Short name=hARP5 Alternative name(s): Sarcoma antigen NY-SAR-16 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 607 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. Ref.9 Ref.10 |
| Subunit structure | Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Interacts with DDB1. Interacts with ACTR8; the interaction is observed in asynchronous (interphase) cells but not in metaphase-arrested cells indicative for a possible dissociation of the INO80 complex in mitotic cells. Ref.7 Ref.10 |
| Subcellular location | Nucleus. Cytoplasm. Note: Predominantly nuclear but undergoes nucleo-cytoplasmic shuttling. Localized to interphase nuclei, but not nucleoli; excluded from chromosomes as mitosis progresses. Ref.6 Ref.7 Ref.9 |
| Sequence similarities | Belongs to the actin family. ARP5 subfamily. |
| Sequence caution | The sequence AAO65164.1 differs from that shown. Reason: Frameshift at positions 319, 343 and 347. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| ACTR8 | Q9H981 | 2 | EBI-769418,EBI-769597 | |
| DDB1 | Q16531 | 3 | EBI-769418,EBI-350322 | |
| INO80 | Q9ULG1 | 6 | EBI-769418,EBI-769345 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 607 | 607 | Actin-related protein 5 | PRO_0000247842 | |||||
Regions | |||||||||
| Coiled coil | 288 – 327 | 40 | Potential | ||||||
| Coiled coil | 355 – 384 | 30 | Potential | ||||||
Natural variations | |||||||||
| Natural variant | 298 | 1 | R → L. Ref.3 Corresponds to variant rs17853829 [ dbSNP | Ensembl ]. | VAR_027158 | |||||
| Natural variant | 461 | 1 | I → L. Corresponds to variant rs35805905 [ dbSNP | Ensembl ]. | VAR_048189 | |||||
| Natural variant | 483 | 1 | I → V. Ref.3 Corresponds to variant rs2245231 [ dbSNP | Ensembl ]. | VAR_027159 | |||||
| Natural variant | 580 | 1 | P → L. Corresponds to variant rs3752289 [ dbSNP | Ensembl ]. | VAR_027160 | |||||
Experimental info | |||||||||
| Sequence conflict | 69 – 70 | 2 | RG → AR in AAO65164. Ref.4 | ||||||
| Sequence conflict | 481 | 1 | K → E in BAB14270. Ref.1 | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [2] | "The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. Rogers J.Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-298 AND VAL-483. Tissue: Brain, Cervix and Ovary. |
| [4] | "Immunomic analysis of human sarcoma." Lee S.-Y., Obata Y., Yoshida M., Stockert E., Williamson B., Jungbluth A.A., Chen Y.-T., Old L.J., Scanlan M.J. Proc. Natl. Acad. Sci. U.S.A. 100:2651-2656(2003) [PubMed: 12601173] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 69-348. |
| [5] | "A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex." Jin J., Cai Y., Yao T., Gottschalk A.J., Florens L., Swanson S.K., Gutierrez J.L., Coleman M.K., Workman J.L., Mushegian A., Washburn M.P., Conaway R.C., Conaway J.W. J. Biol. Chem. 280:41207-41212(2005) [PubMed: 16230350] [Abstract] Cited for: MASS SPECTROMETRY, IDENTIFICATION IN THE INO80 COMPLEX. |
| [6] | "A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair." Wu S., Shi Y., Mulligan P., Gay F., Landry J., Liu H., Lu J., Qi H.H., Wang W., Nickoloff J.A., Wu C., Shi Y. Nat. Struct. Mol. Biol. 14:1165-1172(2007) [PubMed: 18026119] [Abstract] Cited for: SUBCELLULAR LOCATION, ASSOCIATION WITH THE INO80 COMPLEX. |
| [7] | "The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment." Aoyama N., Oka A., Kitayama K., Kurumizaka H., Harata M. Exp. Cell Res. 314:859-868(2008) [PubMed: 18163988] [Abstract] Cited for: INTERACTION WITH ACTR8, SUBCELLULAR LOCATION. |
| [8] | "Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex." Yao T., Song L., Jin J., Cai Y., Takahashi H., Swanson S.K., Washburn M.P., Florens L., Conaway R.C., Cohen R.E., Conaway J.W. Mol. Cell 31:909-917(2008) [PubMed: 18922472] [Abstract] Cited for: IDENTIFICATION IN THE INO80 COMPLEX, MASS SPECTROMETRY. |
| [9] | "The human actin-related protein hArp5: nucleo-cytoplasmic shuttling and involvement in DNA repair." Kitayama K., Kamo M., Oma Y., Matsuda R., Uchida T., Ikura T., Tashiro S., Ohyama T., Winsor B., Harata M. Exp. Cell Res. 315:206-217(2009) [PubMed: 19014934] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION. |
| [10] | "INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway." Jiang Y., Wang X., Bao S., Guo R., Johnson D.G., Shen X., Li L. Proc. Natl. Acad. Sci. U.S.A. 107:17274-17279(2010) [PubMed: 20855601] [Abstract] Cited for: FUNCTION IN DNA REPAIR, INTERACTION WITH DDB1, FUNCTION OF THE INO80 COMPLEX. |
| [11] | "Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling." Chen L., Cai Y., Jin J., Florens L., Swanson S.K., Washburn M.P., Conaway J.W., Conaway R.C. J. Biol. Chem. 286:11283-11289(2011) [PubMed: 21303910] [Abstract] Cited for: IDENTIFICATION IN THE INO80 COMPLEX. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AK022847 mRNA. Translation: BAB14270.1. AL133519 Genomic DNA. Translation: CAD37358.1. BC001324 mRNA. Translation: AAH01324.1. BC006162 mRNA. Translation: AAH06162.1. BC038402 mRNA. Translation: AAH38402.1. AY211911 mRNA. Translation: AAO65164.1. Frameshift. |
| IPI | IPI00292787. |
| RefSeq | NP_079131.3. NM_024855.3. |
| UniGene | Hs.371585. |
3D structure databases | |
| ProteinModelPortal | Q9H9F9. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9H9F9. 14 interactions. |
| STRING | Q9H9F9. |
Polymorphism databases | |
| DMDM | 110832751. |
Proteomic databases | |
| PRIDE | Q9H9F9. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000243903; ENSP00000243903; ENSG00000101442. |
| GeneID | 79913. |
| KEGG | hsa:79913. |
| UCSC | uc002xjd.2. human. |
Organism-specific databases | |
| CTD | 79913. |
| GeneCards | GC20P037377. |
| H-InvDB | HIX0015810. |
| HGNC | HGNC:14671. ACTR5. |
| neXtProt | NX_Q9H9F9. |
| PharmGKB | PA24490. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG16466. |
| GeneTree | ENSGT00550000075062. |
| HOGENOM | HBG315355. |
| HOVERGEN | HBG059801. |
| InParanoid | Q9H9F9. |
| OMA | TTVQPVF. |
| OrthoDB | EOG4DZ1V0. |
| PhylomeDB | Q9H9F9. |
Gene expression databases | |
| ArrayExpress | Q9H9F9. |
| Bgee | Q9H9F9. |
| CleanEx | HS_ACTR5. |
| Genevestigator | Q9H9F9. |
| GermOnline | ENSG00000101442. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR004000. Actin-like. IPR004001. Actin_CS. [Graphical view] |
| KO | K11672. |
| PANTHER | PTHR11937. Actin_like. 1 hit. |
| Pfam | PF00022. Actin. 1 hit. [Graphical view] |
| SMART | SM00268. ACTIN. 1 hit. [Graphical view] |
| PROSITE | PS00432. ACTINS_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 69786. |
Entry information
| Entry name | ARP5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9H9F9 Secondary accession number(s): Q86WF7 Q9BVB7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 20 Human chromosome 20: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with