Q9H9E3 (COG4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Conserved oligomeric Golgi complex subunit 4
Short name=COG complex subunit 4

Alternative name(s):
Component of oligomeric Golgi complex 4

Gene names

Name:

COG4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	785 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. Ref.8
Subunit structure	Monomer. Component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Mediates interaction of SCFD1 with the COG complex. Interacts with STX5. Ref.8 Ref.10
Subcellular location	Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side Probable Ref.6.
Involvement in disease	Congenital disorder of glycosylation 2J (CDG2J) [MIM:613489]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10 Ref.11
Sequence similarities	Belongs to the COG4 family.
Sequence caution	The sequence BAB15483.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Congenital disorder of glycosylation Disease mutation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Golgi organization Inferred from mutant phenotype Ref.8. Source: UniProtKB Golgi vesicle prefusion complex stabilization Inferred from mutant phenotype Ref.8. Source: UniProtKB protein transport Inferred from electronic annotation. Source: UniProtKB-KW retrograde vesicle-mediated transport, Golgi to ER Inferred from mutant phenotype Ref.8. Source: UniProtKB
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell Golgi transport complex Inferred from direct assay PubMed 15047703. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
COG1	Q8WTW3	2	EBI-368382,EBI-368371
COG2	Q14746	2	EBI-368382,EBI-389449
COG5	Q9UP83	2	EBI-368382,EBI-389502
COG7	P83436	2	EBI-368382,EBI-389534

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H9E3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H9E3-2)

Also known as: Cog4S;

The sequence of this isoform differs from the canonical sequence as follows:
     331-337: FRHVQNN → NFVFSFF
     338-785: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 3 (identifier: Q9H9E3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 785

785

Conserved oligomeric Golgi complex subunit 4

PRO_0000213504

Regions

Region

1 – 84

84

Interacts with SCFD1

Region

85 – 153

69

Interacts with STX5

Region

618 – 740

123

D domain

Region

741 – 785

45

E domain; essential for proper cell surface glycosylation

Natural variations

Alternative sequence

1 – 73

73

Missing in isoform 3.

VSP_037551

Alternative sequence

331 – 337

7

FRHVQNN → NFVFSFF in isoform 2.

VSP_001127

Alternative sequence

338 – 785

448

Missing in isoform 2.

VSP_001128

Natural variant

158

1

T → I. Ref.1 Ref.2 Ref.4
Corresponds to variant rs3931036 [ dbSNP | Ensembl ].

VAR_058009

Natural variant

729

1

R → W in CDG2J; severe defects in glycosylation. Ref.10 Ref.11

VAR_063767

Experimental info

Mutagenesis

729

1

R → A: Severe defects in glycosylation. Ref.10

Mutagenesis

764

1

E → A: Severe defects in glycosylation. Ref.10

Sequence conflict

177

1

E → G in BAB14286. Ref.2

Sequence conflict

234

1

K → R in BAB14286. Ref.2

Sequence conflict

285

1

T → A in BAB14286. Ref.2

Sequence conflict

486

1

E → G in BAB15483. Ref.2

Sequence conflict

588

1

S → G in BAB14286. Ref.2

Sequence conflict

588

1

S → G in BAG59950. Ref.2

Sequence conflict

644

1

A → S in AAH06306. Ref.4

Secondary structure

1

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785

Helix Strand Turn

Details...

Helix

537 – 572

36

Turn

573 – 575

3

Helix

580 – 615

36

Helix

617 – 625

9

Helix

626 – 629

4

Helix

636 – 644

9

Helix

649 – 666

18

Helix

669 – 691

23

Helix

698 – 716

19

Helix

723 – 726

4

Helix

728 – 737

10

Helix

742 – 747

6

Helix

750 – 753

4

Helix

762 – 769

8

Helix

777 – 782

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 2, 2010. Version 3. Checksum: 93E8597991934AD2	FASTA	785	89,083
	10 20 30 40 50 60 MADLDSPPKL SGVQQPSEGV GGGRCSEISA ELIRSLTELQ ELEAVYERLC GEEKVVEREL 70 80 90 100 110 120 DALLEQQNTI ESKMVTLHRM GPNLQLIEGD AKQLAGMITF TCNLAENVSS KVRQLDLAKN 130 140 150 160 170 180 RLYQAIQRAD DILDLKFCMD GVQTALRSED YEQAAAHTHR YLCLDKSVIE LSRQGKEGSM 190 200 210 220 230 240 IDANLKLLQE AEQRLKAIVA EKFAIATKEG DLPQVERFFK IFPLLGLHEE GLRKFSEYLC 250 260 270 280 290 300 KQVASKAEEN LLMVLGTDMS DRRAAVIFAD TLTLLFEGIA RIVETHQPIV ETYYGPGRLY 310 320 330 340 350 360 TLIKYLQVEC DRQVEKVVDK FIKQRDYHQQ FRHVQNNLMR NSTTEKIEPR ELDPILTEVT 370 380 390 400 410 420 LMNARSELYL RFLKKRISSD FEVGDSMASE EVKQEHQKCL DKLLNNCLLS CTMQELIGLY 430 440 450 460 470 480 VTMEEYFMRE TVNKAVALDT YEKGQLTSSM VDDVFYIVKK CIGRALSSSS IDCLCAMINL 490 500 510 520 530 540 ATTELESDFR DVLCNKLRMG FPATTFQDIQ RGVTSAVNIM HSSLQQGKFD TKGIESTDEA 550 560 570 580 590 600 KMSFLVTLNN VEVCSENIST LKKTLESDCT KLFSQGIGGE QAQAKFDSCL SDLAAVSNKF 610 620 630 640 650 660 RDLLQEGLTE LNSTAIKPQV QPWINSFFSV SHNIEEEEFN DYEANDPWVQ QFILNLEQQM 670 680 690 700 710 720 AEFKASLSPV IYDSLTGLMT SLVAVELEKV VLKSTFNRLG GLQFDKELRS LIAYLTTVTT 730 740 750 760 770 780 WTIRDKFARL SQMATILNLE RVTEILDYWG PNSGPLTWRL TPAEVRQVLA LRIDFRSEDI KRLRL
	Isoform 2 (Cog4S) [UniParc]. Checksum: 3255EF1D38584CC9	FASTA	337	38,245
	10 20 30 40 50 60 MADLDSPPKL SGVQQPSEGV GGGRCSEISA ELIRSLTELQ ELEAVYERLC GEEKVVEREL 70 80 90 100 110 120 DALLEQQNTI ESKMVTLHRM GPNLQLIEGD AKQLAGMITF TCNLAENVSS KVRQLDLAKN 130 140 150 160 170 180 RLYQAIQRAD DILDLKFCMD GVQTALRSED YEQAAAHTHR YLCLDKSVIE LSRQGKEGSM 190 200 210 220 230 240 IDANLKLLQE AEQRLKAIVA EKFAIATKEG DLPQVERFFK IFPLLGLHEE GLRKFSEYLC 250 260 270 280 290 300 KQVASKAEEN LLMVLGTDMS DRRAAVIFAD TLTLLFEGIA RIVETHQPIV ETYYGPGRLY 310 320 330 TLIKYLQVEC DRQVEKVVDK FIKQRDYHQQ NFVFSFF
	Isoform 3 [UniParc]. Checksum: E6426B98B87E5226	FASTA	712	81,098
	10 20 30 40 50 60 MVTLHRMGPN LQLIEGDAKQ LAGMITFTCN LAENVSSKVR QLDLAKNRLY QAIQRADDIL 70 80 90 100 110 120 DLKFCMDGVQ TALRSEDYEQ AAAHTHRYLC LDKSVIELSR QGKEGSMIDA NLKLLQEAEQ 130 140 150 160 170 180 RLKAIVAEKF AIATKEGDLP QVERFFKIFP LLGLHEEGLR KFSEYLCKQV ASKAEENLLM 190 200 210 220 230 240 VLGTDMSDRR AAVIFADTLT LLFEGIARIV ETHQPIVETY YGPGRLYTLI KYLQVECDRQ 250 260 270 280 290 300 VEKVVDKFIK QRDYHQQFRH VQNNLMRNST TEKIEPRELD PILTEVTLMN ARSELYLRFL 310 320 330 340 350 360 KKRISSDFEV GDSMASEEVK QEHQKCLDKL LNNCLLSCTM QELIGLYVTM EEYFMRETVN 370 380 390 400 410 420 KAVALDTYEK GQLTSSMVDD VFYIVKKCIG RALSSSSIDC LCAMINLATT ELESDFRDVL 430 440 450 460 470 480 CNKLRMGFPA TTFQDIQRGV TSAVNIMHSS LQQGKFDTKG IESTDEAKMS FLVTLNNVEV 490 500 510 520 530 540 CSENISTLKK TLESDCTKLF SQGIGGEQAQ AKFDSCLSDL AAVSNKFRDL LQEGLTELNS 550 560 570 580 590 600 TAIKPQVQPW INSFFSVSHN IEEEEFNDYE ANDPWVQQFI LNLEQQMAEF KASLSPVIYD 610 620 630 640 650 660 SLTGLMTSLV AVELEKVVLK STFNRLGGLQ FDKELRSLIA YLTTVTTWTI RDKFARLSQM 670 680 690 700 710 ATILNLERVT EILDYWGPNS GPLTWRLTPA EVRQVLALRI DFRSEDIKRL RL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cog4S, a splicing variant of Cog4." Ariga H. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ILE-158. Tissue: T-cell.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ILE-158. Tissue: Brain, Ileal mucosa and Testis.
[3]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-158. Tissue: Muscle, Placenta, Skin and Testis.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 229-785 (ISOFORM 1). Tissue: Uterus.
[6]	"The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic." Whyte J.R., Munro S. Dev. Cell 1:527-537(2001) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[7]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[8]	"Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing." Laufman O., Kedan A., Hong W., Lev S. EMBO J. 28:2006-2017(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH SCFD1 AND STX5.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]	"Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene." Richardson B.C., Smith R.D., Ungar D., Nakamura A., Jeffrey P.D., Lupashin V.V., Hughson F.M. Proc. Natl. Acad. Sci. U.S.A. 106:13329-13334(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 525-785, SUBUNIT, IDENTIFICATION OF DOMAINS D AND E, CHARACTERIZATION OF VARIANT CDG2J TRP-729, MUTAGENESIS OF ARG-729 AND GLU-764.
[11]	"Golgi function and dysfunction in the first COG4-deficient CDG type II patient." Reynders E., Foulquier F., Leao Teles E., Quelhas D., Morelle W., Rabouille C., Annaert W., Matthijs G. Hum. Mol. Genet. 18:3244-3256(2009) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT CDG2J TRP-729.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB088369 mRNA. Translation: BAC05682.1.
AK022874 mRNA. Translation: BAB14286.1.
AK026435 mRNA. Translation: BAB15483.1. Different initiation.
AK297557 mRNA. Translation: BAG59950.1.
AC106804 Genomic DNA. No translation available.
BC000796 mRNA. Translation: AAH00796.1.
BC006306 mRNA. Translation: AAH06306.2.
BC013347 mRNA. Translation: AAH13347.2.
BC072438 mRNA. Translation: AAH72438.1.
AL050101 mRNA. Translation: CAB43272.1.

IPI

IPI00149849.
IPI00220800.
IPI01012765.

RefSeq

NP_001182068.1. NM_001195139.1.
NP_056201.2. NM_015386.2.

UniGene

Hs.208680.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3HR0	X-ray	1.90	A/B	525-785	[»]

ProteinModelPortal

Q9H9E3.

SMR

Q9H9E3. Positions 536-785.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-32635N.

IntAct

Q9H9E3. 8 interactions.

STRING

9606.ENSP00000315775.

PTM databases

PhosphoSite

Q9H9E3.

Polymorphism databases

DMDM

311033464.

Proteomic databases

PaxDb

Q9H9E3.

PRIDE

Q9H9E3.

Protocols and materials databases

DNASU

25839.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000393612; ENSP00000377236; ENSG00000103051.
ENST00000482252; ENSP00000432802; ENSG00000103051.

GeneID

25839.

KEGG

hsa:25839.

UCSC

uc002ezc.3. human.

Organism-specific databases

CTD

25839.

GeneCards

GC16M070514.

H-InvDB

HIX0013201.

HGNC

HGNC:18620. COG4.

HPA

HPA040924.
HPA042539.

MIM

606976. gene.
613489. phenotype.

neXtProt

NX_Q9H9E3.

Orphanet

263501. CDG syndrome type IIj.

PharmGKB

PA38603.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG321175.

HOVERGEN

HBG031403.

InParanoid

Q9H9E3.

OrthoDB

EOG4X3H0S.

PhylomeDB

Q9H9E3.

Gene expression databases

ArrayExpress

Q9H9E3.

Bgee

Q9H9E3.

CleanEx

HS_COG4.

Genevestigator

Q9H9E3.

GermOnline

ENSG00000103051. Homo sapiens.

Family and domain databases

InterPro

IPR013167. COG_su4.
[Graphical view]

Pfam

PF08318. COG4. 1 hit.
[Graphical view]

SMART

SM00762. Cog4. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9H9E3.

GenomeRNAi

25839.

NextBio

47151.

SOURCE

Search...

Entry information

Entry name

COG4_HUMAN

Accession

Primary (citable) accession number: Q9H9E3
Secondary accession number(s): B4DMN8 , C9JS23, Q96D40, Q9BRF0, Q9BVZ2, Q9H5Y4, Q9Y3W3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	November 2, 2010
Last modified:	May 1, 2013
This is version 108 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.