Reviewed, UniProtKB/Swiss-Prot Q9H9E1 (ANRA2_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat family A protein 2
Alternative name(s):
    RFXANK-like 2

Gene names

Name:	ANKRA2
Synonyms:	ANKRA

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery.
Subunit structure	Interacts directly and specifically with the cytoplasmic tail of LRP2/megalin. Interacts with AHRR By similarity.
Subcellular location	Cytoplasm › cytoskeleton By similarity. Membrane; Peripheral membrane protein By similarity.
Sequence similarities	Contains 3 ANK repeats.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Membrane
Domain	ANK repeat Repeat
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Ref.1 Inferred from direct assay. Source: UniProtKB extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	low-density lipoprotein binding Ref.1 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Ankyrin repeat family A protein 2		PRO_0000066895
Regions
	Repeat	181 – 213	33	ANK 1
	Repeat	214 – 246	33	ANK 2
	Repeat	247 – 279	33	ANK 3

Sequences

	Sequence		Length	Mass (Da)
	Q9H9E1-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 31C653B10B4ED6E1	FASTA	313	34,272
	10 20 30 40 50 60 MDTSTNLDIG AQLIVEECPS TYSLTGMPDI KIEHPLDPNS EEGSAQGVAM GMKFILPNRF 70 80 90 100 110 120 DMNVCSRFVK SLNEEDSKNI QDQVNSDLEV ASVLFKAECN IHTSPSPGIQ VRHVYTPSTT 130 140 150 160 170 180 KHFSPIKQST TLTNKHRGNE VSTTPLLANS LSVHQLAAQG EMLYLATRIE QENVINHTDE 190 200 210 220 230 240 EGFTPLMWAA AHGQIAVVEF LLQNGADPQL LGKGRESALS LACSKGYTDI VKMLLDCGVD 250 260 270 280 290 300 VNEYDWNGGT PLLYAVHGNH VKCVKMLLES GADPTIETDS GYNSMDLAVA LGYRSVQQVI 310 ESHLLKLLQN IKE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of ANKRA, a novel ankyrin repeat protein that interacts with the cytoplasmic domain of megalin." Rader K., Orlando R.A., Lou X., Farquhar M.G. J. Am. Soc. Nephrol. 11:2167-2178(2000) [PubMed: 11095640] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	Mao Y., Xie Y., Zhou Z., Zhao W., Zhao S., Wang W., Huang Y., Wang S., Tang R., Chen X., Wu C. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF314032 mRNA. Translation: AAK01621.1. AK022876 mRNA. Translation: BAB14288.1. AF251051 mRNA. Translation: AAK34941.1. BC012917 mRNA. Translation: AAH12917.1.
IPI	IPI00011902.
RefSeq	NP_075526.1.
UniGene	Hs.239154
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9H9E1.
Genome annotation databases
Ensembl	ENST00000296785; ENSP00000296785; ENSG00000164331; Homo sapiens. [Genome view]
GeneID	57763.
KEGG	hsa:57763.
UCSC	uc003kcu.1. human.
Organism-specific databases
CTD	57763.
GeneCards	GC05M072883.
H-InvDB	HIX0004945.
HGNC	HGNC:13208. ANKRA2.
MIM	605787. gene.
PharmGKB	PA24803.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9H9E1.
HOVERGEN	Q9H9E1.
OMA	DIKIEHQ
OrthoDB	EOG9NW24J
Enzyme and pathway databases
Pathway_Interaction_DB	hdac_classii_pathway. Signaling events mediated by HDAC Class II.
Gene expression databases
ArrayExpress	Q9H9E1.
Bgee	Q9H9E1.
CleanEx	HS_ANKRA2.
Genevestigator	Q9H9E1.
GermOnline	ENSG00000164331. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 3 hits. [Graphical view]
SMART	SM00248. ANK. 3 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 3 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	64713.
SOURCE	Search...

Entry information

Entry name

ANRA2_HUMAN

Accession

Primary (citable) accession number: Q9H9E1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
Last sequence update:	March 1, 2001
Last modified:	November 24, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.