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Protein

Ankyrin repeat family A protein 2

Gene

ANKRA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery.

GO - Molecular functioni

  • low-density lipoprotein particle binding Source: UniProtKB
  • transcription cofactor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat family A protein 2
Alternative name(s):
RFXANK-like protein 2
Gene namesi
Name:ANKRA2
Synonyms:ANKRA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:13208. ANKRA2.

Subcellular locationi

GO - Cellular componenti

  • cytoskeleton Source: UniProtKB-SubCell
  • cytosol Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24803.

Polymorphism and mutation databases

BioMutaiANKRA2.
DMDMi27734215.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Ankyrin repeat family A protein 2PRO_0000066895Add
BLAST

Proteomic databases

EPDiQ9H9E1.
MaxQBiQ9H9E1.
PaxDbiQ9H9E1.
PeptideAtlasiQ9H9E1.
PRIDEiQ9H9E1.

PTM databases

iPTMnetiQ9H9E1.
PhosphoSiteiQ9H9E1.

Expressioni

Gene expression databases

BgeeiENSG00000164331.
CleanExiHS_ANKRA2.
ExpressionAtlasiQ9H9E1. baseline and differential.
GenevisibleiQ9H9E1. HS.

Organism-specific databases

HPAiHPA065263.

Interactioni

Subunit structurei

Interacts with the cytoplasmic tail of LRP2/megalin, HDAC4, HDAC5, and HDAC9, all these interactions occur via the recognition of a PxLPxI/L motif. Interacts with AHRR (By similarity). Interacts with NEK6.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HDAC4P565243EBI-10215533,EBI-308629

Protein-protein interaction databases

BioGridi121758. 31 interactions.
IntActiQ9H9E1. 1 interaction.
STRINGi9606.ENSP00000296785.

Structurei

Secondary structure

1
313
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi144 – 1474Combined sources
Helixi148 – 1503Combined sources
Helixi153 – 1586Combined sources
Helixi162 – 17110Combined sources
Helixi185 – 1917Combined sources
Helixi195 – 2039Combined sources
Helixi218 – 2258Combined sources
Helixi228 – 23710Combined sources
Helixi251 – 2577Combined sources
Helixi261 – 2699Combined sources
Helixi284 – 2918Combined sources
Helixi294 – 30714Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3SO8X-ray1.90A149-310[»]
3V2OX-ray1.89A148-313[»]
3V2XX-ray1.85A148-313[»]
3V31X-ray1.57A148-313[»]
4LG6X-ray1.80A142-313[»]
4QQIX-ray2.03A142-313[»]
ProteinModelPortaliQ9H9E1.
SMRiQ9H9E1. Positions 106-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati148 – 18033ANK 1Add
BLAST
Repeati181 – 21333ANK 2Add
BLAST
Repeati214 – 24633ANK 3Add
BLAST
Repeati247 – 27933ANK 4Add
BLAST
Repeati280 – 31334ANK 5Add
BLAST

Domaini

The three central ANK repeats mediate binding to the PxLPxI/L motif of interactors.1 Publication

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0502. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00820000127028.
HOGENOMiHOG000033969.
HOVERGENiHBG017718.
InParanoidiQ9H9E1.
OMAiNAMDMAV.
OrthoDBiEOG091G0BD5.
PhylomeDBiQ9H9E1.
TreeFamiTF333112.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H9E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSTNLDIG AQLIVEECPS TYSLTGMPDI KIEHPLDPNS EEGSAQGVAM
60 70 80 90 100
GMKFILPNRF DMNVCSRFVK SLNEEDSKNI QDQVNSDLEV ASVLFKAECN
110 120 130 140 150
IHTSPSPGIQ VRHVYTPSTT KHFSPIKQST TLTNKHRGNE VSTTPLLANS
160 170 180 190 200
LSVHQLAAQG EMLYLATRIE QENVINHTDE EGFTPLMWAA AHGQIAVVEF
210 220 230 240 250
LLQNGADPQL LGKGRESALS LACSKGYTDI VKMLLDCGVD VNEYDWNGGT
260 270 280 290 300
PLLYAVHGNH VKCVKMLLES GADPTIETDS GYNSMDLAVA LGYRSVQQVI
310
ESHLLKLLQN IKE
Length:313
Mass (Da):34,272
Last modified:March 1, 2001 - v1
Checksum:i31C653B10B4ED6E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314032 mRNA. Translation: AAK01621.1.
AK022876 mRNA. Translation: BAB14288.1.
AF251051 mRNA. Translation: AAK34941.1.
BC012917 mRNA. Translation: AAH12917.1.
CCDSiCCDS4020.1.
RefSeqiNP_075526.1. NM_023039.4.
UniGeneiHs.239154.

Genome annotation databases

EnsembliENST00000296785; ENSP00000296785; ENSG00000164331.
GeneIDi57763.
KEGGihsa:57763.
UCSCiuc003kcu.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314032 mRNA. Translation: AAK01621.1.
AK022876 mRNA. Translation: BAB14288.1.
AF251051 mRNA. Translation: AAK34941.1.
BC012917 mRNA. Translation: AAH12917.1.
CCDSiCCDS4020.1.
RefSeqiNP_075526.1. NM_023039.4.
UniGeneiHs.239154.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3SO8X-ray1.90A149-310[»]
3V2OX-ray1.89A148-313[»]
3V2XX-ray1.85A148-313[»]
3V31X-ray1.57A148-313[»]
4LG6X-ray1.80A142-313[»]
4QQIX-ray2.03A142-313[»]
ProteinModelPortaliQ9H9E1.
SMRiQ9H9E1. Positions 106-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121758. 31 interactions.
IntActiQ9H9E1. 1 interaction.
STRINGi9606.ENSP00000296785.

PTM databases

iPTMnetiQ9H9E1.
PhosphoSiteiQ9H9E1.

Polymorphism and mutation databases

BioMutaiANKRA2.
DMDMi27734215.

Proteomic databases

EPDiQ9H9E1.
MaxQBiQ9H9E1.
PaxDbiQ9H9E1.
PeptideAtlasiQ9H9E1.
PRIDEiQ9H9E1.

Protocols and materials databases

DNASUi57763.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296785; ENSP00000296785; ENSG00000164331.
GeneIDi57763.
KEGGihsa:57763.
UCSCiuc003kcu.3. human.

Organism-specific databases

CTDi57763.
GeneCardsiANKRA2.
HGNCiHGNC:13208. ANKRA2.
HPAiHPA065263.
MIMi605787. gene.
neXtProtiNX_Q9H9E1.
PharmGKBiPA24803.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0502. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00820000127028.
HOGENOMiHOG000033969.
HOVERGENiHBG017718.
InParanoidiQ9H9E1.
OMAiNAMDMAV.
OrthoDBiEOG091G0BD5.
PhylomeDBiQ9H9E1.
TreeFamiTF333112.

Miscellaneous databases

GenomeRNAii57763.
PROiQ9H9E1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164331.
CleanExiHS_ANKRA2.
ExpressionAtlasiQ9H9E1. baseline and differential.
GenevisibleiQ9H9E1. HS.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANRA2_HUMAN
AccessioniPrimary (citable) accession number: Q9H9E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.