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Protein

Ankyrin repeat family A protein 2

Gene

ANKRA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin (By similarity).By similarity1 Publication

GO - Molecular functioni

  • histone deacetylase binding Source: UniProtKB
  • low-density lipoprotein particle receptor binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • transcription cofactor activity Source: GO_Central
  • ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat family A protein 2
Alternative name(s):
RFXANK-like protein 2
Gene namesi
Name:ANKRA2
Synonyms:ANKRA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164331.9.
HGNCiHGNC:13208. ANKRA2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31K → R: No effect on interaction with CCDC8. 1 Publication1
Mutagenesisi188W → A: Loss of interaction with CCDC8. Decreased affinity for HDAC4. 2 Publications1
Mutagenesisi254Y → A: Decreased affinity for HDAC4. 1 Publication1

Organism-specific databases

DisGeNETi57763.
OpenTargetsiENSG00000164331.
PharmGKBiPA24803.

Polymorphism and mutation databases

BioMutaiANKRA2.
DMDMi27734215.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000668951 – 313Ankyrin repeat family A protein 2Add BLAST313

Proteomic databases

EPDiQ9H9E1.
MaxQBiQ9H9E1.
PaxDbiQ9H9E1.
PeptideAtlasiQ9H9E1.
PRIDEiQ9H9E1.

PTM databases

iPTMnetiQ9H9E1.
PhosphoSitePlusiQ9H9E1.

Expressioni

Gene expression databases

BgeeiENSG00000164331.
CleanExiHS_ANKRA2.
ExpressionAtlasiQ9H9E1. baseline and differential.
GenevisibleiQ9H9E1. HS.

Organism-specific databases

HPAiHPA065263.

Interactioni

Subunit structurei

Interacts (via ANK repeats) with CCDC8 (via PxLPxI/L motif); mediates the interaction with the 3M complex which is composed of CCDC8, CUL7 and OBSL1 (PubMed:25752541). Interacts (via ANK repeats) with HDAC4 (via PxLPxI/L motif) (PubMed:22649097). Interacts (via ANK repeats) with HDAC5 (via PxLPxI/L motif) (PubMed:22649097). Interacts (via ANK repeats) with LRP2/megalin (via PxLPxI/L motif) (PubMed:22649097). Interacts (via ANK repeats) with RFX7 (via PxLPxI/L motif) (PubMed:25752541). Interacts with AHRR (By similarity). Interacts with NEK6 (PubMed:20873783).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HDAC4P565243EBI-10215533,EBI-308629

GO - Molecular functioni

  • histone deacetylase binding Source: UniProtKB
  • low-density lipoprotein particle receptor binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121758. 31 interactors.
CORUMiQ9H9E1.
ELMiQ9H9E1.
IntActiQ9H9E1. 4 interactors.
STRINGi9606.ENSP00000296785.

Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi144 – 147Combined sources4
Helixi148 – 150Combined sources3
Helixi153 – 158Combined sources6
Helixi162 – 171Combined sources10
Helixi185 – 191Combined sources7
Helixi195 – 203Combined sources9
Helixi218 – 225Combined sources8
Helixi228 – 237Combined sources10
Helixi251 – 257Combined sources7
Helixi261 – 269Combined sources9
Helixi284 – 291Combined sources8
Helixi294 – 307Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SO8X-ray1.90A149-310[»]
3V2OX-ray1.89A148-313[»]
3V2XX-ray1.85A148-313[»]
3V31X-ray1.57A148-313[»]
4LG6X-ray1.80A142-313[»]
4QQIX-ray2.03A142-313[»]
ProteinModelPortaliQ9H9E1.
SMRiQ9H9E1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati148 – 180ANK 1Add BLAST33
Repeati181 – 213ANK 2Add BLAST33
Repeati214 – 246ANK 3Add BLAST33
Repeati247 – 279ANK 4Add BLAST33
Repeati280 – 313ANK 5Add BLAST34

Domaini

The ankyrin repeats, mainly ANK 2, ANK 3 and ANK 4, mediate interaction with a wide array of PxLPxI/L motif-containing proteins including HDAC4 and LRP2. The PxLPxI/L motif of interactors can contain a Ser or a Thr residue in position 2, which phosphorylation prevents the interaction with ANKRA2.2 Publications

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0502. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00900000140947.
HOGENOMiHOG000033969.
HOVERGENiHBG017718.
InParanoidiQ9H9E1.
KOiK21486.
OMAiNAMDMAV.
OrthoDBiEOG091G0BD5.
PhylomeDBiQ9H9E1.
TreeFamiTF333112.

Family and domain databases

CDDicd00204. ANK. 1 hit.
Gene3Di1.25.40.20. 2 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR036770. Ankyrin_rpt-contain_sf.
PfamiView protein in Pfam
PF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PRINTSiPR01415. ANKYRIN.
SMARTiView protein in SMART
SM00248. ANK. 3 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9H9E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSTNLDIG AQLIVEECPS TYSLTGMPDI KIEHPLDPNS EEGSAQGVAM
60 70 80 90 100
GMKFILPNRF DMNVCSRFVK SLNEEDSKNI QDQVNSDLEV ASVLFKAECN
110 120 130 140 150
IHTSPSPGIQ VRHVYTPSTT KHFSPIKQST TLTNKHRGNE VSTTPLLANS
160 170 180 190 200
LSVHQLAAQG EMLYLATRIE QENVINHTDE EGFTPLMWAA AHGQIAVVEF
210 220 230 240 250
LLQNGADPQL LGKGRESALS LACSKGYTDI VKMLLDCGVD VNEYDWNGGT
260 270 280 290 300
PLLYAVHGNH VKCVKMLLES GADPTIETDS GYNSMDLAVA LGYRSVQQVI
310
ESHLLKLLQN IKE
Length:313
Mass (Da):34,272
Last modified:March 1, 2001 - v1
Checksum:i31C653B10B4ED6E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314032 mRNA. Translation: AAK01621.1.
AK022876 mRNA. Translation: BAB14288.1.
AF251051 mRNA. Translation: AAK34941.1.
BC012917 mRNA. Translation: AAH12917.1.
CCDSiCCDS4020.1.
RefSeqiNP_075526.1. NM_023039.4.
UniGeneiHs.239154.

Genome annotation databases

EnsembliENST00000296785; ENSP00000296785; ENSG00000164331.
GeneIDi57763.
KEGGihsa:57763.
UCSCiuc003kcu.3. human.

Similar proteinsi

Entry informationi

Entry nameiANRA2_HUMAN
AccessioniPrimary (citable) accession number: Q9H9E1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references