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Protein

Zinc finger protein 408

Gene

ZNF408

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri353 – 37523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri496 – 51823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri524 – 54623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri551 – 57323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri579 – 60123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri607 – 62923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. identical protein binding Source: IntAct
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 408
Alternative name(s):
PR domain zinc finger protein 17
Gene namesi
Name:ZNF408
Synonyms:PFM14, PRDM17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:20041. ZNF408.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

Orphaneti891. Familial exudative vitreoretinopathy.
PharmGKBiPA134936136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 720720Zinc finger protein 408PRO_0000047569Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei322 – 3221Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H9D4.
PaxDbiQ9H9D4.
PRIDEiQ9H9D4.

PTM databases

PhosphoSiteiQ9H9D4.

Expressioni

Gene expression databases

BgeeiQ9H9D4.
CleanExiHS_ZNF408.
GenevestigatoriQ9H9D4.

Organism-specific databases

HPAiHPA017892.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-347633,EBI-347633
CEP70Q8NHQ13EBI-347633,EBI-739624
EXOSC2Q138683EBI-347633,EBI-301735
FHL2Q141923EBI-347633,EBI-701903
LDOC1O957513EBI-347633,EBI-740738
LSM2Q9Y3334EBI-347633,EBI-347416
MDFIQ997503EBI-347633,EBI-724076

Protein-protein interaction databases

BioGridi122894. 38 interactions.
IntActiQ9H9D4. 27 interactions.
MINTiMINT-1032881.
STRINGi9606.ENSP00000309606.

Structurei

3D structure databases

ProteinModelPortaliQ9H9D4.
SMRiQ9H9D4. Positions 321-629.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri353 – 37523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri496 – 51823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri524 – 54623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri551 – 57323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri579 – 60123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri607 – 62923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00730000111301.
HOGENOMiHOG000231441.
HOVERGENiHBG079382.
InParanoidiQ9H9D4.
OMAiQCPPRAK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9H9D4.
TreeFamiTF331495.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H9D4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEAEELLLE GKKALQLARE PRLGLDLGWN PSGEGCTQGL KDVPPEPTRD
60 70 80 90 100
ILALKSLPRG LALGPSLAKE QRLGVWCVGD PLQPGLLWGP LEEESASKEK
110 120 130 140 150
GEGVKPRQEE NLSLGPWGDV CACEQSSGWT SLVQRGRLES EGNVAPVRIS
160 170 180 190 200
ERLHLQVYQL VLPGSELLLW PQPSSEGPSL TQPGLDKEAA VAVVTEVESA
210 220 230 240 250
VQQEVASPGE DAAEPCIDPG SQSPSGIQAE NMVSPGLKFP TQDRISKDSQ
260 270 280 290 300
PLGPLLQDGD VDEECPAQAQ MPPELQSNSA TQQDPDGSGA SFSSSARGTQ
310 320 330 340 350
PHGYLAKKLH SPSDQCPPRA KTPEPGAQQS GFPTLSRSPP GPAGSSPKQG
360 370 380 390 400
RRYRCGECGK AFLQLCHLKK HAFVHTGHKP FLCTECGKSY SSEESFKAHM
410 420 430 440 450
LGHRGVRPFP CPQCDKAYGT QRDLKEHQVV HSGARPFACD QCGKAFARRP
460 470 480 490 500
SLRLHRKTHQ VPAAPAPCPC PVCGRPLANQ GSLRNHMRLH TGEKPFLCPH
510 520 530 540 550
CGRAFRQRGN LRGHLRLHTG ERPYRCPHCA DAFPQLPELR RHLISHTGEA
560 570 580 590 600
HLCPVCGKAL RDPHTLRAHE RLHSGERPFP CPQCGRAYTL ATKLRRHLKS
610 620 630 640 650
HLEDKPYRCP TCGMGYTLPQ SLRRHQLSHR PEAPCSPPSV PSAASEPTVV
660 670 680 690 700
LLQAEPQLLD THREEEVSPA RDVVEVTISE SQEKCFVVPE EPDAAPSLVL
710 720
IHKDMGLGAW AEVVEVEMGT
Length:720
Mass (Da):78,439
Last modified:March 1, 2001 - v1
Checksum:i0D3CDA7572D17721
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti337 – 3371R → P.
Corresponds to variant rs36017347 [ dbSNP | Ensembl ].
VAR_052823

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF346626 mRNA. Translation: AAK29075.1.
AK022889 mRNA. Translation: BAB14295.1.
BC013355 mRNA. Translation: AAH13355.1.
BC015708 mRNA. Translation: AAH15708.1.
CCDSiCCDS7923.1.
RefSeqiNP_001171680.1. NM_001184751.1.
NP_079017.1. NM_024741.2.
UniGeneiHs.656931.

Genome annotation databases

EnsembliENST00000311764; ENSP00000309606; ENSG00000175213.
GeneIDi79797.
KEGGihsa:79797.
UCSCiuc001nde.2. human.

Polymorphism databases

DMDMi17368963.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF346626 mRNA. Translation: AAK29075.1.
AK022889 mRNA. Translation: BAB14295.1.
BC013355 mRNA. Translation: AAH13355.1.
BC015708 mRNA. Translation: AAH15708.1.
CCDSiCCDS7923.1.
RefSeqiNP_001171680.1. NM_001184751.1.
NP_079017.1. NM_024741.2.
UniGeneiHs.656931.

3D structure databases

ProteinModelPortaliQ9H9D4.
SMRiQ9H9D4. Positions 321-629.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122894. 38 interactions.
IntActiQ9H9D4. 27 interactions.
MINTiMINT-1032881.
STRINGi9606.ENSP00000309606.

PTM databases

PhosphoSiteiQ9H9D4.

Polymorphism databases

DMDMi17368963.

Proteomic databases

MaxQBiQ9H9D4.
PaxDbiQ9H9D4.
PRIDEiQ9H9D4.

Protocols and materials databases

DNASUi79797.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311764; ENSP00000309606; ENSG00000175213.
GeneIDi79797.
KEGGihsa:79797.
UCSCiuc001nde.2. human.

Organism-specific databases

CTDi79797.
GeneCardsiGC11P046722.
HGNCiHGNC:20041. ZNF408.
HPAiHPA017892.
neXtProtiNX_Q9H9D4.
Orphaneti891. Familial exudative vitreoretinopathy.
PharmGKBiPA134936136.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00730000111301.
HOGENOMiHOG000231441.
HOVERGENiHBG079382.
InParanoidiQ9H9D4.
OMAiQCPPRAK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9H9D4.
TreeFamiTF331495.

Miscellaneous databases

ChiTaRSiZNF408. human.
GenomeRNAii79797.
NextBioi69342.
PROiQ9H9D4.

Gene expression databases

BgeeiQ9H9D4.
CleanExiHS_ZNF408.
GenevestigatoriQ9H9D4.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A family of novel PR-domain (PRDM) genes as candidate tumor suppressors."
    Du Y., Huang S.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Uterus.
  4. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-322, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiZN408_HUMAN
AccessioniPrimary (citable) accession number: Q9H9D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: March 4, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.