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Q9H9D4 (ZN408_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 408
Alternative name(s):
PR domain zinc finger protein 17
Gene names
Name:ZNF408
Synonyms:PFM14, PRDM17
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length720 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Contains 10 C2H2-type zinc fingers.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 720720Zinc finger protein 408
PRO_0000047569

Regions

Zinc finger353 – 37523C2H2-type 1
Zinc finger381 – 40323C2H2-type 2
Zinc finger409 – 43123C2H2-type 3
Zinc finger437 – 45923C2H2-type 4
Zinc finger468 – 49023C2H2-type 5
Zinc finger496 – 51823C2H2-type 6
Zinc finger524 – 54623C2H2-type 7
Zinc finger551 – 57323C2H2-type 8
Zinc finger579 – 60123C2H2-type 9
Zinc finger607 – 62923C2H2-type 10

Natural variations

Natural variant3371R → P.
Corresponds to variant rs36017347 [ dbSNP | Ensembl ].
VAR_052823

Sequences

Sequence LengthMass (Da)Tools
Q9H9D4 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 0D3CDA7572D17721

FASTA72078,439
        10         20         30         40         50         60 
MEEAEELLLE GKKALQLARE PRLGLDLGWN PSGEGCTQGL KDVPPEPTRD ILALKSLPRG 

        70         80         90        100        110        120 
LALGPSLAKE QRLGVWCVGD PLQPGLLWGP LEEESASKEK GEGVKPRQEE NLSLGPWGDV 

       130        140        150        160        170        180 
CACEQSSGWT SLVQRGRLES EGNVAPVRIS ERLHLQVYQL VLPGSELLLW PQPSSEGPSL 

       190        200        210        220        230        240 
TQPGLDKEAA VAVVTEVESA VQQEVASPGE DAAEPCIDPG SQSPSGIQAE NMVSPGLKFP 

       250        260        270        280        290        300 
TQDRISKDSQ PLGPLLQDGD VDEECPAQAQ MPPELQSNSA TQQDPDGSGA SFSSSARGTQ 

       310        320        330        340        350        360 
PHGYLAKKLH SPSDQCPPRA KTPEPGAQQS GFPTLSRSPP GPAGSSPKQG RRYRCGECGK 

       370        380        390        400        410        420 
AFLQLCHLKK HAFVHTGHKP FLCTECGKSY SSEESFKAHM LGHRGVRPFP CPQCDKAYGT 

       430        440        450        460        470        480 
QRDLKEHQVV HSGARPFACD QCGKAFARRP SLRLHRKTHQ VPAAPAPCPC PVCGRPLANQ 

       490        500        510        520        530        540 
GSLRNHMRLH TGEKPFLCPH CGRAFRQRGN LRGHLRLHTG ERPYRCPHCA DAFPQLPELR 

       550        560        570        580        590        600 
RHLISHTGEA HLCPVCGKAL RDPHTLRAHE RLHSGERPFP CPQCGRAYTL ATKLRRHLKS 

       610        620        630        640        650        660 
HLEDKPYRCP TCGMGYTLPQ SLRRHQLSHR PEAPCSPPSV PSAASEPTVV LLQAEPQLLD 

       670        680        690        700        710        720 
THREEEVSPA RDVVEVTISE SQEKCFVVPE EPDAAPSLVL IHKDMGLGAW AEVVEVEMGT 

« Hide

References

« Hide 'large scale' references
[1]"A family of novel PR-domain (PRDM) genes as candidate tumor suppressors."
Du Y., Huang S.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung and Uterus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF346626 mRNA. Translation: AAK29075.1.
AK022889 mRNA. Translation: BAB14295.1.
BC013355 mRNA. Translation: AAH13355.1.
BC015708 mRNA. Translation: AAH15708.1.
RefSeqNP_001171680.1. NM_001184751.1.
NP_079017.1. NM_024741.2.
UniGeneHs.656931.

3D structure databases

ProteinModelPortalQ9H9D4.
SMRQ9H9D4. Positions 41-174, 321-629.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122894. 35 interactions.
IntActQ9H9D4. 27 interactions.
MINTMINT-1032881.
STRING9606.ENSP00000309606.

PTM databases

PhosphoSiteQ9H9D4.

Polymorphism databases

DMDM17368963.

Proteomic databases

PaxDbQ9H9D4.
PRIDEQ9H9D4.

Protocols and materials databases

DNASU79797.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000311764; ENSP00000309606; ENSG00000175213.
GeneID79797.
KEGGhsa:79797.
UCSCuc001nde.2. human.

Organism-specific databases

CTD79797.
GeneCardsGC11P046722.
HGNCHGNC:20041. ZNF408.
HPAHPA017892.
neXtProtNX_Q9H9D4.
Orphanet891. Familial exudative vitreoretinopathy.
PharmGKBPA134936136.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000231441.
HOVERGENHBG079382.
InParanoidQ9H9D4.
OMAQCPPRAK.
OrthoDBEOG7KSX7Q.
PhylomeDBQ9H9D4.
TreeFamTF331495.

Gene expression databases

BgeeQ9H9D4.
CleanExHS_ZNF408.
GenevestigatorQ9H9D4.

Family and domain databases

Gene3D3.30.160.60. 10 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF408. human.
GenomeRNAi79797.
NextBio69342.
PROQ9H9D4.

Entry information

Entry nameZN408_HUMAN
AccessionPrimary (citable) accession number: Q9H9D4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM