Q9H9D4 (ZN408_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 408

Alternative name(s):
PR domain zinc finger protein 17

Gene names

Name:	ZNF408
Synonyms:	PFM14, PRDM17

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	720 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Contains 10 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		4	EBI-347633,EBI-347633
CEP70	Q8NHQ1	3	EBI-347633,EBI-739624
EXOSC2	Q13868	3	EBI-347633,EBI-301735
FHL2	Q14192	3	EBI-347633,EBI-701903
LDOC1	O95751	3	EBI-347633,EBI-740738
LSM2	Q9Y333	4	EBI-347633,EBI-347416
MDFI	Q99750	3	EBI-347633,EBI-724076

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 720	720	Zinc finger protein 408		PRO_0000047569
Regions
	Zinc finger	353 – 375	23	C2H2-type 1
	Zinc finger	381 – 403	23	C2H2-type 2
	Zinc finger	409 – 431	23	C2H2-type 3
	Zinc finger	437 – 459	23	C2H2-type 4
	Zinc finger	468 – 490	23	C2H2-type 5
	Zinc finger	496 – 518	23	C2H2-type 6
	Zinc finger	524 – 546	23	C2H2-type 7
	Zinc finger	551 – 573	23	C2H2-type 8
	Zinc finger	579 – 601	23	C2H2-type 9
	Zinc finger	607 – 629	23	C2H2-type 10
Natural variations
	Natural variant	337	1	R → P. Corresponds to variant rs36017347 [ dbSNP | Ensembl ].		VAR_052823

Sequences

	Sequence		Length	Mass (Da)
	Q9H9D4 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 0D3CDA7572D17721	FASTA	720	78,439
	10 20 30 40 50 60 MEEAEELLLE GKKALQLARE PRLGLDLGWN PSGEGCTQGL KDVPPEPTRD ILALKSLPRG 70 80 90 100 110 120 LALGPSLAKE QRLGVWCVGD PLQPGLLWGP LEEESASKEK GEGVKPRQEE NLSLGPWGDV 130 140 150 160 170 180 CACEQSSGWT SLVQRGRLES EGNVAPVRIS ERLHLQVYQL VLPGSELLLW PQPSSEGPSL 190 200 210 220 230 240 TQPGLDKEAA VAVVTEVESA VQQEVASPGE DAAEPCIDPG SQSPSGIQAE NMVSPGLKFP 250 260 270 280 290 300 TQDRISKDSQ PLGPLLQDGD VDEECPAQAQ MPPELQSNSA TQQDPDGSGA SFSSSARGTQ 310 320 330 340 350 360 PHGYLAKKLH SPSDQCPPRA KTPEPGAQQS GFPTLSRSPP GPAGSSPKQG RRYRCGECGK 370 380 390 400 410 420 AFLQLCHLKK HAFVHTGHKP FLCTECGKSY SSEESFKAHM LGHRGVRPFP CPQCDKAYGT 430 440 450 460 470 480 QRDLKEHQVV HSGARPFACD QCGKAFARRP SLRLHRKTHQ VPAAPAPCPC PVCGRPLANQ 490 500 510 520 530 540 GSLRNHMRLH TGEKPFLCPH CGRAFRQRGN LRGHLRLHTG ERPYRCPHCA DAFPQLPELR 550 560 570 580 590 600 RHLISHTGEA HLCPVCGKAL RDPHTLRAHE RLHSGERPFP CPQCGRAYTL ATKLRRHLKS 610 620 630 640 650 660 HLEDKPYRCP TCGMGYTLPQ SLRRHQLSHR PEAPCSPPSV PSAASEPTVV LLQAEPQLLD 670 680 690 700 710 720 THREEEVSPA RDVVEVTISE SQEKCFVVPE EPDAAPSLVL IHKDMGLGAW AEVVEVEMGT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A family of novel PR-domain (PRDM) genes as candidate tumor suppressors." Du Y., Huang S. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Uterus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF346626 mRNA. Translation: AAK29075.1. AK022889 mRNA. Translation: BAB14295.1. BC013355 mRNA. Translation: AAH13355.1. BC015708 mRNA. Translation: AAH15708.1.
IPI	IPI00015481.
RefSeq	NP_001171680.1. NM_001184751.1. NP_079017.1. NM_024741.2.
UniGene	Hs.656931.
3D structure databases
ProteinModelPortal	Q9H9D4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H9D4. 27 interactions.
MINT	MINT-1032881.
STRING	9606.ENSP00000309606.
PTM databases
PhosphoSite	Q9H9D4.
Polymorphism databases
DMDM	17368963.
Proteomic databases
PaxDb	Q9H9D4.
PRIDE	Q9H9D4.
Protocols and materials databases
DNASU	79797.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000311764; ENSP00000309606; ENSG00000175213.
GeneID	79797.
KEGG	hsa:79797.
UCSC	uc001nde.2. human.
Organism-specific databases
CTD	79797.
GeneCards	GC11P046722.
HGNC	HGNC:20041. ZNF408.
HPA	HPA017892.
neXtProt	NX_Q9H9D4.
PharmGKB	PA134936136.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000231441.
HOVERGEN	HBG079382.
InParanoid	Q9H9D4.
OMA	KTHQVPA.
OrthoDB	EOG41VK2G.
PhylomeDB	Q9H9D4.
Gene expression databases
Bgee	Q9H9D4.
CleanEx	HS_ZNF408.
Genevestigator	Q9H9D4.
GermOnline	ENSG00000175213. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 10 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 10 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 10 hits. PS50157. ZINC_FINGER_C2H2_2. 10 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZNF408. human.
GenomeRNAi	79797.
NextBio	69342.

Entry information

Entry name

ZN408_HUMAN

Accession

Primary (citable) accession number: Q9H9D4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.