Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9H9D4

- ZN408_HUMAN

UniProt

Q9H9D4 - ZN408_HUMAN

Protein

Zinc finger protein 408

Gene

ZNF408

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri353 – 37523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri381 – 40323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri409 – 43123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri437 – 45923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri468 – 49023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri496 – 51823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri524 – 54623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri551 – 57323C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri579 – 60123C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri607 – 62923C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. identical protein binding Source: IntAct
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 408
    Alternative name(s):
    PR domain zinc finger protein 17
    Gene namesi
    Name:ZNF408
    Synonyms:PFM14, PRDM17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:20041. ZNF408.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti891. Familial exudative vitreoretinopathy.
    PharmGKBiPA134936136.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 720720Zinc finger protein 408PRO_0000047569Add
    BLAST

    Proteomic databases

    MaxQBiQ9H9D4.
    PaxDbiQ9H9D4.
    PRIDEiQ9H9D4.

    PTM databases

    PhosphoSiteiQ9H9D4.

    Expressioni

    Gene expression databases

    BgeeiQ9H9D4.
    CleanExiHS_ZNF408.
    GenevestigatoriQ9H9D4.

    Organism-specific databases

    HPAiHPA017892.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself4EBI-347633,EBI-347633
    CEP70Q8NHQ13EBI-347633,EBI-739624
    EXOSC2Q138683EBI-347633,EBI-301735
    FHL2Q141923EBI-347633,EBI-701903
    LDOC1O957513EBI-347633,EBI-740738
    LSM2Q9Y3334EBI-347633,EBI-347416
    MDFIQ997503EBI-347633,EBI-724076

    Protein-protein interaction databases

    BioGridi122894. 35 interactions.
    IntActiQ9H9D4. 27 interactions.
    MINTiMINT-1032881.
    STRINGi9606.ENSP00000309606.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H9D4.
    SMRiQ9H9D4. Positions 321-657.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri353 – 37523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri381 – 40323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri409 – 43123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri437 – 45923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri468 – 49023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri496 – 51823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri524 – 54623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri551 – 57323C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri579 – 60123C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri607 – 62923C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000231441.
    HOVERGENiHBG079382.
    InParanoidiQ9H9D4.
    OMAiQCPPRAK.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ9H9D4.
    TreeFamiTF331495.

    Family and domain databases

    Gene3Di3.30.160.60. 10 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 10 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H9D4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEAEELLLE GKKALQLARE PRLGLDLGWN PSGEGCTQGL KDVPPEPTRD    50
    ILALKSLPRG LALGPSLAKE QRLGVWCVGD PLQPGLLWGP LEEESASKEK 100
    GEGVKPRQEE NLSLGPWGDV CACEQSSGWT SLVQRGRLES EGNVAPVRIS 150
    ERLHLQVYQL VLPGSELLLW PQPSSEGPSL TQPGLDKEAA VAVVTEVESA 200
    VQQEVASPGE DAAEPCIDPG SQSPSGIQAE NMVSPGLKFP TQDRISKDSQ 250
    PLGPLLQDGD VDEECPAQAQ MPPELQSNSA TQQDPDGSGA SFSSSARGTQ 300
    PHGYLAKKLH SPSDQCPPRA KTPEPGAQQS GFPTLSRSPP GPAGSSPKQG 350
    RRYRCGECGK AFLQLCHLKK HAFVHTGHKP FLCTECGKSY SSEESFKAHM 400
    LGHRGVRPFP CPQCDKAYGT QRDLKEHQVV HSGARPFACD QCGKAFARRP 450
    SLRLHRKTHQ VPAAPAPCPC PVCGRPLANQ GSLRNHMRLH TGEKPFLCPH 500
    CGRAFRQRGN LRGHLRLHTG ERPYRCPHCA DAFPQLPELR RHLISHTGEA 550
    HLCPVCGKAL RDPHTLRAHE RLHSGERPFP CPQCGRAYTL ATKLRRHLKS 600
    HLEDKPYRCP TCGMGYTLPQ SLRRHQLSHR PEAPCSPPSV PSAASEPTVV 650
    LLQAEPQLLD THREEEVSPA RDVVEVTISE SQEKCFVVPE EPDAAPSLVL 700
    IHKDMGLGAW AEVVEVEMGT 720
    Length:720
    Mass (Da):78,439
    Last modified:March 1, 2001 - v1
    Checksum:i0D3CDA7572D17721
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti337 – 3371R → P.
    Corresponds to variant rs36017347 [ dbSNP | Ensembl ].
    VAR_052823

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF346626 mRNA. Translation: AAK29075.1.
    AK022889 mRNA. Translation: BAB14295.1.
    BC013355 mRNA. Translation: AAH13355.1.
    BC015708 mRNA. Translation: AAH15708.1.
    CCDSiCCDS7923.1.
    RefSeqiNP_001171680.1. NM_001184751.1.
    NP_079017.1. NM_024741.2.
    UniGeneiHs.656931.

    Genome annotation databases

    EnsembliENST00000311764; ENSP00000309606; ENSG00000175213.
    GeneIDi79797.
    KEGGihsa:79797.
    UCSCiuc001nde.2. human.

    Polymorphism databases

    DMDMi17368963.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF346626 mRNA. Translation: AAK29075.1 .
    AK022889 mRNA. Translation: BAB14295.1 .
    BC013355 mRNA. Translation: AAH13355.1 .
    BC015708 mRNA. Translation: AAH15708.1 .
    CCDSi CCDS7923.1.
    RefSeqi NP_001171680.1. NM_001184751.1.
    NP_079017.1. NM_024741.2.
    UniGenei Hs.656931.

    3D structure databases

    ProteinModelPortali Q9H9D4.
    SMRi Q9H9D4. Positions 321-657.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122894. 35 interactions.
    IntActi Q9H9D4. 27 interactions.
    MINTi MINT-1032881.
    STRINGi 9606.ENSP00000309606.

    PTM databases

    PhosphoSitei Q9H9D4.

    Polymorphism databases

    DMDMi 17368963.

    Proteomic databases

    MaxQBi Q9H9D4.
    PaxDbi Q9H9D4.
    PRIDEi Q9H9D4.

    Protocols and materials databases

    DNASUi 79797.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311764 ; ENSP00000309606 ; ENSG00000175213 .
    GeneIDi 79797.
    KEGGi hsa:79797.
    UCSCi uc001nde.2. human.

    Organism-specific databases

    CTDi 79797.
    GeneCardsi GC11P046722.
    HGNCi HGNC:20041. ZNF408.
    HPAi HPA017892.
    neXtProti NX_Q9H9D4.
    Orphaneti 891. Familial exudative vitreoretinopathy.
    PharmGKBi PA134936136.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000231441.
    HOVERGENi HBG079382.
    InParanoidi Q9H9D4.
    OMAi QCPPRAK.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q9H9D4.
    TreeFami TF331495.

    Miscellaneous databases

    ChiTaRSi ZNF408. human.
    GenomeRNAii 79797.
    NextBioi 69342.
    PROi Q9H9D4.

    Gene expression databases

    Bgeei Q9H9D4.
    CleanExi HS_ZNF408.
    Genevestigatori Q9H9D4.

    Family and domain databases

    Gene3Di 3.30.160.60. 10 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 10 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A family of novel PR-domain (PRDM) genes as candidate tumor suppressors."
      Du Y., Huang S.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Uterus.

    Entry informationi

    Entry nameiZN408_HUMAN
    AccessioniPrimary (citable) accession number: Q9H9D4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3