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Protein

Sideroflexin-1

Gene

SFXN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Might be involved in the transport of a component required for iron utilization into or out of the mitochondria.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Names & Taxonomyi

Protein namesi
Recommended name:
Sideroflexin-1
Alternative name(s):
Tricarboxylate carrier protein
Short name:
TCC
Gene namesi
Name:SFXN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:16085. SFXN1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei103 – 12018HelicalSequence analysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence analysisAdd
BLAST
Transmembranei175 – 19521HelicalSequence analysisAdd
BLAST
Transmembranei229 – 24921HelicalSequence analysisAdd
BLAST
Transmembranei267 – 28721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38090.

Polymorphism and mutation databases

BioMutaiSFXN1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources1 Publication
Chaini2 – 322321Sideroflexin-1PRO_0000177032Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H9B4.
MaxQBiQ9H9B4.
PaxDbiQ9H9B4.
PeptideAtlasiQ9H9B4.
PRIDEiQ9H9B4.
TopDownProteomicsiQ9H9B4.

PTM databases

iPTMnetiQ9H9B4.
PhosphoSiteiQ9H9B4.
SwissPalmiQ9H9B4.

Expressioni

Gene expression databases

BgeeiQ9H9B4.
CleanExiHS_SFXN1.
ExpressionAtlasiQ9H9B4. baseline and differential.
GenevisibleiQ9H9B4. HS.

Organism-specific databases

HPAiHPA019543.
HPA063745.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PGRMC1O002641EBI-355861,EBI-1045534
TSC22D1Q157141EBI-355861,EBI-712609

Protein-protein interaction databases

BioGridi125107. 46 interactions.
IntActiQ9H9B4. 15 interactions.
MINTiMINT-1151298.
STRINGi9606.ENSP00000316905.

Structurei

3D structure databases

ProteinModelPortaliQ9H9B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sideroflexin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3767. Eukaryota.
ENOG410YU8V. LUCA.
GeneTreeiENSGT00390000002026.
HOGENOMiHOG000203440.
HOVERGENiHBG056083.
InParanoidiQ9H9B4.
OMAiKVVHDYR.
PhylomeDBiQ9H9B4.
TreeFamiTF313205.

Family and domain databases

InterProiIPR004686. Mtc.
[Graphical view]
PANTHERiPTHR11153. PTHR11153. 1 hit.
PfamiPF03820. Mtc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00798. mtc. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H9B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGELPPNIN IKEPRWDQST FIGRANHFFT VTDPRNILLT NEQLESARKI
60 70 80 90 100
VHDYRQGIVP PGLTENELWR AKYIYDSAFH PDTGEKMILI GRMSAQVPMN
110 120 130 140 150
MTITGCMMTF YRTTPAVLFW QWINQSFNAV VNYTNRSGDA PLTVNELGTA
160 170 180 190 200
YVSATTGAVA TALGLNALTK HVSPLIGRFV PFAAVAAANC INIPLMRQRE
210 220 230 240 250
LKVGIPVTDE NGNRLGESAN AAKQAITQVV VSRILMAAPG MAIPPFIMNT
260 270 280 290 300
LEKKAFLKRF PWMSAPIQVG LVGFCLVFAT PLCCALFPQK SSMSVTSLEA
310 320
ELQAKIQESH PELRRVYFNK GL
Length:322
Mass (Da):35,619
Last modified:January 23, 2007 - v4
Checksum:i47E03172F27990DB
GO

Sequence cautioni

The sequence AAH20517.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14003.1 differs from that shown.Cloning artifact.Curated
The sequence BAB14318.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731Y → K in BAB14318 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261N → S.
Corresponds to variant rs17065105 [ dbSNP | Ensembl ].
VAR_051966
Natural varianti266 – 2661P → S.
Corresponds to variant rs34907038 [ dbSNP | Ensembl ].
VAR_051967

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327346 mRNA. Translation: AAL56007.1.
AK022287 mRNA. Translation: BAB14003.1. Sequence problems.
AK022938 mRNA. Translation: BAB14318.1. Different initiation.
AK056915 mRNA. Translation: BAG51825.1.
BX648188 mRNA. No translation available.
AC091393 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61370.1.
CH471062 Genomic DNA. Translation: EAW61372.1.
CH471062 Genomic DNA. Translation: EAW61374.1.
CH471062 Genomic DNA. Translation: EAW61375.1.
BC020517 mRNA. Translation: AAH20517.1. Different initiation.
BC063241 mRNA. Translation: AAH63241.1.
CCDSiCCDS4394.1.
RefSeqiNP_073591.2. NM_022754.6.
UniGeneiHs.369440.

Genome annotation databases

EnsembliENST00000321442; ENSP00000316905; ENSG00000164466.
GeneIDi94081.
KEGGihsa:94081.
UCSCiuc003mda.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327346 mRNA. Translation: AAL56007.1.
AK022287 mRNA. Translation: BAB14003.1. Sequence problems.
AK022938 mRNA. Translation: BAB14318.1. Different initiation.
AK056915 mRNA. Translation: BAG51825.1.
BX648188 mRNA. No translation available.
AC091393 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61370.1.
CH471062 Genomic DNA. Translation: EAW61372.1.
CH471062 Genomic DNA. Translation: EAW61374.1.
CH471062 Genomic DNA. Translation: EAW61375.1.
BC020517 mRNA. Translation: AAH20517.1. Different initiation.
BC063241 mRNA. Translation: AAH63241.1.
CCDSiCCDS4394.1.
RefSeqiNP_073591.2. NM_022754.6.
UniGeneiHs.369440.

3D structure databases

ProteinModelPortaliQ9H9B4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125107. 46 interactions.
IntActiQ9H9B4. 15 interactions.
MINTiMINT-1151298.
STRINGi9606.ENSP00000316905.

PTM databases

iPTMnetiQ9H9B4.
PhosphoSiteiQ9H9B4.
SwissPalmiQ9H9B4.

Polymorphism and mutation databases

BioMutaiSFXN1.

Proteomic databases

EPDiQ9H9B4.
MaxQBiQ9H9B4.
PaxDbiQ9H9B4.
PeptideAtlasiQ9H9B4.
PRIDEiQ9H9B4.
TopDownProteomicsiQ9H9B4.

Protocols and materials databases

DNASUi94081.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321442; ENSP00000316905; ENSG00000164466.
GeneIDi94081.
KEGGihsa:94081.
UCSCiuc003mda.3. human.

Organism-specific databases

CTDi94081.
GeneCardsiSFXN1.
HGNCiHGNC:16085. SFXN1.
HPAiHPA019543.
HPA063745.
MIMi615569. gene.
neXtProtiNX_Q9H9B4.
PharmGKBiPA38090.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3767. Eukaryota.
ENOG410YU8V. LUCA.
GeneTreeiENSGT00390000002026.
HOGENOMiHOG000203440.
HOVERGENiHBG056083.
InParanoidiQ9H9B4.
OMAiKVVHDYR.
PhylomeDBiQ9H9B4.
TreeFamiTF313205.

Miscellaneous databases

ChiTaRSiSFXN1. human.
GeneWikiiSFXN1.
GenomeRNAii94081.
PROiQ9H9B4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H9B4.
CleanExiHS_SFXN1.
ExpressionAtlasiQ9H9B4. baseline and differential.
GenevisibleiQ9H9B4. HS.

Family and domain databases

InterProiIPR004686. Mtc.
[Graphical view]
PANTHERiPTHR11153. PTHR11153. 1 hit.
PfamiPF03820. Mtc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00798. mtc. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Li N., Chen T., Wan T., Zhang W., Cao X.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland, Prostate and Teratocarcinoma.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and PNS.
  7. Bienvenut W.V.
    Submitted (JUN-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-12; 16-48; 56-70; 73-86; 137-170; 203-214; 224-233 AND 291-314, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: B-cell lymphoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSFXN1_HUMAN
AccessioniPrimary (citable) accession number: Q9H9B4
Secondary accession number(s): B3KPW3, D3DQN2, Q9HA53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 135 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.