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Protein

CCR4-NOT transcription complex subunit 10

Gene

CNOT10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

RNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

ReactomeiR-HSA-429947. Deadenylation of mRNA.
R-HSA-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.

Names & Taxonomyi

Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 10
Gene namesi
Name:CNOT10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:23817. CNOT10.

Subcellular locationi

GO - Cellular componenti

  • CCR4-NOT complex Source: UniProtKB
  • cytosol Source: Reactome
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134862503.

Polymorphism and mutation databases

BioMutaiCNOT10.
DMDMi74733982.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 744743CCR4-NOT transcription complex subunit 10PRO_0000314579Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H9A5.
MaxQBiQ9H9A5.
PaxDbiQ9H9A5.
PeptideAtlasiQ9H9A5.
PRIDEiQ9H9A5.

PTM databases

iPTMnetiQ9H9A5.
PhosphoSiteiQ9H9A5.

Expressioni

Gene expression databases

BgeeiQ9H9A5.
CleanExiHS_CNOT10.
ExpressionAtlasiQ9H9A5. baseline and differential.
GenevisibleiQ9H9A5. HS.

Organism-specific databases

HPAiHPA035614.
HPA041450.

Interactioni

Subunit structurei

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CNOT11Q9UKZ14EBI-1054261,EBI-2562014

Protein-protein interaction databases

BioGridi117411. 38 interactions.
DIPiDIP-46839N.
IntActiQ9H9A5. 24 interactions.
MINTiMINT-6781568.
STRINGi9606.ENSP00000330060.

Structurei

3D structure databases

ProteinModelPortaliQ9H9A5.
SMRiQ9H9A5. Positions 110-138, 548-576, 644-676.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili74 – 10734Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the CNOT10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2471. Eukaryota.
ENOG410XQQJ. LUCA.
GeneTreeiENSGT00390000001827.
HOGENOMiHOG000111843.
HOVERGENiHBG077464.
InParanoidiQ9H9A5.
KOiK12607.
OMAiSDQGAEK.
OrthoDBiEOG7R56SC.
PhylomeDBiQ9H9A5.
TreeFamiTF323368.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 8 hits.

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H9A5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAADKPADQG AEKHEGTGQS SGITDQEKEL STNAFQAFTS GNYDACLQHL
60 70 80 90 100
ACLQDINKDD YKIILNTAVA EFFKSNQTTT DNLRQTLNQL KNQVHSAVEE
110 120 130 140 150
MDGLDDVENS MLYYNQAVIL YHLRQYTEAI SVGEKLYQFI EPFEEKFAQA
160 170 180 190 200
VCFLLVDLYI LTYQAEKALH LLAVLEKMIS QGNNNKNGKN ETGNNNNKDG
210 220 230 240 250
SNHKAESGAL IEAAKSKIHQ YKVRAYIQMK SLKACKREIK SVMNTAGNSA
260 270 280 290 300
PSLFLKSNFE YLRGNYRKAV KLLNSSNIAE HPGFMKTGEC LRCMFWNNLG
310 320 330 340 350
CIHFAMSKHN LGIFYFKKAL QENDNVCAQL SAGSTDPGKK FSGRPMCTLL
360 370 380 390 400
TNKRYELLYN CGIQLLHIGR PLAAFECLIE AVQVYHANPR LWLRLAECCI
410 420 430 440 450
AANKGTSEQE TKGLPSKKGI VQSIVGQGYH RKIVLASQSI QNTVYNDGQS
460 470 480 490 500
SAIPVASMEF AAICLRNALL LLPEEQQDPK QENGAKNSNQ LGGNTESSES
510 520 530 540 550
SETCSSKSHD GDKFIPAPPS SPLRKQELEN LKCSILACSA YVALALGDNL
560 570 580 590 600
MALNHADKLL QQPKLSGSLK FLGHLYAAEA LISLDRISDA ITHLNPENVT
610 620 630 640 650
DVSLGISSNE QDQGSDKGEN EAMESSGKRA PQCYPSSVNS ARTVMLFNLG
660 670 680 690 700
SAYCLRSEYD KARKCLHQAA SMIHPKEVPP EAILLAVYLE LQNGNTQLAL
710 720 730 740
QIIKRNQLLP AVKTHSEVRK KPVFQPVHPI QPIQMPAFTT VQRK
Length:744
Mass (Da):82,310
Last modified:March 1, 2001 - v1
Checksum:iBA1984B71F0A1E7A
GO
Isoform 2 (identifier: Q9H9A5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-144: Missing.

Show »
Length:743
Mass (Da):82,181
Checksum:i46D04260B4E124E7
GO
Isoform 3 (identifier: Q9H9A5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-532: SSKSHDGDKFIPAPPSSPLRKQELENLK → R

Show »
Length:717
Mass (Da):79,377
Checksum:i4981E1632AB0368B
GO
Isoform 4 (identifier: Q9H9A5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-532: SSKSHDGDKFIPAPPSSPLRKQELENLK → R
     556-577: Missing.

Show »
Length:695
Mass (Da):76,968
Checksum:iDEA9C9A66A253FE1
GO
Isoform 5 (identifier: Q9H9A5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-293: Missing.

Show »
Length:451
Mass (Da):49,483
Checksum:i8F1BA3511B5863D5
GO
Isoform 6 (identifier: Q9H9A5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MAADKPA → MKSIGVKTVKVCGSKSSVRIEGQPCSLGQSRRKVKLMGERSYTLSIGNGDYFWANKEMLWDYVQTLS

Note: No experimental confirmation available.
Show »
Length:804
Mass (Da):89,141
Checksum:iB1B0728C82613355
GO

Sequence cautioni

The sequence BAB13876.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51K → R in BAB14108 (PubMed:14702039).Curated
Sequence conflicti52 – 521C → R in BAB14478 (PubMed:14702039).Curated
Sequence conflicti270 – 2701V → M in BAB13876 (PubMed:14702039).Curated
Sequence conflicti478 – 4781D → G in BAB14108 (PubMed:14702039).Curated
Sequence conflicti509 – 5091H → Y in BAB14108 (PubMed:14702039).Curated
Sequence conflicti518 – 5181P → L in BAH13647 (PubMed:14702039).Curated
Sequence conflicti622 – 6221A → T in BAB14478 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti348 – 3481T → S.1 Publication
Corresponds to variant rs11558687 [ dbSNP | Ensembl ].
VAR_053982
Natural varianti736 – 7361P → S.1 Publication
Corresponds to variant rs17849684 [ dbSNP | Ensembl ].
VAR_037957

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 293293Missing in isoform 5. 1 PublicationVSP_030311Add
BLAST
Alternative sequencei1 – 77MAADKPA → MKSIGVKTVKVCGSKSSVRI EGQPCSLGQSRRKVKLMGER SYTLSIGNGDYFWANKEMLW DYVQTLS in isoform 6. 1 PublicationVSP_045557
Alternative sequencei144 – 1441Missing in isoform 2. 1 PublicationVSP_030312
Alternative sequencei505 – 53228SSKSH…LENLK → R in isoform 3 and isoform 4. 2 PublicationsVSP_030313Add
BLAST
Alternative sequencei556 – 57722Missing in isoform 4. 1 PublicationVSP_030314Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021695 mRNA. Translation: BAB13876.1. Different initiation.
AK022576 mRNA. Translation: BAB14108.1.
AK022952 mRNA. Translation: BAB14327.1.
AK023227 mRNA. Translation: BAB14478.1.
AK027026 mRNA. Translation: BAB15629.1.
AK302196 mRNA. Translation: BAH13647.1.
AC138972 Genomic DNA. No translation available.
AC139452 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64435.1.
BC002928 mRNA. Translation: AAH02928.1.
BC002931 mRNA. Translation: AAH02931.1.
AL117639 mRNA. Translation: CAB56027.2.
CCDSiCCDS2655.1. [Q9H9A5-1]
CCDS58821.1. [Q9H9A5-3]
CCDS58822.1. [Q9H9A5-6]
RefSeqiNP_001243670.1. NM_001256741.1. [Q9H9A5-3]
NP_001243671.1. NM_001256742.1. [Q9H9A5-6]
NP_056257.1. NM_015442.2. [Q9H9A5-1]
UniGeneiHs.444851.

Genome annotation databases

EnsembliENST00000328834; ENSP00000330060; ENSG00000182973. [Q9H9A5-1]
ENST00000331889; ENSP00000329376; ENSG00000182973. [Q9H9A5-3]
ENST00000454516; ENSP00000399862; ENSG00000182973. [Q9H9A5-6]
GeneIDi25904.
KEGGihsa:25904.
UCSCiuc003cfc.2. human. [Q9H9A5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021695 mRNA. Translation: BAB13876.1. Different initiation.
AK022576 mRNA. Translation: BAB14108.1.
AK022952 mRNA. Translation: BAB14327.1.
AK023227 mRNA. Translation: BAB14478.1.
AK027026 mRNA. Translation: BAB15629.1.
AK302196 mRNA. Translation: BAH13647.1.
AC138972 Genomic DNA. No translation available.
AC139452 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64435.1.
BC002928 mRNA. Translation: AAH02928.1.
BC002931 mRNA. Translation: AAH02931.1.
AL117639 mRNA. Translation: CAB56027.2.
CCDSiCCDS2655.1. [Q9H9A5-1]
CCDS58821.1. [Q9H9A5-3]
CCDS58822.1. [Q9H9A5-6]
RefSeqiNP_001243670.1. NM_001256741.1. [Q9H9A5-3]
NP_001243671.1. NM_001256742.1. [Q9H9A5-6]
NP_056257.1. NM_015442.2. [Q9H9A5-1]
UniGeneiHs.444851.

3D structure databases

ProteinModelPortaliQ9H9A5.
SMRiQ9H9A5. Positions 110-138, 548-576, 644-676.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117411. 38 interactions.
DIPiDIP-46839N.
IntActiQ9H9A5. 24 interactions.
MINTiMINT-6781568.
STRINGi9606.ENSP00000330060.

PTM databases

iPTMnetiQ9H9A5.
PhosphoSiteiQ9H9A5.

Polymorphism and mutation databases

BioMutaiCNOT10.
DMDMi74733982.

Proteomic databases

EPDiQ9H9A5.
MaxQBiQ9H9A5.
PaxDbiQ9H9A5.
PeptideAtlasiQ9H9A5.
PRIDEiQ9H9A5.

Protocols and materials databases

DNASUi25904.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328834; ENSP00000330060; ENSG00000182973. [Q9H9A5-1]
ENST00000331889; ENSP00000329376; ENSG00000182973. [Q9H9A5-3]
ENST00000454516; ENSP00000399862; ENSG00000182973. [Q9H9A5-6]
GeneIDi25904.
KEGGihsa:25904.
UCSCiuc003cfc.2. human. [Q9H9A5-1]

Organism-specific databases

CTDi25904.
GeneCardsiCNOT10.
HGNCiHGNC:23817. CNOT10.
HPAiHPA035614.
HPA041450.
neXtProtiNX_Q9H9A5.
PharmGKBiPA134862503.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2471. Eukaryota.
ENOG410XQQJ. LUCA.
GeneTreeiENSGT00390000001827.
HOGENOMiHOG000111843.
HOVERGENiHBG077464.
InParanoidiQ9H9A5.
KOiK12607.
OMAiSDQGAEK.
OrthoDBiEOG7R56SC.
PhylomeDBiQ9H9A5.
TreeFamiTF323368.

Enzyme and pathway databases

ReactomeiR-HSA-429947. Deadenylation of mRNA.
R-HSA-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.

Miscellaneous databases

ChiTaRSiCNOT10. human.
GenomeRNAii25904.
PROiQ9H9A5.

Gene expression databases

BgeeiQ9H9A5.
CleanExiHS_CNOT10.
ExpressionAtlasiQ9H9A5. baseline and differential.
GenevisibleiQ9H9A5. HS.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 8 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 5 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 85-744 (ISOFORM 4), VARIANT SER-348.
    Tissue: Embryo and Testis.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT SER-736.
    Tissue: Skin.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 482-744 (ISOFORM 1).
    Tissue: Testis.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION IN THE CCR4-NOT COMPLEX, COMPOSITION OF THE CCR4-NOT COMPLEX.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex."
    Mauxion F., Preve B., Seraphin B.
    RNA Biol. 10:267-276(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE CCR4-NOT COMPLEX.
  10. "Trypanosome CNOT10 is essential for the integrity of the NOT deadenylase complex and for degradation of many mRNAs."
    Farber V., Erben E., Sharma S., Stoecklin G., Clayton C.
    Nucleic Acids Res. 41:1211-1222(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain."
    Bawankar P., Loh B., Wohlbold L., Schmidt S., Izaurralde E.
    RNA Biol. 10:228-244(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CNOT11.
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCNO10_HUMAN
AccessioniPrimary (citable) accession number: Q9H9A5
Secondary accession number(s): B7Z7L1
, F8WAF2, Q9BU30, Q9H5J7, Q9H8X1, Q9H9W0, Q9HAH3, Q9UFJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.