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Protein

Pantothenate kinase 3

Gene

PANK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the physiological regulation of the intracellular CoA concentration.By similarity

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.

Enzyme regulationi

Regulated by feedback inhibition by CoA and its thioesters.By similarity

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase 4 (PANK4), Pantothenate kinase 3 (PANK3), Pantothenate kinase 1 (PANK1), Pantothenate kinase 2, mitochondrial (PANK2)
  2. Phosphopantothenate--cysteine ligase (PPCS)
  3. Phosphopantothenoylcysteine decarboxylase (PPCDC)
  4. Bifunctional coenzyme A synthase (COASY)
  5. Bifunctional coenzyme A synthase (COASY)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei192Acetyl-CoA1 Publication1
Binding sitei195Acetyl-CoA1 Publication1
Binding sitei207Acetyl-CoA1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS04372-MONOMER.
ZFISH:HS04372-MONOMER.
BRENDAi2.7.1.33. 2681.
ReactomeiR-HSA-196783. Coenzyme A biosynthesis.
UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate kinase 3 (EC:2.7.1.33)
Short name:
hPanK3
Alternative name(s):
Pantothenic acid kinase 3
Gene namesi
Name:PANK3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:19365. PANK3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120137.
PharmGKBiPA134903180.

Chemistry databases

ChEMBLiCHEMBL3407328.

Polymorphism and mutation databases

BioMutaiPANK3.
DMDMi27805668.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001618041 – 370Pantothenate kinase 3Add BLAST370

Proteomic databases

EPDiQ9H999.
MaxQBiQ9H999.
PaxDbiQ9H999.
PeptideAtlasiQ9H999.
PRIDEiQ9H999.

PTM databases

iPTMnetiQ9H999.
PhosphoSitePlusiQ9H999.
SwissPalmiQ9H999.

Expressioni

Tissue specificityi

Highly expressed in the liver.1 Publication

Gene expression databases

BgeeiENSG00000120137.
CleanExiHS_PANK3.
ExpressionAtlasiQ9H999. baseline and differential.
GenevisibleiQ9H999. HS.

Organism-specific databases

HPAiHPA021795.
HPA062358.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi122774. 1 interactor.
STRINGi9606.ENSP00000239231.

Chemistry databases

BindingDBiQ9H999.

Structurei

Secondary structure

1370
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 18Combined sources6
Beta strandi20 – 31Combined sources12
Helixi35 – 40Combined sources6
Helixi43 – 54Combined sources12
Beta strandi56 – 58Combined sources3
Turni59 – 61Combined sources3
Beta strandi62 – 64Combined sources3
Helixi66 – 68Combined sources3
Beta strandi70 – 75Combined sources6
Beta strandi78 – 88Combined sources11
Helixi89 – 91Combined sources3
Helixi92 – 99Combined sources8
Helixi102 – 104Combined sources3
Helixi105 – 107Combined sources3
Beta strandi110 – 115Combined sources6
Helixi116 – 120Combined sources5
Helixi122 – 125Combined sources4
Beta strandi132 – 135Combined sources4
Helixi138 – 152Combined sources15
Beta strandi159 – 164Combined sources6
Turni165 – 167Combined sources3
Turni169 – 171Combined sources3
Beta strandi173 – 176Combined sources4
Beta strandi184 – 201Combined sources18
Beta strandi204 – 212Combined sources9
Helixi215 – 226Combined sources12
Helixi231 – 240Combined sources10
Helixi243 – 245Combined sources3
Beta strandi247 – 249Combined sources3
Helixi250 – 254Combined sources5
Turni259 – 262Combined sources4
Beta strandi267 – 270Combined sources4
Helixi273 – 276Combined sources4
Helixi278 – 283Combined sources6
Helixi286 – 312Combined sources27
Beta strandi316 – 321Combined sources6
Helixi322 – 324Combined sources3
Helixi328 – 341Combined sources14
Turni342 – 344Combined sources3
Beta strandi347 – 351Combined sources5
Turni352 – 355Combined sources4
Helixi357 – 363Combined sources7
Helixi364 – 368Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I7PX-ray2.05A/B/C/D12-368[»]
3MK6X-ray1.98A/B/C/D12-368[»]
3SMSX-ray2.20A10-370[»]
5KPRX-ray1.83A12-370[»]
5KPTX-ray2.30A12-370[»]
5KPZX-ray2.40A12-370[»]
5KQ8X-ray2.00A12-370[»]
5KQDX-ray2.60A12-370[»]
ProteinModelPortaliQ9H999.
SMRiQ9H999.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H999.

Family & Domainsi

Sequence similaritiesi

Belongs to the type II pantothenate kinase family.Curated

Phylogenomic databases

eggNOGiKOG2201. Eukaryota.
COG5146. LUCA.
GeneTreeiENSGT00390000020719.
HOGENOMiHOG000194690.
HOVERGENiHBG053495.
InParanoidiQ9H999.
KOiK09680.
OMAiHDLPTFI.
OrthoDBiEOG091G0851.
PhylomeDBiQ9H999.
TreeFamiTF314866.

Family and domain databases

InterProiIPR004567. Type_II_PanK.
[Graphical view]
PfamiPF03630. Fumble. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00555. panK_eukar. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H999-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIKDAKKPS FPWFGMDIGG TLVKLSYFEP IDITAEEEQE EVESLKSIRK
60 70 80 90 100
YLTSNVAYGS TGIRDVHLEL KDLTLFGRRG NLHFIRFPTQ DLPTFIQMGR
110 120 130 140 150
DKNFSTLQTV LCATGGGAYK FEKDFRTIGN LHLHKLDELD CLVKGLLYID
160 170 180 190 200
SVSFNGQAEC YYFANASEPE RCQKMPFNLD DPYPLLVVNI GSGVSILAVH
210 220 230 240 250
SKDNYKRVTG TSLGGGTFLG LCSLLTGCES FEEALEMASK GDSTQADKLV
260 270 280 290 300
RDIYGGDYER FGLPGWAVAS SFGNMIYKEK RESVSKEDLA RATLVTITNN
310 320 330 340 350
IGSVARMCAV NEKINRVVFV GNFLRVNTLS MKLLAYALDY WSKGQLKALF
360 370
LEHEGYFGAV GALLGLPNFS
Length:370
Mass (Da):41,094
Last modified:March 1, 2001 - v1
Checksum:i71EEFA56079F352D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti335A → V in BAD97005 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022961 mRNA. Translation: BAB14333.1.
AK223285 mRNA. Translation: BAD97005.1.
CH471062 Genomic DNA. Translation: EAW61503.1.
CH471062 Genomic DNA. Translation: EAW61505.1.
BC013705 mRNA. Translation: AAH13705.1.
BK000011 mRNA. Translation: DAA00005.1.
CCDSiCCDS4368.1.
RefSeqiNP_078870.1. NM_024594.3.
UniGeneiHs.388400.
Hs.591729.

Genome annotation databases

EnsembliENST00000239231; ENSP00000239231; ENSG00000120137.
GeneIDi79646.
KEGGihsa:79646.
UCSCiuc003lzy.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022961 mRNA. Translation: BAB14333.1.
AK223285 mRNA. Translation: BAD97005.1.
CH471062 Genomic DNA. Translation: EAW61503.1.
CH471062 Genomic DNA. Translation: EAW61505.1.
BC013705 mRNA. Translation: AAH13705.1.
BK000011 mRNA. Translation: DAA00005.1.
CCDSiCCDS4368.1.
RefSeqiNP_078870.1. NM_024594.3.
UniGeneiHs.388400.
Hs.591729.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I7PX-ray2.05A/B/C/D12-368[»]
3MK6X-ray1.98A/B/C/D12-368[»]
3SMSX-ray2.20A10-370[»]
5KPRX-ray1.83A12-370[»]
5KPTX-ray2.30A12-370[»]
5KPZX-ray2.40A12-370[»]
5KQ8X-ray2.00A12-370[»]
5KQDX-ray2.60A12-370[»]
ProteinModelPortaliQ9H999.
SMRiQ9H999.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122774. 1 interactor.
STRINGi9606.ENSP00000239231.

Chemistry databases

BindingDBiQ9H999.
ChEMBLiCHEMBL3407328.

PTM databases

iPTMnetiQ9H999.
PhosphoSitePlusiQ9H999.
SwissPalmiQ9H999.

Polymorphism and mutation databases

BioMutaiPANK3.
DMDMi27805668.

Proteomic databases

EPDiQ9H999.
MaxQBiQ9H999.
PaxDbiQ9H999.
PeptideAtlasiQ9H999.
PRIDEiQ9H999.

Protocols and materials databases

DNASUi79646.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239231; ENSP00000239231; ENSG00000120137.
GeneIDi79646.
KEGGihsa:79646.
UCSCiuc003lzy.4. human.

Organism-specific databases

CTDi79646.
GeneCardsiPANK3.
HGNCiHGNC:19365. PANK3.
HPAiHPA021795.
HPA062358.
MIMi606161. gene.
neXtProtiNX_Q9H999.
OpenTargetsiENSG00000120137.
PharmGKBiPA134903180.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2201. Eukaryota.
COG5146. LUCA.
GeneTreeiENSGT00390000020719.
HOGENOMiHOG000194690.
HOVERGENiHBG053495.
InParanoidiQ9H999.
KOiK09680.
OMAiHDLPTFI.
OrthoDBiEOG091G0851.
PhylomeDBiQ9H999.
TreeFamiTF314866.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.
BioCyciMetaCyc:HS04372-MONOMER.
ZFISH:HS04372-MONOMER.
BRENDAi2.7.1.33. 2681.
ReactomeiR-HSA-196783. Coenzyme A biosynthesis.

Miscellaneous databases

ChiTaRSiPANK3. human.
EvolutionaryTraceiQ9H999.
GenomeRNAii79646.
PROiQ9H999.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120137.
CleanExiHS_PANK3.
ExpressionAtlasiQ9H999. baseline and differential.
GenevisibleiQ9H999. HS.

Family and domain databases

InterProiIPR004567. Type_II_PanK.
[Graphical view]
PfamiPF03630. Fumble. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00555. panK_eukar. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPANK3_HUMAN
AccessioniPrimary (citable) accession number: Q9H999
Secondary accession number(s): D3DQL1, Q53FJ9, Q7RTX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.