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Q9H999

- PANK3_HUMAN

UniProt

Q9H999 - PANK3_HUMAN

Protein

Pantothenate kinase 3

Gene

PANK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Plays a role in the physiological regulation of the intracellular CoA concentration.By similarity

    Catalytic activityi

    ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.

    Enzyme regulationi

    Regulated by feedback inhibition by CoA and its thioesters.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei192 – 1921Acetyl-CoA1 Publication
    Binding sitei195 – 1951Acetyl-CoA1 Publication
    Binding sitei207 – 2071Acetyl-CoA1 Publication

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantothenate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. coenzyme A biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Coenzyme A biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_11218. Coenzyme A biosynthesis.
    UniPathwayiUPA00241; UER00352.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate kinase 3 (EC:2.7.1.33)
    Short name:
    hPanK3
    Alternative name(s):
    Pantothenic acid kinase 3
    Gene namesi
    Name:PANK3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:19365. PANK3.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134903180.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 370370Pantothenate kinase 3PRO_0000161804Add
    BLAST

    Proteomic databases

    MaxQBiQ9H999.
    PaxDbiQ9H999.
    PRIDEiQ9H999.

    PTM databases

    PhosphoSiteiQ9H999.

    Expressioni

    Tissue specificityi

    Highly expressed in the liver.1 Publication

    Gene expression databases

    ArrayExpressiQ9H999.
    BgeeiQ9H999.
    CleanExiHS_PANK3.
    GenevestigatoriQ9H999.

    Organism-specific databases

    HPAiHPA021795.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    BioGridi122774. 2 interactions.
    STRINGi9606.ENSP00000239231.

    Structurei

    Secondary structure

    1
    370
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi14 – 185
    Beta strandi20 – 3112
    Helixi36 – 5217
    Beta strandi56 – 583
    Turni59 – 613
    Helixi64 – 685
    Beta strandi70 – 756
    Beta strandi78 – 8811
    Helixi89 – 913
    Helixi92 – 10110
    Helixi105 – 1073
    Beta strandi108 – 1158
    Helixi118 – 1214
    Turni122 – 1243
    Beta strandi132 – 1354
    Helixi138 – 15215
    Beta strandi159 – 1646
    Turni165 – 1673
    Turni169 – 1713
    Beta strandi173 – 1764
    Beta strandi184 – 20118
    Beta strandi204 – 2129
    Helixi215 – 22612
    Helixi231 – 24010
    Helixi243 – 2453
    Beta strandi247 – 2493
    Helixi250 – 2545
    Helixi259 – 2613
    Beta strandi267 – 2704
    Helixi273 – 2764
    Helixi278 – 2836
    Helixi286 – 31227
    Beta strandi317 – 3215
    Helixi322 – 3243
    Helixi329 – 34113
    Turni342 – 3443
    Beta strandi348 – 3514
    Turni352 – 3554
    Helixi357 – 3648
    Turni365 – 3673

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2I7PX-ray2.05A/B/C/D12-368[»]
    3MK6X-ray1.98A/B/C/D12-368[»]
    3SMSX-ray2.20A10-370[»]
    ProteinModelPortaliQ9H999.
    SMRiQ9H999. Positions 12-365.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9H999.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the type II pantothenate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG5146.
    HOGENOMiHOG000194690.
    HOVERGENiHBG053495.
    InParanoidiQ9H999.
    KOiK09680.
    OMAiYPLLIVN.
    OrthoDBiEOG7R2BJR.
    PhylomeDBiQ9H999.
    TreeFamiTF314866.

    Family and domain databases

    InterProiIPR004567. Type_II_PanK.
    [Graphical view]
    PfamiPF03630. Fumble. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00555. panK_eukar. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9H999-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIKDAKKPS FPWFGMDIGG TLVKLSYFEP IDITAEEEQE EVESLKSIRK    50
    YLTSNVAYGS TGIRDVHLEL KDLTLFGRRG NLHFIRFPTQ DLPTFIQMGR 100
    DKNFSTLQTV LCATGGGAYK FEKDFRTIGN LHLHKLDELD CLVKGLLYID 150
    SVSFNGQAEC YYFANASEPE RCQKMPFNLD DPYPLLVVNI GSGVSILAVH 200
    SKDNYKRVTG TSLGGGTFLG LCSLLTGCES FEEALEMASK GDSTQADKLV 250
    RDIYGGDYER FGLPGWAVAS SFGNMIYKEK RESVSKEDLA RATLVTITNN 300
    IGSVARMCAV NEKINRVVFV GNFLRVNTLS MKLLAYALDY WSKGQLKALF 350
    LEHEGYFGAV GALLGLPNFS 370
    Length:370
    Mass (Da):41,094
    Last modified:March 1, 2001 - v1
    Checksum:i71EEFA56079F352D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti335 – 3351A → V in BAD97005. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022961 mRNA. Translation: BAB14333.1.
    AK223285 mRNA. Translation: BAD97005.1.
    CH471062 Genomic DNA. Translation: EAW61503.1.
    CH471062 Genomic DNA. Translation: EAW61505.1.
    BC013705 mRNA. Translation: AAH13705.1.
    BK000011 mRNA. Translation: DAA00005.1.
    CCDSiCCDS4368.1.
    RefSeqiNP_078870.1. NM_024594.3.
    UniGeneiHs.388400.
    Hs.591729.

    Genome annotation databases

    EnsembliENST00000239231; ENSP00000239231; ENSG00000120137.
    GeneIDi79646.
    KEGGihsa:79646.
    UCSCiuc003lzz.2. human.

    Polymorphism databases

    DMDMi27805668.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022961 mRNA. Translation: BAB14333.1 .
    AK223285 mRNA. Translation: BAD97005.1 .
    CH471062 Genomic DNA. Translation: EAW61503.1 .
    CH471062 Genomic DNA. Translation: EAW61505.1 .
    BC013705 mRNA. Translation: AAH13705.1 .
    BK000011 mRNA. Translation: DAA00005.1 .
    CCDSi CCDS4368.1.
    RefSeqi NP_078870.1. NM_024594.3.
    UniGenei Hs.388400.
    Hs.591729.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2I7P X-ray 2.05 A/B/C/D 12-368 [» ]
    3MK6 X-ray 1.98 A/B/C/D 12-368 [» ]
    3SMS X-ray 2.20 A 10-370 [» ]
    ProteinModelPortali Q9H999.
    SMRi Q9H999. Positions 12-365.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122774. 2 interactions.
    STRINGi 9606.ENSP00000239231.

    PTM databases

    PhosphoSitei Q9H999.

    Polymorphism databases

    DMDMi 27805668.

    Proteomic databases

    MaxQBi Q9H999.
    PaxDbi Q9H999.
    PRIDEi Q9H999.

    Protocols and materials databases

    DNASUi 79646.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000239231 ; ENSP00000239231 ; ENSG00000120137 .
    GeneIDi 79646.
    KEGGi hsa:79646.
    UCSCi uc003lzz.2. human.

    Organism-specific databases

    CTDi 79646.
    GeneCardsi GC05M167975.
    HGNCi HGNC:19365. PANK3.
    HPAi HPA021795.
    MIMi 606161. gene.
    neXtProti NX_Q9H999.
    PharmGKBi PA134903180.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5146.
    HOGENOMi HOG000194690.
    HOVERGENi HBG053495.
    InParanoidi Q9H999.
    KOi K09680.
    OMAi YPLLIVN.
    OrthoDBi EOG7R2BJR.
    PhylomeDBi Q9H999.
    TreeFami TF314866.

    Enzyme and pathway databases

    UniPathwayi UPA00241 ; UER00352 .
    Reactomei REACT_11218. Coenzyme A biosynthesis.

    Miscellaneous databases

    ChiTaRSi PANK3. human.
    EvolutionaryTracei Q9H999.
    GenomeRNAii 79646.
    NextBioi 68786.
    PROi Q9H999.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H999.
    Bgeei Q9H999.
    CleanExi HS_PANK3.
    Genevestigatori Q9H999.

    Family and domain databases

    InterProi IPR004567. Type_II_PanK.
    [Graphical view ]
    Pfami PF03630. Fumble. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00555. panK_eukar. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Synovium.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymph.
    5. "A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome."
      Zhou B., Westaway S.K., Levinson B., Johnson M.A., Gitschier J., Hayflick S.J.
      Nat. Genet. 28:345-349(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder."
      Hong B.S., Senisterra G., Rabeh W.M., Vedadi M., Leonardi R., Zhang Y.M., Rock C.O., Jackowski S., Park H.W.
      J. Biol. Chem. 282:27984-27993(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 12-368 IN COMPLEX WITH ACETYL-COA, SUBUNIT.

    Entry informationi

    Entry nameiPANK3_HUMAN
    AccessioniPrimary (citable) accession number: Q9H999
    Secondary accession number(s): D3DQL1, Q53FJ9, Q7RTX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 17, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3