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Q9H999

- PANK3_HUMAN

UniProt

Q9H999 - PANK3_HUMAN

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Protein

Pantothenate kinase 3

Gene

PANK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in the physiological regulation of the intracellular CoA concentration.By similarity

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.

Enzyme regulationi

Regulated by feedback inhibition by CoA and its thioesters.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei192 – 1921Acetyl-CoA1 Publication
Binding sitei195 – 1951Acetyl-CoA1 Publication
Binding sitei207 – 2071Acetyl-CoA1 Publication

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantothenate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. coenzyme A biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_11218. Coenzyme A biosynthesis.
UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate kinase 3 (EC:2.7.1.33)
Short name:
hPanK3
Alternative name(s):
Pantothenic acid kinase 3
Gene namesi
Name:PANK3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:19365. PANK3.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134903180.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Pantothenate kinase 3PRO_0000161804Add
BLAST

Proteomic databases

MaxQBiQ9H999.
PaxDbiQ9H999.
PRIDEiQ9H999.

PTM databases

PhosphoSiteiQ9H999.

Expressioni

Tissue specificityi

Highly expressed in the liver.1 Publication

Gene expression databases

BgeeiQ9H999.
CleanExiHS_PANK3.
ExpressionAtlasiQ9H999. baseline and differential.
GenevestigatoriQ9H999.

Organism-specific databases

HPAiHPA021795.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi122774. 2 interactions.
STRINGi9606.ENSP00000239231.

Structurei

Secondary structure

1
370
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi14 – 185
Beta strandi20 – 3112
Helixi36 – 5217
Beta strandi56 – 583
Turni59 – 613
Helixi64 – 685
Beta strandi70 – 756
Beta strandi78 – 8811
Helixi89 – 913
Helixi92 – 10110
Helixi105 – 1073
Beta strandi108 – 1158
Helixi118 – 1214
Turni122 – 1243
Beta strandi132 – 1354
Helixi138 – 15215
Beta strandi159 – 1646
Turni165 – 1673
Turni169 – 1713
Beta strandi173 – 1764
Beta strandi184 – 20118
Beta strandi204 – 2129
Helixi215 – 22612
Helixi231 – 24010
Helixi243 – 2453
Beta strandi247 – 2493
Helixi250 – 2545
Helixi259 – 2613
Beta strandi267 – 2704
Helixi273 – 2764
Helixi278 – 2836
Helixi286 – 31227
Beta strandi317 – 3215
Helixi322 – 3243
Helixi329 – 34113
Turni342 – 3443
Beta strandi348 – 3514
Turni352 – 3554
Helixi357 – 3648
Turni365 – 3673

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2I7PX-ray2.05A/B/C/D12-368[»]
3MK6X-ray1.98A/B/C/D12-368[»]
3SMSX-ray2.20A10-370[»]
ProteinModelPortaliQ9H999.
SMRiQ9H999. Positions 12-365.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H999.

Family & Domainsi

Sequence similaritiesi

Belongs to the type II pantothenate kinase family.Curated

Phylogenomic databases

eggNOGiCOG5146.
GeneTreeiENSGT00390000020719.
HOGENOMiHOG000194690.
HOVERGENiHBG053495.
InParanoidiQ9H999.
KOiK09680.
OMAiYPLLIVN.
OrthoDBiEOG7R2BJR.
PhylomeDBiQ9H999.
TreeFamiTF314866.

Family and domain databases

InterProiIPR004567. Type_II_PanK.
[Graphical view]
PfamiPF03630. Fumble. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00555. panK_eukar. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H999-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIKDAKKPS FPWFGMDIGG TLVKLSYFEP IDITAEEEQE EVESLKSIRK
60 70 80 90 100
YLTSNVAYGS TGIRDVHLEL KDLTLFGRRG NLHFIRFPTQ DLPTFIQMGR
110 120 130 140 150
DKNFSTLQTV LCATGGGAYK FEKDFRTIGN LHLHKLDELD CLVKGLLYID
160 170 180 190 200
SVSFNGQAEC YYFANASEPE RCQKMPFNLD DPYPLLVVNI GSGVSILAVH
210 220 230 240 250
SKDNYKRVTG TSLGGGTFLG LCSLLTGCES FEEALEMASK GDSTQADKLV
260 270 280 290 300
RDIYGGDYER FGLPGWAVAS SFGNMIYKEK RESVSKEDLA RATLVTITNN
310 320 330 340 350
IGSVARMCAV NEKINRVVFV GNFLRVNTLS MKLLAYALDY WSKGQLKALF
360 370
LEHEGYFGAV GALLGLPNFS
Length:370
Mass (Da):41,094
Last modified:March 1, 2001 - v1
Checksum:i71EEFA56079F352D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti335 – 3351A → V in BAD97005. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022961 mRNA. Translation: BAB14333.1.
AK223285 mRNA. Translation: BAD97005.1.
CH471062 Genomic DNA. Translation: EAW61503.1.
CH471062 Genomic DNA. Translation: EAW61505.1.
BC013705 mRNA. Translation: AAH13705.1.
BK000011 mRNA. Translation: DAA00005.1.
CCDSiCCDS4368.1.
RefSeqiNP_078870.1. NM_024594.3.
UniGeneiHs.388400.
Hs.591729.

Genome annotation databases

EnsembliENST00000239231; ENSP00000239231; ENSG00000120137.
GeneIDi79646.
KEGGihsa:79646.
UCSCiuc003lzz.2. human.

Polymorphism databases

DMDMi27805668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022961 mRNA. Translation: BAB14333.1 .
AK223285 mRNA. Translation: BAD97005.1 .
CH471062 Genomic DNA. Translation: EAW61503.1 .
CH471062 Genomic DNA. Translation: EAW61505.1 .
BC013705 mRNA. Translation: AAH13705.1 .
BK000011 mRNA. Translation: DAA00005.1 .
CCDSi CCDS4368.1.
RefSeqi NP_078870.1. NM_024594.3.
UniGenei Hs.388400.
Hs.591729.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2I7P X-ray 2.05 A/B/C/D 12-368 [» ]
3MK6 X-ray 1.98 A/B/C/D 12-368 [» ]
3SMS X-ray 2.20 A 10-370 [» ]
ProteinModelPortali Q9H999.
SMRi Q9H999. Positions 12-365.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122774. 2 interactions.
STRINGi 9606.ENSP00000239231.

PTM databases

PhosphoSitei Q9H999.

Polymorphism databases

DMDMi 27805668.

Proteomic databases

MaxQBi Q9H999.
PaxDbi Q9H999.
PRIDEi Q9H999.

Protocols and materials databases

DNASUi 79646.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000239231 ; ENSP00000239231 ; ENSG00000120137 .
GeneIDi 79646.
KEGGi hsa:79646.
UCSCi uc003lzz.2. human.

Organism-specific databases

CTDi 79646.
GeneCardsi GC05M167975.
HGNCi HGNC:19365. PANK3.
HPAi HPA021795.
MIMi 606161. gene.
neXtProti NX_Q9H999.
PharmGKBi PA134903180.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5146.
GeneTreei ENSGT00390000020719.
HOGENOMi HOG000194690.
HOVERGENi HBG053495.
InParanoidi Q9H999.
KOi K09680.
OMAi YPLLIVN.
OrthoDBi EOG7R2BJR.
PhylomeDBi Q9H999.
TreeFami TF314866.

Enzyme and pathway databases

UniPathwayi UPA00241 ; UER00352 .
Reactomei REACT_11218. Coenzyme A biosynthesis.

Miscellaneous databases

ChiTaRSi PANK3. human.
EvolutionaryTracei Q9H999.
GenomeRNAii 79646.
NextBioi 68786.
PROi Q9H999.
SOURCEi Search...

Gene expression databases

Bgeei Q9H999.
CleanExi HS_PANK3.
ExpressionAtlasi Q9H999. baseline and differential.
Genevestigatori Q9H999.

Family and domain databases

InterProi IPR004567. Type_II_PanK.
[Graphical view ]
Pfami PF03630. Fumble. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00555. panK_eukar. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Synovium.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.
  5. "A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome."
    Zhou B., Westaway S.K., Levinson B., Johnson M.A., Gitschier J., Hayflick S.J.
    Nat. Genet. 28:345-349(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder."
    Hong B.S., Senisterra G., Rabeh W.M., Vedadi M., Leonardi R., Zhang Y.M., Rock C.O., Jackowski S., Park H.W.
    J. Biol. Chem. 282:27984-27993(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 12-368 IN COMPLEX WITH ACETYL-COA, SUBUNIT.

Entry informationi

Entry nameiPANK3_HUMAN
AccessioniPrimary (citable) accession number: Q9H999
Secondary accession number(s): D3DQL1, Q53FJ9, Q7RTX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3