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Protein

Protein-glutamate O-methyltransferase

Gene

ARMT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Methylates PCNA, suggesting it is involved in the DNA damage response.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei258S-adenosyl-L-methionine1 Publication1
Binding sitei291S-adenosyl-L-methionine1 Publication1

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • protein carboxyl O-methyltransferase activity Source: UniProtKB
  • S-adenosylmethionine-dependent methyltransferase activity Source: UniProtKB

GO - Biological processi

  • cellular response to DNA damage stimulus Source: UniProtKB-KW
  • methylation Source: UniProtKB
  • regulation of response to DNA damage stimulus Source: UniProtKB

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processDNA damage
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamate O-methyltransferaseCurated (EC:2.1.1.-1 Publication)
Alternative name(s):
Acidic residue methyltransferase 11 Publication
Gene namesi
Name:ARMT11 PublicationImported
Synonyms:C6orf211Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000146476.10.
HGNCiHGNC:17872. ARMT1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000146476.
PharmGKBiPA134870747.

Polymorphism and mutation databases

BioMutaiC6orf211.
DMDMi74752737.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002307952 – 441Protein-glutamate O-methyltransferaseAdd BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei40N6-acetyllysineCombined sources1
Modified residuei102PhosphoserineCombined sources1

Post-translational modificationi

Automethylated.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9H993.
MaxQBiQ9H993.
PaxDbiQ9H993.
PeptideAtlasiQ9H993.
PRIDEiQ9H993.

PTM databases

iPTMnetiQ9H993.
PhosphoSitePlusiQ9H993.

Expressioni

Gene expression databases

BgeeiENSG00000146476.
CleanExiHS_C6orf211.
ExpressionAtlasiQ9H993. baseline and differential.
GenevisibleiQ9H993. HS.

Organism-specific databases

HPAiHPA003004.
HPA005819.

Interactioni

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122754. 29 interactors.
IntActiQ9H993. 3 interactors.
STRINGi9606.ENSP00000356263.

Structurei

3D structure databases

ProteinModelPortaliQ9H993.
SMRiQ9H993.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARMT1 family.Curated

Phylogenomic databases

eggNOGiKOG3870. Eukaryota.
ENOG410XPAF. LUCA.
GeneTreeiENSGT00530000064023.
HOGENOMiHOG000172710.
HOVERGENiHBG054833.
InParanoidiQ9H993.
OMAiRIWAIFR.
OrthoDBiEOG091G0557.
PhylomeDBiQ9H993.
TreeFamiTF314853.

Family and domain databases

InterProiView protein in InterPro
IPR036075. AF1104-like_sf.
IPR002791. DUF89.
PfamiView protein in Pfam
PF01937. DUF89. 1 hit.
SUPFAMiSSF111321. SSF111321. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H993-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVVPASLSG QDVGSFAYLT IKDRIPQILT KVIDTLHRHK SEFFEKHGEE
60 70 80 90 100
GVEAEKKAIS LLSKLRNELQ TDKPFIPLVE KFVDTDIWNQ YLEYQQSLLN
110 120 130 140 150
ESDGKSRWFY SPWLLVECYM YRRIHEAIIQ SPPIDYFDVF KESKEQNFYG
160 170 180 190 200
SQESIIALCT HLQQLIRTIE DLDENQLKDE FFKLLQISLW GNKCDLSLSG
210 220 230 240 250
GESSSQNTNV LNSLEDLKPF ILLNDMEHLW SLLSNCKKTR EKASATRVYI
260 270 280 290 300
VLDNSGFELV TDLILADFLL SSELATEVHF YGKTIPWFVS DTTIHDFNWL
310 320 330 340 350
IEQVKHSNHK WMSKCGADWE EYIKMGKWVY HNHIFWTLPH EYCAMPQVAP
360 370 380 390 400
DLYAELQKAH LILFKGDLNY RKLTGDRKWE FSVPFHQALN GFHPAPLCTI
410 420 430 440
RTLKAEIQVG LQPGQGEQLL ASEPSWWTTG KYGIFQYDGP L
Length:441
Mass (Da):51,172
Last modified:March 1, 2001 - v1
Checksum:i3BE4D15528FDFC4E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120 – 121MY → ID in AAH11348 (PubMed:15489334).Curated2
Sequence conflicti148F → S in CAB53692 (PubMed:17974005).Curated1
Sequence conflicti173D → Y in AAH11348 (PubMed:15489334).Curated1
Sequence conflicti220F → Y in CAB53692 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05309073K → N. Corresponds to variant dbSNP:rs35036943Ensembl.1
Natural variantiVAR_02579177P → R1 PublicationCorresponds to variant dbSNP:rs17850732Ensembl.1
Natural variantiVAR_053091150G → E. Corresponds to variant dbSNP:rs35734927Ensembl.1
Natural variantiVAR_053092154S → A. Corresponds to variant dbSNP:rs34437617Ensembl.1
Natural variantiVAR_053093161H → P. Corresponds to variant dbSNP:rs36037706Ensembl.1
Natural variantiVAR_053094264I → V. Corresponds to variant dbSNP:rs35989216Ensembl.1
Natural variantiVAR_053095317A → T. Corresponds to variant dbSNP:rs35972078Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022972 mRNA. Translation: BAB14339.1.
AL590543 Genomic DNA. No translation available.
BC011348 mRNA. Translation: AAH11348.1.
AL110241 mRNA. Translation: CAB53692.2.
CCDSiCCDS5233.1.
PIRiT14772.
RefSeqiNP_001273491.1. NM_001286562.1.
NP_078849.1. NM_024573.2.
UniGeneiHs.15929.

Genome annotation databases

EnsembliENST00000367294; ENSP00000356263; ENSG00000146476.
GeneIDi79624.
KEGGihsa:79624.
UCSCiuc003qok.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiARMT1_HUMAN
AccessioniPrimary (citable) accession number: Q9H993
Secondary accession number(s): Q96FC6, Q9UFY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries