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Q9H977

- WDR54_HUMAN

UniProt

Q9H977 - WDR54_HUMAN

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Protein

WD repeat-containing protein 54

Gene

WDR54

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ9H977.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 54
Gene namesi
Name:WDR54
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:25770. WDR54.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670589.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334WD repeat-containing protein 54PRO_0000051415Add
BLAST

Proteomic databases

MaxQBiQ9H977.
PaxDbiQ9H977.
PRIDEiQ9H977.

PTM databases

PhosphoSiteiQ9H977.

Expressioni

Gene expression databases

BgeeiQ9H977.
CleanExiHS_WDR54.
ExpressionAtlasiQ9H977. baseline and differential.
GenevestigatoriQ9H977.

Organism-specific databases

HPAiHPA043257.
HPA053558.

Interactioni

Protein-protein interaction databases

BioGridi123853. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9H977.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati116 – 15540WD 1Add
BLAST
Repeati162 – 20645WD 2Add
BLAST
Repeati208 – 24740WD 3Add
BLAST
Repeati250 – 28940WD 4Add
BLAST

Sequence similaritiesi

Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG43745.
GeneTreeiENSGT00390000014530.
HOGENOMiHOG000007356.
HOVERGENiHBG061221.
InParanoidiQ9H977.
OMAiPITDIAT.
PhylomeDBiQ9H977.
TreeFamiTF329316.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H977-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFRWERSIPL RGSAAALCNN LSVLQLPARN LTYFGVVHGP SAQLLSAAPE
60 70 80 90 100
GVPLAQRQLH AKEGAGVSPP LITQVHWCVL PFRVLLVLTS HRGIQMYESN
110 120 130 140 150
GYTMVYWHAL DSGDASPVQA VFARGIAASG HFICVGTWSG RVLVFDIPAK
160 170 180 190 200
GPNIVLSEEL AGHQMPITDI ATEPAQGQDC VADMVTADDS GLLCVWRSGP
210 220 230 240 250
EFTLLTRIPG FGVPCPSVQL WQGIIAAGYG NGQVHLYEAT TGNLHVQINA
260 270 280 290 300
HARAICALDL ASEVGKLLSA GEDTFVHIWK LSRNPESGYI EVEHCHGECV
310 320 330
ADTQLCGARF CDSSGNSFAV TGYDLAEIRR FSSV
Length:334
Mass (Da):35,891
Last modified:March 1, 2001 - v1
Checksum:iF0B10168F9C84D34
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti243 – 2431N → D in BAD96416. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK023015 mRNA. Translation: BAB14358.1.
AK222696 mRNA. Translation: BAD96416.1.
CH471053 Genomic DNA. Translation: EAW99677.1.
CH471053 Genomic DNA. Translation: EAW99680.1.
BC051848 mRNA. Translation: AAH51848.1.
CCDSiCCDS1940.1.
RefSeqiNP_115494.1. NM_032118.2.
XP_005264643.1. XM_005264586.1.
UniGeneiHs.643480.

Genome annotation databases

EnsembliENST00000348227; ENSP00000006526; ENSG00000005448.
GeneIDi84058.
KEGGihsa:84058.
UCSCiuc002slb.3. human.

Polymorphism databases

DMDMi74761551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK023015 mRNA. Translation: BAB14358.1 .
AK222696 mRNA. Translation: BAD96416.1 .
CH471053 Genomic DNA. Translation: EAW99677.1 .
CH471053 Genomic DNA. Translation: EAW99680.1 .
BC051848 mRNA. Translation: AAH51848.1 .
CCDSi CCDS1940.1.
RefSeqi NP_115494.1. NM_032118.2.
XP_005264643.1. XM_005264586.1.
UniGenei Hs.643480.

3D structure databases

ProteinModelPortali Q9H977.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123853. 6 interactions.

PTM databases

PhosphoSitei Q9H977.

Polymorphism databases

DMDMi 74761551.

Proteomic databases

MaxQBi Q9H977.
PaxDbi Q9H977.
PRIDEi Q9H977.

Protocols and materials databases

DNASUi 84058.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000348227 ; ENSP00000006526 ; ENSG00000005448 .
GeneIDi 84058.
KEGGi hsa:84058.
UCSCi uc002slb.3. human.

Organism-specific databases

CTDi 84058.
GeneCardsi GC02P074648.
HGNCi HGNC:25770. WDR54.
HPAi HPA043257.
HPA053558.
neXtProti NX_Q9H977.
PharmGKBi PA142670589.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43745.
GeneTreei ENSGT00390000014530.
HOGENOMi HOG000007356.
HOVERGENi HBG061221.
InParanoidi Q9H977.
OMAi PITDIAT.
PhylomeDBi Q9H977.
TreeFami TF329316.

Enzyme and pathway databases

SignaLinki Q9H977.

Miscellaneous databases

ChiTaRSi WDR54. human.
GenomeRNAii 84058.
NextBioi 73203.
PROi Q9H977.

Gene expression databases

Bgeei Q9H977.
CleanExi HS_WDR54.
ExpressionAtlasi Q9H977. baseline and differential.
Genevestigatori Q9H977.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 3 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  5. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiWDR54_HUMAN
AccessioniPrimary (citable) accession number: Q9H977
Secondary accession number(s): D6W5I3, Q53H85, Q86V45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3