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Q9H977

- WDR54_HUMAN

UniProt

Q9H977 - WDR54_HUMAN

Protein

WD repeat-containing protein 54

Gene

WDR54

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    SignaLinkiQ9H977.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WD repeat-containing protein 54
    Gene namesi
    Name:WDR54
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:25770. WDR54.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670589.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 334334WD repeat-containing protein 54PRO_0000051415Add
    BLAST

    Proteomic databases

    MaxQBiQ9H977.
    PaxDbiQ9H977.
    PRIDEiQ9H977.

    PTM databases

    PhosphoSiteiQ9H977.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H977.
    BgeeiQ9H977.
    CleanExiHS_WDR54.
    GenevestigatoriQ9H977.

    Organism-specific databases

    HPAiHPA043257.
    HPA053558.

    Interactioni

    Protein-protein interaction databases

    BioGridi123853. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H977.
    SMRiQ9H977. Positions 84-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati116 – 15540WD 1Add
    BLAST
    Repeati162 – 20645WD 2Add
    BLAST
    Repeati208 – 24740WD 3Add
    BLAST
    Repeati250 – 28940WD 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG43745.
    HOGENOMiHOG000007356.
    HOVERGENiHBG061221.
    InParanoidiQ9H977.
    OMAiPITDIAT.
    PhylomeDBiQ9H977.
    TreeFamiTF329316.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 1 hit.
    [Graphical view]
    SMARTiSM00320. WD40. 3 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H977-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFRWERSIPL RGSAAALCNN LSVLQLPARN LTYFGVVHGP SAQLLSAAPE    50
    GVPLAQRQLH AKEGAGVSPP LITQVHWCVL PFRVLLVLTS HRGIQMYESN 100
    GYTMVYWHAL DSGDASPVQA VFARGIAASG HFICVGTWSG RVLVFDIPAK 150
    GPNIVLSEEL AGHQMPITDI ATEPAQGQDC VADMVTADDS GLLCVWRSGP 200
    EFTLLTRIPG FGVPCPSVQL WQGIIAAGYG NGQVHLYEAT TGNLHVQINA 250
    HARAICALDL ASEVGKLLSA GEDTFVHIWK LSRNPESGYI EVEHCHGECV 300
    ADTQLCGARF CDSSGNSFAV TGYDLAEIRR FSSV 334
    Length:334
    Mass (Da):35,891
    Last modified:March 1, 2001 - v1
    Checksum:iF0B10168F9C84D34
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti243 – 2431N → D in BAD96416. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023015 mRNA. Translation: BAB14358.1.
    AK222696 mRNA. Translation: BAD96416.1.
    CH471053 Genomic DNA. Translation: EAW99677.1.
    CH471053 Genomic DNA. Translation: EAW99680.1.
    BC051848 mRNA. Translation: AAH51848.1.
    CCDSiCCDS1940.1.
    RefSeqiNP_115494.1. NM_032118.2.
    XP_005264643.1. XM_005264586.1.
    UniGeneiHs.643480.

    Genome annotation databases

    EnsembliENST00000348227; ENSP00000006526; ENSG00000005448.
    GeneIDi84058.
    KEGGihsa:84058.
    UCSCiuc002slb.3. human.

    Polymorphism databases

    DMDMi74761551.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023015 mRNA. Translation: BAB14358.1 .
    AK222696 mRNA. Translation: BAD96416.1 .
    CH471053 Genomic DNA. Translation: EAW99677.1 .
    CH471053 Genomic DNA. Translation: EAW99680.1 .
    BC051848 mRNA. Translation: AAH51848.1 .
    CCDSi CCDS1940.1.
    RefSeqi NP_115494.1. NM_032118.2.
    XP_005264643.1. XM_005264586.1.
    UniGenei Hs.643480.

    3D structure databases

    ProteinModelPortali Q9H977.
    SMRi Q9H977. Positions 84-148.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123853. 1 interaction.

    PTM databases

    PhosphoSitei Q9H977.

    Polymorphism databases

    DMDMi 74761551.

    Proteomic databases

    MaxQBi Q9H977.
    PaxDbi Q9H977.
    PRIDEi Q9H977.

    Protocols and materials databases

    DNASUi 84058.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000348227 ; ENSP00000006526 ; ENSG00000005448 .
    GeneIDi 84058.
    KEGGi hsa:84058.
    UCSCi uc002slb.3. human.

    Organism-specific databases

    CTDi 84058.
    GeneCardsi GC02P074648.
    HGNCi HGNC:25770. WDR54.
    HPAi HPA043257.
    HPA053558.
    neXtProti NX_Q9H977.
    PharmGKBi PA142670589.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43745.
    HOGENOMi HOG000007356.
    HOVERGENi HBG061221.
    InParanoidi Q9H977.
    OMAi PITDIAT.
    PhylomeDBi Q9H977.
    TreeFami TF329316.

    Enzyme and pathway databases

    SignaLinki Q9H977.

    Miscellaneous databases

    ChiTaRSi WDR54. human.
    GenomeRNAii 84058.
    NextBioi 73203.
    PROi Q9H977.

    Gene expression databases

    ArrayExpressi Q9H977.
    Bgeei Q9H977.
    CleanExi HS_WDR54.
    Genevestigatori Q9H977.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 1 hit.
    [Graphical view ]
    SMARTi SM00320. WD40. 3 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    5. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiWDR54_HUMAN
    AccessioniPrimary (citable) accession number: Q9H977
    Secondary accession number(s): D6W5I3, Q53H85, Q86V45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3