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Protein

WD repeat-containing protein 54

Gene

WDR54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ9H977.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 54
Gene namesi
Name:WDR54
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000005448.16.
HGNCiHGNC:25770. WDR54.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000005448.
PharmGKBiPA142670589.

Polymorphism and mutation databases

BioMutaiWDR54.
DMDMi74761551.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514151 – 334WD repeat-containing protein 54Add BLAST334

Proteomic databases

EPDiQ9H977.
MaxQBiQ9H977.
PaxDbiQ9H977.
PeptideAtlasiQ9H977.
PRIDEiQ9H977.

PTM databases

iPTMnetiQ9H977.
PhosphoSitePlusiQ9H977.

Expressioni

Gene expression databases

BgeeiENSG00000005448.
CleanExiHS_WDR54.
ExpressionAtlasiQ9H977. baseline and differential.
GenevisibleiQ9H977. HS.

Organism-specific databases

HPAiHPA043257.
HPA053558.

Interactioni

Protein-protein interaction databases

BioGridi123853. 33 interactors.
IntActiQ9H977. 2 interactors.
STRINGi9606.ENSP00000006526.

Structurei

3D structure databases

ProteinModelPortaliQ9H977.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 47WD 1Add BLAST42
Repeati58 – 99WD 2Add BLAST42
Repeati105 – 147WD 3Add BLAST43
Repeati155 – 198WD 4Add BLAST44
Repeati243 – 281WD 5Add BLAST39
Repeati289 – 333WD 6Add BLAST45

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IHHY. Eukaryota.
ENOG410XS69. LUCA.
GeneTreeiENSGT00390000014530.
HOGENOMiHOG000007356.
HOVERGENiHBG061221.
InParanoidiQ9H977.
OMAiTQLCGAR.
OrthoDBiEOG091G0FN3.
PhylomeDBiQ9H977.
TreeFamiTF329316.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiView protein in InterPro
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
IPR036322. WD40_repeat_dom_sf.
SMARTiView protein in SMART
SM00320. WD40. 3 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRWERSIPL RGSAAALCNN LSVLQLPARN LTYFGVVHGP SAQLLSAAPE
60 70 80 90 100
GVPLAQRQLH AKEGAGVSPP LITQVHWCVL PFRVLLVLTS HRGIQMYESN
110 120 130 140 150
GYTMVYWHAL DSGDASPVQA VFARGIAASG HFICVGTWSG RVLVFDIPAK
160 170 180 190 200
GPNIVLSEEL AGHQMPITDI ATEPAQGQDC VADMVTADDS GLLCVWRSGP
210 220 230 240 250
EFTLLTRIPG FGVPCPSVQL WQGIIAAGYG NGQVHLYEAT TGNLHVQINA
260 270 280 290 300
HARAICALDL ASEVGKLLSA GEDTFVHIWK LSRNPESGYI EVEHCHGECV
310 320 330
ADTQLCGARF CDSSGNSFAV TGYDLAEIRR FSSV
Length:334
Mass (Da):35,891
Last modified:March 1, 2001 - v1
Checksum:iF0B10168F9C84D34
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti243N → D in BAD96416 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023015 mRNA. Translation: BAB14358.1.
AK222696 mRNA. Translation: BAD96416.1.
CH471053 Genomic DNA. Translation: EAW99677.1.
CH471053 Genomic DNA. Translation: EAW99680.1.
BC051848 mRNA. Translation: AAH51848.1.
CCDSiCCDS1940.1.
RefSeqiNP_001307752.1. NM_001320823.1.
NP_001307753.1. NM_001320824.1.
NP_001307754.1. NM_001320825.1.
NP_115494.1. NM_032118.3.
UniGeneiHs.643480.

Genome annotation databases

EnsembliENST00000348227; ENSP00000006526; ENSG00000005448.
GeneIDi84058.
KEGGihsa:84058.
UCSCiuc002slb.4. human.

Similar proteinsi

Entry informationi

Entry nameiWDR54_HUMAN
AccessioniPrimary (citable) accession number: Q9H977
Secondary accession number(s): D6W5I3, Q53H85, Q86V45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2001
Last modified: November 22, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM