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Q9H974

- QTRD1_HUMAN

UniProt

Q9H974 - QTRD1_HUMAN

Protein

Queuine tRNA-ribosyltransferase subunit QTRTD1

Gene

QTRTD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Interacts with QTRT1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GUN anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).UniRule annotation

    Catalytic activityi

    Guanine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei272 – 2721NucleophileUniRule annotation
    Metal bindingi351 – 3511ZincUniRule annotation
    Metal bindingi353 – 3531ZincUniRule annotation
    Metal bindingi356 – 3561ZincUniRule annotation
    Metal bindingi382 – 3821ZincUniRule annotation

    GO - Molecular functioni

    1. queuine tRNA-ribosyltransferase activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. queuosine biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Queuosine biosynthesis, tRNA processing

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00392.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Queuine tRNA-ribosyltransferase subunit QTRTD1UniRule annotation (EC:2.4.2.29UniRule annotation)
    Alternative name(s):
    Queuine tRNA-ribosyltransferase domain-containing protein 1UniRule annotation
    Gene namesi
    Name:QTRTD1UniRule annotation
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:25771. QTRTD1.

    Subcellular locationi

    Cytoplasm UniRule annotation. Mitochondrion UniRule annotation
    Note: May associate with the mitochondrion outer membrane.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134925851.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 415415Queuine tRNA-ribosyltransferase subunit QTRTD1PRO_0000295633Add
    BLAST

    Proteomic databases

    MaxQBiQ9H974.
    PaxDbiQ9H974.
    PRIDEiQ9H974.

    PTM databases

    PhosphoSiteiQ9H974.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H974.
    BgeeiQ9H974.
    CleanExiHS_QTRTD1.
    GenevestigatoriQ9H974.

    Organism-specific databases

    HPAiHPA036827.
    HPA036828.

    Interactioni

    Subunit structurei

    Interacts with QTRT1.UniRule annotation

    Protein-protein interaction databases

    BioGridi122812. 7 interactions.
    IntActiQ9H974. 3 interactions.
    STRINGi9606.ENSP00000281273.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H974.
    SMRiQ9H974. Positions 70-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the queuine tRNA-ribosyltransferase family. QTRTD1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0343.
    HOGENOMiHOG000243329.
    HOVERGENiHBG057274.
    InParanoidiQ9H974.
    KOiK15407.
    OMAiMHNFEHY.
    PhylomeDBiQ9H974.
    TreeFamiTF317105.

    Family and domain databases

    Gene3Di3.20.20.105. 2 hits.
    HAMAPiMF_03043. QTRD1.
    InterProiIPR028592. QTRTD1.
    IPR002616. tRNA_ribo_trans-like.
    [Graphical view]
    PANTHERiPTHR11962. PTHR11962. 1 hit.
    PfamiPF01702. TGT. 1 hit.
    [Graphical view]
    SUPFAMiSSF51713. SSF51713. 2 hits.
    TIGRFAMsiTIGR00449. tgt_general. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H974-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKLSLTKVVN GCRLGKIKNL GKTGDHTMDI PGCLLYTKTG SAPHLTHHTL    50
    HNIHGVPAMA QLTLSSLAEH HEVLTEYKEG VGKFIGMPES LLYCSLHDPV 100
    SPCPAGYVTN KSVSVWSVAG RVEMTVSKFM AIQKALQPDW FQCLSDGEVS 150
    CKEATSIKRV RKSVDRSLLF LDNCLRLQEE SEVLQKSVII GVIEGGDVME 200
    ERLRSARETA KRPVGGFLLD GFQGNPTTLE ARLRLLSSVT AELPEDKPRL 250
    ISGVSRPDEV LECIERGVDL FESFFPYQVT ERGCALTFSF DYQPNPEETL 300
    LQQNGTQEEI KCMDQIKKIE TTGCNQEITS FEINLKEKKY QEDFNPLVRG 350
    CSCYCCKNHT RAYIHHLLVT NELLAGVLLM MHNFEHYFGF FHYIREALKS 400
    DKLAQLKELI HRQAS 415
    Length:415
    Mass (Da):46,713
    Last modified:March 1, 2001 - v1
    Checksum:iC9447FD900DD667B
    GO
    Isoform 2 (identifier: Q9H974-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-123: Missing.

    Show »
    Length:292
    Mass (Da):33,471
    Checksum:iDCFC6BF2B6F7C601
    GO
    Isoform 3 (identifier: Q9H974-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-111: MKLSLTKVVN...PCPAGYVTNK → MVCWQ

    Show »
    Length:309
    Mass (Da):35,377
    Checksum:iA2A2F97FE37E120D
    GO
    Isoform 4 (identifier: Q9H974-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MVCWQDLEESLRM

    Note: No experimental confirmation available.

    Show »
    Length:427
    Mass (Da):48,203
    Checksum:i3D4B55C405EDDAD5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti246 – 2461D → G in CAG33577. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 123123Missing in isoform 2. 1 PublicationVSP_045140Add
    BLAST
    Alternative sequencei1 – 111111MKLSL…YVTNK → MVCWQ in isoform 3. 1 PublicationVSP_045141Add
    BLAST
    Alternative sequencei1 – 11M → MVCWQDLEESLRM in isoform 4. 1 PublicationVSP_046859

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023022 mRNA. Translation: BAB14361.1.
    AK296938 mRNA. Translation: BAH12458.1.
    AK299313 mRNA. Translation: BAH12998.1.
    CR457296 mRNA. Translation: CAG33577.1.
    AL833709 mRNA. No translation available.
    AC092896 Genomic DNA. No translation available.
    AC128687 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79613.1.
    BC034559 mRNA. Translation: AAH34559.1.
    BC039265 mRNA. Translation: AAH39265.1.
    CCDSiCCDS33828.1. [Q9H974-1]
    CCDS58844.1. [Q9H974-4]
    CCDS58845.1. [Q9H974-3]
    CCDS58846.1. [Q9H974-2]
    RefSeqiNP_001243764.1. NM_001256835.1. [Q9H974-4]
    NP_001243765.1. NM_001256836.1. [Q9H974-3]
    NP_001243766.1. NM_001256837.1. [Q9H974-2]
    NP_078914.1. NM_024638.3. [Q9H974-1]
    XP_005247827.1. XM_005247770.1. [Q9H974-2]
    UniGeneiHs.477162.

    Genome annotation databases

    EnsembliENST00000281273; ENSP00000281273; ENSG00000151576. [Q9H974-1]
    ENST00000479882; ENSP00000418056; ENSG00000151576. [Q9H974-2]
    ENST00000485050; ENSP00000420682; ENSG00000151576. [Q9H974-4]
    ENST00000493014; ENSP00000419169; ENSG00000151576. [Q9H974-3]
    GeneIDi79691.
    KEGGihsa:79691.
    UCSCiuc003eay.4. human. [Q9H974-1]
    uc011bir.3. human.

    Polymorphism databases

    DMDMi74752736.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023022 mRNA. Translation: BAB14361.1 .
    AK296938 mRNA. Translation: BAH12458.1 .
    AK299313 mRNA. Translation: BAH12998.1 .
    CR457296 mRNA. Translation: CAG33577.1 .
    AL833709 mRNA. No translation available.
    AC092896 Genomic DNA. No translation available.
    AC128687 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79613.1 .
    BC034559 mRNA. Translation: AAH34559.1 .
    BC039265 mRNA. Translation: AAH39265.1 .
    CCDSi CCDS33828.1. [Q9H974-1 ]
    CCDS58844.1. [Q9H974-4 ]
    CCDS58845.1. [Q9H974-3 ]
    CCDS58846.1. [Q9H974-2 ]
    RefSeqi NP_001243764.1. NM_001256835.1. [Q9H974-4 ]
    NP_001243765.1. NM_001256836.1. [Q9H974-3 ]
    NP_001243766.1. NM_001256837.1. [Q9H974-2 ]
    NP_078914.1. NM_024638.3. [Q9H974-1 ]
    XP_005247827.1. XM_005247770.1. [Q9H974-2 ]
    UniGenei Hs.477162.

    3D structure databases

    ProteinModelPortali Q9H974.
    SMRi Q9H974. Positions 70-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122812. 7 interactions.
    IntActi Q9H974. 3 interactions.
    STRINGi 9606.ENSP00000281273.

    PTM databases

    PhosphoSitei Q9H974.

    Polymorphism databases

    DMDMi 74752736.

    Proteomic databases

    MaxQBi Q9H974.
    PaxDbi Q9H974.
    PRIDEi Q9H974.

    Protocols and materials databases

    DNASUi 79691.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000281273 ; ENSP00000281273 ; ENSG00000151576 . [Q9H974-1 ]
    ENST00000479882 ; ENSP00000418056 ; ENSG00000151576 . [Q9H974-2 ]
    ENST00000485050 ; ENSP00000420682 ; ENSG00000151576 . [Q9H974-4 ]
    ENST00000493014 ; ENSP00000419169 ; ENSG00000151576 . [Q9H974-3 ]
    GeneIDi 79691.
    KEGGi hsa:79691.
    UCSCi uc003eay.4. human. [Q9H974-1 ]
    uc011bir.3. human.

    Organism-specific databases

    CTDi 79691.
    GeneCardsi GC03P113724.
    HGNCi HGNC:25771. QTRTD1.
    HPAi HPA036827.
    HPA036828.
    neXtProti NX_Q9H974.
    PharmGKBi PA134925851.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0343.
    HOGENOMi HOG000243329.
    HOVERGENi HBG057274.
    InParanoidi Q9H974.
    KOi K15407.
    OMAi MHNFEHY.
    PhylomeDBi Q9H974.
    TreeFami TF317105.

    Enzyme and pathway databases

    UniPathwayi UPA00392 .

    Miscellaneous databases

    GenomeRNAii 79691.
    NextBioi 35535501.
    PROi Q9H974.

    Gene expression databases

    ArrayExpressi Q9H974.
    Bgeei Q9H974.
    CleanExi HS_QTRTD1.
    Genevestigatori Q9H974.

    Family and domain databases

    Gene3Di 3.20.20.105. 2 hits.
    HAMAPi MF_03043. QTRD1.
    InterProi IPR028592. QTRTD1.
    IPR002616. tRNA_ribo_trans-like.
    [Graphical view ]
    PANTHERi PTHR11962. PTHR11962. 1 hit.
    Pfami PF01702. TGT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51713. SSF51713. 2 hits.
    TIGRFAMsi TIGR00449. tgt_general. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Tongue.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Lymph node.
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lymph and Testis.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiQTRD1_HUMAN
    AccessioniPrimary (citable) accession number: Q9H974
    Secondary accession number(s): A6NGE9
    , B7Z472, B7Z5R2, J3KR78, Q6IA59
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3