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Protein

Uncharacterized protein C14orf93

Gene

C14orf93

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C14orf93
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100802.14
HGNCiHGNC:20162 C14orf93
neXtProtiNX_Q9H972

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100802
PharmGKBiPA134982493

Polymorphism and mutation databases

DMDMi33301115

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002095018 – 538Uncharacterized protein C14orf93Add BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki128Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki221Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei224PhosphoserineCombined sources1
Modified residuei285PhosphoserineCombined sources1
Modified residuei428PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9H972
PaxDbiQ9H972
PeptideAtlasiQ9H972
PRIDEiQ9H972

PTM databases

iPTMnetiQ9H972
PhosphoSitePlusiQ9H972

Expressioni

Gene expression databases

BgeeiENSG00000100802
CleanExiHS_C14orf93
ExpressionAtlasiQ9H972 baseline and differential
GenevisibleiQ9H972 HS

Organism-specific databases

HPAiHPA002569

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121959, 5 interactors
IntActiQ9H972, 4 interactors
MINTiQ9H972
STRINGi9606.ENSP00000299088

Structurei

3D structure databases

ProteinModelPortaliQ9H972
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi19 – 24Poly-Cys6
Compositional biasi257 – 260Poly-Ala4

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II26 Eukaryota
ENOG410YVIZ LUCA
GeneTreeiENSGT00390000012708
HOVERGENiHBG051014
InParanoidiQ9H972
OMAiKCCCCAC
OrthoDBiEOG091G0ALI
PhylomeDBiQ9H972
TreeFamiTF336941

Family and domain databases

InterProiView protein in InterPro
IPR028101 DUF4616
PANTHERiPTHR14375 PTHR14375, 1 hit
PfamiView protein in Pfam
PF15394 DUF4616, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H972-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFSATILFS PPSGSEARCC CCACKSETNG GNTGSQGGNP PPSTPITVTG
60 70 80 90 100
HGLAVQSSEQ LLHVIYQRVD KAVGLAEAAL GLARANNELL KRLQEEVGDL
110 120 130 140 150
RQGKVSIPDE DGESRAHSSP PEEPGPLKES PGEAFKALSA VEEECDSVGS
160 170 180 190 200
GVQVVIEELR QLGAASVGPG PLGFPATQRD MRLPGCTLAA SEAAPLLNPL
210 220 230 240 250
VDDYVASEGA VQRVLVPAYA KQLSPATQLA IQRATPETGP ENGTKLPPPR
260 270 280 290 300
PEDMLNAAAA LDSALEESGP GSTGELRHSL GLTVSPCRTR GSGQKNSRRK
310 320 330 340 350
RDLVLSKLVH NVHNHITNDK RFNGSESIKS SWNISVVKFL LEKLKQELVT
360 370 380 390 400
SPHNYTDKEL KGACVAYFLT KRREYRNSLN PFKGLKEKEE KKLRSRRYRL
410 420 430 440 450
FANRSSIMRH FGPEDQRLWN DVTEELMSDE EDSLNEPGVW VARPPRFRAQ
460 470 480 490 500
RLTELCYHLD ANSKHGTKAN RVYGPPSDRL PSAEAQLLPP ELYNPNFQEE
510 520 530
EDEGGDENAP GSPSFDQPHK TCCPDLNSFI EIKVEKDE
Length:538
Mass (Da):58,697
Last modified:March 1, 2001 - v1
Checksum:i0F4B47ABCC3F960C
GO
Isoform 2 (identifier: Q9H972-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-477: Missing.

Note: No experimental confirmation available.
Show »
Length:498
Mass (Da):54,165
Checksum:i89FCD64BA7DBDE23
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti394R → L in AAH14299 (PubMed:15489334).Curated1
Sequence conflicti438G → S in BAB13988 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050875190A → V. Corresponds to variant dbSNP:rs3829409Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007850438 – 477Missing in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023026 mRNA Translation: BAB14363.1
AK022216 mRNA Translation: BAB13988.1
BX161383 mRNA Translation: CAD61874.1
BX161417 mRNA Translation: CAD61892.1
BX161474 mRNA Translation: CAD61930.1
BX161507 mRNA Translation: CAD61946.1
AL132780 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66196.1
CH471078 Genomic DNA Translation: EAW66198.1
CH471078 Genomic DNA Translation: EAW66199.1
CH471078 Genomic DNA Translation: EAW66200.1
CH471078 Genomic DNA Translation: EAW66201.1
CH471078 Genomic DNA Translation: EAW66202.1
CH471078 Genomic DNA Translation: EAW66203.1
BC014299 mRNA Translation: AAH14299.1
CCDSiCCDS61400.1 [Q9H972-2]
CCDS9583.1 [Q9H972-1]
RefSeqiNP_001124178.1, NM_001130706.2 [Q9H972-1]
NP_001124180.1, NM_001130708.2 [Q9H972-1]
NP_001269897.1, NM_001282968.1
NP_001269898.1, NM_001282969.1
NP_001269899.1, NM_001282970.1 [Q9H972-2]
NP_068763.2, NM_021944.3 [Q9H972-1]
XP_005268028.1, XM_005267971.1 [Q9H972-1]
XP_005268029.1, XM_005267972.1 [Q9H972-1]
XP_006720294.1, XM_006720231.1
XP_006720295.1, XM_006720232.2
XP_011535361.1, XM_011537059.1 [Q9H972-1]
XP_011535362.1, XM_011537060.2 [Q9H972-1]
XP_011535364.1, XM_011537062.1 [Q9H972-1]
XP_016877058.1, XM_017021569.1 [Q9H972-1]
XP_016877059.1, XM_017021570.1 [Q9H972-1]
XP_016877060.1, XM_017021571.1 [Q9H972-1]
XP_016877061.1, XM_017021572.1 [Q9H972-1]
XP_016877062.1, XM_017021573.1 [Q9H972-1]
XP_016877063.1, XM_017021574.1 [Q9H972-1]
XP_016877064.1, XM_017021575.1
XP_016877065.1, XM_017021576.1
XP_016877066.1, XM_017021577.1
UniGeneiHs.255874

Genome annotation databases

EnsembliENST00000299088; ENSP00000299088; ENSG00000100802 [Q9H972-1]
ENST00000341470; ENSP00000341353; ENSG00000100802 [Q9H972-2]
ENST00000397379; ENSP00000380535; ENSG00000100802 [Q9H972-1]
ENST00000397382; ENSP00000380538; ENSG00000100802 [Q9H972-1]
GeneIDi60686
KEGGihsa:60686
UCSCiuc001wia.6 human [Q9H972-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCN093_HUMAN
AccessioniPrimary (citable) accession number: Q9H972
Secondary accession number(s): B7WP03
, D3DS38, D3DS39, Q86SE6, Q96CF7, Q9HA68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health