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Protein

Uncharacterized protein C14orf93

Gene

C14orf93

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C14orf93
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20162. C14orf93.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100802.
PharmGKBiPA134982493.

Polymorphism and mutation databases

DMDMi33301115.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002095018 – 538Uncharacterized protein C14orf93Add BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei224PhosphoserineCombined sources1
Modified residuei285PhosphoserineCombined sources1
Modified residuei428PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H972.
PaxDbiQ9H972.
PeptideAtlasiQ9H972.
PRIDEiQ9H972.

PTM databases

iPTMnetiQ9H972.
PhosphoSitePlusiQ9H972.

Expressioni

Gene expression databases

BgeeiENSG00000100802.
CleanExiHS_C14orf93.
ExpressionAtlasiQ9H972. baseline and differential.
GenevisibleiQ9H972. HS.

Organism-specific databases

HPAiHPA002569.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MRFAP1Q9Y6053EBI-10329620,EBI-995714

Protein-protein interaction databases

BioGridi121959. 5 interactors.
IntActiQ9H972. 3 interactors.
STRINGi9606.ENSP00000299088.

Structurei

3D structure databases

ProteinModelPortaliQ9H972.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi19 – 24Poly-Cys6
Compositional biasi257 – 260Poly-Ala4

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II26. Eukaryota.
ENOG410YVIZ. LUCA.
GeneTreeiENSGT00390000012708.
HOVERGENiHBG051014.
InParanoidiQ9H972.
OMAiKCCCCAC.
OrthoDBiEOG091G0ALI.
PhylomeDBiQ9H972.
TreeFamiTF336941.

Family and domain databases

InterProiIPR028101. DUF4616.
[Graphical view]
PANTHERiPTHR14375. PTHR14375. 1 hit.
PfamiPF15394. DUF4616. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H972-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFSATILFS PPSGSEARCC CCACKSETNG GNTGSQGGNP PPSTPITVTG
60 70 80 90 100
HGLAVQSSEQ LLHVIYQRVD KAVGLAEAAL GLARANNELL KRLQEEVGDL
110 120 130 140 150
RQGKVSIPDE DGESRAHSSP PEEPGPLKES PGEAFKALSA VEEECDSVGS
160 170 180 190 200
GVQVVIEELR QLGAASVGPG PLGFPATQRD MRLPGCTLAA SEAAPLLNPL
210 220 230 240 250
VDDYVASEGA VQRVLVPAYA KQLSPATQLA IQRATPETGP ENGTKLPPPR
260 270 280 290 300
PEDMLNAAAA LDSALEESGP GSTGELRHSL GLTVSPCRTR GSGQKNSRRK
310 320 330 340 350
RDLVLSKLVH NVHNHITNDK RFNGSESIKS SWNISVVKFL LEKLKQELVT
360 370 380 390 400
SPHNYTDKEL KGACVAYFLT KRREYRNSLN PFKGLKEKEE KKLRSRRYRL
410 420 430 440 450
FANRSSIMRH FGPEDQRLWN DVTEELMSDE EDSLNEPGVW VARPPRFRAQ
460 470 480 490 500
RLTELCYHLD ANSKHGTKAN RVYGPPSDRL PSAEAQLLPP ELYNPNFQEE
510 520 530
EDEGGDENAP GSPSFDQPHK TCCPDLNSFI EIKVEKDE
Length:538
Mass (Da):58,697
Last modified:March 1, 2001 - v1
Checksum:i0F4B47ABCC3F960C
GO
Isoform 2 (identifier: Q9H972-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-477: Missing.

Note: No experimental confirmation available.
Show »
Length:498
Mass (Da):54,165
Checksum:i89FCD64BA7DBDE23
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti394R → L in AAH14299 (PubMed:15489334).Curated1
Sequence conflicti438G → S in BAB13988 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050875190A → V.Corresponds to variant rs3829409dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007850438 – 477Missing in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023026 mRNA. Translation: BAB14363.1.
AK022216 mRNA. Translation: BAB13988.1.
BX161383 mRNA. Translation: CAD61874.1.
BX161417 mRNA. Translation: CAD61892.1.
BX161474 mRNA. Translation: CAD61930.1.
BX161507 mRNA. Translation: CAD61946.1.
AL132780 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66196.1.
CH471078 Genomic DNA. Translation: EAW66198.1.
CH471078 Genomic DNA. Translation: EAW66199.1.
CH471078 Genomic DNA. Translation: EAW66200.1.
CH471078 Genomic DNA. Translation: EAW66201.1.
CH471078 Genomic DNA. Translation: EAW66202.1.
CH471078 Genomic DNA. Translation: EAW66203.1.
BC014299 mRNA. Translation: AAH14299.1.
CCDSiCCDS61400.1. [Q9H972-2]
CCDS9583.1. [Q9H972-1]
RefSeqiNP_001124178.1. NM_001130706.2. [Q9H972-1]
NP_001124180.1. NM_001130708.2. [Q9H972-1]
NP_001269897.1. NM_001282968.1.
NP_001269898.1. NM_001282969.1.
NP_001269899.1. NM_001282970.1. [Q9H972-2]
NP_068763.2. NM_021944.3. [Q9H972-1]
XP_005268028.1. XM_005267971.1. [Q9H972-1]
XP_005268029.1. XM_005267972.1. [Q9H972-1]
XP_006720294.1. XM_006720231.1.
XP_006720295.1. XM_006720232.2.
XP_011535361.1. XM_011537059.1. [Q9H972-1]
XP_011535362.1. XM_011537060.2. [Q9H972-1]
XP_011535364.1. XM_011537062.1. [Q9H972-1]
XP_016877058.1. XM_017021569.1. [Q9H972-1]
XP_016877059.1. XM_017021570.1. [Q9H972-1]
XP_016877060.1. XM_017021571.1. [Q9H972-1]
XP_016877061.1. XM_017021572.1. [Q9H972-1]
XP_016877062.1. XM_017021573.1. [Q9H972-1]
XP_016877063.1. XM_017021574.1. [Q9H972-1]
XP_016877064.1. XM_017021575.1.
XP_016877065.1. XM_017021576.1.
XP_016877066.1. XM_017021577.1.
UniGeneiHs.255874.

Genome annotation databases

EnsembliENST00000299088; ENSP00000299088; ENSG00000100802. [Q9H972-1]
ENST00000341470; ENSP00000341353; ENSG00000100802. [Q9H972-2]
ENST00000397379; ENSP00000380535; ENSG00000100802. [Q9H972-1]
ENST00000397382; ENSP00000380538; ENSG00000100802. [Q9H972-1]
GeneIDi60686.
KEGGihsa:60686.
UCSCiuc001wia.6. human. [Q9H972-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023026 mRNA. Translation: BAB14363.1.
AK022216 mRNA. Translation: BAB13988.1.
BX161383 mRNA. Translation: CAD61874.1.
BX161417 mRNA. Translation: CAD61892.1.
BX161474 mRNA. Translation: CAD61930.1.
BX161507 mRNA. Translation: CAD61946.1.
AL132780 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66196.1.
CH471078 Genomic DNA. Translation: EAW66198.1.
CH471078 Genomic DNA. Translation: EAW66199.1.
CH471078 Genomic DNA. Translation: EAW66200.1.
CH471078 Genomic DNA. Translation: EAW66201.1.
CH471078 Genomic DNA. Translation: EAW66202.1.
CH471078 Genomic DNA. Translation: EAW66203.1.
BC014299 mRNA. Translation: AAH14299.1.
CCDSiCCDS61400.1. [Q9H972-2]
CCDS9583.1. [Q9H972-1]
RefSeqiNP_001124178.1. NM_001130706.2. [Q9H972-1]
NP_001124180.1. NM_001130708.2. [Q9H972-1]
NP_001269897.1. NM_001282968.1.
NP_001269898.1. NM_001282969.1.
NP_001269899.1. NM_001282970.1. [Q9H972-2]
NP_068763.2. NM_021944.3. [Q9H972-1]
XP_005268028.1. XM_005267971.1. [Q9H972-1]
XP_005268029.1. XM_005267972.1. [Q9H972-1]
XP_006720294.1. XM_006720231.1.
XP_006720295.1. XM_006720232.2.
XP_011535361.1. XM_011537059.1. [Q9H972-1]
XP_011535362.1. XM_011537060.2. [Q9H972-1]
XP_011535364.1. XM_011537062.1. [Q9H972-1]
XP_016877058.1. XM_017021569.1. [Q9H972-1]
XP_016877059.1. XM_017021570.1. [Q9H972-1]
XP_016877060.1. XM_017021571.1. [Q9H972-1]
XP_016877061.1. XM_017021572.1. [Q9H972-1]
XP_016877062.1. XM_017021573.1. [Q9H972-1]
XP_016877063.1. XM_017021574.1. [Q9H972-1]
XP_016877064.1. XM_017021575.1.
XP_016877065.1. XM_017021576.1.
XP_016877066.1. XM_017021577.1.
UniGeneiHs.255874.

3D structure databases

ProteinModelPortaliQ9H972.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121959. 5 interactors.
IntActiQ9H972. 3 interactors.
STRINGi9606.ENSP00000299088.

PTM databases

iPTMnetiQ9H972.
PhosphoSitePlusiQ9H972.

Polymorphism and mutation databases

DMDMi33301115.

Proteomic databases

MaxQBiQ9H972.
PaxDbiQ9H972.
PeptideAtlasiQ9H972.
PRIDEiQ9H972.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299088; ENSP00000299088; ENSG00000100802. [Q9H972-1]
ENST00000341470; ENSP00000341353; ENSG00000100802. [Q9H972-2]
ENST00000397379; ENSP00000380535; ENSG00000100802. [Q9H972-1]
ENST00000397382; ENSP00000380538; ENSG00000100802. [Q9H972-1]
GeneIDi60686.
KEGGihsa:60686.
UCSCiuc001wia.6. human. [Q9H972-1]

Organism-specific databases

CTDi60686.
GeneCardsiC14orf93.
HGNCiHGNC:20162. C14orf93.
HPAiHPA002569.
neXtProtiNX_Q9H972.
OpenTargetsiENSG00000100802.
PharmGKBiPA134982493.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II26. Eukaryota.
ENOG410YVIZ. LUCA.
GeneTreeiENSGT00390000012708.
HOVERGENiHBG051014.
InParanoidiQ9H972.
OMAiKCCCCAC.
OrthoDBiEOG091G0ALI.
PhylomeDBiQ9H972.
TreeFamiTF336941.

Miscellaneous databases

GenomeRNAii60686.
PROiQ9H972.

Gene expression databases

BgeeiENSG00000100802.
CleanExiHS_C14orf93.
ExpressionAtlasiQ9H972. baseline and differential.
GenevisibleiQ9H972. HS.

Family and domain databases

InterProiIPR028101. DUF4616.
[Graphical view]
PANTHERiPTHR14375. PTHR14375. 1 hit.
PfamiPF15394. DUF4616. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCN093_HUMAN
AccessioniPrimary (citable) accession number: Q9H972
Secondary accession number(s): B7WP03
, D3DS38, D3DS39, Q86SE6, Q96CF7, Q9HA68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.