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Protein

WD repeat-containing protein 76

Gene

WDR76

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ9H967

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 76
Gene namesi
Name:WDR76
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000092470.11
HGNCiHGNC:25773 WDR76
neXtProtiNX_Q9H967

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi79968
OpenTargetsiENSG00000092470
PharmGKBiPA142670580

Polymorphism and mutation databases

BioMutaiWDR76
DMDMi313104049

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002426911 – 626WD repeat-containing protein 76Add BLAST626

Proteomic databases

EPDiQ9H967
MaxQBiQ9H967
PaxDbiQ9H967
PeptideAtlasiQ9H967
PRIDEiQ9H967
ProteomicsDBi81286

PTM databases

iPTMnetiQ9H967
PhosphoSitePlusiQ9H967

Expressioni

Gene expression databases

BgeeiENSG00000092470
CleanExiHS_WDR76
ExpressionAtlasiQ9H967 baseline and differential
GenevisibleiQ9H967 HS

Organism-specific databases

HPAiHPA039804
HPA040626

Interactioni

Subunit structurei

Interacts with CUL4A and/or CUL4B.1 Publication

Protein-protein interaction databases

BioGridi123035, 58 interactors
IntActiQ9H967, 10 interactors
STRINGi9606.ENSP00000263795

Structurei

3D structure databases

ProteinModelPortaliQ9H967
SMRiQ9H967
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati311 – 352WD 1Add BLAST42
Repeati358 – 400WD 2Add BLAST43
Repeati402 – 441WD 3Add BLAST40
Repeati446 – 485WD 4Add BLAST40
Repeati493 – 533WD 5Add BLAST41
Repeati535 – 565WD 6Add BLAST31
Repeati590 – 626WD 7Add BLAST37

Sequence similaritiesi

Belongs to the WD repeat DDB2/WDR76 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG4328 Eukaryota
ENOG410XRID LUCA
GeneTreeiENSGT00510000048144
HOGENOMiHOG000081507
HOVERGENiHBG079574
InParanoidiQ9H967
OMAiGMVISED
OrthoDBiEOG091G07AQ
PhylomeDBiQ9H967
TreeFamiTF314788

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR033052 Cmr1/WDR76
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR14773:SF0 PTHR14773:SF0, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSGAAAEK ADSRQRPQMK VNEYKENQNI AYVSLRPAQT TVLIKTAKVY
60 70 80 90 100
LAPFSLSNYQ LDQLMCPKSL SEKNSNNEVA CKKTKIKKTC RRIIPPKMKN
110 120 130 140 150
TSSKAESTLQ NSSSAVHTES NKLQPKRTAD AMNLSVDVES SQDGDSDEDT
160 170 180 190 200
TPSLDFSGLS PYERKRLKNI SENADFFASL QLSESAARLR EMIEKRQPPK
210 220 230 240 250
SKRKKPKREN GIGCRRSMRL LKVDPSGVSL PAAPTPPTLV ADETPLLPPG
260 270 280 290 300
PLEMTSENQE DNNERFKGFL HTWAGMSKPS SKNTEKGLSS IKSYKANLNG
310 320 330 340 350
MVISEDTVYK VTTGPIFSMA LHPSETRTLV AVGAKFGQVG LCDLTQQPKE
360 370 380 390 400
DGVYVFHPHS QPVSCLYFSP ANPAHILSLS YDGTLRCGDF SRAIFEEVYR
410 420 430 440 450
NERSSFSSFD FLAEDASTLI VGHWDGNMSL VDRRTPGTSY EKLTSSSMGK
460 470 480 490 500
IRTVHVHPVH RQYFITAGLR DTHIYDARRL NSRRSQPLIS LTEHTKSIAS
510 520 530 540 550
AYFSPLTGNR VVTTCADCNL RIFDSSCISS KIPLLTTIRH NTFTGRWLTR
560 570 580 590 600
FQAMWDPKQE DCVIVGSMAH PRRVEIFHET GKRVHSFGGE YLVSVCSINA
610 620
MHPTRYILAG GNSSGKIHVF MNEKSC
Length:626
Mass (Da):69,769
Last modified:November 30, 2010 - v2
Checksum:iDC6DE3A59250EFA1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026862153S → A3 PublicationsCorresponds to variant dbSNP:rs678084Ensembl.1
Natural variantiVAR_026863614S → G. Corresponds to variant dbSNP:rs3742985Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF011624 mRNA Translation: ABK41114.1
AK023035 mRNA Translation: BAB14369.1
AK290933 mRNA Translation: BAF83622.1
AC018512 Genomic DNA No translation available.
AC023356 Genomic DNA No translation available.
BC025247 mRNA Translation: AAH25247.1
BC051855 mRNA Translation: AAH51855.1
CCDSiCCDS10106.1
RefSeqiNP_001161413.1, NM_001167941.1
NP_079184.2, NM_024908.3
XP_005254737.1, XM_005254680.3
UniGeneiHs.250154

Genome annotation databases

EnsembliENST00000263795; ENSP00000263795; ENSG00000092470
GeneIDi79968
KEGGihsa:79968
UCSCiuc001zti.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWDR76_HUMAN
AccessioniPrimary (citable) accession number: Q9H967
Secondary accession number(s): A0MNP5, Q05CI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 30, 2010
Last modified: June 20, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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