UniProtKB - Q9H967 (WDR76_HUMAN)
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Protein
WD repeat-containing protein 76
Gene
WDR76
Organism
Homo sapiens (Human)
Status
Functioni
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.By similarity
GO - Molecular functioni
- DNA binding Source: GO_Central
GO - Biological processi
- cellular response to DNA damage stimulus Source: InterPro
- regulation of DNA damage checkpoint Source: GO_Central
Enzyme and pathway databases
SignaLinki | Q9H967. |
Names & Taxonomyi
Protein namesi | Recommended name: WD repeat-containing protein 76 |
Gene namesi | Name:WDR76 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000092470.11. |
HGNCi | HGNC:25773. WDR76. |
neXtProti | NX_Q9H967. |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 79968. |
OpenTargetsi | ENSG00000092470. |
PharmGKBi | PA142670580. |
Polymorphism and mutation databases
BioMutai | WDR76. |
DMDMi | 313104049. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000242691 | 1 – 626 | WD repeat-containing protein 76Add BLAST | 626 |
Proteomic databases
EPDi | Q9H967. |
MaxQBi | Q9H967. |
PaxDbi | Q9H967. |
PeptideAtlasi | Q9H967. |
PRIDEi | Q9H967. |
PTM databases
iPTMneti | Q9H967. |
PhosphoSitePlusi | Q9H967. |
Expressioni
Gene expression databases
Bgeei | ENSG00000092470. |
CleanExi | HS_WDR76. |
ExpressionAtlasi | Q9H967. baseline and differential. |
Genevisiblei | Q9H967. HS. |
Organism-specific databases
HPAi | HPA039804. HPA040626. |
Interactioni
Subunit structurei
Interacts with CUL4A and/or CUL4B.1 Publication
Protein-protein interaction databases
BioGridi | 123035. 58 interactors. |
IntActi | Q9H967. 10 interactors. |
STRINGi | 9606.ENSP00000263795. |
Structurei
3D structure databases
ProteinModelPortali | Q9H967. |
SMRi | Q9H967. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 311 – 352 | WD 1Add BLAST | 42 | |
Repeati | 358 – 400 | WD 2Add BLAST | 43 | |
Repeati | 402 – 441 | WD 3Add BLAST | 40 | |
Repeati | 446 – 485 | WD 4Add BLAST | 40 | |
Repeati | 493 – 533 | WD 5Add BLAST | 41 | |
Repeati | 535 – 565 | WD 6Add BLAST | 31 | |
Repeati | 590 – 626 | WD 7Add BLAST | 37 |
Sequence similaritiesi
Belongs to the WD repeat DDB2/WDR76 family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG4328. Eukaryota. ENOG410XRID. LUCA. |
GeneTreei | ENSGT00510000048144. |
HOGENOMi | HOG000081507. |
HOVERGENi | HBG079574. |
InParanoidi | Q9H967. |
OMAi | GMVISED. |
OrthoDBi | EOG091G07AQ. |
PhylomeDBi | Q9H967. |
TreeFami | TF314788. |
Family and domain databases
Gene3Di | 2.130.10.10. 1 hit. |
InterProi | View protein in InterPro IPR033052. Cmr1/WDR76. IPR015943. WD40/YVTN_repeat-like_dom_sf. IPR001680. WD40_repeat. IPR036322. WD40_repeat_dom_sf. |
PANTHERi | PTHR14773:SF0. PTHR14773:SF0. 1 hit. |
SMARTi | View protein in SMART SM00320. WD40. 5 hits. |
SUPFAMi | SSF50978. SSF50978. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q9H967-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRSGAAAEK ADSRQRPQMK VNEYKENQNI AYVSLRPAQT TVLIKTAKVY
60 70 80 90 100
LAPFSLSNYQ LDQLMCPKSL SEKNSNNEVA CKKTKIKKTC RRIIPPKMKN
110 120 130 140 150
TSSKAESTLQ NSSSAVHTES NKLQPKRTAD AMNLSVDVES SQDGDSDEDT
160 170 180 190 200
TPSLDFSGLS PYERKRLKNI SENADFFASL QLSESAARLR EMIEKRQPPK
210 220 230 240 250
SKRKKPKREN GIGCRRSMRL LKVDPSGVSL PAAPTPPTLV ADETPLLPPG
260 270 280 290 300
PLEMTSENQE DNNERFKGFL HTWAGMSKPS SKNTEKGLSS IKSYKANLNG
310 320 330 340 350
MVISEDTVYK VTTGPIFSMA LHPSETRTLV AVGAKFGQVG LCDLTQQPKE
360 370 380 390 400
DGVYVFHPHS QPVSCLYFSP ANPAHILSLS YDGTLRCGDF SRAIFEEVYR
410 420 430 440 450
NERSSFSSFD FLAEDASTLI VGHWDGNMSL VDRRTPGTSY EKLTSSSMGK
460 470 480 490 500
IRTVHVHPVH RQYFITAGLR DTHIYDARRL NSRRSQPLIS LTEHTKSIAS
510 520 530 540 550
AYFSPLTGNR VVTTCADCNL RIFDSSCISS KIPLLTTIRH NTFTGRWLTR
560 570 580 590 600
FQAMWDPKQE DCVIVGSMAH PRRVEIFHET GKRVHSFGGE YLVSVCSINA
610 620
MHPTRYILAG GNSSGKIHVF MNEKSC
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026862 | 153 | S → A3 PublicationsCorresponds to variant dbSNP:rs678084Ensembl. | 1 | |
Natural variantiVAR_026863 | 614 | S → G. Corresponds to variant dbSNP:rs3742985Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF011624 mRNA. Translation: ABK41114.1. AK023035 mRNA. Translation: BAB14369.1. AK290933 mRNA. Translation: BAF83622.1. AC018512 Genomic DNA. No translation available. AC023356 Genomic DNA. No translation available. BC025247 mRNA. Translation: AAH25247.1. BC051855 mRNA. Translation: AAH51855.1. |
CCDSi | CCDS10106.1. |
RefSeqi | NP_001161413.1. NM_001167941.1. NP_079184.2. NM_024908.3. XP_005254737.1. XM_005254680.3. |
UniGenei | Hs.250154. |
Genome annotation databases
Ensembli | ENST00000263795; ENSP00000263795; ENSG00000092470. |
GeneIDi | 79968. |
KEGGi | hsa:79968. |
UCSCi | uc001zti.3. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | WDR76_HUMAN | |
Accessioni | Q9H967Primary (citable) accession number: Q9H967 Secondary accession number(s): A0MNP5, Q05CI4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | November 30, 2010 | |
Last modified: | February 28, 2018 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |