Q9H967 (WDR76_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 76

Gene names

Name:

WDR76

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	626 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with CUL4A and/or CUL4B. Ref.1
Sequence similarities	Belongs to the WD repeat DDB2/WDR76 family. Contains 7 WD repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 626	626	WD repeat-containing protein 76		PRO_0000242691
Regions
	Repeat	311 – 352	42	WD 1
	Repeat	358 – 400	43	WD 2
	Repeat	402 – 441	40	WD 3
	Repeat	446 – 485	40	WD 4
	Repeat	493 – 533	41	WD 5
	Repeat	535 – 565	31	WD 6
	Repeat	590 – 626	37	WD 7
Natural variations
	Natural variant	153	1	S → A. Ref.1 Ref.2 Ref.4 Corresponds to variant rs678084 [ dbSNP | Ensembl ].		VAR_026862
	Natural variant	614	1	S → G. Corresponds to variant rs3742985 [ dbSNP | Ensembl ].		VAR_026863

Sequences

	Sequence		Length	Mass (Da)
	Q9H967 [UniParc]. Last modified November 30, 2010. Version 2. Checksum: DC6DE3A59250EFA1	FASTA	626	69,769
	10 20 30 40 50 60 MSRSGAAAEK ADSRQRPQMK VNEYKENQNI AYVSLRPAQT TVLIKTAKVY LAPFSLSNYQ 70 80 90 100 110 120 LDQLMCPKSL SEKNSNNEVA CKKTKIKKTC RRIIPPKMKN TSSKAESTLQ NSSSAVHTES 130 140 150 160 170 180 NKLQPKRTAD AMNLSVDVES SQDGDSDEDT TPSLDFSGLS PYERKRLKNI SENADFFASL 190 200 210 220 230 240 QLSESAARLR EMIEKRQPPK SKRKKPKREN GIGCRRSMRL LKVDPSGVSL PAAPTPPTLV 250 260 270 280 290 300 ADETPLLPPG PLEMTSENQE DNNERFKGFL HTWAGMSKPS SKNTEKGLSS IKSYKANLNG 310 320 330 340 350 360 MVISEDTVYK VTTGPIFSMA LHPSETRTLV AVGAKFGQVG LCDLTQQPKE DGVYVFHPHS 370 380 390 400 410 420 QPVSCLYFSP ANPAHILSLS YDGTLRCGDF SRAIFEEVYR NERSSFSSFD FLAEDASTLI 430 440 450 460 470 480 VGHWDGNMSL VDRRTPGTSY EKLTSSSMGK IRTVHVHPVH RQYFITAGLR DTHIYDARRL 490 500 510 520 530 540 NSRRSQPLIS LTEHTKSIAS AYFSPLTGNR VVTTCADCNL RIFDSSCISS KIPLLTTIRH 550 560 570 580 590 600 NTFTGRWLTR FQAMWDPKQE DCVIVGSMAH PRRVEIFHET GKRVHSFGGE YLVSVCSINA 610 620 MHPTRYILAG GNSSGKIHVF MNEKSC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation." Higa L.A., Wu M., Ye T., Kobayashi R., Sun H., Zhang H. Nat. Cell Biol. 8:1277-1283(2006) [PubMed: 17041588] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CUL4A AND/OR CUL4B, VARIANT ALA-153.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-153. Tissue: Teratocarcinoma.
[3]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed: 16572171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-153. Tissue: Eye and Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EF011624 mRNA. Translation: ABK41114.1. AK023035 mRNA. Translation: BAB14369.1. AK290933 mRNA. Translation: BAF83622.1. AC018512 Genomic DNA. No translation available. AC023356 Genomic DNA. No translation available. BC025247 mRNA. Translation: AAH25247.1. BC051855 mRNA. Translation: AAH51855.1.
IPI	IPI00016542.
RefSeq	NP_001161413.1. NM_001167941.1. NP_079184.2. NM_024908.3.
UniGene	Hs.250154.
3D structure databases
ProteinModelPortal	Q9H967.
SMR	Q9H967. Positions 311-623.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H967. 1 interaction.
STRING	Q9H967.
Polymorphism databases
DMDM	74761550.
Proteomic databases
PRIDE	Q9H967.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263795; ENSP00000263795; ENSG00000092470.
GeneID	79968.
KEGG	hsa:79968.
UCSC	uc001zti.1. human.
Organism-specific databases
CTD	79968.
GeneCards	GC15P044119.
H-InvDB	HIX0022461.
HGNC	HGNC:25773. WDR76.
HPA	HPA039804. HPA040626.
neXtProt	NX_Q9H967.
PharmGKB	PA142670580.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19852.
GeneTree	ENSGT00510000048144.
HOGENOM	HBG402786.
HOVERGEN	HBG079574.
InParanoid	Q9H967.
OMA	PGTSYEK.
OrthoDB	EOG43BMNH.
PhylomeDB	Q9H967.
Gene expression databases
ArrayExpress	Q9H967.
Bgee	Q9H967.
CleanEx	HS_WDR76.
Genevestigator	Q9H967.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 2 hits. [Graphical view]
SMART	SM00320. WD40. 5 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	69977.

Entry information

Entry name

WDR76_HUMAN

Accession

Primary (citable) accession number: Q9H967
Secondary accession number(s): A0MNP5, Q05CI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	November 30, 2010
Last modified:	January 25, 2012
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.