WDR76

Functionⁱ

Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.By similarity

GO - Molecular functionⁱ

DNA binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to DNA damage stimulus Source: InterPro
regulation of DNA damage checkpoint Source: GO_Central

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

SignaLinkⁱ	Q9H967

SignaLinkⁱ

Q9H967

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: WD repeat-containing protein 76
Gene namesⁱ	Name:WDR76
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000092470.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25773 WDR76
neXtProtⁱ	NX_Q9H967

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79968
Open Targets More...OpenTargetsⁱ	ENSG00000092470
PharmGKBⁱ	PA142670580

Polymorphism and mutation databases

BioMutaⁱ	WDR76
DMDMⁱ	313104049

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000242691	1 – 626	WD repeat-containing protein 76Add BLAST		626

Proteomic databases

EPDⁱ	Q9H967
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H967
PaxDbⁱ	Q9H967
PeptideAtlas More...PeptideAtlasⁱ	Q9H967
PRIDEⁱ	Q9H967
ProteomicsDBⁱ	81286

PTM databases

iPTMnetⁱ	Q9H967
PhosphoSitePlusⁱ	Q9H967

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000092470
CleanExⁱ	HS_WDR76
ExpressionAtlasⁱ	Q9H967 baseline and differential
Genevisibleⁱ	Q9H967 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039804 HPA040626

HPAⁱ

HPA039804
HPA040626

Interactionⁱ

Subunit structureⁱ

Interacts with CUL4A and/or CUL4B.1 Publication

Protein-protein interaction databases

BioGridⁱ	123035, 58 interactors
IntActⁱ	Q9H967, 10 interactors
STRINGⁱ	9606.ENSP00000263795

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H967
SMRⁱ	Q9H967
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	311 – 352	WD 1Add BLAST	42
Repeatⁱ	358 – 400	WD 2Add BLAST	43
Repeatⁱ	402 – 441	WD 3Add BLAST	40
Repeatⁱ	446 – 485	WD 4Add BLAST	40
Repeatⁱ	493 – 533	WD 5Add BLAST	41
Repeatⁱ	535 – 565	WD 6Add BLAST	31
Repeatⁱ	590 – 626	WD 7Add BLAST	37

Sequence similaritiesⁱ

Belongs to the WD repeat DDB2/WDR76 family.Curated

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG4328 Eukaryota ENOG410XRID LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048144
HOGENOMⁱ	HOG000081507
HOVERGENⁱ	HBG079574
InParanoidⁱ	Q9H967
OMAⁱ	GMVISED
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07AQ
PhylomeDBⁱ	Q9H967
TreeFamⁱ	TF314788

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR033052 Cmr1/WDR76 IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR14773:SF0 PTHR14773:SF0, 1 hit
SMARTⁱ	View protein in SMART SM00320 WD40, 5 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9H967-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSRSGAAAEK ADSRQRPQMK VNEYKENQNI AYVSLRPAQT TVLIKTAKVY 
        60         70         80         90        100
LAPFSLSNYQ LDQLMCPKSL SEKNSNNEVA CKKTKIKKTC RRIIPPKMKN 
       110        120        130        140        150
TSSKAESTLQ NSSSAVHTES NKLQPKRTAD AMNLSVDVES SQDGDSDEDT 
       160        170        180        190        200
TPSLDFSGLS PYERKRLKNI SENADFFASL QLSESAARLR EMIEKRQPPK 
       210        220        230        240        250
SKRKKPKREN GIGCRRSMRL LKVDPSGVSL PAAPTPPTLV ADETPLLPPG 
       260        270        280        290        300
PLEMTSENQE DNNERFKGFL HTWAGMSKPS SKNTEKGLSS IKSYKANLNG 
       310        320        330        340        350
MVISEDTVYK VTTGPIFSMA LHPSETRTLV AVGAKFGQVG LCDLTQQPKE 
       360        370        380        390        400
DGVYVFHPHS QPVSCLYFSP ANPAHILSLS YDGTLRCGDF SRAIFEEVYR 
       410        420        430        440        450
NERSSFSSFD FLAEDASTLI VGHWDGNMSL VDRRTPGTSY EKLTSSSMGK 
       460        470        480        490        500
IRTVHVHPVH RQYFITAGLR DTHIYDARRL NSRRSQPLIS LTEHTKSIAS 
       510        520        530        540        550
AYFSPLTGNR VVTTCADCNL RIFDSSCISS KIPLLTTIRH NTFTGRWLTR 
       560        570        580        590        600
FQAMWDPKQE DCVIVGSMAH PRRVEIFHET GKRVHSFGGE YLVSVCSINA 
       610        620 
MHPTRYILAG GNSSGKIHVF MNEKSC

Length:626

Mass (Da):69,769

Last modified:November 30, 2010 - v2

Checksum:ⁱDC6DE3A59250EFA1

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_026862	153	S → A3 PublicationsCorresponds to variant dbSNP:rs678084Ensembl.		1
Natural variantⁱVAR_026863	614	S → G. Corresponds to variant dbSNP:rs3742985Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF011624 mRNA Translation: ABK41114.1 AK023035 mRNA Translation: BAB14369.1 AK290933 mRNA Translation: BAF83622.1 AC018512 Genomic DNA No translation available. AC023356 Genomic DNA No translation available. BC025247 mRNA Translation: AAH25247.1 BC051855 mRNA Translation: AAH51855.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10106.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001161413.1, NM_001167941.1 NP_079184.2, NM_024908.3 XP_005254737.1, XM_005254680.3
UniGeneⁱ	Hs.250154

Genome annotation databases

Ensemblⁱ	ENST00000263795; ENSP00000263795; ENSG00000092470
GeneIDⁱ	79968
KEGGⁱ	hsa:79968
UCSC genome browser More...UCSCⁱ	uc001zti.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length
Q9H967	WD repeat-containing protein 76 (Fragment)		HUMAN		228
UPI0004F09D43		CALJA		697
UPI000809C04C		Cebus capucinus imitator		673
UPI000533F739		SAIBB		634
WD repeat-containing protein 76		PONAB		627
+26

Protein	Similar proteins		Species	Score	Length
Q9H967	WD repeat-containing protein 76		MOUSE		622
UPI000A30D34D		MUSPA		622
UPI000A315E96		MUSCR		622
UPI000D1F1091		Yangtze finless porpoise		630
UPI000BB74875		DELLE		631
+186

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF011624 mRNA Translation: ABK41114.1 AK023035 mRNA Translation: BAB14369.1 AK290933 mRNA Translation: BAF83622.1 AC018512 Genomic DNA No translation available. AC023356 Genomic DNA No translation available. BC025247 mRNA Translation: AAH25247.1 BC051855 mRNA Translation: AAH51855.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10106.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001161413.1, NM_001167941.1 NP_079184.2, NM_024908.3 XP_005254737.1, XM_005254680.3
UniGeneⁱ	Hs.250154

3D structure databases

ProteinModelPortalⁱ	Q9H967
SMRⁱ	Q9H967
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123035, 58 interactors
IntActⁱ	Q9H967, 10 interactors
STRINGⁱ	9606.ENSP00000263795

PTM databases

iPTMnetⁱ	Q9H967
PhosphoSitePlusⁱ	Q9H967

Polymorphism and mutation databases

BioMutaⁱ	WDR76
DMDMⁱ	313104049

Proteomic databases

EPDⁱ	Q9H967
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H967
PaxDbⁱ	Q9H967
PeptideAtlas More...PeptideAtlasⁱ	Q9H967
PRIDEⁱ	Q9H967
ProteomicsDBⁱ	81286

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000263795; ENSP00000263795; ENSG00000092470
GeneIDⁱ	79968
KEGGⁱ	hsa:79968
UCSC genome browser More...UCSCⁱ	uc001zti.3 human

Organism-specific databases

CTDⁱ	79968
DisGeNET More...DisGeNETⁱ	79968
EuPathDBⁱ	HostDB:ENSG00000092470.11
GeneCardsⁱ	WDR76
H-InvDBⁱ	HIX0022461
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25773 WDR76
Human Protein Atlas More...HPAⁱ	HPA039804 HPA040626
neXtProtⁱ	NX_Q9H967
Open Targets More...OpenTargetsⁱ	ENSG00000092470
PharmGKBⁱ	PA142670580
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4328 Eukaryota ENOG410XRID LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048144
HOGENOMⁱ	HOG000081507
HOVERGENⁱ	HBG079574
InParanoidⁱ	Q9H967
OMAⁱ	GMVISED
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07AQ
PhylomeDBⁱ	Q9H967
TreeFamⁱ	TF314788

Enzyme and pathway databases

SignaLinkⁱ	Q9H967

SignaLinkⁱ

Q9H967

Miscellaneous databases

ChiTaRSⁱ	WDR76 human
GenomeRNAiⁱ	79968
Protein Ontology More...PROⁱ	PR:Q9H967

Gene expression databases

Bgeeⁱ	ENSG00000092470
CleanExⁱ	HS_WDR76
ExpressionAtlasⁱ	Q9H967 baseline and differential
Genevisibleⁱ	Q9H967 HS

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR033052 Cmr1/WDR76 IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR14773:SF0 PTHR14773:SF0, 1 hit
SMARTⁱ	View protein in SMART SM00320 WD40, 5 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	WDR76_HUMAN
Accessionⁱ	Q9H967Primary (citable) accession number: Q9H967 Secondary accession number(s): A0MNP5, Q05CI4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
	Last sequence update:	November 30, 2010
	Last modified:	June 20, 2018
	This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q9H967 (WDR76_HUMAN)

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WD repeat-containing protein 76

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ