WD repeat-containing protein 76 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q9H967 (WDR76_HUMAN)

Last modified June 16, 2009. Version 58. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 76

Gene names

Name:

WDR76

Organism

Homo sapiens (Human)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	626 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure

Interacts with CUL4A and/or CUL4B. Ref.1

Sequence similarities

Belongs to the WD repeat DDB2/WDR76 family.

Contains 7 WD repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat WD repeat
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

626

WD repeat-containing protein 76

PRO_0000242691

Regions

Repeat

42

WD 1

Repeat

43

WD 2

Repeat

40

WD 3

Repeat

40

WD 4

Repeat

41

WD 5

Repeat

31

WD 6

Repeat

37

WD 7

Natural variations

Natural variant

1

A → S: dbSNP rs678084. Ref.3

VAR_026862

Natural variant

1

S → G: dbSNP rs3742985.

VAR_026863

Sequences

Sequence

Length

Mass (Da)

Tools

Q9H967-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: B4D1A472DC1738EF
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626

69,753

        10         20         30         40         50         60 
MSRSGAAAEK ADSRQRPQMK VNEYKENQNI AYVSLRPAQT TVLIKTAKVY LAPFSLSNYQ 

        70         80         90        100        110        120 
LDQLMCPKSL SEKNSNNEVA CKKTKIKKTC RRIIPPKMKN TSSKAESTLQ NSSSAVHTES 

       130        140        150        160        170        180 
NKLQPKRTAD AMNLSVDVES SQDGDSDEDT TPALDFSGLS PYERKRLKNI SENADFFASL 

       190        200        210        220        230        240 
QLSESAARLR EMIEKRQPPK SKRKKPKREN GIGCRRSMRL LKVDPSGVSL PAAPTPPTLV 

       250        260        270        280        290        300 
ADETPLLPPG PLEMTSENQE DNNERFKGFL HTWAGMSKPS SKNTEKGLSS IKSYKANLNG 

       310        320        330        340        350        360 
MVISEDTVYK VTTGPIFSMA LHPSETRTLV AVGAKFGQVG LCDLTQQPKE DGVYVFHPHS 

       370        380        390        400        410        420 
QPVSCLYFSP ANPAHILSLS YDGTLRCGDF SRAIFEEVYR NERSSFSSFD FLAEDASTLI 

       430        440        450        460        470        480 
VGHWDGNMSL VDRRTPGTSY EKLTSSSMGK IRTVHVHPVH RQYFITAGLR DTHIYDARRL 

       490        500        510        520        530        540 
NSRRSQPLIS LTEHTKSIAS AYFSPLTGNR VVTTCADCNL RIFDSSCISS KIPLLTTIRH 

       550        560        570        580        590        600 
NTFTGRWLTR FQAMWDPKQE DCVIVGSMAH PRRVEIFHET GKRVHSFGGE YLVSVCSINA 

       610        620 
MHPTRYILAG GNSSGKIHVF MNEKSC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation." Higa L.A., Wu M., Ye T., Kobayashi R., Sun H., Zhang H. Nat. Cell Biol. 8:1277-1283(2006) [PubMed: 17041588] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CUL4A AND/OR CUL4B.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Teratocarcinoma.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-153. Tissue: Eye and Kidney.

Cross-references

Sequence databases
	EF011624 mRNA. Translation: ABK41114.1. AK023035 mRNA. Translation: BAB14369.1. AK290933 mRNA. Translation: BAF83622.1. BC025247 mRNA. Translation: AAH25247.1. BC051855 mRNA. Translation: AAH51855.1.
IPI	IPI00016542.
RefSeq	NP_079184.1.
UniGene	Hs.250154
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q9H967.
Genome annotation databases
Ensembl	ENSG00000092470. Homo sapiens. [Contig view]
GeneID	79968.
KEGG	hsa:79968.
NMPDR	fig\|9606.3.peg.10630.
Organism-specific databases
GeneCards	GC15P041907.
HGNC	HGNC:25773. WDR76.
PharmGKB	PA142670580.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9H967.
HOVERGEN	Q9H967.
Gene expression databases
ArrayExpress	Q9H967.
Bgee	Q9H967.
CleanEx	HS_WDR76.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR019781. WD40_repeat_sg. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 2 hits. [Graphical view]
SMART	SM00320. WD40. 5 hits. [Graphical view]
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	69977.

Entry information

Entry name

WDR76_HUMAN

Accession

Primary (citable) accession number: Q9H967
Secondary accession number(s): A0MNP5, Q05CI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	March 1, 2001
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Relevant documents

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents