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Protein

WD repeat-containing protein 76

Gene

WDR76

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9H967.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 76
Gene namesi
Name:WDR76
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:25773. WDR76.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670580.

Polymorphism and mutation databases

BioMutaiWDR76.
DMDMi313104049.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 626626WD repeat-containing protein 76PRO_0000242691Add
BLAST

Proteomic databases

EPDiQ9H967.
MaxQBiQ9H967.
PaxDbiQ9H967.
PRIDEiQ9H967.

PTM databases

iPTMnetiQ9H967.
PhosphoSiteiQ9H967.

Expressioni

Gene expression databases

BgeeiQ9H967.
CleanExiHS_WDR76.
ExpressionAtlasiQ9H967. baseline and differential.
GenevisibleiQ9H967. HS.

Organism-specific databases

HPAiHPA039804.
HPA040626.

Interactioni

Subunit structurei

Interacts with CUL4A and/or CUL4B.1 Publication

Protein-protein interaction databases

BioGridi123035. 56 interactions.
IntActiQ9H967. 10 interactions.
MINTiMINT-3069089.
STRINGi9606.ENSP00000263795.

Structurei

3D structure databases

ProteinModelPortaliQ9H967.
SMRiQ9H967. Positions 318-609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati311 – 35242WD 1Add
BLAST
Repeati358 – 40043WD 2Add
BLAST
Repeati402 – 44140WD 3Add
BLAST
Repeati446 – 48540WD 4Add
BLAST
Repeati493 – 53341WD 5Add
BLAST
Repeati535 – 56531WD 6Add
BLAST
Repeati590 – 62637WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat DDB2/WDR76 family.Curated
Contains 7 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG4328. Eukaryota.
ENOG410XRID. LUCA.
GeneTreeiENSGT00510000048144.
HOGENOMiHOG000081507.
HOVERGENiHBG079574.
InParanoidiQ9H967.
OMAiVHTESNK.
OrthoDBiEOG7RNK08.
PhylomeDBiQ9H967.
TreeFamiTF314788.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR033052. Cmr1/WDR76.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR14773:SF0. PTHR14773:SF0. 1 hit.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSGAAAEK ADSRQRPQMK VNEYKENQNI AYVSLRPAQT TVLIKTAKVY
60 70 80 90 100
LAPFSLSNYQ LDQLMCPKSL SEKNSNNEVA CKKTKIKKTC RRIIPPKMKN
110 120 130 140 150
TSSKAESTLQ NSSSAVHTES NKLQPKRTAD AMNLSVDVES SQDGDSDEDT
160 170 180 190 200
TPSLDFSGLS PYERKRLKNI SENADFFASL QLSESAARLR EMIEKRQPPK
210 220 230 240 250
SKRKKPKREN GIGCRRSMRL LKVDPSGVSL PAAPTPPTLV ADETPLLPPG
260 270 280 290 300
PLEMTSENQE DNNERFKGFL HTWAGMSKPS SKNTEKGLSS IKSYKANLNG
310 320 330 340 350
MVISEDTVYK VTTGPIFSMA LHPSETRTLV AVGAKFGQVG LCDLTQQPKE
360 370 380 390 400
DGVYVFHPHS QPVSCLYFSP ANPAHILSLS YDGTLRCGDF SRAIFEEVYR
410 420 430 440 450
NERSSFSSFD FLAEDASTLI VGHWDGNMSL VDRRTPGTSY EKLTSSSMGK
460 470 480 490 500
IRTVHVHPVH RQYFITAGLR DTHIYDARRL NSRRSQPLIS LTEHTKSIAS
510 520 530 540 550
AYFSPLTGNR VVTTCADCNL RIFDSSCISS KIPLLTTIRH NTFTGRWLTR
560 570 580 590 600
FQAMWDPKQE DCVIVGSMAH PRRVEIFHET GKRVHSFGGE YLVSVCSINA
610 620
MHPTRYILAG GNSSGKIHVF MNEKSC
Length:626
Mass (Da):69,769
Last modified:November 30, 2010 - v2
Checksum:iDC6DE3A59250EFA1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti153 – 1531S → A.3 Publications
Corresponds to variant rs678084 [ dbSNP | Ensembl ].
VAR_026862
Natural varianti614 – 6141S → G.
Corresponds to variant rs3742985 [ dbSNP | Ensembl ].
VAR_026863

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF011624 mRNA. Translation: ABK41114.1.
AK023035 mRNA. Translation: BAB14369.1.
AK290933 mRNA. Translation: BAF83622.1.
AC018512 Genomic DNA. No translation available.
AC023356 Genomic DNA. No translation available.
BC025247 mRNA. Translation: AAH25247.1.
BC051855 mRNA. Translation: AAH51855.1.
CCDSiCCDS10106.1.
RefSeqiNP_001161413.1. NM_001167941.1.
NP_079184.2. NM_024908.3.
XP_005254737.1. XM_005254680.2.
UniGeneiHs.250154.

Genome annotation databases

EnsembliENST00000263795; ENSP00000263795; ENSG00000092470.
GeneIDi79968.
KEGGihsa:79968.
UCSCiuc001zti.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF011624 mRNA. Translation: ABK41114.1.
AK023035 mRNA. Translation: BAB14369.1.
AK290933 mRNA. Translation: BAF83622.1.
AC018512 Genomic DNA. No translation available.
AC023356 Genomic DNA. No translation available.
BC025247 mRNA. Translation: AAH25247.1.
BC051855 mRNA. Translation: AAH51855.1.
CCDSiCCDS10106.1.
RefSeqiNP_001161413.1. NM_001167941.1.
NP_079184.2. NM_024908.3.
XP_005254737.1. XM_005254680.2.
UniGeneiHs.250154.

3D structure databases

ProteinModelPortaliQ9H967.
SMRiQ9H967. Positions 318-609.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123035. 56 interactions.
IntActiQ9H967. 10 interactions.
MINTiMINT-3069089.
STRINGi9606.ENSP00000263795.

PTM databases

iPTMnetiQ9H967.
PhosphoSiteiQ9H967.

Polymorphism and mutation databases

BioMutaiWDR76.
DMDMi313104049.

Proteomic databases

EPDiQ9H967.
MaxQBiQ9H967.
PaxDbiQ9H967.
PRIDEiQ9H967.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263795; ENSP00000263795; ENSG00000092470.
GeneIDi79968.
KEGGihsa:79968.
UCSCiuc001zti.3. human.

Organism-specific databases

CTDi79968.
GeneCardsiWDR76.
H-InvDBHIX0022461.
HGNCiHGNC:25773. WDR76.
HPAiHPA039804.
HPA040626.
neXtProtiNX_Q9H967.
PharmGKBiPA142670580.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4328. Eukaryota.
ENOG410XRID. LUCA.
GeneTreeiENSGT00510000048144.
HOGENOMiHOG000081507.
HOVERGENiHBG079574.
InParanoidiQ9H967.
OMAiVHTESNK.
OrthoDBiEOG7RNK08.
PhylomeDBiQ9H967.
TreeFamiTF314788.

Enzyme and pathway databases

SignaLinkiQ9H967.

Miscellaneous databases

ChiTaRSiWDR76. human.
GenomeRNAii79968.
NextBioi69977.
PROiQ9H967.

Gene expression databases

BgeeiQ9H967.
CleanExiHS_WDR76.
ExpressionAtlasiQ9H967. baseline and differential.
GenevisibleiQ9H967. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR033052. Cmr1/WDR76.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR14773:SF0. PTHR14773:SF0. 1 hit.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation."
    Higa L.A., Wu M., Ye T., Kobayashi R., Sun H., Zhang H.
    Nat. Cell Biol. 8:1277-1283(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CUL4A AND/OR CUL4B, VARIANT ALA-153.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-153.
    Tissue: Teratocarcinoma.
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-153.
    Tissue: Eye and Kidney.

Entry informationi

Entry nameiWDR76_HUMAN
AccessioniPrimary (citable) accession number: Q9H967
Secondary accession number(s): A0MNP5, Q05CI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 30, 2010
Last modified: May 11, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.