WDR76

Functionⁱ

Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.By similarity

GO - Molecular functionⁱ

DNA binding Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

cellular response to DNA damage stimulus Source: InterPro
regulation of DNA damage checkpoint Source: GO_Central

Complete GO annotation...

Enzyme and pathway databases

SignaLinkⁱ	Q9H967.

SignaLinkⁱ

Q9H967.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: WD repeat-containing protein 76
Gene namesⁱ	Name:WDR76
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25773. WDR76.

HGNCⁱ

HGNC:25773. WDR76.

Subcellular locationⁱ

GO - Cellular componentⁱ

nucleus Source: GO_Central

Complete GO annotation...

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79968.
Open Targets More...OpenTargetsⁱ	ENSG00000092470.
PharmGKBⁱ	PA142670580.

Polymorphism and mutation databases

BioMutaⁱ	WDR76.
DMDMⁱ	313104049.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000242691	1 – 626	WD repeat-containing protein 76Add BLAST		626

Proteomic databases

EPDⁱ	Q9H967.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H967.
PaxDbⁱ	Q9H967.
PeptideAtlas More...PeptideAtlasⁱ	Q9H967.
PRIDEⁱ	Q9H967.

PTM databases

iPTMnetⁱ	Q9H967.
PhosphoSitePlusⁱ	Q9H967.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000092470.
CleanExⁱ	HS_WDR76.
ExpressionAtlasⁱ	Q9H967. baseline and differential.
Genevisibleⁱ	Q9H967. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039804. HPA040626.

HPAⁱ

HPA039804.
HPA040626.

Interactionⁱ

Subunit structureⁱ

Interacts with CUL4A and/or CUL4B.1 Publication

Protein-protein interaction databases

BioGridⁱ	123035. 58 interactors.
IntActⁱ	Q9H967. 10 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-3069089.
STRINGⁱ	9606.ENSP00000263795.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H967.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	311 – 352	WD 1Add BLAST	42
Repeatⁱ	358 – 400	WD 2Add BLAST	43
Repeatⁱ	402 – 441	WD 3Add BLAST	40
Repeatⁱ	446 – 485	WD 4Add BLAST	40
Repeatⁱ	493 – 533	WD 5Add BLAST	41
Repeatⁱ	535 – 565	WD 6Add BLAST	31
Repeatⁱ	590 – 626	WD 7Add BLAST	37

Sequence similaritiesⁱ

Belongs to the WD repeat DDB2/WDR76 family.Curated

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG4328. Eukaryota. ENOG410XRID. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048144.
HOGENOMⁱ	HOG000081507.
HOVERGENⁱ	HBG079574.
InParanoidⁱ	Q9H967.
OMAⁱ	GMVISED.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07AQ.
PhylomeDBⁱ	Q9H967.
TreeFamⁱ	TF314788.

Family and domain databases

Gene3Dⁱ	2.130.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR033052. Cmr1/WDR76. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR017986. WD40_repeat_dom.
PANTHERⁱ	PTHR14773:SF2. PTHR14773:SF2. 1 hit.
SMARTⁱ	View protein in SMART SM00320. WD40. 5 hits.
SUPFAMⁱ	SSF50978. SSF50978. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9H967-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSRSGAAAEK ADSRQRPQMK VNEYKENQNI AYVSLRPAQT TVLIKTAKVY 
        60         70         80         90        100
LAPFSLSNYQ LDQLMCPKSL SEKNSNNEVA CKKTKIKKTC RRIIPPKMKN 
       110        120        130        140        150
TSSKAESTLQ NSSSAVHTES NKLQPKRTAD AMNLSVDVES SQDGDSDEDT 
       160        170        180        190        200
TPSLDFSGLS PYERKRLKNI SENADFFASL QLSESAARLR EMIEKRQPPK 
       210        220        230        240        250
SKRKKPKREN GIGCRRSMRL LKVDPSGVSL PAAPTPPTLV ADETPLLPPG 
       260        270        280        290        300
PLEMTSENQE DNNERFKGFL HTWAGMSKPS SKNTEKGLSS IKSYKANLNG 
       310        320        330        340        350
MVISEDTVYK VTTGPIFSMA LHPSETRTLV AVGAKFGQVG LCDLTQQPKE 
       360        370        380        390        400
DGVYVFHPHS QPVSCLYFSP ANPAHILSLS YDGTLRCGDF SRAIFEEVYR 
       410        420        430        440        450
NERSSFSSFD FLAEDASTLI VGHWDGNMSL VDRRTPGTSY EKLTSSSMGK 
       460        470        480        490        500
IRTVHVHPVH RQYFITAGLR DTHIYDARRL NSRRSQPLIS LTEHTKSIAS 
       510        520        530        540        550
AYFSPLTGNR VVTTCADCNL RIFDSSCISS KIPLLTTIRH NTFTGRWLTR 
       560        570        580        590        600
FQAMWDPKQE DCVIVGSMAH PRRVEIFHET GKRVHSFGGE YLVSVCSINA 
       610        620 
MHPTRYILAG GNSSGKIHVF MNEKSC

Length:626

Mass (Da):69,769

Last modified:November 30, 2010 - v2

Checksum:ⁱDC6DE3A59250EFA1

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_026862	153	S → A3 PublicationsCorresponds to variant dbSNP:rs678084Ensembl.		1
Natural variantⁱVAR_026863	614	S → G. Corresponds to variant dbSNP:rs3742985Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF011624 mRNA. Translation: ABK41114.1. AK023035 mRNA. Translation: BAB14369.1. AK290933 mRNA. Translation: BAF83622.1. AC018512 Genomic DNA. No translation available. AC023356 Genomic DNA. No translation available. BC025247 mRNA. Translation: AAH25247.1. BC051855 mRNA. Translation: AAH51855.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10106.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001161413.1. NM_001167941.1. NP_079184.2. NM_024908.3. XP_005254737.1. XM_005254680.3.
UniGeneⁱ	Hs.250154.

Genome annotation databases

Ensemblⁱ	ENST00000263795; ENSP00000263795; ENSG00000092470.
GeneIDⁱ	79968.
KEGGⁱ	hsa:79968.
UCSC genome browser More...UCSCⁱ	uc001zti.3. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9H967	C9JE56 A0A0C4DFX7	Homo sapiens (Human)	626	UniRef100_Q9H967	Cluster: WD repeat-containing protein 76	3

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9H967	C9JE56 A0A0C4DFX7 UPI0004F09D43 UPI000809C04C UPI000533F739 UPI000533F05F F7AMS8 H2NN31 G1R0E3 A9X1C6 +18	Homo sapiens (Human) Callithrix jacchus (White-tufted-ear marmoset) Cebus capucinus imitator Saimiri boliviensis boliviensis (Bolivian squirrel monkey) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Papio anubis (Olive baboon) Gorilla gorilla gorilla (Western lowland gorilla) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Pan paniscus (Pygmy chimpanzee) (Bonobo) And more	626	UniRef90_Q9H967	Cluster: WD repeat-containing protein 76	29

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9H967	A6PWY4 A6PWY4-2 UPI000436DF27 UPI000A30D34D UPI000A304E6D UPI000A312D99 UPI000A315E96 UPI00062AC36D C1FY54 UPI00042B98E1 +141	Mus musculus (Mouse) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Mus caroli (Ryukyu mouse) (Ricefield mouse) Dasypus novemcinctus (Nine-banded armadillo) Chelonia mydas (Green sea-turtle) (Chelonia agassizi) Chrysemys picta bellii (Western painted turtle) (Emys bellii) Oryctolagus cuniculus (Rabbit) Rattus norvegicus (Rat) Hipposideros armiger (great roundleaf bat) Tupaia chinensis (Chinese tree shrew) And more	622	UniRef50_A6PWY4	Cluster: WD repeat-containing protein 76	152

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF011624 mRNA. Translation: ABK41114.1. AK023035 mRNA. Translation: BAB14369.1. AK290933 mRNA. Translation: BAF83622.1. AC018512 Genomic DNA. No translation available. AC023356 Genomic DNA. No translation available. BC025247 mRNA. Translation: AAH25247.1. BC051855 mRNA. Translation: AAH51855.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10106.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001161413.1. NM_001167941.1. NP_079184.2. NM_024908.3. XP_005254737.1. XM_005254680.3.
UniGeneⁱ	Hs.250154.

3D structure databases

ProteinModelPortalⁱ	Q9H967.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123035. 58 interactors.
IntActⁱ	Q9H967. 10 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-3069089.
STRINGⁱ	9606.ENSP00000263795.

PTM databases

iPTMnetⁱ	Q9H967.
PhosphoSitePlusⁱ	Q9H967.

Polymorphism and mutation databases

BioMutaⁱ	WDR76.
DMDMⁱ	313104049.

Proteomic databases

EPDⁱ	Q9H967.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H967.
PaxDbⁱ	Q9H967.
PeptideAtlas More...PeptideAtlasⁱ	Q9H967.
PRIDEⁱ	Q9H967.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000263795; ENSP00000263795; ENSG00000092470.
GeneIDⁱ	79968.
KEGGⁱ	hsa:79968.
UCSC genome browser More...UCSCⁱ	uc001zti.3. human.

Organism-specific databases

CTDⁱ	79968.
DisGeNET More...DisGeNETⁱ	79968.
GeneCardsⁱ	WDR76.
H-InvDBⁱ	HIX0022461.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25773. WDR76.
Human Protein Atlas More...HPAⁱ	HPA039804. HPA040626.
neXtProtⁱ	NX_Q9H967.
Open Targets More...OpenTargetsⁱ	ENSG00000092470.
PharmGKBⁱ	PA142670580.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4328. Eukaryota. ENOG410XRID. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048144.
HOGENOMⁱ	HOG000081507.
HOVERGENⁱ	HBG079574.
InParanoidⁱ	Q9H967.
OMAⁱ	GMVISED.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07AQ.
PhylomeDBⁱ	Q9H967.
TreeFamⁱ	TF314788.

Enzyme and pathway databases

SignaLinkⁱ	Q9H967.

SignaLinkⁱ

Q9H967.

Miscellaneous databases

ChiTaRSⁱ	WDR76. human.
GenomeRNAiⁱ	79968.
Protein Ontology More...PROⁱ	PR:Q9H967.

Gene expression databases

Bgeeⁱ	ENSG00000092470.
CleanExⁱ	HS_WDR76.
ExpressionAtlasⁱ	Q9H967. baseline and differential.
Genevisibleⁱ	Q9H967. HS.

Family and domain databases

Gene3Dⁱ	2.130.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR033052. Cmr1/WDR76. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR017986. WD40_repeat_dom.
PANTHERⁱ	PTHR14773:SF2. PTHR14773:SF2. 1 hit.
SMARTⁱ	View protein in SMART SM00320. WD40. 5 hits.
SUPFAMⁱ	SSF50978. SSF50978. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	WDR76_HUMAN
Accessionⁱ	Q9H967Primary (citable) accession number: Q9H967 Secondary accession number(s): A0MNP5, Q05CI4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
	Last sequence update:	November 30, 2010
	Last modified:	August 30, 2017
	This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9H967 (WDR76_HUMAN)

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WD repeat-containing protein 76

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ