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UniProtKB - Q9H967 (WDR76_HUMAN)

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Protein

WD repeat-containing protein 76

Gene

WDR76

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9H967.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 76
Gene namesi
Name:WDR76
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:25773. WDR76.

Pathology & Biotechi

Organism-specific databases

DisGeNETi79968.
OpenTargetsiENSG00000092470.
PharmGKBiPA142670580.

Polymorphism and mutation databases

BioMutaiWDR76.
DMDMi313104049.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002426911 – 626WD repeat-containing protein 76Add BLAST626

Proteomic databases

EPDiQ9H967.
MaxQBiQ9H967.
PaxDbiQ9H967.
PeptideAtlasiQ9H967.
PRIDEiQ9H967.

PTM databases

iPTMnetiQ9H967.
PhosphoSitePlusiQ9H967.

Expressioni

Gene expression databases

BgeeiENSG00000092470.
CleanExiHS_WDR76.
ExpressionAtlasiQ9H967. baseline and differential.
GenevisibleiQ9H967. HS.

Organism-specific databases

HPAiHPA039804.
HPA040626.

Interactioni

Subunit structurei

Interacts with CUL4A and/or CUL4B.1 Publication

Protein-protein interaction databases

BioGridi123035. 56 interactors.
IntActiQ9H967. 10 interactors.
MINTiMINT-3069089.
STRINGi9606.ENSP00000263795.

Structurei

3D structure databases

ProteinModelPortaliQ9H967.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati311 – 352WD 1Add BLAST42
Repeati358 – 400WD 2Add BLAST43
Repeati402 – 441WD 3Add BLAST40
Repeati446 – 485WD 4Add BLAST40
Repeati493 – 533WD 5Add BLAST41
Repeati535 – 565WD 6Add BLAST31
Repeati590 – 626WD 7Add BLAST37

Sequence similaritiesi

Belongs to the WD repeat DDB2/WDR76 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG4328. Eukaryota.
ENOG410XRID. LUCA.
GeneTreeiENSGT00510000048144.
HOGENOMiHOG000081507.
HOVERGENiHBG079574.
InParanoidiQ9H967.
OMAiGMVISED.
OrthoDBiEOG091G07AQ.
PhylomeDBiQ9H967.
TreeFamiTF314788.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR033052. Cmr1/WDR76.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
PANTHERiPTHR14773:SF2. PTHR14773:SF2. 1 hit.
SMARTiView protein in SMART
SM00320. WD40. 5 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSGAAAEK ADSRQRPQMK VNEYKENQNI AYVSLRPAQT TVLIKTAKVY 
        60         70         80         90        100
LAPFSLSNYQ LDQLMCPKSL SEKNSNNEVA CKKTKIKKTC RRIIPPKMKN 
       110        120        130        140        150
TSSKAESTLQ NSSSAVHTES NKLQPKRTAD AMNLSVDVES SQDGDSDEDT 
       160        170        180        190        200
TPSLDFSGLS PYERKRLKNI SENADFFASL QLSESAARLR EMIEKRQPPK 
       210        220        230        240        250
SKRKKPKREN GIGCRRSMRL LKVDPSGVSL PAAPTPPTLV ADETPLLPPG 
       260        270        280        290        300
PLEMTSENQE DNNERFKGFL HTWAGMSKPS SKNTEKGLSS IKSYKANLNG 
       310        320        330        340        350
MVISEDTVYK VTTGPIFSMA LHPSETRTLV AVGAKFGQVG LCDLTQQPKE 
       360        370        380        390        400
DGVYVFHPHS QPVSCLYFSP ANPAHILSLS YDGTLRCGDF SRAIFEEVYR 
       410        420        430        440        450
NERSSFSSFD FLAEDASTLI VGHWDGNMSL VDRRTPGTSY EKLTSSSMGK 
       460        470        480        490        500
IRTVHVHPVH RQYFITAGLR DTHIYDARRL NSRRSQPLIS LTEHTKSIAS 
       510        520        530        540        550
AYFSPLTGNR VVTTCADCNL RIFDSSCISS KIPLLTTIRH NTFTGRWLTR 
       560        570        580        590        600
FQAMWDPKQE DCVIVGSMAH PRRVEIFHET GKRVHSFGGE YLVSVCSINA 
       610        620 
MHPTRYILAG GNSSGKIHVF MNEKSC
Length:626
Mass (Da):69,769
Last modified:November 30, 2010 - v2
Checksum:iDC6DE3A59250EFA1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026862153S → A3 PublicationsCorresponds to variant dbSNP:rs678084Ensembl.1
Natural variantiVAR_026863614S → G. Corresponds to variant dbSNP:rs3742985Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF011624 mRNA. Translation: ABK41114.1.
AK023035 mRNA. Translation: BAB14369.1.
AK290933 mRNA. Translation: BAF83622.1.
AC018512 Genomic DNA. No translation available.
AC023356 Genomic DNA. No translation available.
BC025247 mRNA. Translation: AAH25247.1.
BC051855 mRNA. Translation: AAH51855.1.
CCDSiCCDS10106.1.
RefSeqiNP_001161413.1. NM_001167941.1.
NP_079184.2. NM_024908.3.
XP_005254737.1. XM_005254680.3.
UniGeneiHs.250154.

Genome annotation databases

EnsembliENST00000263795; ENSP00000263795; ENSG00000092470.
GeneIDi79968.
KEGGihsa:79968.
UCSCiuc001zti.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF011624 mRNA. Translation: ABK41114.1.
AK023035 mRNA. Translation: BAB14369.1.
AK290933 mRNA. Translation: BAF83622.1.
AC018512 Genomic DNA. No translation available.
AC023356 Genomic DNA. No translation available.
BC025247 mRNA. Translation: AAH25247.1.
BC051855 mRNA. Translation: AAH51855.1.
CCDSiCCDS10106.1.
RefSeqiNP_001161413.1. NM_001167941.1.
NP_079184.2. NM_024908.3.
XP_005254737.1. XM_005254680.3.
UniGeneiHs.250154.

3D structure databases

ProteinModelPortaliQ9H967.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123035. 56 interactors.
IntActiQ9H967. 10 interactors.
MINTiMINT-3069089.
STRINGi9606.ENSP00000263795.

PTM databases

iPTMnetiQ9H967.
PhosphoSitePlusiQ9H967.

Polymorphism and mutation databases

BioMutaiWDR76.
DMDMi313104049.

Proteomic databases

EPDiQ9H967.
MaxQBiQ9H967.
PaxDbiQ9H967.
PeptideAtlasiQ9H967.
PRIDEiQ9H967.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263795; ENSP00000263795; ENSG00000092470.
GeneIDi79968.
KEGGihsa:79968.
UCSCiuc001zti.3. human.

Organism-specific databases

CTDi79968.
DisGeNETi79968.
GeneCardsiWDR76.
H-InvDBiHIX0022461.
HGNCiHGNC:25773. WDR76.
HPAiHPA039804.
HPA040626.
neXtProtiNX_Q9H967.
OpenTargetsiENSG00000092470.
PharmGKBiPA142670580.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4328. Eukaryota.
ENOG410XRID. LUCA.
GeneTreeiENSGT00510000048144.
HOGENOMiHOG000081507.
HOVERGENiHBG079574.
InParanoidiQ9H967.
OMAiGMVISED.
OrthoDBiEOG091G07AQ.
PhylomeDBiQ9H967.
TreeFamiTF314788.

Enzyme and pathway databases

SignaLinkiQ9H967.

Miscellaneous databases

ChiTaRSiWDR76. human.
GenomeRNAii79968.
PROiPR:Q9H967.

Gene expression databases

BgeeiENSG00000092470.
CleanExiHS_WDR76.
ExpressionAtlasiQ9H967. baseline and differential.
GenevisibleiQ9H967. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR033052. Cmr1/WDR76.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
PANTHERiPTHR14773:SF2. PTHR14773:SF2. 1 hit.
SMARTiView protein in SMART
SM00320. WD40. 5 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiWDR76_HUMAN
AccessioniPrimary (citable) accession number: Q9H967
Secondary accession number(s): A0MNP5, Q05CI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 30, 2010
Last modified: June 7, 2017
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.