Q9H943 (CJ068_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C10orf68

Gene names

Name:

C10orf68

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	628 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H943-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q9H943-2)

The sequence of this isoform differs from the canonical sequence as follows:
     276-276: K → IKNEAASELPDTAENLPAMYPSISDLIIQFDLNKVVE
     392-392: K → KEHLADDTGRGIIKGSINAQLKGHQKTDK

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9H943-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MTEEQTYQAAEKSQ → MVPASASGEGLRELLLVQEGEVGADMSH
     94-131: Missing.
     392-392: K → KEHLADDTGRGIIKGSINAQLKGHQKTDK

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 628	628	Uncharacterized protein C10orf68		PRO_0000089801
Natural variations
	Alternative sequence	1 – 14	14	MTEEQ…AEKSQ → MVPASASGEGLRELLLVQEG EVGADMSH in isoform 3.		VSP_040359
	Alternative sequence	94 – 131	38	Missing in isoform 3.		VSP_040360
	Alternative sequence	276	1	K → IKNEAASELPDTAENLPAMY PSISDLIIQFDLNKVVE in isoform 2.		VSP_014599
	Alternative sequence	392	1	K → KEHLADDTGRGIIKGSINAQ LKGHQKTDK in isoform 2 and isoform 3.		VSP_014600
	Natural variant	388	1	G → A. Ref.1 Ref.3 Corresponds to variant rs4448627 [ dbSNP | Ensembl ].		VAR_033692
	Natural variant	510	1	M → T. Corresponds to variant rs2504011 [ dbSNP | Ensembl ].		VAR_024308
	Natural variant	607	1	V → I. Ref.1 Ref.3 Corresponds to variant rs1418538 [ dbSNP | Ensembl ].		VAR_033693
Experimental info
	Sequence conflict	39	1	I → V in BAB14400. Ref.1
	Sequence conflict	39	1	I → V in AAI25092. Ref.3
	Sequence conflict	100	1	L → P in BAB14400. Ref.1
	Sequence conflict	205	1	N → S in BAB14400. Ref.1
	Sequence conflict	326	1	R → Q in BAC05140. Ref.1
	Sequence conflict	530	1	T → A in BAC05140. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 2. Checksum: 7A9AB1E1B308F06E	FASTA	628	71,535
	10 20 30 40 50 60 MTEEQTYQAA EKSQAHNEVP NERLVVEHQE SLSKTKLQIK KQETSTEQPL TTPDKEPNEN 70 80 90 100 110 120 LILRHQDSMS KSEMQVKEQR TLKGQRIITH DEEPGKNLVL EHQDSVSKLE MQIEKTKKLP 130 140 150 160 170 180 REKRHSTHDE ESGENPMLKH QDSVSKIQVQ LEIQETSEGE GRSIPDKNSM FVHQDSVSKL 190 200 210 220 230 240 QMQEKKKITP GRERRNTRIV VPNENVISVH QDSKSKLQMQ EKKQINSGVE RHKTFPLEIK 250 260 270 280 290 300 KKDISLEHLL PEEKVLLSRS ESQTKKLQAK VTSRKKTDIE SLRGALGRRL LNDEFKTQSK 310 320 330 340 350 360 SFPGPDIEQL TDAFGRDILK DEFKTRSKSL PETDERLHST TERGTINDAI KTQLKRKSYP 370 380 390 400 410 420 ETVLKHLKGV NGKDIIKHLI NIQSKSHGET DKNFFAYATG RGLMKESTTT QLKSHPETDK 430 440 450 460 470 480 EFLADAIGRG IIIGPITTQL KSHRETDKEL LKDAIGRDII KGPISAQLKS HQETDVEPLT 490 500 510 520 530 540 NAIGSSKTIG EIKTQLRTHY DVNLFKNKDM SVQRQEGIFT RSITPSKFPT KVINLSPFEN 550 560 570 580 590 600 KEETYEYSSP YVTAPSKAIY RTYRAGPSFS KDIHLPLLNQ LPSGHSKVVT LSQKTIEFTL 610 620 PTVTNTVGKP TYKVLHAAAR KSVPHPYF
	Isoform 2 [UniParc]. Checksum: E1F7B7DF525DDDA4	FASTA	692	78,492
	10 20 30 40 50 60 MTEEQTYQAA EKSQAHNEVP NERLVVEHQE SLSKTKLQIK KQETSTEQPL TTPDKEPNEN 70 80 90 100 110 120 LILRHQDSMS KSEMQVKEQR TLKGQRIITH DEEPGKNLVL EHQDSVSKLE MQIEKTKKLP 130 140 150 160 170 180 REKRHSTHDE ESGENPMLKH QDSVSKIQVQ LEIQETSEGE GRSIPDKNSM FVHQDSVSKL 190 200 210 220 230 240 QMQEKKKITP GRERRNTRIV VPNENVISVH QDSKSKLQMQ EKKQINSGVE RHKTFPLEIK 250 260 270 280 290 300 KKDISLEHLL PEEKVLLSRS ESQTKKLQAK VTSRKIKNEA ASELPDTAEN LPAMYPSISD 310 320 330 340 350 360 LIIQFDLNKV VETDIESLRG ALGRRLLNDE FKTQSKSFPG PDIEQLTDAF GRDILKDEFK 370 380 390 400 410 420 TRSKSLPETD ERLHSTTERG TINDAIKTQL KRKSYPETVL KHLKGVNGKD IIKHLINIQS 430 440 450 460 470 480 KSHGETDKEH LADDTGRGII KGSINAQLKG HQKTDKNFFA YATGRGLMKE STTTQLKSHP 490 500 510 520 530 540 ETDKEFLADA IGRGIIIGPI TTQLKSHRET DKELLKDAIG RDIIKGPISA QLKSHQETDV 550 560 570 580 590 600 EPLTNAIGSS KTIGEIKTQL RTHYDVNLFK NKDMSVQRQE GIFTRSITPS KFPTKVINLS 610 620 630 640 650 660 PFENKEETYE YSSPYVTAPS KAIYRTYRAG PSFSKDIHLP LLNQLPSGHS KVVTLSQKTI 670 680 690 EFTLPTVTNT VGKPTYKVLH AAARKSVPHP YF
	Isoform 3 [UniParc]. Checksum: 44848EBD78D7C34B	FASTA	632	71,310
	10 20 30 40 50 60 MVPASASGEG LRELLLVQEG EVGADMSHAH NEVPNERLVV EHQESLSKTK LQIKKQETST 70 80 90 100 110 120 EQPLTTPDKE PNENLILRHQ DSMSKSEMQV KEQRTLKGQR IITHDEESGE NPMLKHQDSV 130 140 150 160 170 180 SKIQVQLEIQ ETSEGEGRSI PDKNSMFVHQ DSVSKLQMQE KKKITPGRER RNTRIVVPNE 190 200 210 220 230 240 NVISVHQDSK SKLQMQEKKQ INSGVERHKT FPLEIKKKDI SLEHLLPEEK VLLSRSESQT 250 260 270 280 290 300 KKLQAKVTSR KKTDIESLRG ALGRRLLNDE FKTQSKSFPG PDIEQLTDAF GRDILKDEFK 310 320 330 340 350 360 TRSKSLPETD ERLHSTTERG TINDAIKTQL KRKSYPETVL KHLKGVNGKD IIKHLINIQS 370 380 390 400 410 420 KSHGETDKEH LADDTGRGII KGSINAQLKG HQKTDKNFFA YATGRGLMKE STTTQLKSHP 430 440 450 460 470 480 ETDKEFLADA IGRGIIIGPI TTQLKSHRET DKELLKDAIG RDIIKGPISA QLKSHQETDV 490 500 510 520 530 540 EPLTNAIGSS KTIGEIKTQL RTHYDVNLFK NKDMSVQRQE GIFTRSITPS KFPTKVINLS 550 560 570 580 590 600 PFENKEETYE YSSPYVTAPS KAIYRTYRAG PSFSKDIHLP LLNQLPSGHS KVVTLSQKTI 610 620 630 EFTLPTVTNT VGKPTYKVLH AAARKSVPHP YF

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 194-628 (ISOFORM 2), VARIANTS ALA-388 AND ILE-607. Tissue: Teratocarcinoma and Testis.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS ALA-388 AND ILE-607.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK023093 mRNA. Translation: BAB14400.1. AK097668 mRNA. Translation: BAC05140.1. AL356053 , AL354750, AL365203, AL591850 Genomic DNA. Translation: CAQ06687.1. AL354750 , AL356053, AL365203, AL591850 Genomic DNA. Translation: CAQ06850.1. AL365203 , AL354750, AL356053, AL591850 Genomic DNA. Translation: CAQ08110.1. AL591850 , AL354750, AL356053, AL365203 Genomic DNA. Translation: CAQ09810.1. BC125091 mRNA. Translation: AAI25092.1.
IPI	IPI00413658. IPI00607785. IPI00972981.
RefSeq	NP_078964.2. NM_024688.2.
UniGene	Hs.585464.
3D structure databases
ProteinModelPortal	Q9H943.
ModBase	Search...
Polymorphism databases
DMDM	68565303.
Proteomic databases
PRIDE	Q9H943.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302316; ENSP00000303710; ENSG00000150076.
GeneID	79741.
KEGG	hsa:79741.
Organism-specific databases
CTD	79741.
GeneCards	GC10P032896.
HGNC	HGNC:25779. C10orf68.
HPA	HPA039300.
neXtProt	NX_Q9H943.
PharmGKB	PA134955273.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000004865.
HOVERGEN	HBG079994.
OrthoDB	EOG4548Z5.
Gene expression databases
ArrayExpress	Q9H943.
Bgee	Q9H943.
Genevestigator	Q9H943.
GermOnline	ENSG00000150076. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	69145.

Entry information

Entry name

CJ068_HUMAN

Accession

Primary (citable) accession number: Q9H943
Secondary accession number(s): B0QZ71, Q08AN7, Q8N7T7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	January 11, 2011
Last modified:	January 25, 2012
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.