Reviewed, UniProtKB/Swiss-Prot Q9H939 (PPIP2_HUMAN)

Names and origin

Protein names

Recommended name:
    Proline-serine-threonine phosphatase-interacting protein 2

Gene names

Name:

PSTPIP2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds to F-actin. May be involved in regulation of the actin cytoskeleton By similarity.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.
Post-translational modification	Phosphorylated on tyrosine By similarity.
Sequence similarities	Contains 1 FCH domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H939-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H939-2)

The sequence of this isoform differs from the canonical sequence as follows:
     248-334: MYEQVRKSLE...LVDDYSLLYQ → HPSCMRISTP...KINETRAFSG

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 334	333	Proline-serine-threonine phosphatase-interacting protein 2		PRO_0000058541
Regions
	Domain	4 – 89	86	FCH
	Coiled coil	66 – 166	101	Potential
Amino acid modifications
	Modified residue	323	1	Phosphotyrosine By similarity
	Modified residue	329	1	Phosphotyrosine By similarity
Natural variations
	Alternative sequence	248 – 334	87	MYEQV…SLLYQ → HPSCMRISTPPRRMQSQQER LQGLTWQGEDPSQFLKAHQM IPITLWLMTTVCSISKINET RAFSG in isoform 2.		VSP_004070

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: DD7DDCD5AE5D9165	FASTA	334	38,832
	10 20 30 40 50 60 MTRSLFKGNF WSADILSTIG YDNIIQHLNN GRKNCKEFED FLKERAAIEE RYGKDLLNLS 70 80 90 100 110 120 RKKPCGQSEI NTLKRALEVF KQQVDNVAQC HIQLAQSLRE EARKMEEFRE KQKLQRKKTE 130 140 150 160 170 180 LIMDAIHKQK SLQFKKTMDA KKNYEQKCRD KDEAEQAVSR SANLVNPKQQ EKLFVKLATS 190 200 210 220 230 240 KTAVEDSDKA YMLHIGTLDK VREEWQSEHI KACEAFEAQE CERINFFRNA LWLHVNQLSQ 250 260 270 280 290 300 QCVTSDEMYE QVRKSLEMCS IQRDIEYFVN QRKTGQIPPA PIMHENFYSS QKNAVPAGKA 310 320 330 TGPNLARRGP LPIPKSSPDD PNYSLVDDYS LLYQ
	Isoform 2. Checksum: 366C0F8B5A1CA272	FASTA	312	36,446
	10 20 30 40 50 60 MTRSLFKGNF WSADILSTIG YDNIIQHLNN GRKNCKEFED FLKERAAIEE RYGKDLLNLS 70 80 90 100 110 120 RKKPCGQSEI NTLKRALEVF KQQVDNVAQC HIQLAQSLRE EARKMEEFRE KQKLQRKKTE 130 140 150 160 170 180 LIMDAIHKQK SLQFKKTMDA KKNYEQKCRD KDEAEQAVSR SANLVNPKQQ EKLFVKLATS 190 200 210 220 230 240 KTAVEDSDKA YMLHIGTLDK VREEWQSEHI KACEAFEAQE CERINFFRNA LWLHVNQLSQ 250 260 270 280 290 300 QCVTSDEHPS CMRISTPPRR MQSQQERLQG LTWQGEDPSQ FLKAHQMIPI TLWLMTTVCS 310 ISKINETRAF SG

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 113-334 (ISOFORM 1).
[3]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK023100 mRNA. Translation: BAB14404.1. Different initiation. BC035395 mRNA. Translation: AAH35395.1.
IPI	IPI00016620. IPI00170554.
RefSeq	NP_077748.3.
UniGene	Hs.567384
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q9H939.
Proteomic databases
PRIDE	Q9H939.
Genome annotation databases
Ensembl	ENSG00000152229. Homo sapiens. [Contig view]
GeneID	9050.
KEGG	hsa:9050.
Organism-specific databases
GeneCards	GC18M041817.
HGNC	HGNC:9581. PSTPIP2.
PharmGKB	PA33932.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9H939.
HOVERGEN	Q9H939.
Gene expression databases
ArrayExpress	Q9H939.
Bgee	Q9H939.
CleanEx	HS_PSTPIP2.
GermOnline	ENSG00000152229. Homo sapiens.
Family and domain databases
InterPro	IPR001060. FCH. [Graphical view]
Pfam	PF00611. FCH. 1 hit. [Graphical view]
SMART	SM00055. FCH. 1 hit. [Graphical view]
PROSITE	PS50133. FCH. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	33907.

Entry information

Entry name

PPIP2_HUMAN

Accession

Primary (citable) accession number: Q9H939

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 56 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)