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Q9H939 (PPIP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proline-serine-threonine phosphatase-interacting protein 2

Short name=PEST phosphatase-interacting protein 2
Gene names
Name:PSTPIP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to F-actin. May be involved in regulation of the actin cytoskeleton By similarity.

Subcellular location

Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.

Post-translational modification

Phosphorylated on tyrosine By similarity.

Sequence similarities

Contains 1 FCH domain.

Sequence caution

The sequence BAB14404.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoskeleton

Inferred from electronic annotation. Source: Ensembl

cytosol

Inferred from electronic annotation. Source: Ensembl

membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H939-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H939-2)

The sequence of this isoform differs from the canonical sequence as follows:
     248-334: MYEQVRKSLE...LVDDYSLLYQ → HPSCMRISTP...KINETRAFSG
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 334333Proline-serine-threonine phosphatase-interacting protein 2
PRO_0000058541

Regions

Domain4 – 8986FCH
Coiled coil66 – 166101 Potential

Amino acid modifications

Modified residue3231Phosphotyrosine By similarity
Modified residue3291Phosphotyrosine By similarity

Natural variations

Alternative sequence248 – 33487MYEQV…SLLYQ → HPSCMRISTPPRRMQSQQER LQGLTWQGEDPSQFLKAHQM IPITLWLMTTVCSISKINET RAFSG in isoform 2.
VSP_004070
Natural variant3221N → D.
Corresponds to variant rs2276199 [ dbSNP | Ensembl ].
VAR_059708
Natural variant3221N → S.
Corresponds to variant rs16978507 [ dbSNP | Ensembl ].
VAR_059709

Experimental info

Sequence conflict2841Y → H in BAB14404. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 20, 2010. Version 4.
Checksum: DD7DC17EC3F6E165

FASTA33438,858
        10         20         30         40         50         60 
MTRSLFKGNF WSADILSTIG YDNIIQHLNN GRKNCKEFED FLKERAAIEE RYGKDLLNLS 

        70         80         90        100        110        120 
RKKPCGQSEI NTLKRALEVF KQQVDNVAQC HIQLAQSLRE EARKMEEFRE KQKLQRKKTE 

       130        140        150        160        170        180 
LIMDAIHKQK SLQFKKTMDA KKNYEQKCRD KDEAEQAVSR SANLVNPKQQ EKLFVKLATS 

       190        200        210        220        230        240 
KTAVEDSDKA YMLHIGTLDK VREEWQSEHI KACEAFEAQE CERINFFRNA LWLHVNQLSQ 

       250        260        270        280        290        300 
QCVTSDEMYE QVRKSLEMCS IQRDIEYFVN QRKTGQIPPA PIMYENFYSS QKNAVPAGKA 

       310        320        330 
TGPNLARRGP LPIPKSSPDD PNYSLVDDYS LLYQ 

« Hide

Isoform 2 [UniParc].

Checksum: 366C0F8B5A1CA272
Show »

FASTA31236,446

References

[1]"DNA sequence and analysis of human chromosome 18."
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. expand/collapse author list , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 113-334 (ISOFORM 1).
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC012569 Genomic DNA. No translation available.
AC090355 Genomic DNA. No translation available.
BC035395 mRNA. Translation: AAH35395.1.
AK023100 mRNA. Translation: BAB14404.1. Different initiation.
RefSeqNP_077748.3. NM_024430.3.
UniGeneHs.567384.

3D structure databases

ProteinModelPortalQ9H939.
SMRQ9H939. Positions 21-268.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114512. 4 interactions.
IntActQ9H939. 4 interactions.
MINTMINT-4781125.
STRING9606.ENSP00000387261.

PTM databases

PhosphoSiteQ9H939.

Polymorphism databases

DMDM294862539.

Proteomic databases

PaxDbQ9H939.
PRIDEQ9H939.

Protocols and materials databases

DNASU9050.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000409746; ENSP00000387261; ENSG00000152229. [Q9H939-1]
ENST00000589328; ENSP00000468622; ENSG00000152229. [Q9H939-2]
GeneID9050.
KEGGhsa:9050.
UCSCuc002lbp.4. human. [Q9H939-1]
uc002lbq.4. human. [Q9H939-2]

Organism-specific databases

CTD9050.
GeneCardsGC18M043563.
H-InvDBHIX0014425.
HGNCHGNC:9581. PSTPIP2.
HPAHPA040923.
HPA040944.
neXtProtNX_Q9H939.
PharmGKBPA33932.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG303711.
HOGENOMHOG000294218.
HOVERGENHBG052960.
InParanoidQ9H939.
OMAYENFYCP.
OrthoDBEOG7BCNBS.
PhylomeDBQ9H939.
TreeFamTF313677.

Gene expression databases

BgeeQ9H939.
CleanExHS_PSTPIP2.
GenevestigatorQ9H939.

Family and domain databases

InterProIPR001060. FCH_dom.
[Graphical view]
PfamPF00611. FCH. 1 hit.
[Graphical view]
SMARTSM00055. FCH. 1 hit.
[Graphical view]
PROSITEPS50133. FCH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPSTPIP2. human.
GeneWikiPSTPIP2.
GenomeRNAi9050.
NextBio33907.
PROQ9H939.

Entry information

Entry namePPIP2_HUMAN
AccessionPrimary (citable) accession number: Q9H939
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: April 20, 2010
Last modified: April 16, 2014
This is version 103 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM