Q9H939 (PPIP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proline-serine-threonine phosphatase-interacting protein 2
Short name=PEST phosphatase-interacting protein 2

Gene names

Name:

PSTPIP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to F-actin. May be involved in regulation of the actin cytoskeleton By similarity.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.
Post-translational modification	Phosphorylated on tyrosine By similarity.
Sequence similarities	Contains 1 FCH domain.
Sequence caution	The sequence BAB14404.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoskeleton Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: Compara membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H939-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H939-2)

The sequence of this isoform differs from the canonical sequence as follows:
     248-334: MYEQVRKSLE...LVDDYSLLYQ → HPSCMRISTP...KINETRAFSG

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 334	333	Proline-serine-threonine phosphatase-interacting protein 2		PRO_0000058541
Regions
	Domain	4 – 89	86	FCH
	Coiled coil	66 – 166	101	Potential
Amino acid modifications
	Modified residue	323	1	Phosphotyrosine By similarity
	Modified residue	329	1	Phosphotyrosine By similarity
Natural variations
	Alternative sequence	248 – 334	87	MYEQV…SLLYQ → HPSCMRISTPPRRMQSQQER LQGLTWQGEDPSQFLKAHQM IPITLWLMTTVCSISKINET RAFSG in isoform 2.		VSP_004070
	Natural variant	322	1	N → D. Corresponds to variant rs2276199 [ dbSNP | Ensembl ].		VAR_059708
	Natural variant	322	1	N → S. Corresponds to variant rs16978507 [ dbSNP | Ensembl ].		VAR_059709
Experimental info
	Sequence conflict	284	1	Y → H in BAB14404. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 20, 2010. Version 4. Checksum: DD7DC17EC3F6E165	FASTA	334	38,858
	10 20 30 40 50 60 MTRSLFKGNF WSADILSTIG YDNIIQHLNN GRKNCKEFED FLKERAAIEE RYGKDLLNLS 70 80 90 100 110 120 RKKPCGQSEI NTLKRALEVF KQQVDNVAQC HIQLAQSLRE EARKMEEFRE KQKLQRKKTE 130 140 150 160 170 180 LIMDAIHKQK SLQFKKTMDA KKNYEQKCRD KDEAEQAVSR SANLVNPKQQ EKLFVKLATS 190 200 210 220 230 240 KTAVEDSDKA YMLHIGTLDK VREEWQSEHI KACEAFEAQE CERINFFRNA LWLHVNQLSQ 250 260 270 280 290 300 QCVTSDEMYE QVRKSLEMCS IQRDIEYFVN QRKTGQIPPA PIMYENFYSS QKNAVPAGKA 310 320 330 TGPNLARRGP LPIPKSSPDD PNYSLVDDYS LLYQ
	Isoform 2 [UniParc]. Checksum: 366C0F8B5A1CA272	FASTA	312	36,446
	10 20 30 40 50 60 MTRSLFKGNF WSADILSTIG YDNIIQHLNN GRKNCKEFED FLKERAAIEE RYGKDLLNLS 70 80 90 100 110 120 RKKPCGQSEI NTLKRALEVF KQQVDNVAQC HIQLAQSLRE EARKMEEFRE KQKLQRKKTE 130 140 150 160 170 180 LIMDAIHKQK SLQFKKTMDA KKNYEQKCRD KDEAEQAVSR SANLVNPKQQ EKLFVKLATS 190 200 210 220 230 240 KTAVEDSDKA YMLHIGTLDK VREEWQSEHI KACEAFEAQE CERINFFRNA LWLHVNQLSQ 250 260 270 280 290 300 QCVTSDEHPS CMRISTPPRR MQSQQERLQG LTWQGEDPSQ FLKAHQMIPI TLWLMTTVCS 310 ISKINETRAF SG

References

[1]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 113-334 (ISOFORM 1).
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC012569 Genomic DNA. No translation available. AC090355 Genomic DNA. No translation available. BC035395 mRNA. Translation: AAH35395.1. AK023100 mRNA. Translation: BAB14404.1. Different initiation.
IPI	IPI00016620. IPI00170554.
RefSeq	NP_077748.3. NM_024430.3.
UniGene	Hs.567384.
3D structure databases
ProteinModelPortal	Q9H939.
SMR	Q9H939. Positions 21-268.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H939. 3 interactions.
STRING	9606.ENSP00000387261.
PTM databases
PhosphoSite	Q9H939.
Polymorphism databases
DMDM	294862539.
Proteomic databases
PaxDb	Q9H939.
PRIDE	Q9H939.
Protocols and materials databases
DNASU	9050.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000409746; ENSP00000387261; ENSG00000152229. ENST00000589328; ENSP00000468622; ENSG00000152229.
GeneID	9050.
KEGG	hsa:9050.
UCSC	uc002lbp.4. human. uc002lbq.4. human.
Organism-specific databases
CTD	9050.
GeneCards	GC18M043563.
H-InvDB	HIX0014425.
HGNC	HGNC:9581. PSTPIP2.
HPA	HPA040923. HPA040944.
neXtProt	NX_Q9H939.
PharmGKB	PA33932.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG303711.
HOGENOM	HOG000294218.
HOVERGEN	HBG052960.
InParanoid	Q9H939.
OMA	NAAPPGK.
OrthoDB	EOG4F1X3Z.
Gene expression databases
Bgee	Q9H939.
CleanEx	HS_PSTPIP2.
Genevestigator	Q9H939.
GermOnline	ENSG00000152229. Homo sapiens.
Family and domain databases
InterPro	IPR001060. FCH_dom. [Graphical view]
Pfam	PF00611. FCH. 1 hit. [Graphical view]
SMART	SM00055. FCH. 1 hit. [Graphical view]
PROSITE	PS50133. FCH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PSTPIP2. human.
GenomeRNAi	9050.
NextBio	33907.

Entry information

Entry name

PPIP2_HUMAN

Accession

Primary (citable) accession number: Q9H939

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	April 20, 2010
Last modified:	May 1, 2013
This is version 95 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.