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Reviewed, UniProtKB/Swiss-Prot Q9H939 (PPIP2_HUMAN)

Last modified June 16, 2009. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Proline-serine-threonine phosphatase-interacting protein 2
Gene names
Name: PSTPIP2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Binds to F-actin. May be involved in regulation of the actin cytoskeleton By similarity.

Subcellular location

Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.

Post-translational modification

Phosphorylated on tyrosine By similarity.

Sequence similarities

Contains 1 FCH domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   PTMPhosphoprotein
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H939-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H939-2)

The sequence of this isoform differs from the canonical sequence as follows:
     248-334: MYEQVRKSLE...LVDDYSLLYQ → HPSCMRISTP...KINETRAFSG
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 334333Proline-serine-threonine phosphatase-interacting protein 2
PRO_0000058541

Regions

Domain4 – 8986FCH
Coiled coil66 – 166101 Potential

Amino acid modifications

Modified residue3231Phosphotyrosine By similarity
Modified residue3291Phosphotyrosine By similarity

Natural variations

Alternative sequence248 – 33487MYEQV…SLLYQ → HPSCMRISTPPRRMQSQQER LQGLTWQGEDPSQFLKAHQM IPITLWLMTTVCSISKINET RAFSG in isoform 2.
VSP_004070

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: DD7DDCD5AE5D9165

FASTA33438,832
        10         20         30         40         50         60 
MTRSLFKGNF WSADILSTIG YDNIIQHLNN GRKNCKEFED FLKERAAIEE RYGKDLLNLS 

        70         80         90        100        110        120 
RKKPCGQSEI NTLKRALEVF KQQVDNVAQC HIQLAQSLRE EARKMEEFRE KQKLQRKKTE 

       130        140        150        160        170        180 
LIMDAIHKQK SLQFKKTMDA KKNYEQKCRD KDEAEQAVSR SANLVNPKQQ EKLFVKLATS 

       190        200        210        220        230        240 
KTAVEDSDKA YMLHIGTLDK VREEWQSEHI KACEAFEAQE CERINFFRNA LWLHVNQLSQ 

       250        260        270        280        290        300 
QCVTSDEMYE QVRKSLEMCS IQRDIEYFVN QRKTGQIPPA PIMHENFYSS QKNAVPAGKA 

       310        320        330 
TGPNLARRGP LPIPKSSPDD PNYSLVDDYS LLYQ 

« Hide

Isoform 2.

Checksum: 366C0F8B5A1CA272
Show »

FASTA31236,446

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 113-334 (ISOFORM 1).
[3]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases

AK023100 mRNA. Translation: BAB14404.1. Different initiation.
BC035395 mRNA. Translation: AAH35395.1.
IPIIPI00016620.
IPI00170554.
RefSeqNP_077748.3.
UniGeneHs.567384

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteQ9H939.

Proteomic databases

PRIDEQ9H939.

Genome annotation databases

EnsemblENSG00000152229. Homo sapiens. [Contig view]
GeneID9050.
KEGGhsa:9050.

Organism-specific databases

GeneCardsGC18M041817.
HGNCHGNC:9581. PSTPIP2.
PharmGKBPA33932.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9H939.
HOVERGENQ9H939.

Gene expression databases

ArrayExpressQ9H939.
BgeeQ9H939.
CleanExHS_PSTPIP2.
GermOnlineENSG00000152229. Homo sapiens.

Family and domain databases

InterProIPR001060. FCH.
[Graphical view]
PfamPF00611. FCH. 1 hit.
[Graphical view]
SMARTSM00055. FCH. 1 hit.
[Graphical view]
PROSITEPS50133. FCH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio33907.

Entry information

Entry namePPIP2_HUMAN
AccessionPrimary (citable) accession number: Q9H939
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: January 23, 2007
Last modified: June 16, 2009
This is version 56 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents