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Q9H939

- PPIP2_HUMAN

UniProt

Q9H939 - PPIP2_HUMAN

Protein

Proline-serine-threonine phosphatase-interacting protein 2

Gene

PSTPIP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 4 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Binds to F-actin. May be involved in regulation of the actin cytoskeleton By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proline-serine-threonine phosphatase-interacting protein 2
    Short name:
    PEST phosphatase-interacting protein 2
    Gene namesi
    Name:PSTPIP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:9581. PSTPIP2.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. cytoskeleton Source: Ensembl
    2. cytosol Source: Ensembl
    3. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33932.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 334333Proline-serine-threonine phosphatase-interacting protein 2PRO_0000058541Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei323 – 3231PhosphotyrosineBy similarity
    Modified residuei329 – 3291PhosphotyrosineBy similarity

    Post-translational modificationi

    Phosphorylated on tyrosine.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9H939.
    PaxDbiQ9H939.
    PRIDEiQ9H939.

    PTM databases

    PhosphoSiteiQ9H939.

    Expressioni

    Gene expression databases

    BgeeiQ9H939.
    CleanExiHS_PSTPIP2.
    GenevestigatoriQ9H939.

    Organism-specific databases

    HPAiHPA040923.
    HPA040944.

    Interactioni

    Protein-protein interaction databases

    BioGridi114512. 4 interactions.
    IntActiQ9H939. 4 interactions.
    MINTiMINT-4781125.
    STRINGi9606.ENSP00000387261.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H939.
    SMRiQ9H939. Positions 21-268.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 8986FCHPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili66 – 166101Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FCH domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG303711.
    HOGENOMiHOG000294218.
    HOVERGENiHBG052960.
    InParanoidiQ9H939.
    OMAiYENFYCP.
    OrthoDBiEOG7BCNBS.
    PhylomeDBiQ9H939.
    TreeFamiTF313677.

    Family and domain databases

    InterProiIPR001060. FCH_dom.
    [Graphical view]
    PfamiPF00611. FCH. 1 hit.
    [Graphical view]
    SMARTiSM00055. FCH. 1 hit.
    [Graphical view]
    PROSITEiPS50133. FCH. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H939-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTRSLFKGNF WSADILSTIG YDNIIQHLNN GRKNCKEFED FLKERAAIEE    50
    RYGKDLLNLS RKKPCGQSEI NTLKRALEVF KQQVDNVAQC HIQLAQSLRE 100
    EARKMEEFRE KQKLQRKKTE LIMDAIHKQK SLQFKKTMDA KKNYEQKCRD 150
    KDEAEQAVSR SANLVNPKQQ EKLFVKLATS KTAVEDSDKA YMLHIGTLDK 200
    VREEWQSEHI KACEAFEAQE CERINFFRNA LWLHVNQLSQ QCVTSDEMYE 250
    QVRKSLEMCS IQRDIEYFVN QRKTGQIPPA PIMYENFYSS QKNAVPAGKA 300
    TGPNLARRGP LPIPKSSPDD PNYSLVDDYS LLYQ 334
    Length:334
    Mass (Da):38,858
    Last modified:April 20, 2010 - v4
    Checksum:iDD7DC17EC3F6E165
    GO
    Isoform 2 (identifier: Q9H939-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         248-334: MYEQVRKSLE...LVDDYSLLYQ → HPSCMRISTP...KINETRAFSG

    Note: No experimental confirmation available.

    Show »
    Length:312
    Mass (Da):36,446
    Checksum:i366C0F8B5A1CA272
    GO

    Sequence cautioni

    The sequence BAB14404.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti284 – 2841Y → H in BAB14404. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti322 – 3221N → D.
    Corresponds to variant rs2276199 [ dbSNP | Ensembl ].
    VAR_059708
    Natural varianti322 – 3221N → S.
    Corresponds to variant rs16978507 [ dbSNP | Ensembl ].
    VAR_059709

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei248 – 33487MYEQV…SLLYQ → HPSCMRISTPPRRMQSQQER LQGLTWQGEDPSQFLKAHQM IPITLWLMTTVCSISKINET RAFSG in isoform 2. 1 PublicationVSP_004070Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC012569 Genomic DNA. No translation available.
    AC090355 Genomic DNA. No translation available.
    BC035395 mRNA. Translation: AAH35395.1.
    AK023100 mRNA. Translation: BAB14404.1. Different initiation.
    CCDSiCCDS32820.2. [Q9H939-1]
    RefSeqiNP_077748.3. NM_024430.3. [Q9H939-1]
    UniGeneiHs.567384.

    Genome annotation databases

    EnsembliENST00000409746; ENSP00000387261; ENSG00000152229. [Q9H939-1]
    ENST00000589328; ENSP00000468622; ENSG00000152229. [Q9H939-2]
    GeneIDi9050.
    KEGGihsa:9050.
    UCSCiuc002lbp.4. human. [Q9H939-1]
    uc002lbq.4. human. [Q9H939-2]

    Polymorphism databases

    DMDMi294862539.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC012569 Genomic DNA. No translation available.
    AC090355 Genomic DNA. No translation available.
    BC035395 mRNA. Translation: AAH35395.1 .
    AK023100 mRNA. Translation: BAB14404.1 . Different initiation.
    CCDSi CCDS32820.2. [Q9H939-1 ]
    RefSeqi NP_077748.3. NM_024430.3. [Q9H939-1 ]
    UniGenei Hs.567384.

    3D structure databases

    ProteinModelPortali Q9H939.
    SMRi Q9H939. Positions 21-268.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114512. 4 interactions.
    IntActi Q9H939. 4 interactions.
    MINTi MINT-4781125.
    STRINGi 9606.ENSP00000387261.

    PTM databases

    PhosphoSitei Q9H939.

    Polymorphism databases

    DMDMi 294862539.

    Proteomic databases

    MaxQBi Q9H939.
    PaxDbi Q9H939.
    PRIDEi Q9H939.

    Protocols and materials databases

    DNASUi 9050.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000409746 ; ENSP00000387261 ; ENSG00000152229 . [Q9H939-1 ]
    ENST00000589328 ; ENSP00000468622 ; ENSG00000152229 . [Q9H939-2 ]
    GeneIDi 9050.
    KEGGi hsa:9050.
    UCSCi uc002lbp.4. human. [Q9H939-1 ]
    uc002lbq.4. human. [Q9H939-2 ]

    Organism-specific databases

    CTDi 9050.
    GeneCardsi GC18M043563.
    H-InvDB HIX0014425.
    HGNCi HGNC:9581. PSTPIP2.
    HPAi HPA040923.
    HPA040944.
    neXtProti NX_Q9H939.
    PharmGKBi PA33932.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303711.
    HOGENOMi HOG000294218.
    HOVERGENi HBG052960.
    InParanoidi Q9H939.
    OMAi YENFYCP.
    OrthoDBi EOG7BCNBS.
    PhylomeDBi Q9H939.
    TreeFami TF313677.

    Miscellaneous databases

    ChiTaRSi PSTPIP2. human.
    GeneWikii PSTPIP2.
    GenomeRNAii 9050.
    NextBioi 33907.
    PROi Q9H939.

    Gene expression databases

    Bgeei Q9H939.
    CleanExi HS_PSTPIP2.
    Genevestigatori Q9H939.

    Family and domain databases

    InterProi IPR001060. FCH_dom.
    [Graphical view ]
    Pfami PF00611. FCH. 1 hit.
    [Graphical view ]
    SMARTi SM00055. FCH. 1 hit.
    [Graphical view ]
    PROSITEi PS50133. FCH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 113-334 (ISOFORM 1).
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPPIP2_HUMAN
    AccessioniPrimary (citable) accession number: Q9H939
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 106 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3