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Q9H939

- PPIP2_HUMAN

UniProt

Q9H939 - PPIP2_HUMAN

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Protein

Proline-serine-threonine phosphatase-interacting protein 2

Gene

PSTPIP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-serine-threonine phosphatase-interacting protein 2
Short name:
PEST phosphatase-interacting protein 2
Gene namesi
Name:PSTPIP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:9581. PSTPIP2.

Subcellular locationi

Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. cytoskeleton Source: Ensembl
  2. cytosol Source: Ensembl
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33932.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 334333Proline-serine-threonine phosphatase-interacting protein 2PRO_0000058541Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei323 – 3231PhosphotyrosineBy similarity
Modified residuei329 – 3291PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylated on tyrosine.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H939.
PaxDbiQ9H939.
PRIDEiQ9H939.

PTM databases

PhosphoSiteiQ9H939.

Expressioni

Gene expression databases

BgeeiQ9H939.
CleanExiHS_PSTPIP2.
GenevestigatoriQ9H939.

Organism-specific databases

HPAiHPA040923.
HPA040944.

Interactioni

Protein-protein interaction databases

BioGridi114512. 4 interactions.
IntActiQ9H939. 4 interactions.
MINTiMINT-4781125.
STRINGi9606.ENSP00000387261.

Structurei

3D structure databases

ProteinModelPortaliQ9H939.
SMRiQ9H939. Positions 21-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 8986FCHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili66 – 166101Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 FCH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG303711.
GeneTreeiENSGT00730000110901.
HOGENOMiHOG000294218.
HOVERGENiHBG052960.
InParanoidiQ9H939.
OMAiYENFYCP.
OrthoDBiEOG7BCNBS.
PhylomeDBiQ9H939.
TreeFamiTF313677.

Family and domain databases

InterProiIPR001060. FCH_dom.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
[Graphical view]
SMARTiSM00055. FCH. 1 hit.
[Graphical view]
PROSITEiPS50133. FCH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H939-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTRSLFKGNF WSADILSTIG YDNIIQHLNN GRKNCKEFED FLKERAAIEE
60 70 80 90 100
RYGKDLLNLS RKKPCGQSEI NTLKRALEVF KQQVDNVAQC HIQLAQSLRE
110 120 130 140 150
EARKMEEFRE KQKLQRKKTE LIMDAIHKQK SLQFKKTMDA KKNYEQKCRD
160 170 180 190 200
KDEAEQAVSR SANLVNPKQQ EKLFVKLATS KTAVEDSDKA YMLHIGTLDK
210 220 230 240 250
VREEWQSEHI KACEAFEAQE CERINFFRNA LWLHVNQLSQ QCVTSDEMYE
260 270 280 290 300
QVRKSLEMCS IQRDIEYFVN QRKTGQIPPA PIMYENFYSS QKNAVPAGKA
310 320 330
TGPNLARRGP LPIPKSSPDD PNYSLVDDYS LLYQ
Length:334
Mass (Da):38,858
Last modified:April 20, 2010 - v4
Checksum:iDD7DC17EC3F6E165
GO
Isoform 2 (identifier: Q9H939-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-334: MYEQVRKSLE...LVDDYSLLYQ → HPSCMRISTP...KINETRAFSG

Note: No experimental confirmation available.

Show »
Length:312
Mass (Da):36,446
Checksum:i366C0F8B5A1CA272
GO

Sequence cautioni

The sequence BAB14404.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti284 – 2841Y → H in BAB14404. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti322 – 3221N → D.
Corresponds to variant rs2276199 [ dbSNP | Ensembl ].
VAR_059708
Natural varianti322 – 3221N → S.
Corresponds to variant rs16978507 [ dbSNP | Ensembl ].
VAR_059709

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei248 – 33487MYEQV…SLLYQ → HPSCMRISTPPRRMQSQQER LQGLTWQGEDPSQFLKAHQM IPITLWLMTTVCSISKINET RAFSG in isoform 2. 1 PublicationVSP_004070Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012569 Genomic DNA. No translation available.
AC090355 Genomic DNA. No translation available.
BC035395 mRNA. Translation: AAH35395.1.
AK023100 mRNA. Translation: BAB14404.1. Different initiation.
CCDSiCCDS32820.2. [Q9H939-1]
RefSeqiNP_077748.3. NM_024430.3. [Q9H939-1]
UniGeneiHs.567384.

Genome annotation databases

EnsembliENST00000409746; ENSP00000387261; ENSG00000152229. [Q9H939-1]
ENST00000589328; ENSP00000468622; ENSG00000152229. [Q9H939-2]
GeneIDi9050.
KEGGihsa:9050.
UCSCiuc002lbp.4. human. [Q9H939-1]
uc002lbq.4. human. [Q9H939-2]

Polymorphism databases

DMDMi294862539.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012569 Genomic DNA. No translation available.
AC090355 Genomic DNA. No translation available.
BC035395 mRNA. Translation: AAH35395.1 .
AK023100 mRNA. Translation: BAB14404.1 . Different initiation.
CCDSi CCDS32820.2. [Q9H939-1 ]
RefSeqi NP_077748.3. NM_024430.3. [Q9H939-1 ]
UniGenei Hs.567384.

3D structure databases

ProteinModelPortali Q9H939.
SMRi Q9H939. Positions 21-268.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114512. 4 interactions.
IntActi Q9H939. 4 interactions.
MINTi MINT-4781125.
STRINGi 9606.ENSP00000387261.

PTM databases

PhosphoSitei Q9H939.

Polymorphism databases

DMDMi 294862539.

Proteomic databases

MaxQBi Q9H939.
PaxDbi Q9H939.
PRIDEi Q9H939.

Protocols and materials databases

DNASUi 9050.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000409746 ; ENSP00000387261 ; ENSG00000152229 . [Q9H939-1 ]
ENST00000589328 ; ENSP00000468622 ; ENSG00000152229 . [Q9H939-2 ]
GeneIDi 9050.
KEGGi hsa:9050.
UCSCi uc002lbp.4. human. [Q9H939-1 ]
uc002lbq.4. human. [Q9H939-2 ]

Organism-specific databases

CTDi 9050.
GeneCardsi GC18M043563.
H-InvDB HIX0014425.
HGNCi HGNC:9581. PSTPIP2.
HPAi HPA040923.
HPA040944.
neXtProti NX_Q9H939.
PharmGKBi PA33932.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG303711.
GeneTreei ENSGT00730000110901.
HOGENOMi HOG000294218.
HOVERGENi HBG052960.
InParanoidi Q9H939.
OMAi YENFYCP.
OrthoDBi EOG7BCNBS.
PhylomeDBi Q9H939.
TreeFami TF313677.

Miscellaneous databases

ChiTaRSi PSTPIP2. human.
GeneWikii PSTPIP2.
GenomeRNAii 9050.
NextBioi 33907.
PROi Q9H939.

Gene expression databases

Bgeei Q9H939.
CleanExi HS_PSTPIP2.
Genevestigatori Q9H939.

Family and domain databases

InterProi IPR001060. FCH_dom.
[Graphical view ]
Pfami PF00611. FCH. 1 hit.
[Graphical view ]
SMARTi SM00055. FCH. 1 hit.
[Graphical view ]
PROSITEi PS50133. FCH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 113-334 (ISOFORM 1).
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPPIP2_HUMAN
AccessioniPrimary (citable) accession number: Q9H939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 107 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3