Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9H930

- SP14L_HUMAN

UniProt

Q9H930 - SP14L_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Nuclear body protein SP140-like protein

Gene

SP140L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri403 – 44947PHD-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear body protein SP140-like protein
Gene namesi
Name:SP140L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:25105. SP140L.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164726206.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580Nuclear body protein SP140-like proteinPRO_0000321936Add
BLAST

Proteomic databases

MaxQBiQ9H930.
PaxDbiQ9H930.
PRIDEiQ9H930.

PTM databases

PhosphoSiteiQ9H930.

Expressioni

Gene expression databases

BgeeiQ9H930.
CleanExiHS_SP140L.
ExpressionAtlasiQ9H930. baseline and differential.
GenevestigatoriQ9H930.

Organism-specific databases

HPAiHPA055864.

Interactioni

Protein-protein interaction databases

BioGridi125019. 3 interactions.
STRINGi9606.ENSP00000397911.

Structurei

3D structure databases

ProteinModelPortaliQ9H930.
SMRiQ9H930. Positions 293-377, 400-577.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 149117HSRPROSITE-ProRule annotationAdd
BLAST
Domaini293 – 37482SANDPROSITE-ProRule annotationAdd
BLAST
Domaini484 – 55471BromoPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 HSR domain.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation
Contains 1 SAND domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri403 – 44947PHD-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG300534.
GeneTreeiENSGT00510000046835.
HOGENOMiHOG000089984.
InParanoidiQ9H930.
OMAiCDTCSRA.
OrthoDBiEOG7G1V5G.
PhylomeDBiQ9H930.
TreeFamiTF335091.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.10.390.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
IPR004865. Sp100.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF00628. PHD. 1 hit.
PF01342. SAND. 1 hit.
PF03172. Sp100. 1 hit.
[Graphical view]
SMARTiSM00297. BROMO. 1 hit.
SM00249. PHD. 1 hit.
SM00258. SAND. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
SSF63763. SSF63763. 1 hit.
PROSITEiPS50014. BROMODOMAIN_2. 1 hit.
PS51414. HSR. 1 hit.
PS50864. SAND. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 4 (identifier: Q9H930-4) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGGGSDLST RGLNGGVSQV ANEMNHLPAH SQSLQRLFTE DQDVDEGLVY
60 70 80 90 100
DTVFKHFKRH KLEISNAIKK TFPFLEGLRD RELITNKMFE DSEDSCRNLV
110 120 130 140 150
PVQRVVYNVL SELEKTFNLS VLEALFSEVN MQEYPDLIHI YKSFKNAIQD
160 170 180 190 200
KLSFQESDRK EREERPDIKL SLKQGEVPES PEARKESDQA CGKMDTVDIA
210 220 230 240 250
NNSTLGKPKR KRRKKKGHGW SRMGTRTQKN NQQNDNSKAD GQLVSSEKKA
260 270 280 290 300
NMNLKDLSKI RGRKRGKPGT HFTQSDRAPQ KRVRSRASRK HKDETVDFQA
310 320 330 340 350
PLLPVTCGGV KGILHKEKLE QGTLAKCIQT EDGKWFTPME FEIKGGYARS
360 370 380 390 400
KNWRLSVRCG GWPLRRLMEE GSLPNPPRIY YRNKKRILKS QNNSSVDPCM
410 420 430 440 450
RNLDECEVCR DGGELFCCDT CSRVFHEDCH IPPVESEKTP WNCIFCRMKE
460 470 480 490 500
SPGSQQCCQE SEVLERQMCP EEQLKCEFLL LKVYCCSESS FFAKIPYYYY
510 520 530 540 550
IREACQGLKE PMWLDKIKKR LNEHGYPQVE GFVQDMRLIF QNHRASYKYK
560 570 580
DFGQMGLRLE AEFEKDFKEV FAIQETNGNS
Length:580
Mass (Da):67,005
Last modified:February 22, 2012 - v3
Checksum:iC79CABFD2E1D6FB0
GO
Isoform 1 (identifier: Q9H930-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     430-580: HIPPVESEKT...FAIQETNGNS → HIPPVESEK

Show »
Length:438
Mass (Da):50,075
Checksum:i5E35B3DED0DD61D7
GO
Isoform 2 (identifier: Q9H930-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-321: Missing.

Note: No experimental confirmation available.

Show »
Length:545
Mass (Da):63,150
Checksum:i3918E36F255E536F
GO
Isoform 3 (identifier: Q9H930-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     213-216: RKKK → SKNK
     217-580: Missing.

Note: No experimental confirmation available.

Show »
Length:129
Mass (Da):14,926
Checksum:i9FABEBF35962DD64
GO

Sequence cautioni

The sequence AAX88869.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAB14413.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti223 – 2231M → T in BAB14413. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti88 – 881M → T.
Corresponds to variant rs4973318 [ dbSNP | Ensembl ].
VAR_059144
Natural varianti225 – 2251T → M.
Corresponds to variant rs28497362 [ dbSNP | Ensembl ].
VAR_059145
Natural varianti377 – 3771P → S.
Corresponds to variant rs7590429 [ dbSNP | Ensembl ].
VAR_059146

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8787Missing in isoform 3. 1 PublicationVSP_031830Add
BLAST
Alternative sequencei213 – 2164RKKK → SKNK in isoform 3. 1 PublicationVSP_031831
Alternative sequencei217 – 580364Missing in isoform 3. 1 PublicationVSP_031832Add
BLAST
Alternative sequencei287 – 32135Missing in isoform 2. 1 PublicationVSP_031833Add
BLAST
Alternative sequencei430 – 580151HIPPV…TNGNS → HIPPVESEK in isoform 1. 1 PublicationVSP_040889Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009949 Genomic DNA. Translation: AAX88869.1. Sequence problems.
BC004921 mRNA. Translation: AAH04921.1.
BC105007 mRNA. No translation available.
BQ690359 mRNA. No translation available.
AK023116 mRNA. Translation: BAB14413.1. Different initiation.
CCDSiCCDS46538.1. [Q9H930-4]
RefSeqiNP_612411.4. NM_138402.4. [Q9H930-4]
XP_006712918.1. XM_006712855.1. [Q9H930-2]
UniGeneiHs.589661.

Genome annotation databases

EnsembliENST00000415673; ENSP00000397911; ENSG00000185404. [Q9H930-4]
ENST00000444636; ENSP00000395195; ENSG00000185404. [Q9H930-1]
ENST00000458341; ENSP00000395223; ENSG00000185404. [Q9H930-3]
GeneIDi93349.
KEGGihsa:93349.
UCSCiuc010fxm.1. human. [Q9H930-4]
uc010fxn.2. human. [Q9H930-3]

Polymorphism databases

DMDMi378405242.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009949 Genomic DNA. Translation: AAX88869.1 . Sequence problems.
BC004921 mRNA. Translation: AAH04921.1 .
BC105007 mRNA. No translation available.
BQ690359 mRNA. No translation available.
AK023116 mRNA. Translation: BAB14413.1 . Different initiation.
CCDSi CCDS46538.1. [Q9H930-4 ]
RefSeqi NP_612411.4. NM_138402.4. [Q9H930-4 ]
XP_006712918.1. XM_006712855.1. [Q9H930-2 ]
UniGenei Hs.589661.

3D structure databases

ProteinModelPortali Q9H930.
SMRi Q9H930. Positions 293-377, 400-577.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125019. 3 interactions.
STRINGi 9606.ENSP00000397911.

PTM databases

PhosphoSitei Q9H930.

Polymorphism databases

DMDMi 378405242.

Proteomic databases

MaxQBi Q9H930.
PaxDbi Q9H930.
PRIDEi Q9H930.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000415673 ; ENSP00000397911 ; ENSG00000185404 . [Q9H930-4 ]
ENST00000444636 ; ENSP00000395195 ; ENSG00000185404 . [Q9H930-1 ]
ENST00000458341 ; ENSP00000395223 ; ENSG00000185404 . [Q9H930-3 ]
GeneIDi 93349.
KEGGi hsa:93349.
UCSCi uc010fxm.1. human. [Q9H930-4 ]
uc010fxn.2. human. [Q9H930-3 ]

Organism-specific databases

CTDi 93349.
GeneCardsi GC02P231191.
HGNCi HGNC:25105. SP140L.
HPAi HPA055864.
neXtProti NX_Q9H930.
PharmGKBi PA164726206.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG300534.
GeneTreei ENSGT00510000046835.
HOGENOMi HOG000089984.
InParanoidi Q9H930.
OMAi CDTCSRA.
OrthoDBi EOG7G1V5G.
PhylomeDBi Q9H930.
TreeFami TF335091.

Miscellaneous databases

GenomeRNAii 93349.
NextBioi 78053.
PROi Q9H930.

Gene expression databases

Bgeei Q9H930.
CleanExi HS_SP140L.
ExpressionAtlasi Q9H930. baseline and differential.
Genevestigatori Q9H930.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.10.390.10. 1 hit.
3.30.40.10. 1 hit.
InterProi IPR001487. Bromodomain.
IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
IPR004865. Sp100.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00439. Bromodomain. 1 hit.
PF00628. PHD. 1 hit.
PF01342. SAND. 1 hit.
PF03172. Sp100. 1 hit.
[Graphical view ]
SMARTi SM00297. BROMO. 1 hit.
SM00249. PHD. 1 hit.
SM00258. SAND. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
SSF63763. SSF63763. 1 hit.
PROSITEi PS50014. BROMODOMAIN_2. 1 hit.
PS51414. HSR. 1 hit.
PS50864. SAND. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-580 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 430-580 (ISOFORM 4).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 172-580 (ISOFORM 1).
    Tissue: Teratocarcinoma.

Entry informationi

Entry nameiSP14L_HUMAN
AccessioniPrimary (citable) accession number: Q9H930
Secondary accession number(s): Q2M375, Q4ZG65, Q9BSP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 22, 2012
Last modified: October 29, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3