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Protein

Nuclear body protein SP140-like protein

Gene

SP140L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri403 – 449PHD-typePROSITE-ProRule annotationAdd BLAST47

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear body protein SP140-like protein
Gene namesi
Name:SP140L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000185404.16.
HGNCiHGNC:25105. SP140L.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi93349.
OpenTargetsiENSG00000185404.
PharmGKBiPA164726206.

Polymorphism and mutation databases

BioMutaiSP140L.
DMDMi378405242.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003219361 – 580Nuclear body protein SP140-like proteinAdd BLAST580

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki169Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei180PhosphoserineCombined sources1
Cross-linki292Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9H930.
PaxDbiQ9H930.
PeptideAtlasiQ9H930.
PRIDEiQ9H930.

PTM databases

iPTMnetiQ9H930.
PhosphoSitePlusiQ9H930.

Expressioni

Gene expression databases

BgeeiENSG00000185404.
CleanExiHS_SP140L.
ExpressionAtlasiQ9H930. baseline and differential.
GenevisibleiQ9H930. HS.

Organism-specific databases

HPAiHPA055864.

Interactioni

Protein-protein interaction databases

BioGridi125019. 8 interactors.
IntActiQ9H930. 6 interactors.
STRINGi9606.ENSP00000397911.

Structurei

3D structure databases

ProteinModelPortaliQ9H930.
SMRiQ9H930.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 149HSRPROSITE-ProRule annotationAdd BLAST117
Domaini293 – 374SANDPROSITE-ProRule annotationAdd BLAST82
Domaini484 – 554BromoPROSITE-ProRule annotationAdd BLAST71

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri403 – 449PHD-typePROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG41112UW. LUCA.
GeneTreeiENSGT00510000046835.
HOGENOMiHOG000089984.
InParanoidiQ9H930.
OMAiHNPPRKY.
OrthoDBiEOG091G01MN.
PhylomeDBiQ9H930.
TreeFamiTF335091.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.10.390.10. 1 hit.
3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001487. Bromodomain.
IPR036427. Bromodomain-like_sf.
IPR004865. HSR_dom.
IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
IPR030411. SP140.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
PANTHERiPTHR13711:SF231. PTHR13711:SF231. 2 hits.
PfamiView protein in Pfam
PF00439. Bromodomain. 1 hit.
PF03172. HSR. 1 hit.
PF00628. PHD. 1 hit.
PF01342. SAND. 1 hit.
SMARTiView protein in SMART
SM00297. BROMO. 1 hit.
SM00249. PHD. 1 hit.
SM00258. SAND. 1 hit.
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
SSF63763. SSF63763. 1 hit.
PROSITEiView protein in PROSITE
PS50014. BROMODOMAIN_2. 1 hit.
PS51414. HSR. 1 hit.
PS50864. SAND. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 4 (identifier: Q9H930-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGGGSDLST RGLNGGVSQV ANEMNHLPAH SQSLQRLFTE DQDVDEGLVY
60 70 80 90 100
DTVFKHFKRH KLEISNAIKK TFPFLEGLRD RELITNKMFE DSEDSCRNLV
110 120 130 140 150
PVQRVVYNVL SELEKTFNLS VLEALFSEVN MQEYPDLIHI YKSFKNAIQD
160 170 180 190 200
KLSFQESDRK EREERPDIKL SLKQGEVPES PEARKESDQA CGKMDTVDIA
210 220 230 240 250
NNSTLGKPKR KRRKKKGHGW SRMGTRTQKN NQQNDNSKAD GQLVSSEKKA
260 270 280 290 300
NMNLKDLSKI RGRKRGKPGT HFTQSDRAPQ KRVRSRASRK HKDETVDFQA
310 320 330 340 350
PLLPVTCGGV KGILHKEKLE QGTLAKCIQT EDGKWFTPME FEIKGGYARS
360 370 380 390 400
KNWRLSVRCG GWPLRRLMEE GSLPNPPRIY YRNKKRILKS QNNSSVDPCM
410 420 430 440 450
RNLDECEVCR DGGELFCCDT CSRVFHEDCH IPPVESEKTP WNCIFCRMKE
460 470 480 490 500
SPGSQQCCQE SEVLERQMCP EEQLKCEFLL LKVYCCSESS FFAKIPYYYY
510 520 530 540 550
IREACQGLKE PMWLDKIKKR LNEHGYPQVE GFVQDMRLIF QNHRASYKYK
560 570 580
DFGQMGLRLE AEFEKDFKEV FAIQETNGNS
Length:580
Mass (Da):67,005
Last modified:February 22, 2012 - v3
Checksum:iC79CABFD2E1D6FB0
GO
Isoform 1 (identifier: Q9H930-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     430-580: HIPPVESEKT...FAIQETNGNS → HIPPVESEK

Show »
Length:438
Mass (Da):50,075
Checksum:i5E35B3DED0DD61D7
GO
Isoform 2 (identifier: Q9H930-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-321: Missing.

Note: No experimental confirmation available.
Show »
Length:545
Mass (Da):63,150
Checksum:i3918E36F255E536F
GO
Isoform 3 (identifier: Q9H930-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     213-216: RKKK → SKNK
     217-580: Missing.

Note: No experimental confirmation available.
Show »
Length:129
Mass (Da):14,926
Checksum:i9FABEBF35962DD64
GO

Sequence cautioni

Q9H930: The sequence AAX88869 differs from that shown. Reason: Erroneous gene model prediction.Curated
Q9H930: The sequence BAB14413 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti223M → T in BAB14413 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05914488M → T. Corresponds to variant dbSNP:rs4973318Ensembl.1
Natural variantiVAR_059145225T → M. Corresponds to variant dbSNP:rs28497362Ensembl.1
Natural variantiVAR_059146377P → S. Corresponds to variant dbSNP:rs7590429Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0318301 – 87Missing in isoform 3. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_031831213 – 216RKKK → SKNK in isoform 3. 1 Publication4
Alternative sequenceiVSP_031832217 – 580Missing in isoform 3. 1 PublicationAdd BLAST364
Alternative sequenceiVSP_031833287 – 321Missing in isoform 2. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_040889430 – 580HIPPV…TNGNS → HIPPVESEK in isoform 1. 1 PublicationAdd BLAST151

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009949 Genomic DNA. Translation: AAX88869.1. Sequence problems.
BC004921 mRNA. Translation: AAH04921.1.
BC105007 mRNA. No translation available.
BQ690359 mRNA. No translation available.
AK023116 mRNA. Translation: BAB14413.1. Different initiation.
CCDSiCCDS46538.1. [Q9H930-4]
RefSeqiNP_612411.4. NM_138402.4. [Q9H930-4]
XP_006712918.1. XM_006712855.2. [Q9H930-2]
UniGeneiHs.589661.

Genome annotation databases

EnsembliENST00000415673; ENSP00000397911; ENSG00000185404. [Q9H930-4]
ENST00000444636; ENSP00000395195; ENSG00000185404. [Q9H930-1]
ENST00000458341; ENSP00000395223; ENSG00000185404. [Q9H930-3]
GeneIDi93349.
KEGGihsa:93349.
UCSCiuc010fxm.2. human. [Q9H930-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSP14L_HUMAN
AccessioniPrimary (citable) accession number: Q9H930
Secondary accession number(s): Q2M375, Q4ZG65, Q9BSP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 22, 2012
Last modified: October 25, 2017
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations