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Protein

RING finger protein 121

Gene

RNF121

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri226 – 27651RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 121
Gene namesi
Name:RNF121
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:21070. RNF121.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei50 – 7021HelicalSequence analysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence analysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence analysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence analysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134985388.

Polymorphism and mutation databases

BioMutaiRNF121.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 327326RING finger protein 121PRO_0000261407Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H920.
MaxQBiQ9H920.
PaxDbiQ9H920.
PRIDEiQ9H920.

PTM databases

PhosphoSiteiQ9H920.

Expressioni

Gene expression databases

BgeeiQ9H920.
CleanExiHS_RNF121.
ExpressionAtlasiQ9H920. baseline and differential.
GenevisibleiQ9H920. HS.

Organism-specific databases

HPAiHPA046041.

Interactioni

Protein-protein interaction databases

BioGridi120585. 1 interaction.
STRINGi9606.ENSP00000354571.

Structurei

3D structure databases

ProteinModelPortaliQ9H920.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNF121 family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri226 – 27651RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1734. Eukaryota.
ENOG410XP8B. LUCA.
GeneTreeiENSGT00390000013075.
HOGENOMiHOG000021822.
HOVERGENiHBG061177.
InParanoidiQ9H920.
OMAiVIENTYK.
OrthoDBiEOG7R831T.
PhylomeDBiQ9H920.
TreeFamiTF314357.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H920-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVVEVEVG GGAAGERELD EVDMSDLSPE EQWRVEHARM HAKHRGHEAM
60 70 80 90 100
HAEMVLILIA TLVVAQLLLV QWKQRHPRSY NMVTLFQMWV VPLYFTVKLH
110 120 130 140 150
WWRFLVIWIL FSAVTAFVTF RATRKPLVQT TPRLVYKWFL LIYKISYATG
160 170 180 190 200
IVGYMAVMFT LFGLNLLFKI KPEDAMDFGI SLLFYGLYYG VLERDFAEMC
210 220 230 240 250
ADYMASTIGF YSESGMPTKH LSDSVCAVCG QQIFVDVSEE GIIENTYRLS
260 270 280 290 300
CNHVFHEFCI RGWCIVGKKQ TCPYCKEKVD LKRMFSNPWE RPHVMYGQLL
310 320
DWLRYLVAWQ PVIIGVVQGI NYILGLE
Length:327
Mass (Da):37,882
Last modified:March 1, 2001 - v1
Checksum:iFFC170FF52AB15CD
GO
Isoform 2 (identifier: Q9H920-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Note: No experimental confirmation available.
Show »
Length:246
Mass (Da):28,736
Checksum:i6EDD49B9924630B7
GO

Sequence cautioni

The sequence AAH09672.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH63680.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti327 – 3271E → D in CAG33579 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8181Missing in isoform 2. 1 PublicationVSP_054133Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023139 mRNA. Translation: BAB14423.1.
AK094508 mRNA. Translation: BAG52880.1.
CR457298 mRNA. Translation: CAG33579.1.
AP002490 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74810.1.
BC009672 mRNA. Translation: AAH09672.2. Different initiation.
BC063680 mRNA. Translation: AAH63680.1. Different initiation.
CCDSiCCDS8203.1. [Q9H920-1]
RefSeqiNP_060790.2. NM_018320.4. [Q9H920-1]
XP_006718693.1. XM_006718630.1. [Q9H920-2]
XP_011543452.1. XM_011545150.1. [Q9H920-2]
UniGeneiHs.368554.

Genome annotation databases

EnsembliENST00000361756; ENSP00000354571; ENSG00000137522. [Q9H920-1]
GeneIDi55298.
UCSCiuc001ora.4. human. [Q9H920-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023139 mRNA. Translation: BAB14423.1.
AK094508 mRNA. Translation: BAG52880.1.
CR457298 mRNA. Translation: CAG33579.1.
AP002490 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74810.1.
BC009672 mRNA. Translation: AAH09672.2. Different initiation.
BC063680 mRNA. Translation: AAH63680.1. Different initiation.
CCDSiCCDS8203.1. [Q9H920-1]
RefSeqiNP_060790.2. NM_018320.4. [Q9H920-1]
XP_006718693.1. XM_006718630.1. [Q9H920-2]
XP_011543452.1. XM_011545150.1. [Q9H920-2]
UniGeneiHs.368554.

3D structure databases

ProteinModelPortaliQ9H920.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120585. 1 interaction.
STRINGi9606.ENSP00000354571.

PTM databases

PhosphoSiteiQ9H920.

Polymorphism and mutation databases

BioMutaiRNF121.

Proteomic databases

EPDiQ9H920.
MaxQBiQ9H920.
PaxDbiQ9H920.
PRIDEiQ9H920.

Protocols and materials databases

DNASUi55298.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361756; ENSP00000354571; ENSG00000137522. [Q9H920-1]
GeneIDi55298.
UCSCiuc001ora.4. human. [Q9H920-1]

Organism-specific databases

CTDi55298.
GeneCardsiRNF121.
HGNCiHGNC:21070. RNF121.
HPAiHPA046041.
neXtProtiNX_Q9H920.
PharmGKBiPA134985388.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1734. Eukaryota.
ENOG410XP8B. LUCA.
GeneTreeiENSGT00390000013075.
HOGENOMiHOG000021822.
HOVERGENiHBG061177.
InParanoidiQ9H920.
OMAiVIENTYK.
OrthoDBiEOG7R831T.
PhylomeDBiQ9H920.
TreeFamiTF314357.

Miscellaneous databases

ChiTaRSiRNF121. human.
GenomeRNAii55298.
NextBioi35469799.
PROiQ9H920.

Gene expression databases

BgeeiQ9H920.
CleanExiHS_RNF121.
ExpressionAtlasiQ9H920. baseline and differential.
GenevisibleiQ9H920. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain cortex and Teratocarcinoma.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-327 (ISOFORM 1).
    Tissue: Duodenum and Pancreas.
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiRN121_HUMAN
AccessioniPrimary (citable) accession number: Q9H920
Secondary accession number(s): B3KSW8
, Q6IA57, Q6P449, Q96DB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.