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Protein

Jupiter microtubule associated homolog 2

Gene

JPT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Jupiter microtubule associated homolog 2Imported
Alternative name(s):
Hematological and neurological expressed 1-like protein1 Publication
Short name:
HN1-like protein
Gene namesi
Name:JPT2Imported
Synonyms:C16orf34, HN1L1 Publication
ORF Names:L11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000206053.12.
HGNCiHGNC:14137. JPT2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi90861.
OpenTargetsiENSG00000206053.
PharmGKBiPA162391043.

Polymorphism and mutation databases

BioMutaiHN1L.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000549211 – 190Jupiter microtubule associated homolog 2Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei35PhosphothreonineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei69PhosphoserineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H910.
MaxQBiQ9H910.
PaxDbiQ9H910.
PeptideAtlasiQ9H910.
PRIDEiQ9H910.
TopDownProteomicsiQ9H910-1. [Q9H910-1]

PTM databases

iPTMnetiQ9H910.
PhosphoSitePlusiQ9H910.

Expressioni

Tissue specificityi

Expressed in liver, kidney, prostate, testis and uterus.1 Publication

Inductioni

Up-regulated in squamous cell carcinoma (SCC) adenocarcinoma (AC), adenosquamous cell carcinoma (ASCC), bronchioalveolar carcinoma (BAC), breast and uterus tumors.1 Publication

Gene expression databases

BgeeiENSG00000206053.
CleanExiHS_HN1L.
ExpressionAtlasiQ9H910. baseline and differential.
GenevisibleiQ9H910. HS.

Organism-specific databases

HPAiHPA041888.
HPA041908.

Interactioni

Protein-protein interaction databases

BioGridi124774. 14 interactors.
IntActiQ9H910. 8 interactors.
STRINGi9606.ENSP00000248098.

Structurei

3D structure databases

ProteinModelPortaliQ9H910.
SMRiQ9H910.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the JUPITER family.Curated

Phylogenomic databases

eggNOGiENOG410IY2U. Eukaryota.
ENOG4111V7S. LUCA.
GeneTreeiENSGT00390000007652.
HOGENOMiHOG000231170.
HOVERGENiHBG055006.
InParanoidiQ9H910.
OMAiRSHNRVL.
OrthoDBiEOG091G0NGB.
PhylomeDBiQ9H910.
TreeFamiTF327169.

Family and domain databases

InterProiView protein in InterPro
IPR033335. JUPITER.
PANTHERiPTHR34930. PTHR34930. 1 hit.
PfamiView protein in Pfam
PF17054. JUPITER. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H910-1) [UniParc]FASTAAdd to basket
Also known as: HN1LA

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFQVPDSEGG RAGSRAMKPP GGESSNLFGS PEEATPSSRP NRMASNIFGP
60 70 80 90 100
TEEPQNIPKR TNPPGGKGSG IFDESTPVQT RQHLNPPGGK TSDIFGSPVT
110 120 130 140 150
ATSRLAHPNK PKDHVFLCEG EEPKSDLKAA RSIPAGAEPG EKGSARKAGP
160 170 180 190
AKEQEPMPTV DSHEPRLGPR PRSHNKVLNP PGGKSSISFY
Length:190
Mass (Da):20,063
Last modified:March 1, 2001 - v1
Checksum:i9132F17687193192
GO
Isoform 2 (identifier: Q9H910-2) [UniParc]FASTAAdd to basket
Also known as: HN1LB, HN1LC

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MFQVPDSEGGRAGSRAM → M

Show »
Length:174
Mass (Da):18,416
Checksum:iD8555196DA197D09
GO
Isoform 3 (identifier: Q9H910-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-14: S → SRKWQLLTGSLASTSPSLLSGQGPWAPLQ

Note: No experimental confirmation available.
Show »
Length:218
Mass (Da):23,026
Checksum:iF191DB78D1D0FA62
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0147061 – 17MFQVP…GSRAM → M in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_05742314S → SRKWQLLTGSLASTSPSLLS GQGPWAPLQ in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY323831 Genomic DNA. Translation: AAP72616.1.
AY323978 mRNA. Translation: AAP83791.1.
AY323979 mRNA. Translation: AAP83792.1.
AY598330 mRNA. Translation: AAT06741.1.
AK023154 mRNA. Translation: BAB14434.1.
AE006639 Genomic DNA. Translation: AAK61289.1.
AK296998 mRNA. Translation: BAG59536.1.
AL031009 Genomic DNA. No translation available.
AL031710 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85635.1.
CH471112 Genomic DNA. Translation: EAW85638.1.
BC014438 mRNA. Translation: AAH14438.1.
BC060853 mRNA. Translation: AAH60853.1.
CCDSiCCDS10441.1. [Q9H910-1]
RefSeqiNP_653171.1. NM_144570.2. [Q9H910-1]
UniGeneiHs.513261.

Genome annotation databases

EnsembliENST00000248098; ENSP00000248098; ENSG00000206053. [Q9H910-1]
ENST00000382711; ENSP00000372158; ENSG00000206053. [Q9H910-2]
ENST00000562684; ENSP00000457694; ENSG00000206053. [Q9H910-3]
GeneIDi90861.
KEGGihsa:90861.
UCSCiuc002cmg.4. human. [Q9H910-1]
uc010uvi.3. human.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiJUPI2_HUMAN
AccessioniPrimary (citable) accession number: Q9H910
Secondary accession number(s): B1AJY2, B4DLH4, Q6EIC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2001
Last modified: November 22, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families