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Protein

Hematological and neurological expressed 1-like protein

Gene

HN1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Hematological and neurological expressed 1-like protein
Short name:
HN1-like protein
Gene namesi
Name:HN1L
Synonyms:C16orf34
ORF Names:L11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14137. HN1L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162391043.

Polymorphism and mutation databases

BioMutaiHN1L.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Hematological and neurological expressed 1-like proteinPRO_0000054921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei30 – 301PhosphoserineCombined sources
Modified residuei35 – 351PhosphothreonineCombined sources
Modified residuei45 – 451PhosphoserineCombined sources
Modified residuei69 – 691PhosphoserineCombined sources
Modified residuei97 – 971PhosphoserineCombined sources
Modified residuei132 – 1321PhosphoserineCombined sources
Modified residuei144 – 1441PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H910.
MaxQBiQ9H910.
PaxDbiQ9H910.
PeptideAtlasiQ9H910.
PRIDEiQ9H910.
TopDownProteomicsiQ9H910-1. [Q9H910-1]

PTM databases

iPTMnetiQ9H910.
PhosphoSiteiQ9H910.

Expressioni

Tissue specificityi

Expressed in liver, kidney, prostate, testis and uterus.1 Publication

Inductioni

Up-regulated in squamous cell carcinoma (SCC) adenocarcinoma (AC), adenosquamous cell carcinoma (ASCC), bronchioalveolar carcinoma (BAC), breast and uterus tumors.1 Publication

Gene expression databases

BgeeiENSG00000206053.
CleanExiHS_HN1L.
ExpressionAtlasiQ9H910. baseline and differential.
GenevisibleiQ9H910. HS.

Organism-specific databases

HPAiHPA041888.
HPA041908.

Interactioni

Protein-protein interaction databases

BioGridi124774. 12 interactions.
IntActiQ9H910. 8 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9H910.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HN1 family.Curated

Phylogenomic databases

eggNOGiENOG410IY2U. Eukaryota.
ENOG4111V7S. LUCA.
GeneTreeiENSGT00390000007652.
HOGENOMiHOG000231170.
HOVERGENiHBG055006.
InParanoidiQ9H910.
OMAiRSHNRVL.
OrthoDBiEOG091G0NGB.
PhylomeDBiQ9H910.
TreeFamiTF327169.

Family and domain databases

InterProiIPR033335. JUPITER/HN1/HN1L.
[Graphical view]
PANTHERiPTHR34930. PTHR34930. 1 hit.
PfamiPF17054. JUPITER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H910-1) [UniParc]FASTAAdd to basket
Also known as: HN1LA

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFQVPDSEGG RAGSRAMKPP GGESSNLFGS PEEATPSSRP NRMASNIFGP
60 70 80 90 100
TEEPQNIPKR TNPPGGKGSG IFDESTPVQT RQHLNPPGGK TSDIFGSPVT
110 120 130 140 150
ATSRLAHPNK PKDHVFLCEG EEPKSDLKAA RSIPAGAEPG EKGSARKAGP
160 170 180 190
AKEQEPMPTV DSHEPRLGPR PRSHNKVLNP PGGKSSISFY
Length:190
Mass (Da):20,063
Last modified:March 1, 2001 - v1
Checksum:i9132F17687193192
GO
Isoform 2 (identifier: Q9H910-2) [UniParc]FASTAAdd to basket
Also known as: HN1LB, HN1LC

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MFQVPDSEGGRAGSRAM → M

Show »
Length:174
Mass (Da):18,416
Checksum:iD8555196DA197D09
GO
Isoform 3 (identifier: Q9H910-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-14: S → SRKWQLLTGSLASTSPSLLSGQGPWAPLQ

Note: No experimental confirmation available.
Show »
Length:218
Mass (Da):23,026
Checksum:iF191DB78D1D0FA62
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1717MFQVP…GSRAM → M in isoform 2. 1 PublicationVSP_014706Add
BLAST
Alternative sequencei14 – 141S → SRKWQLLTGSLASTSPSLLS GQGPWAPLQ in isoform 3. 1 PublicationVSP_057423

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY323831 Genomic DNA. Translation: AAP72616.1.
AY323978 mRNA. Translation: AAP83791.1.
AY323979 mRNA. Translation: AAP83792.1.
AY598330 mRNA. Translation: AAT06741.1.
AK023154 mRNA. Translation: BAB14434.1.
AE006639 Genomic DNA. Translation: AAK61289.1.
AK296998 mRNA. Translation: BAG59536.1.
AL031009, AL031710 Genomic DNA. Translation: CAA19770.2.
AL031710, AL031009 Genomic DNA. Translation: CAM26365.1.
CH471112 Genomic DNA. Translation: EAW85635.1.
CH471112 Genomic DNA. Translation: EAW85638.1.
BC014438 mRNA. Translation: AAH14438.1.
BC060853 mRNA. Translation: AAH60853.1.
CCDSiCCDS10441.1. [Q9H910-1]
RefSeqiNP_653171.1. NM_144570.2. [Q9H910-1]
UniGeneiHs.513261.

Genome annotation databases

EnsembliENST00000248098; ENSP00000248098; ENSG00000206053. [Q9H910-1]
ENST00000382711; ENSP00000372158; ENSG00000206053. [Q9H910-2]
ENST00000562684; ENSP00000457694; ENSG00000206053. [Q9H910-3]
GeneIDi90861.
KEGGihsa:90861.
UCSCiuc002cmg.4. human. [Q9H910-1]
uc010uvi.3. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY323831 Genomic DNA. Translation: AAP72616.1.
AY323978 mRNA. Translation: AAP83791.1.
AY323979 mRNA. Translation: AAP83792.1.
AY598330 mRNA. Translation: AAT06741.1.
AK023154 mRNA. Translation: BAB14434.1.
AE006639 Genomic DNA. Translation: AAK61289.1.
AK296998 mRNA. Translation: BAG59536.1.
AL031009, AL031710 Genomic DNA. Translation: CAA19770.2.
AL031710, AL031009 Genomic DNA. Translation: CAM26365.1.
CH471112 Genomic DNA. Translation: EAW85635.1.
CH471112 Genomic DNA. Translation: EAW85638.1.
BC014438 mRNA. Translation: AAH14438.1.
BC060853 mRNA. Translation: AAH60853.1.
CCDSiCCDS10441.1. [Q9H910-1]
RefSeqiNP_653171.1. NM_144570.2. [Q9H910-1]
UniGeneiHs.513261.

3D structure databases

ProteinModelPortaliQ9H910.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124774. 12 interactions.
IntActiQ9H910. 8 interactions.

PTM databases

iPTMnetiQ9H910.
PhosphoSiteiQ9H910.

Polymorphism and mutation databases

BioMutaiHN1L.

Proteomic databases

EPDiQ9H910.
MaxQBiQ9H910.
PaxDbiQ9H910.
PeptideAtlasiQ9H910.
PRIDEiQ9H910.
TopDownProteomicsiQ9H910-1. [Q9H910-1]

Protocols and materials databases

DNASUi90861.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248098; ENSP00000248098; ENSG00000206053. [Q9H910-1]
ENST00000382711; ENSP00000372158; ENSG00000206053. [Q9H910-2]
ENST00000562684; ENSP00000457694; ENSG00000206053. [Q9H910-3]
GeneIDi90861.
KEGGihsa:90861.
UCSCiuc002cmg.4. human. [Q9H910-1]
uc010uvi.3. human.

Organism-specific databases

CTDi90861.
GeneCardsiHN1L.
HGNCiHGNC:14137. HN1L.
HPAiHPA041888.
HPA041908.
neXtProtiNX_Q9H910.
PharmGKBiPA162391043.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY2U. Eukaryota.
ENOG4111V7S. LUCA.
GeneTreeiENSGT00390000007652.
HOGENOMiHOG000231170.
HOVERGENiHBG055006.
InParanoidiQ9H910.
OMAiRSHNRVL.
OrthoDBiEOG091G0NGB.
PhylomeDBiQ9H910.
TreeFamiTF327169.

Miscellaneous databases

ChiTaRSiHN1L. human.
GeneWikiiHN1L.
GenomeRNAii90861.
PROiQ9H910.

Gene expression databases

BgeeiENSG00000206053.
CleanExiHS_HN1L.
ExpressionAtlasiQ9H910. baseline and differential.
GenevisibleiQ9H910. HS.

Family and domain databases

InterProiIPR033335. JUPITER/HN1/HN1L.
[Graphical view]
PANTHERiPTHR34930. PTHR34930. 1 hit.
PfamiPF17054. JUPITER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHN1L_HUMAN
AccessioniPrimary (citable) accession number: Q9H910
Secondary accession number(s): B1AJY2, B4DLH4, Q6EIC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.