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Q9H8Y5

- ANKZ1_HUMAN

UniProt

Q9H8Y5 - ANKZ1_HUMAN

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Protein

Ankyrin repeat and zinc finger domain-containing protein 1

Gene
ANKZF1, ZNF744
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri72 – 9625C2H2-typeAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and zinc finger domain-containing protein 1
Alternative name(s):
Zinc finger protein 744
Gene namesi
Name:ANKZF1
Synonyms:ZNF744
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:25527. ANKZF1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485305.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 726726Ankyrin repeat and zinc finger domain-containing protein 1PRO_0000247278Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei258 – 2581Phosphoserine1 Publication
Modified residuei398 – 3981Phosphoserine2 Publications
Modified residuei533 – 5331Phosphoserine1 Publication
Modified residuei607 – 6071Phosphothreonine1 Publication
Modified residuei675 – 6751Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H8Y5.
PaxDbiQ9H8Y5.
PeptideAtlasiQ9H8Y5.
PRIDEiQ9H8Y5.

PTM databases

PhosphoSiteiQ9H8Y5.

Expressioni

Gene expression databases

ArrayExpressiQ9H8Y5.
BgeeiQ9H8Y5.
CleanExiHS_ANKZF1.
GenevestigatoriQ9H8Y5.

Organism-specific databases

HPAiHPA035208.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ORFQ9Q2G42EBI-724848,EBI-6248094From a different organism.

Protein-protein interaction databases

BioGridi120443. 4 interactions.
IntActiQ9H8Y5. 7 interactions.
MINTiMINT-1387900.
STRINGi9606.ENSP00000321617.

Structurei

3D structure databases

ProteinModelPortaliQ9H8Y5.
SMRiQ9H8Y5. Positions 495-672.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati493 – 52634ANK 1Add
BLAST
Repeati534 – 56330ANK 2Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili609 – 65951 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the ANKZF1/VMS1 family.
Contains 2 ANK repeats.

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG323124.
HOGENOMiHOG000033947.
HOVERGENiHBG080842.
InParanoidiQ9H8Y5.
OMAiAYRCILG.
OrthoDBiEOG7M6D7B.
PhylomeDBiQ9H8Y5.
TreeFamiTF313431.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H8Y5-1 [UniParc]FASTAAdd to Basket

« Hide

MSPAPDAAPA PASISLFDLS ADAPVFQGLS LVSHAPGEAL ARAPRTSCSG    50
SGERESPERK LLQGPMDISE KLFCSTCDQT FQNHQEQREH YKLDWHRFNL 100
KQRLKDKPLL SALDFEKQSS TGDLSSISGS EDSDSASEED LQTLDRERAT 150
FEKLSRPPGF YPHRVLFQNA QGQFLYAYRC VLGPHQDPPE EAELLLQNLQ 200
SRGPRDCVVL MAAAGHFAGA IFQGREVVTH KTFHRYTVRA KRGTAQGLRD 250
ARGGPSHSAG ANLRRYNEAT LYKDVRDLLA GPSWAKALEE AGTILLRAPR 300
SGRSLFFGGK GAPLQRGDPR LWDIPLATRR PTFQELQRVL HKLTTLHVYE 350
EDPREAVRLH SPQTHWKTVR EERKKPTEEE IRKICRDEKE ALGQNEESPK 400
QGSGSEGEDG FQVELELVEL TVGTLDLCES EVLPKRRRRK RNKKEKSRDQ 450
EAGAHRTLLQ QTQEEEPSTQ SSQAVAAPLG PLLDEAKAPG QPELWNALLA 500
ACRAGDVGVL KLQLAPSPAD PRVLSLLSAP LGSGGFTLLH AAAAAGRGSV 550
VRLLLEAGAD PTVQDSRARP PYTVAADKST RNEFRRFMEK NPDAYDYNKA 600
QVPGPLTPEM EARQATRKRE QKAARRQREE QQQRQQEQEE REREEQRRFA 650
ALSDREKRAL AAERRLAAQL GAPTSPIPDS AIVNTRRCWS CGASLQGLTP 700
FHYLDFSFCS TRCLQDHRRQ AGRPSS 726
Length:726
Mass (Da):80,927
Last modified:March 1, 2001 - v1
Checksum:i44F7930A530F1355
GO

Sequence cautioni

The sequence ABD65410.1 differs from that shown. Reason: Frameshift at position 318.
The sequence BAA91596.1 differs from that shown. Reason: Frameshift at position 318.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti569 – 5691R → W.
Corresponds to variant rs2293076 [ dbSNP | Ensembl ].
VAR_048269
Natural varianti676 – 6761P → L.
Corresponds to variant rs2293079 [ dbSNP | Ensembl ].
VAR_048270

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ412564 mRNA. Translation: ABD65410.1. Frameshift.
AK001277 mRNA. Translation: BAA91596.1. Frameshift.
AK023206 mRNA. Translation: BAB14462.1.
BC000238 mRNA. Translation: AAH00238.1.
BC008948 mRNA. Translation: AAH08948.1.
CCDSiCCDS42821.1.
RefSeqiNP_001035869.1. NM_001042410.1.
NP_060559.2. NM_018089.2.
UniGeneiHs.437647.

Genome annotation databases

EnsembliENST00000323348; ENSP00000321617; ENSG00000163516.
ENST00000410034; ENSP00000386337; ENSG00000163516.
GeneIDi55139.
KEGGihsa:55139.
UCSCiuc002vkg.3. human.

Polymorphism databases

DMDMi74761542.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ412564 mRNA. Translation: ABD65410.1 . Frameshift.
AK001277 mRNA. Translation: BAA91596.1 . Frameshift.
AK023206 mRNA. Translation: BAB14462.1 .
BC000238 mRNA. Translation: AAH00238.1 .
BC008948 mRNA. Translation: AAH08948.1 .
CCDSi CCDS42821.1.
RefSeqi NP_001035869.1. NM_001042410.1.
NP_060559.2. NM_018089.2.
UniGenei Hs.437647.

3D structure databases

ProteinModelPortali Q9H8Y5.
SMRi Q9H8Y5. Positions 495-672.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120443. 4 interactions.
IntActi Q9H8Y5. 7 interactions.
MINTi MINT-1387900.
STRINGi 9606.ENSP00000321617.

PTM databases

PhosphoSitei Q9H8Y5.

Polymorphism databases

DMDMi 74761542.

Proteomic databases

MaxQBi Q9H8Y5.
PaxDbi Q9H8Y5.
PeptideAtlasi Q9H8Y5.
PRIDEi Q9H8Y5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000323348 ; ENSP00000321617 ; ENSG00000163516 .
ENST00000410034 ; ENSP00000386337 ; ENSG00000163516 .
GeneIDi 55139.
KEGGi hsa:55139.
UCSCi uc002vkg.3. human.

Organism-specific databases

CTDi 55139.
GeneCardsi GC02P220094.
HGNCi HGNC:25527. ANKZF1.
HPAi HPA035208.
neXtProti NX_Q9H8Y5.
PharmGKBi PA143485305.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG323124.
HOGENOMi HOG000033947.
HOVERGENi HBG080842.
InParanoidi Q9H8Y5.
OMAi AYRCILG.
OrthoDBi EOG7M6D7B.
PhylomeDBi Q9H8Y5.
TreeFami TF313431.

Miscellaneous databases

ChiTaRSi ANKZF1. human.
GeneWikii ANKZF1.
GenomeRNAii 55139.
NextBioi 58830.
PROi Q9H8Y5.

Gene expression databases

ArrayExpressi Q9H8Y5.
Bgeei Q9H8Y5.
CleanExi HS_ANKZF1.
Genevestigatori Q9H8Y5.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
Pfami PF00023. Ank. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 2 hits.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Zhao Y., Li Y., Yuan W., Wu X., Liu M.
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Eye.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-675, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258; SER-398; SER-533 AND THR-607, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-398, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiANKZ1_HUMAN
AccessioniPrimary (citable) accession number: Q9H8Y5
Secondary accession number(s): Q9NVZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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