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Protein

Ankyrin repeat and zinc finger domain-containing protein 1

Gene

ANKZF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri72 – 96C2H2-typeAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and zinc finger domain-containing protein 1
Alternative name(s):
Zinc finger protein 744
Gene namesi
Name:ANKZF1
Synonyms:ZNF744
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25527. ANKZF1.

Subcellular locationi

GO - Cellular componenti

  • Cdc48p-Npl4p-Vms1p AAA ATPase complex Source: GO_Central
  • membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi661 – 662AA → LL: Abolishes interaction with VCP. 1 Publication2

Organism-specific databases

OpenTargetsiENSG00000163516.
PharmGKBiPA143485305.

Polymorphism and mutation databases

BioMutaiANKZF1.
DMDMi74761542.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472781 – 726Ankyrin repeat and zinc finger domain-containing protein 1Add BLAST726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei258PhosphoserineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei398PhosphoserineCombined sources1
Modified residuei533PhosphoserineCombined sources1
Modified residuei607PhosphothreonineCombined sources1
Modified residuei675PhosphoserineCombined sources1
Modified residuei680PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H8Y5.
MaxQBiQ9H8Y5.
PaxDbiQ9H8Y5.
PeptideAtlasiQ9H8Y5.
PRIDEiQ9H8Y5.

PTM databases

iPTMnetiQ9H8Y5.
PhosphoSitePlusiQ9H8Y5.
SwissPalmiQ9H8Y5.

Expressioni

Gene expression databases

BgeeiENSG00000163516.
CleanExiHS_ANKZF1.
ExpressionAtlasiQ9H8Y5. baseline and differential.
GenevisibleiQ9H8Y5. HS.

Organism-specific databases

HPAiHPA035208.
HPA043208.

Interactioni

Subunit structurei

Interacts (via VIM motif) with VCP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ORFQ9Q2G42EBI-724848,EBI-6248094From a different organism.

Protein-protein interaction databases

BioGridi120443. 7 interactors.
IntActiQ9H8Y5. 9 interactors.
MINTiMINT-1387900.
STRINGi9606.ENSP00000321617.

Structurei

3D structure databases

ProteinModelPortaliQ9H8Y5.
SMRiQ9H8Y5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati493 – 526ANK 1Add BLAST34
Repeati534 – 563ANK 2Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni654 – 666VCP/p97-interacting motif (VIM)1 PublicationAdd BLAST13

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili609 – 659Sequence analysisAdd BLAST51

Sequence similaritiesi

Belongs to the ANKZF1/VMS1 family.Curated
Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 C2H2-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri72 – 96C2H2-typeAdd BLAST25

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2505. Eukaryota.
ENOG410XQAG. LUCA.
GeneTreeiENSGT00390000005911.
HOGENOMiHOG000033947.
HOVERGENiHBG080842.
InParanoidiQ9H8Y5.
OMAiQGFYPHR.
OrthoDBiEOG091G06FM.
PhylomeDBiQ9H8Y5.
TreeFamiTF313431.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR007087. Znf_C2H2.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H8Y5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPAPDAAPA PASISLFDLS ADAPVFQGLS LVSHAPGEAL ARAPRTSCSG
60 70 80 90 100
SGERESPERK LLQGPMDISE KLFCSTCDQT FQNHQEQREH YKLDWHRFNL
110 120 130 140 150
KQRLKDKPLL SALDFEKQSS TGDLSSISGS EDSDSASEED LQTLDRERAT
160 170 180 190 200
FEKLSRPPGF YPHRVLFQNA QGQFLYAYRC VLGPHQDPPE EAELLLQNLQ
210 220 230 240 250
SRGPRDCVVL MAAAGHFAGA IFQGREVVTH KTFHRYTVRA KRGTAQGLRD
260 270 280 290 300
ARGGPSHSAG ANLRRYNEAT LYKDVRDLLA GPSWAKALEE AGTILLRAPR
310 320 330 340 350
SGRSLFFGGK GAPLQRGDPR LWDIPLATRR PTFQELQRVL HKLTTLHVYE
360 370 380 390 400
EDPREAVRLH SPQTHWKTVR EERKKPTEEE IRKICRDEKE ALGQNEESPK
410 420 430 440 450
QGSGSEGEDG FQVELELVEL TVGTLDLCES EVLPKRRRRK RNKKEKSRDQ
460 470 480 490 500
EAGAHRTLLQ QTQEEEPSTQ SSQAVAAPLG PLLDEAKAPG QPELWNALLA
510 520 530 540 550
ACRAGDVGVL KLQLAPSPAD PRVLSLLSAP LGSGGFTLLH AAAAAGRGSV
560 570 580 590 600
VRLLLEAGAD PTVQDSRARP PYTVAADKST RNEFRRFMEK NPDAYDYNKA
610 620 630 640 650
QVPGPLTPEM EARQATRKRE QKAARRQREE QQQRQQEQEE REREEQRRFA
660 670 680 690 700
ALSDREKRAL AAERRLAAQL GAPTSPIPDS AIVNTRRCWS CGASLQGLTP
710 720
FHYLDFSFCS TRCLQDHRRQ AGRPSS
Length:726
Mass (Da):80,927
Last modified:March 1, 2001 - v1
Checksum:i44F7930A530F1355
GO

Sequence cautioni

The sequence ABD65410 differs from that shown. Reason: Frameshift at position 318.Curated
The sequence BAA91596 differs from that shown. Reason: Frameshift at position 318.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048269569R → W.Corresponds to variant rs2293076dbSNPEnsembl.1
Natural variantiVAR_048270676P → L.Corresponds to variant rs2293079dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ412564 mRNA. Translation: ABD65410.1. Frameshift.
AK001277 mRNA. Translation: BAA91596.1. Frameshift.
AK023206 mRNA. Translation: BAB14462.1.
BC000238 mRNA. Translation: AAH00238.1.
BC008948 mRNA. Translation: AAH08948.1.
CCDSiCCDS42821.1.
RefSeqiNP_001035869.1. NM_001042410.1.
NP_060559.2. NM_018089.2.
UniGeneiHs.437647.

Genome annotation databases

EnsembliENST00000323348; ENSP00000321617; ENSG00000163516.
ENST00000410034; ENSP00000386337; ENSG00000163516.
GeneIDi55139.
KEGGihsa:55139.
UCSCiuc002vkg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ412564 mRNA. Translation: ABD65410.1. Frameshift.
AK001277 mRNA. Translation: BAA91596.1. Frameshift.
AK023206 mRNA. Translation: BAB14462.1.
BC000238 mRNA. Translation: AAH00238.1.
BC008948 mRNA. Translation: AAH08948.1.
CCDSiCCDS42821.1.
RefSeqiNP_001035869.1. NM_001042410.1.
NP_060559.2. NM_018089.2.
UniGeneiHs.437647.

3D structure databases

ProteinModelPortaliQ9H8Y5.
SMRiQ9H8Y5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120443. 7 interactors.
IntActiQ9H8Y5. 9 interactors.
MINTiMINT-1387900.
STRINGi9606.ENSP00000321617.

PTM databases

iPTMnetiQ9H8Y5.
PhosphoSitePlusiQ9H8Y5.
SwissPalmiQ9H8Y5.

Polymorphism and mutation databases

BioMutaiANKZF1.
DMDMi74761542.

Proteomic databases

EPDiQ9H8Y5.
MaxQBiQ9H8Y5.
PaxDbiQ9H8Y5.
PeptideAtlasiQ9H8Y5.
PRIDEiQ9H8Y5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323348; ENSP00000321617; ENSG00000163516.
ENST00000410034; ENSP00000386337; ENSG00000163516.
GeneIDi55139.
KEGGihsa:55139.
UCSCiuc002vkg.3. human.

Organism-specific databases

CTDi55139.
GeneCardsiANKZF1.
HGNCiHGNC:25527. ANKZF1.
HPAiHPA035208.
HPA043208.
neXtProtiNX_Q9H8Y5.
OpenTargetsiENSG00000163516.
PharmGKBiPA143485305.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2505. Eukaryota.
ENOG410XQAG. LUCA.
GeneTreeiENSGT00390000005911.
HOGENOMiHOG000033947.
HOVERGENiHBG080842.
InParanoidiQ9H8Y5.
OMAiQGFYPHR.
OrthoDBiEOG091G06FM.
PhylomeDBiQ9H8Y5.
TreeFamiTF313431.

Miscellaneous databases

ChiTaRSiANKZF1. human.
GeneWikiiANKZF1.
GenomeRNAii55139.
PROiQ9H8Y5.

Gene expression databases

BgeeiENSG00000163516.
CleanExiHS_ANKZF1.
ExpressionAtlasiQ9H8Y5. baseline and differential.
GenevisibleiQ9H8Y5. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR007087. Znf_C2H2.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANKZ1_HUMAN
AccessioniPrimary (citable) accession number: Q9H8Y5
Secondary accession number(s): Q9NVZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.