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Q9H8Y5

- ANKZ1_HUMAN

UniProt

Q9H8Y5 - ANKZ1_HUMAN

Protein

Ankyrin repeat and zinc finger domain-containing protein 1

Gene

ANKZF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri72 – 9625C2H2-typeAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: IntAct

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ankyrin repeat and zinc finger domain-containing protein 1
    Alternative name(s):
    Zinc finger protein 744
    Gene namesi
    Name:ANKZF1
    Synonyms:ZNF744
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:25527. ANKZF1.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485305.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 726726Ankyrin repeat and zinc finger domain-containing protein 1PRO_0000247278Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei258 – 2581Phosphoserine1 Publication
    Modified residuei398 – 3981Phosphoserine2 Publications
    Modified residuei533 – 5331Phosphoserine1 Publication
    Modified residuei607 – 6071Phosphothreonine1 Publication
    Modified residuei675 – 6751Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9H8Y5.
    PaxDbiQ9H8Y5.
    PeptideAtlasiQ9H8Y5.
    PRIDEiQ9H8Y5.

    PTM databases

    PhosphoSiteiQ9H8Y5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H8Y5.
    BgeeiQ9H8Y5.
    CleanExiHS_ANKZF1.
    GenevestigatoriQ9H8Y5.

    Organism-specific databases

    HPAiHPA035208.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ORFQ9Q2G42EBI-724848,EBI-6248094From a different organism.

    Protein-protein interaction databases

    BioGridi120443. 4 interactions.
    IntActiQ9H8Y5. 7 interactions.
    MINTiMINT-1387900.
    STRINGi9606.ENSP00000321617.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H8Y5.
    SMRiQ9H8Y5. Positions 495-672.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati493 – 52634ANK 1Add
    BLAST
    Repeati534 – 56330ANK 2Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili609 – 65951Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ANKZF1/VMS1 family.Curated
    Contains 2 ANK repeats.PROSITE-ProRule annotation
    Contains 1 C2H2-type zinc finger.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri72 – 9625C2H2-typeAdd
    BLAST

    Keywords - Domaini

    ANK repeat, Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG323124.
    HOGENOMiHOG000033947.
    HOVERGENiHBG080842.
    InParanoidiQ9H8Y5.
    OMAiAYRCILG.
    OrthoDBiEOG7M6D7B.
    PhylomeDBiQ9H8Y5.
    TreeFamiTF313431.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PfamiPF00023. Ank. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 2 hits.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H8Y5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPAPDAAPA PASISLFDLS ADAPVFQGLS LVSHAPGEAL ARAPRTSCSG    50
    SGERESPERK LLQGPMDISE KLFCSTCDQT FQNHQEQREH YKLDWHRFNL 100
    KQRLKDKPLL SALDFEKQSS TGDLSSISGS EDSDSASEED LQTLDRERAT 150
    FEKLSRPPGF YPHRVLFQNA QGQFLYAYRC VLGPHQDPPE EAELLLQNLQ 200
    SRGPRDCVVL MAAAGHFAGA IFQGREVVTH KTFHRYTVRA KRGTAQGLRD 250
    ARGGPSHSAG ANLRRYNEAT LYKDVRDLLA GPSWAKALEE AGTILLRAPR 300
    SGRSLFFGGK GAPLQRGDPR LWDIPLATRR PTFQELQRVL HKLTTLHVYE 350
    EDPREAVRLH SPQTHWKTVR EERKKPTEEE IRKICRDEKE ALGQNEESPK 400
    QGSGSEGEDG FQVELELVEL TVGTLDLCES EVLPKRRRRK RNKKEKSRDQ 450
    EAGAHRTLLQ QTQEEEPSTQ SSQAVAAPLG PLLDEAKAPG QPELWNALLA 500
    ACRAGDVGVL KLQLAPSPAD PRVLSLLSAP LGSGGFTLLH AAAAAGRGSV 550
    VRLLLEAGAD PTVQDSRARP PYTVAADKST RNEFRRFMEK NPDAYDYNKA 600
    QVPGPLTPEM EARQATRKRE QKAARRQREE QQQRQQEQEE REREEQRRFA 650
    ALSDREKRAL AAERRLAAQL GAPTSPIPDS AIVNTRRCWS CGASLQGLTP 700
    FHYLDFSFCS TRCLQDHRRQ AGRPSS 726
    Length:726
    Mass (Da):80,927
    Last modified:March 1, 2001 - v1
    Checksum:i44F7930A530F1355
    GO

    Sequence cautioni

    The sequence ABD65410.1 differs from that shown. Reason: Frameshift at position 318.
    The sequence BAA91596.1 differs from that shown. Reason: Frameshift at position 318.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti569 – 5691R → W.
    Corresponds to variant rs2293076 [ dbSNP | Ensembl ].
    VAR_048269
    Natural varianti676 – 6761P → L.
    Corresponds to variant rs2293079 [ dbSNP | Ensembl ].
    VAR_048270

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ412564 mRNA. Translation: ABD65410.1. Frameshift.
    AK001277 mRNA. Translation: BAA91596.1. Frameshift.
    AK023206 mRNA. Translation: BAB14462.1.
    BC000238 mRNA. Translation: AAH00238.1.
    BC008948 mRNA. Translation: AAH08948.1.
    CCDSiCCDS42821.1.
    RefSeqiNP_001035869.1. NM_001042410.1.
    NP_060559.2. NM_018089.2.
    UniGeneiHs.437647.

    Genome annotation databases

    EnsembliENST00000323348; ENSP00000321617; ENSG00000163516.
    ENST00000410034; ENSP00000386337; ENSG00000163516.
    GeneIDi55139.
    KEGGihsa:55139.
    UCSCiuc002vkg.3. human.

    Polymorphism databases

    DMDMi74761542.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ412564 mRNA. Translation: ABD65410.1 . Frameshift.
    AK001277 mRNA. Translation: BAA91596.1 . Frameshift.
    AK023206 mRNA. Translation: BAB14462.1 .
    BC000238 mRNA. Translation: AAH00238.1 .
    BC008948 mRNA. Translation: AAH08948.1 .
    CCDSi CCDS42821.1.
    RefSeqi NP_001035869.1. NM_001042410.1.
    NP_060559.2. NM_018089.2.
    UniGenei Hs.437647.

    3D structure databases

    ProteinModelPortali Q9H8Y5.
    SMRi Q9H8Y5. Positions 495-672.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120443. 4 interactions.
    IntActi Q9H8Y5. 7 interactions.
    MINTi MINT-1387900.
    STRINGi 9606.ENSP00000321617.

    PTM databases

    PhosphoSitei Q9H8Y5.

    Polymorphism databases

    DMDMi 74761542.

    Proteomic databases

    MaxQBi Q9H8Y5.
    PaxDbi Q9H8Y5.
    PeptideAtlasi Q9H8Y5.
    PRIDEi Q9H8Y5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000323348 ; ENSP00000321617 ; ENSG00000163516 .
    ENST00000410034 ; ENSP00000386337 ; ENSG00000163516 .
    GeneIDi 55139.
    KEGGi hsa:55139.
    UCSCi uc002vkg.3. human.

    Organism-specific databases

    CTDi 55139.
    GeneCardsi GC02P220094.
    HGNCi HGNC:25527. ANKZF1.
    HPAi HPA035208.
    neXtProti NX_Q9H8Y5.
    PharmGKBi PA143485305.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG323124.
    HOGENOMi HOG000033947.
    HOVERGENi HBG080842.
    InParanoidi Q9H8Y5.
    OMAi AYRCILG.
    OrthoDBi EOG7M6D7B.
    PhylomeDBi Q9H8Y5.
    TreeFami TF313431.

    Miscellaneous databases

    ChiTaRSi ANKZF1. human.
    GeneWikii ANKZF1.
    GenomeRNAii 55139.
    NextBioi 58830.
    PROi Q9H8Y5.

    Gene expression databases

    ArrayExpressi Q9H8Y5.
    Bgeei Q9H8Y5.
    CleanExi HS_ANKZF1.
    Genevestigatori Q9H8Y5.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    Pfami PF00023. Ank. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 2 hits.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Zhao Y., Li Y., Yuan W., Wu X., Liu M.
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon and Eye.
    4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-675, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258; SER-398; SER-533 AND THR-607, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-398, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiANKZ1_HUMAN
    AccessioniPrimary (citable) accession number: Q9H8Y5
    Secondary accession number(s): Q9NVZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3