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Protein

Probable palmitoyltransferase ZDHHC11

Gene

ZDHHC11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC11 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 11
Short name:
DHHC-11
Zinc finger protein 399
Gene namesi
Name:ZDHHC11
Synonyms:ZNF399
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:19158. ZDHHC11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79844.
OpenTargetsiENSG00000188818.
PharmGKBiPA38801.

Polymorphism and mutation databases

BioMutaiZDHHC11.
DMDMi28202107.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128831 – 412Probable palmitoyltransferase ZDHHC11Add BLAST412

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9H8X9.
PeptideAtlasiQ9H8X9.
PRIDEiQ9H8X9.

PTM databases

iPTMnetiQ9H8X9.
PhosphoSitePlusiQ9H8X9.

Expressioni

Gene expression databases

BgeeiENSG00000188818.
CleanExiHS_ZDHHC11.
ExpressionAtlasiQ9H8X9. baseline and differential.
GenevisibleiQ9H8X9. HS.

Organism-specific databases

HPAiHPA057886.
HPA069008.

Interactioni

Protein-protein interaction databases

BioGridi122935. 11 interactors.
STRINGi9606.ENSP00000283441.

Structurei

3D structure databases

ProteinModelPortaliQ9H8X9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 175DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000203681.
HOVERGENiHBG059666.
InParanoidiQ9H8X9.
KOiK20027.
OMAiLCHFCTS.
OrthoDBiEOG091G0A1N.
PhylomeDBiQ9H8X9.
TreeFamiTF317498.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H8X9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTRSGSQCS VTPEAILNNE KLVLPPRISR VNGWSLPLHY FQVVTWAVFV
60 70 80 90 100
GLSSATFGIF IPFLPHAWKY IAYVVTGGIF SFHLVVHLIA SCIDPADSNV
110 120 130 140 150
RLMKNYSQPM PLFDRSKHAH VIQNQFCHLC KVTVNKKTKH CISCNKCVSG
160 170 180 190 200
FDHHCKWINN CVGSRNYWFF FSTVASATAG MLCLIAILLY VLVQYLVNPG
210 220 230 240 250
VLRTDPRYED VKNMNTWLLF LPLFPVQVQT LIVVIIGMLV LLLDFLGLVH
260 270 280 290 300
LGQLLIFHIY LKAKKMTTFE YLINNRKEES SKHQAVRKDP YVQMDKGVLQ
310 320 330 340 350
QGAGALGSSA QGVKAKSSLL IHKHLCHFCT SVNQDGDSTA REGDEDPCPS
360 370 380 390 400
ALGAKARNSR LICRRLCQFS TRVHPDGGSM AQEADDAPSI STLGLQQETT
410
EPMKTDSAES ED
Length:412
Mass (Da):45,975
Last modified:March 1, 2001 - v1
Checksum:i7A5B74FBC37B2F9E
GO
Isoform 2 (identifier: Q9H8X9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-213: Missing.
     262-355: KAKKMTTFEY...DPCPSALGAK → SMSPTLSPRS...PRPAGVVPGA
     356-412: Missing.

Note: No experimental confirmation available.
Show »
Length:142
Mass (Da):15,690
Checksum:i23094780DF9A42CD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052975325L → S.Corresponds to variant rs2878468dbSNPEnsembl.1
Natural variantiVAR_024704341R → Q.Corresponds to variant rs1809008dbSNPEnsembl.1
Natural variantiVAR_021998372R → H.Corresponds to variant rs3747738dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559971 – 213Missing in isoform 2. 1 PublicationAdd BLAST213
Alternative sequenceiVSP_055998262 – 355KAKKM…ALGAK → SMSPTLSPRSPQGWVVRAAH LTPLLEYVPNPEPPTPGARV FVPRVRMCSGSASPRSEIMD KKGKSQEEIKSMRTQQAQQE AELTPRPAGVVPGA in isoform 2. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_055999356 – 412Missing in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358673 mRNA. Translation: AAQ89036.1.
AK023215 mRNA. Translation: BAB14468.1.
AC010427 Genomic DNA. No translation available.
AC026740 Genomic DNA. No translation available.
AC122719 Genomic DNA. No translation available.
BC032000 mRNA. Translation: AAH32000.1.
CCDSiCCDS3857.1. [Q9H8X9-1]
RefSeqiNP_079062.1. NM_024786.2. [Q9H8X9-1]
UniGeneiHs.654874.
Hs.732788.

Genome annotation databases

EnsembliENST00000283441; ENSP00000283441; ENSG00000188818. [Q9H8X9-1]
ENST00000511539; ENSP00000427067; ENSG00000188818. [Q9H8X9-2]
GeneIDi79844.
KEGGihsa:79844.
UCSCiuc003jbk.5. human. [Q9H8X9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358673 mRNA. Translation: AAQ89036.1.
AK023215 mRNA. Translation: BAB14468.1.
AC010427 Genomic DNA. No translation available.
AC026740 Genomic DNA. No translation available.
AC122719 Genomic DNA. No translation available.
BC032000 mRNA. Translation: AAH32000.1.
CCDSiCCDS3857.1. [Q9H8X9-1]
RefSeqiNP_079062.1. NM_024786.2. [Q9H8X9-1]
UniGeneiHs.654874.
Hs.732788.

3D structure databases

ProteinModelPortaliQ9H8X9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122935. 11 interactors.
STRINGi9606.ENSP00000283441.

PTM databases

iPTMnetiQ9H8X9.
PhosphoSitePlusiQ9H8X9.

Polymorphism and mutation databases

BioMutaiZDHHC11.
DMDMi28202107.

Proteomic databases

PaxDbiQ9H8X9.
PeptideAtlasiQ9H8X9.
PRIDEiQ9H8X9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283441; ENSP00000283441; ENSG00000188818. [Q9H8X9-1]
ENST00000511539; ENSP00000427067; ENSG00000188818. [Q9H8X9-2]
GeneIDi79844.
KEGGihsa:79844.
UCSCiuc003jbk.5. human. [Q9H8X9-1]

Organism-specific databases

CTDi79844.
DisGeNETi79844.
GeneCardsiZDHHC11.
HGNCiHGNC:19158. ZDHHC11.
HPAiHPA057886.
HPA069008.
neXtProtiNX_Q9H8X9.
OpenTargetsiENSG00000188818.
PharmGKBiPA38801.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000203681.
HOVERGENiHBG059666.
InParanoidiQ9H8X9.
KOiK20027.
OMAiLCHFCTS.
OrthoDBiEOG091G0A1N.
PhylomeDBiQ9H8X9.
TreeFamiTF317498.

Miscellaneous databases

GenomeRNAii79844.
PROiQ9H8X9.

Gene expression databases

BgeeiENSG00000188818.
CleanExiHS_ZDHHC11.
ExpressionAtlasiQ9H8X9. baseline and differential.
GenevisibleiQ9H8X9. HS.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDH11_HUMAN
AccessioniPrimary (citable) accession number: Q9H8X9
Secondary accession number(s): Q6UWR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.