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Protein

Probable palmitoyltransferase ZDHHC11

Gene

ZDHHC11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC11 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 11
Short name:
DHHC-11
Zinc finger protein 399
Gene namesi
Name:ZDHHC11
Synonyms:ZNF399
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000188818.12
HGNCiHGNC:19158 ZDHHC11
neXtProtiNX_Q9H8X9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79844
OpenTargetsiENSG00000188818
PharmGKBiPA38801

Polymorphism and mutation databases

BioMutaiZDHHC11
DMDMi28202107

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128831 – 412Probable palmitoyltransferase ZDHHC11Add BLAST412

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9H8X9
PeptideAtlasiQ9H8X9
PRIDEiQ9H8X9
ProteomicsDBi81254

PTM databases

iPTMnetiQ9H8X9
PhosphoSitePlusiQ9H8X9

Expressioni

Gene expression databases

BgeeiENSG00000188818
CleanExiHS_ZDHHC11
ExpressionAtlasiQ9H8X9 baseline and differential
GenevisibleiQ9H8X9 HS

Organism-specific databases

HPAiHPA057886
HPA069008

Interactioni

Protein-protein interaction databases

BioGridi122935, 14 interactors
STRINGi9606.ENSP00000283441

Structurei

3D structure databases

ProteinModelPortaliQ9H8X9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 175DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00550000074293
HOGENOMiHOG000203681
HOVERGENiHBG059666
InParanoidiQ9H8X9
KOiK20027
OMAiCNKCVSV
OrthoDBiEOG091G0A1N
PhylomeDBiQ9H8X9
TreeFamiTF317498

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H8X9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTRSGSQCS VTPEAILNNE KLVLPPRISR VNGWSLPLHY FQVVTWAVFV
60 70 80 90 100
GLSSATFGIF IPFLPHAWKY IAYVVTGGIF SFHLVVHLIA SCIDPADSNV
110 120 130 140 150
RLMKNYSQPM PLFDRSKHAH VIQNQFCHLC KVTVNKKTKH CISCNKCVSG
160 170 180 190 200
FDHHCKWINN CVGSRNYWFF FSTVASATAG MLCLIAILLY VLVQYLVNPG
210 220 230 240 250
VLRTDPRYED VKNMNTWLLF LPLFPVQVQT LIVVIIGMLV LLLDFLGLVH
260 270 280 290 300
LGQLLIFHIY LKAKKMTTFE YLINNRKEES SKHQAVRKDP YVQMDKGVLQ
310 320 330 340 350
QGAGALGSSA QGVKAKSSLL IHKHLCHFCT SVNQDGDSTA REGDEDPCPS
360 370 380 390 400
ALGAKARNSR LICRRLCQFS TRVHPDGGSM AQEADDAPSI STLGLQQETT
410
EPMKTDSAES ED
Length:412
Mass (Da):45,975
Last modified:March 1, 2001 - v1
Checksum:i7A5B74FBC37B2F9E
GO
Isoform 2 (identifier: Q9H8X9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-213: Missing.
     262-355: KAKKMTTFEY...DPCPSALGAK → SMSPTLSPRS...PRPAGVVPGA
     356-412: Missing.

Note: No experimental confirmation available.
Show »
Length:142
Mass (Da):15,690
Checksum:i23094780DF9A42CD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052975325L → S. Corresponds to variant dbSNP:rs2878468Ensembl.1
Natural variantiVAR_024704341R → Q. Corresponds to variant dbSNP:rs1809008Ensembl.1
Natural variantiVAR_021998372R → H. Corresponds to variant dbSNP:rs3747738Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559971 – 213Missing in isoform 2. 1 PublicationAdd BLAST213
Alternative sequenceiVSP_055998262 – 355KAKKM…ALGAK → SMSPTLSPRSPQGWVVRAAH LTPLLEYVPNPEPPTPGARV FVPRVRMCSGSASPRSEIMD KKGKSQEEIKSMRTQQAQQE AELTPRPAGVVPGA in isoform 2. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_055999356 – 412Missing in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358673 mRNA Translation: AAQ89036.1
AK023215 mRNA Translation: BAB14468.1
AC010427 Genomic DNA No translation available.
AC026740 Genomic DNA No translation available.
AC122719 Genomic DNA No translation available.
BC032000 mRNA Translation: AAH32000.1
CCDSiCCDS3857.1 [Q9H8X9-1]
RefSeqiNP_079062.1, NM_024786.2 [Q9H8X9-1]
UniGeneiHs.654874
Hs.732788

Genome annotation databases

EnsembliENST00000283441; ENSP00000283441; ENSG00000188818 [Q9H8X9-1]
ENST00000511539; ENSP00000427067; ENSG00000188818 [Q9H8X9-2]
GeneIDi79844
KEGGihsa:79844
UCSCiuc003jbk.5 human [Q9H8X9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZDH11_HUMAN
AccessioniPrimary (citable) accession number: Q9H8X9
Secondary accession number(s): Q6UWR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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