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Protein

Tripartite motif-containing protein 45

Gene

TRIM45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri29 – 9870RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri130 – 17647B box-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri186 – 22742B box-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 45
Alternative name(s):
RING finger protein 99
Gene namesi
Name:TRIM45
Synonyms:RNF99
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19018. TRIM45.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134873644.

Polymorphism and mutation databases

BioMutaiTRIM45.
DMDMi90110721.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580Tripartite motif-containing protein 45PRO_0000056266Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki371 – 371Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9H8W5.
PRIDEiQ9H8W5.

PTM databases

iPTMnetiQ9H8W5.
PhosphoSiteiQ9H8W5.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, brain, heart and pancreas.1 Publication

Developmental stagei

Expressed in brain, lung, skeletal muscle, heart and intestine in 80-day old embryo.1 Publication

Gene expression databases

BgeeiQ9H8W5.
CleanExiHS_TRIM45.
ExpressionAtlasiQ9H8W5. baseline and differential.
GenevisibleiQ9H8W5. HS.

Organism-specific databases

HPAiHPA030266.
HPA054308.

Interactioni

Protein-protein interaction databases

BioGridi123205. 13 interactions.
IntActiQ9H8W5. 1 interaction.
STRINGi9606.ENSP00000256649.

Structurei

Secondary structure

1
580
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni399 – 4013Combined sources
Beta strandi403 – 4053Combined sources
Turni407 – 4104Combined sources
Beta strandi411 – 4133Combined sources
Beta strandi418 – 4236Combined sources
Beta strandi429 – 4313Combined sources
Beta strandi439 – 4479Combined sources
Beta strandi454 – 4585Combined sources
Beta strandi461 – 47010Combined sources
Beta strandi472 – 48514Combined sources
Beta strandi492 – 4987Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DS4NMR-A396-501[»]
ProteinModelPortaliQ9H8W5.
SMRiQ9H8W5. Positions 27-122, 393-501.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H8W5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati394 – 497104FilaminAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili281 – 33555Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 2 B box-type zinc fingers.PROSITE-ProRule annotation
Contains 1 filamin repeat.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri29 – 9870RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri130 – 17647B box-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri186 – 22742B box-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITG2. Eukaryota.
ENOG410Z9MF. LUCA.
GeneTreeiENSGT00550000074377.
HOGENOMiHOG000231266.
HOVERGENiHBG054905.
InParanoidiQ9H8W5.
KOiK12021.
OMAiGHPHWSC.
OrthoDBiEOG7PS1F8.
PhylomeDBiQ9H8W5.
TreeFamiTF324196.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProiIPR003649. Bbox_C.
IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00630. Filamin. 1 hit.
PF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00502. BBC. 1 hit.
SM00336. BBOX. 2 hits.
SM00557. IG_FLMN. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS50194. FILAMIN_REPEAT. 1 hit.
PS50119. ZF_BBOX. 2 hits.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H8W5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSENRKPLLG FVSKLTSGTA LGNSGKTHCP LCLGLFKAPR LLPCLHTVCT
60 70 80 90 100
TCLEQLEPFS VVDIRGGDSD TSSEGSIFQE LKPRSLQSQI GILCPVCDAQ
110 120 130 140 150
VDLPMGGVKA LTIDHLAVND VMLESLRGEG QGLVCDLCND REVEKRCQTC
160 170 180 190 200
KANLCHFCCQ AHRRQKKTTY HTMVDLKDLK GYSRIGKPIL CPVHPAEELR
210 220 230 240 250
LFCEFCDRPV CQDCVVGEHR EHPCDFTSNV IHKHGDSVWE LLKGTQPHVE
260 270 280 290 300
ALEEALAQIH IINSALQKRV EAVAADVRTF SEGYIKAIEE HRDKLLKQLE
310 320 330 340 350
DIRAQKENSL QLQKAQLEQL LADMRTGVEF TEHLLTSGSD LEILITKRVV
360 370 380 390 400
VERLRKLNKV QYSTRPGVND KIRFCPQEKA GQCRGYEIYG TINTKEVDPA
410 420 430 440 450
KCVLQGEDLH RAREKQTASF TLLCKDAAGE IMGRGGDNVQ VAVVPKDKKD
460 470 480 490 500
SPVRTMVQDN KDGTYYISYT PKEPGVYTVW VCIKEQHVQG SPFTVMVRRK
510 520 530 540 550
HRPHSGVFHC CTFCSSGGQK TARCACGGTM PGGYLGCGHG HKGHPGHPHW
560 570 580
SCCGKFNEKS ECTWTGGQSA PRSLLRTVAL
Length:580
Mass (Da):64,359
Last modified:March 7, 2006 - v2
Checksum:i44DFADF69D598682
GO
Isoform 2 (identifier: Q9H8W5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-407: Missing.

Note: No experimental confirmation available.
Show »
Length:562
Mass (Da):62,475
Checksum:i8136632096CD39FA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti353 – 3531R → Q.
Corresponds to variant rs34863850 [ dbSNP | Ensembl ].
VAR_044128
Natural varianti375 – 3751C → Y.1 Publication
Corresponds to variant rs749902 [ dbSNP | Ensembl ].
VAR_019931
Natural varianti413 – 4131R → Q.
Corresponds to variant rs3738413 [ dbSNP | Ensembl ].
VAR_019932
Natural varianti496 – 4961M → T.4 Publications
Corresponds to variant rs1289658 [ dbSNP | Ensembl ].
VAR_019933

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei390 – 40718Missing in isoform 2. 1 PublicationVSP_012000Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY669488 mRNA. Translation: AAT76864.1.
AK023243 mRNA. Translation: BAB14484.1.
AK222901 mRNA. Translation: BAD96621.1.
AL391476 Genomic DNA. Translation: CAI12733.1.
AL391476 Genomic DNA. Translation: CAI12734.1.
BC034943 mRNA. Translation: AAH34943.1.
CCDSiCCDS44200.1. [Q9H8W5-2]
CCDS893.1. [Q9H8W5-1]
RefSeqiNP_001139107.1. NM_001145635.1. [Q9H8W5-2]
NP_079464.2. NM_025188.3. [Q9H8W5-1]
UniGeneiHs.301526.

Genome annotation databases

EnsembliENST00000256649; ENSP00000256649; ENSG00000134253. [Q9H8W5-1]
ENST00000369464; ENSP00000358476; ENSG00000134253. [Q9H8W5-2]
GeneIDi80263.
KEGGihsa:80263.
UCSCiuc001egz.3. human. [Q9H8W5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY669488 mRNA. Translation: AAT76864.1.
AK023243 mRNA. Translation: BAB14484.1.
AK222901 mRNA. Translation: BAD96621.1.
AL391476 Genomic DNA. Translation: CAI12733.1.
AL391476 Genomic DNA. Translation: CAI12734.1.
BC034943 mRNA. Translation: AAH34943.1.
CCDSiCCDS44200.1. [Q9H8W5-2]
CCDS893.1. [Q9H8W5-1]
RefSeqiNP_001139107.1. NM_001145635.1. [Q9H8W5-2]
NP_079464.2. NM_025188.3. [Q9H8W5-1]
UniGeneiHs.301526.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DS4NMR-A396-501[»]
ProteinModelPortaliQ9H8W5.
SMRiQ9H8W5. Positions 27-122, 393-501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123205. 13 interactions.
IntActiQ9H8W5. 1 interaction.
STRINGi9606.ENSP00000256649.

PTM databases

iPTMnetiQ9H8W5.
PhosphoSiteiQ9H8W5.

Polymorphism and mutation databases

BioMutaiTRIM45.
DMDMi90110721.

Proteomic databases

PaxDbiQ9H8W5.
PRIDEiQ9H8W5.

Protocols and materials databases

DNASUi80263.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256649; ENSP00000256649; ENSG00000134253. [Q9H8W5-1]
ENST00000369464; ENSP00000358476; ENSG00000134253. [Q9H8W5-2]
GeneIDi80263.
KEGGihsa:80263.
UCSCiuc001egz.3. human. [Q9H8W5-1]

Organism-specific databases

CTDi80263.
GeneCardsiTRIM45.
HGNCiHGNC:19018. TRIM45.
HPAiHPA030266.
HPA054308.
MIMi609318. gene.
neXtProtiNX_Q9H8W5.
PharmGKBiPA134873644.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITG2. Eukaryota.
ENOG410Z9MF. LUCA.
GeneTreeiENSGT00550000074377.
HOGENOMiHOG000231266.
HOVERGENiHBG054905.
InParanoidiQ9H8W5.
KOiK12021.
OMAiGHPHWSC.
OrthoDBiEOG7PS1F8.
PhylomeDBiQ9H8W5.
TreeFamiTF324196.

Enzyme and pathway databases

ReactomeiR-HSA-877300. Interferon gamma signaling.

Miscellaneous databases

EvolutionaryTraceiQ9H8W5.
GeneWikiiTRIM45.
GenomeRNAii80263.
NextBioi70721.
PROiQ9H8W5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H8W5.
CleanExiHS_TRIM45.
ExpressionAtlasiQ9H8W5. baseline and differential.
GenevisibleiQ9H8W5. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProiIPR003649. Bbox_C.
IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00630. Filamin. 1 hit.
PF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00502. BBC. 1 hit.
SM00336. BBOX. 2 hits.
SM00557. IG_FLMN. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS50194. FILAMIN_REPEAT. 1 hit.
PS50119. ZF_BBOX. 2 hits.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1."
    Wang Y., Li Y., Qi X., Yuan W., Ai J., Zhu C., Cao L., Yang H., Liu F., Wu X., Liu M.
    Biochem. Biophys. Res. Commun. 323:9-16(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-496, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Embryonic heart.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-496.
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS TYR-375 AND THR-496.
    Tissue: Kidney.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-496.
    Tissue: Testis.
  6. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
    Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
    Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-371.
    Tissue: Mammary cancer.
  7. "Solution structure of the filamin domain from human tripartite motif protein 45."
    RIKEN structural genomics initiative (RSGI)
    Submitted (DEC-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 396-501.

Entry informationi

Entry nameiTRI45_HUMAN
AccessioniPrimary (citable) accession number: Q9H8W5
Secondary accession number(s): Q53GN0
, Q5T2K4, Q5T2K5, Q8IYV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 7, 2006
Last modified: May 11, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.