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Protein

Tripartite motif-containing protein 45

Gene

TRIM45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.1 Publication

Caution

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri29 – 98RING-typePROSITE-ProRule annotationAdd BLAST70
Zinc fingeri130 – 176B box-type 1PROSITE-ProRule annotationAdd BLAST47
Zinc fingeri186 – 227B box-type 2PROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-877300 Interferon gamma signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 45
Alternative name(s):
RING finger protein 99
Gene namesi
Name:TRIM45
Synonyms:RNF99
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000134253.9
HGNCiHGNC:19018 TRIM45
MIMi609318 gene
neXtProtiNX_Q9H8W5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000134253
PharmGKBiPA134873644

Polymorphism and mutation databases

BioMutaiTRIM45
DMDMi90110721

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562661 – 580Tripartite motif-containing protein 45Add BLAST580

Proteomic databases

PaxDbiQ9H8W5
PeptideAtlasiQ9H8W5
PRIDEiQ9H8W5

PTM databases

iPTMnetiQ9H8W5
PhosphoSitePlusiQ9H8W5

Expressioni

Tissue specificityi

Expressed in skeletal muscle, brain, heart and pancreas.1 Publication

Developmental stagei

Expressed in brain, lung, skeletal muscle, heart and intestine in 80-day old embryo.1 Publication

Gene expression databases

BgeeiENSG00000134253
CleanExiHS_TRIM45
ExpressionAtlasiQ9H8W5 baseline and differential
GenevisibleiQ9H8W5 HS

Organism-specific databases

HPAiHPA030266
HPA054308

Interactioni

Protein-protein interaction databases

BioGridi12320514 interactors.
IntActiQ9H8W5 5 interactors.
STRINGi9606.ENSP00000256649

Structurei

Secondary structure

1580
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni399 – 401Combined sources3
Beta strandi403 – 405Combined sources3
Turni407 – 410Combined sources4
Beta strandi411 – 413Combined sources3
Beta strandi418 – 423Combined sources6
Beta strandi429 – 431Combined sources3
Beta strandi439 – 447Combined sources9
Beta strandi454 – 458Combined sources5
Beta strandi461 – 470Combined sources10
Beta strandi472 – 485Combined sources14
Beta strandi492 – 498Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DS4NMR-A396-501[»]
ProteinModelPortaliQ9H8W5
SMRiQ9H8W5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H8W5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati394 – 497FilaminAdd BLAST104

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili281 – 335Sequence analysisAdd BLAST55

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri29 – 98RING-typePROSITE-ProRule annotationAdd BLAST70
Zinc fingeri130 – 176B box-type 1PROSITE-ProRule annotationAdd BLAST47
Zinc fingeri186 – 227B box-type 2PROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITG2 Eukaryota
ENOG410Z9MF LUCA
GeneTreeiENSGT00890000139359
HOGENOMiHOG000231266
HOVERGENiHBG054905
InParanoidiQ9H8W5
KOiK12021
OMAiCMGLFKA
OrthoDBiEOG091G0AG7
PhylomeDBiQ9H8W5
TreeFamiTF324196

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di2.60.40.101 hit
InterProiView protein in InterPro
IPR003649 Bbox_C
IPR017868 Filamin/ABP280_repeat-like
IPR001298 Filamin/ABP280_rpt
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00630 Filamin, 1 hit
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit
SMARTiView protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 2 hits
SM00557 IG_FLMN, 1 hit
SM00184 RING, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50194 FILAMIN_REPEAT, 1 hit
PS50119 ZF_BBOX, 2 hits
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H8W5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSENRKPLLG FVSKLTSGTA LGNSGKTHCP LCLGLFKAPR LLPCLHTVCT
60 70 80 90 100
TCLEQLEPFS VVDIRGGDSD TSSEGSIFQE LKPRSLQSQI GILCPVCDAQ
110 120 130 140 150
VDLPMGGVKA LTIDHLAVND VMLESLRGEG QGLVCDLCND REVEKRCQTC
160 170 180 190 200
KANLCHFCCQ AHRRQKKTTY HTMVDLKDLK GYSRIGKPIL CPVHPAEELR
210 220 230 240 250
LFCEFCDRPV CQDCVVGEHR EHPCDFTSNV IHKHGDSVWE LLKGTQPHVE
260 270 280 290 300
ALEEALAQIH IINSALQKRV EAVAADVRTF SEGYIKAIEE HRDKLLKQLE
310 320 330 340 350
DIRAQKENSL QLQKAQLEQL LADMRTGVEF TEHLLTSGSD LEILITKRVV
360 370 380 390 400
VERLRKLNKV QYSTRPGVND KIRFCPQEKA GQCRGYEIYG TINTKEVDPA
410 420 430 440 450
KCVLQGEDLH RAREKQTASF TLLCKDAAGE IMGRGGDNVQ VAVVPKDKKD
460 470 480 490 500
SPVRTMVQDN KDGTYYISYT PKEPGVYTVW VCIKEQHVQG SPFTVMVRRK
510 520 530 540 550
HRPHSGVFHC CTFCSSGGQK TARCACGGTM PGGYLGCGHG HKGHPGHPHW
560 570 580
SCCGKFNEKS ECTWTGGQSA PRSLLRTVAL
Length:580
Mass (Da):64,359
Last modified:March 7, 2006 - v2
Checksum:i44DFADF69D598682
GO
Isoform 2 (identifier: Q9H8W5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-407: Missing.

Note: No experimental confirmation available.
Show »
Length:562
Mass (Da):62,475
Checksum:i8136632096CD39FA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_044128353R → Q. Corresponds to variant dbSNP:rs34863850Ensembl.1
Natural variantiVAR_019931375C → Y1 PublicationCorresponds to variant dbSNP:rs749902Ensembl.1
Natural variantiVAR_019932413R → Q. Corresponds to variant dbSNP:rs3738413Ensembl.1
Natural variantiVAR_019933496M → T4 PublicationsCorresponds to variant dbSNP:rs1289658Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012000390 – 407Missing in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY669488 mRNA Translation: AAT76864.1
AK023243 mRNA Translation: BAB14484.1
AK222901 mRNA Translation: BAD96621.1
AL391476 Genomic DNA No translation available.
BC034943 mRNA Translation: AAH34943.1
CCDSiCCDS44200.1 [Q9H8W5-2]
CCDS893.1 [Q9H8W5-1]
RefSeqiNP_001139107.1, NM_001145635.1 [Q9H8W5-2]
NP_079464.2, NM_025188.3 [Q9H8W5-1]
UniGeneiHs.301526

Genome annotation databases

EnsembliENST00000256649; ENSP00000256649; ENSG00000134253 [Q9H8W5-1]
ENST00000369464; ENSP00000358476; ENSG00000134253 [Q9H8W5-2]
GeneIDi80263
KEGGihsa:80263
UCSCiuc001egz.3 human [Q9H8W5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRI45_HUMAN
AccessioniPrimary (citable) accession number: Q9H8W5
Secondary accession number(s): Q53GN0
, Q5T2K4, Q5T2K5, Q8IYV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 7, 2006
Last modified: April 25, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome