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Protein

Pleckstrin homology domain-containing family F member 2

Gene

PLEKHF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 212FYVE-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family F member 2
Short name:
PH domain-containing family F member 2
Alternative name(s):
Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains
Short name:
EAPF
PH and FYVE domain-containing protein 2
Phafin-2
Short name:
Phafin2
Zinc finger FYVE domain-containing protein 18
Gene namesi
Name:PLEKHF2
Synonyms:ZFYVE18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:20757. PLEKHF2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79666.
OpenTargetsiENSG00000175895.
PharmGKBiPA128394715.

Polymorphism and mutation databases

BioMutaiPLEKHF2.
DMDMi74762744.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002516001 – 249Pleckstrin homology domain-containing family F member 2Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei44N6-acetyllysineCombined sources1
Modified residuei239PhosphoserineCombined sources1
Modified residuei248PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H8W4.
MaxQBiQ9H8W4.
PaxDbiQ9H8W4.
PeptideAtlasiQ9H8W4.
PRIDEiQ9H8W4.

PTM databases

iPTMnetiQ9H8W4.
PhosphoSitePlusiQ9H8W4.

Expressioni

Tissue specificityi

Expressed in placenta, ovary and small intestine, as well as in heart and pancreas. Also expressed in peripheral blood mononuclear cells and dendritic cells.1 Publication

Inductioni

Up-regulated by TNF, bacterial lipopolysaccharides (LPS) and phorbol myristate acetate (PMA) (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000175895.
CleanExiHS_PLEKHF2.
GenevisibleiQ9H8W4. HS.

Organism-specific databases

HPAiHPA024829.

Interactioni

Subunit structurei

May interact with EEA1.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122791. 67 interactors.
IntActiQ9H8W4. 108 interactors.
MINTiMINT-1468345.
STRINGi9606.ENSP00000322373.

Structurei

3D structure databases

ProteinModelPortaliQ9H8W4.
SMRiQ9H8W4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 131PHPROSITE-ProRule annotationAdd BLAST97

Domaini

The PH and FYVE domains may be important for TNF-induced localization to the endoplasmic reticulum and for enhanced cellular sensitivity to TNF-induced apoptosis (PubMed:18288467). The FYVE domain is important for binding to the endosomal membrane.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 212FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1729. Eukaryota.
ENOG410XPJK. LUCA.
GeneTreeiENSGT00750000117280.
HOGENOMiHOG000231519.
HOVERGENiHBG059973.
InParanoidiQ9H8W4.
OMAiGEHAAVW.
OrthoDBiEOG091G0OVV.
PhylomeDBiQ9H8W4.
TreeFamiTF315235.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01363. FYVE. 1 hit.
PF00169. PH. 1 hit.
SMARTiView protein in SMART
SM00064. FYVE. 1 hit.
SM00233. PH. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiView protein in PROSITE
PS50003. PH_DOMAIN. 1 hit.
PS50178. ZF_FYVE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H8W4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDRLANSEA NTRRISIVEN CFGAAGQPLT IPGRVLIGEG VLTKLCRKKP
60 70 80 90 100
KARQFFLFND ILVYGNIVIQ KKKYNKQHII PLENVTIDSI KDEGDLRNGW
110 120 130 140 150
LIKTPTKSFA VYAATATEKS EWMNHINKCV TDLLSKSGKT PSNEHAAVWV
160 170 180 190 200
PDSEATVCMR CQKAKFTPVN RRHHCRKCGF VVCGPCSEKR FLLPSQSSKP
210 220 230 240
VRICDFCYDL LSAGDMATCQ PARSDSYSQS LKSPLNDMSD DDDDDDSSD
Length:249
Mass (Da):27,798
Last modified:March 1, 2001 - v1
Checksum:iF5E3F84595A98886
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF434819 mRNA. Translation: AAL30774.1.
AK023249 mRNA. Translation: BAB14486.1.
AL834473 mRNA. Translation: CAD39132.1.
BC011806 mRNA. Translation: AAH11806.1.
CCDSiCCDS6267.1.
RefSeqiNP_078889.1. NM_024613.3.
UniGeneiHs.29724.

Genome annotation databases

EnsembliENST00000315367; ENSP00000322373; ENSG00000175895.
ENST00000519516; ENSP00000427792; ENSG00000175895.
GeneIDi79666.
KEGGihsa:79666.
UCSCiuc003yhn.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF434819 mRNA. Translation: AAL30774.1.
AK023249 mRNA. Translation: BAB14486.1.
AL834473 mRNA. Translation: CAD39132.1.
BC011806 mRNA. Translation: AAH11806.1.
CCDSiCCDS6267.1.
RefSeqiNP_078889.1. NM_024613.3.
UniGeneiHs.29724.

3D structure databases

ProteinModelPortaliQ9H8W4.
SMRiQ9H8W4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122791. 67 interactors.
IntActiQ9H8W4. 108 interactors.
MINTiMINT-1468345.
STRINGi9606.ENSP00000322373.

PTM databases

iPTMnetiQ9H8W4.
PhosphoSitePlusiQ9H8W4.

Polymorphism and mutation databases

BioMutaiPLEKHF2.
DMDMi74762744.

Proteomic databases

EPDiQ9H8W4.
MaxQBiQ9H8W4.
PaxDbiQ9H8W4.
PeptideAtlasiQ9H8W4.
PRIDEiQ9H8W4.

Protocols and materials databases

DNASUi79666.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315367; ENSP00000322373; ENSG00000175895.
ENST00000519516; ENSP00000427792; ENSG00000175895.
GeneIDi79666.
KEGGihsa:79666.
UCSCiuc003yhn.3. human.

Organism-specific databases

CTDi79666.
DisGeNETi79666.
GeneCardsiPLEKHF2.
HGNCiHGNC:20757. PLEKHF2.
HPAiHPA024829.
MIMi615208. gene.
neXtProtiNX_Q9H8W4.
OpenTargetsiENSG00000175895.
PharmGKBiPA128394715.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1729. Eukaryota.
ENOG410XPJK. LUCA.
GeneTreeiENSGT00750000117280.
HOGENOMiHOG000231519.
HOVERGENiHBG059973.
InParanoidiQ9H8W4.
OMAiGEHAAVW.
OrthoDBiEOG091G0OVV.
PhylomeDBiQ9H8W4.
TreeFamiTF315235.

Miscellaneous databases

GeneWikiiPLEKHF2.
GenomeRNAii79666.
PROiPR:Q9H8W4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175895.
CleanExiHS_PLEKHF2.
GenevisibleiQ9H8W4. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01363. FYVE. 1 hit.
PF00169. PH. 1 hit.
SMARTiView protein in SMART
SM00064. FYVE. 1 hit.
SM00233. PH. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiView protein in PROSITE
PS50003. PH_DOMAIN. 1 hit.
PS50178. ZF_FYVE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPKHF2_HUMAN
AccessioniPrimary (citable) accession number: Q9H8W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: June 7, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.