ID   F204A_HUMAN             Reviewed;         233 AA.
AC   Q9H8W3; D3DRC6; Q5T373; Q9H5V5;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   24-JAN-2024, entry version 139.
DE   RecName: Full=Protein FAM204A;
GN   Name=FAM204A; Synonyms=C10orf84;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=B-cell;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q9H8W3; Q14192: FHL2; NbExp=3; IntAct=EBI-8465160, EBI-701903;
CC       Q9H8W3; O60341: KDM1A; NbExp=3; IntAct=EBI-8465160, EBI-710124;
CC       Q9H8W3; Q8NB12: SMYD1; NbExp=4; IntAct=EBI-8465160, EBI-8463848;
CC       Q9H8W3; Q5MJ10: SPANXN2; NbExp=3; IntAct=EBI-8465160, EBI-12023934;
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DR   EMBL; AK023250; BAB14487.1; -; mRNA.
DR   EMBL; AK026630; BAB15514.1; -; mRNA.
DR   EMBL; AL365498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471066; EAW49417.1; -; Genomic_DNA.
DR   EMBL; CH471066; EAW49418.1; -; Genomic_DNA.
DR   EMBL; BC023577; AAH23577.1; -; mRNA.
DR   CCDS; CCDS7605.1; -.
DR   RefSeq; NP_001128144.1; NM_001134672.1.
DR   RefSeq; NP_071346.1; NM_022063.2.
DR   AlphaFoldDB; Q9H8W3; -.
DR   SMR; Q9H8W3; -.
DR   BioGRID; 121970; 24.
DR   IntAct; Q9H8W3; 7.
DR   MINT; Q9H8W3; -.
DR   STRING; 9606.ENSP00000358183; -.
DR   GlyGen; Q9H8W3; 2 sites, 1 O-linked glycan (2 sites).
DR   iPTMnet; Q9H8W3; -.
DR   PhosphoSitePlus; Q9H8W3; -.
DR   BioMuta; FAM204A; -.
DR   DMDM; 50400654; -.
DR   EPD; Q9H8W3; -.
DR   jPOST; Q9H8W3; -.
DR   MassIVE; Q9H8W3; -.
DR   MaxQB; Q9H8W3; -.
DR   PaxDb; 9606-ENSP00000358183; -.
DR   PeptideAtlas; Q9H8W3; -.
DR   ProteomicsDB; 81248; -.
DR   Pumba; Q9H8W3; -.
DR   Antibodypedia; 49195; 30 antibodies from 12 providers.
DR   DNASU; 63877; -.
DR   Ensembl; ENST00000369172.8; ENSP00000358170.4; ENSG00000165669.14.
DR   Ensembl; ENST00000369183.9; ENSP00000358183.4; ENSG00000165669.14.
DR   GeneID; 63877; -.
DR   KEGG; hsa:63877; -.
DR   MANE-Select; ENST00000369183.9; ENSP00000358183.4; NM_022063.3; NP_071346.1.
DR   UCSC; uc001ldo.3; human.
DR   AGR; HGNC:25794; -.
DR   CTD; 63877; -.
DR   GeneCards; FAM204A; -.
DR   HGNC; HGNC:25794; FAM204A.
DR   HPA; ENSG00000165669; Low tissue specificity.
DR   neXtProt; NX_Q9H8W3; -.
DR   OpenTargets; ENSG00000165669; -.
DR   PharmGKB; PA134910767; -.
DR   VEuPathDB; HostDB:ENSG00000165669; -.
DR   eggNOG; ENOG502S9J9; Eukaryota.
DR   GeneTree; ENSGT00390000008978; -.
DR   HOGENOM; CLU_102986_0_0_1; -.
DR   InParanoid; Q9H8W3; -.
DR   OMA; REKHWKE; -.
DR   OrthoDB; 1385577at2759; -.
DR   PhylomeDB; Q9H8W3; -.
DR   TreeFam; TF328607; -.
DR   PathwayCommons; Q9H8W3; -.
DR   SignaLink; Q9H8W3; -.
DR   BioGRID-ORCS; 63877; 72 hits in 1156 CRISPR screens.
DR   ChiTaRS; FAM204A; human.
DR   GenomeRNAi; 63877; -.
DR   Pharos; Q9H8W3; Tdark.
DR   PRO; PR:Q9H8W3; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; Q9H8W3; Protein.
DR   Bgee; ENSG00000165669; Expressed in calcaneal tendon and 183 other cell types or tissues.
DR   ExpressionAtlas; Q9H8W3; baseline and differential.
DR   InterPro; IPR037690; FAM204A.
DR   PANTHER; PTHR14386; PROTEIN FAM204A; 1.
DR   PANTHER; PTHR14386:SF2; PROTEIN FAM204A; 1.
DR   Genevisible; Q9H8W3; HS.
PE   1: Evidence at protein level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..233
FT                   /note="Protein FAM204A"
FT                   /id="PRO_0000089808"
FT   REGION          1..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          144..164
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        31..55
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..95
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        68
FT                   /note="C -> F (in Ref. 1; BAB15514)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        84
FT                   /note="H -> R (in Ref. 1; BAB15514)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   233 AA;  27021 MW;  53F9EA7A560F70FB CRC64;
     MWSGLLPPGL NESDAESNSE DEATLENSGL NLQEDKEDES IRKTEIIDFS TDEPKTETES
     NVNAYEECPS GIPIDMWNKF QELHKKHSEQ KSTTSRFRGK RRKRSRKDKL KNEKELHSEP
     SSNETQWKEL TQYFGVNDRF DPPVKRKKVE KSGLEKRIDQ AVEEWNIEKA EELSNQLATR
     ELGVKIAKAV ACHNFVKAKK EVENSQAARK KKKLAWGFEA KKRWETKSNM GYM
//