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Protein

AN1-type zinc finger protein 3

Gene

ZFAND3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 44A20-typePROSITE-ProRule annotationAdd BLAST33
Zinc fingeri154 – 200AN1-typePROSITE-ProRule annotationAdd BLAST47

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156639-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AN1-type zinc finger protein 3
Alternative name(s):
Testis-expressed sequence 27
Gene namesi
Name:ZFAND3
Synonyms:TEX27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:18019. ZFAND3.

Pathology & Biotechi

Organism-specific databases

DisGeNETi60685.
OpenTargetsiENSG00000156639.
PharmGKBiPA38277.

Polymorphism and mutation databases

BioMutaiZFAND3.
DMDMi74733896.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000763701 – 227AN1-type zinc finger protein 3Add BLAST227

Proteomic databases

EPDiQ9H8U3.
MaxQBiQ9H8U3.
PaxDbiQ9H8U3.
PeptideAtlasiQ9H8U3.
PRIDEiQ9H8U3.

PTM databases

iPTMnetiQ9H8U3.
PhosphoSitePlusiQ9H8U3.

Expressioni

Gene expression databases

BgeeiENSG00000156639.
CleanExiHS_ZFAND3.
ExpressionAtlasiQ9H8U3. baseline and differential.
GenevisibleiQ9H8U3. HS.

Organism-specific databases

HPAiHPA016755.

Interactioni

Protein-protein interaction databases

BioGridi121958. 3 interactors.
IntActiQ9H8U3. 3 interactors.
MINTiMINT-1395602.
STRINGi9606.ENSP00000287218.

Structurei

Secondary structure

1227
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi158 – 160Combined sources3
Helixi166 – 172Combined sources7
Beta strandi175 – 177Combined sources3
Turni182 – 184Combined sources3
Helixi188 – 190Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X4WNMR-A147-200[»]
ProteinModelPortaliQ9H8U3.
SMRiQ9H8U3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H8U3.

Family & Domainsi

Sequence similaritiesi

Contains 1 A20-type zinc finger.PROSITE-ProRule annotation
Contains 1 AN1-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 44A20-typePROSITE-ProRule annotationAdd BLAST33
Zinc fingeri154 – 200AN1-typePROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3173. Eukaryota.
ENOG4111UWC. LUCA.
GeneTreeiENSGT00390000014679.
HOGENOMiHOG000007482.
HOVERGENiHBG083631.
InParanoidiQ9H8U3.
OMAiKNRRRCY.
OrthoDBiEOG091G0NSK.
PhylomeDBiQ9H8U3.
TreeFamiTF354281.

Family and domain databases

Gene3Di4.10.1110.10. 1 hit.
InterProiIPR002653. Znf_A20.
IPR000058. Znf_AN1.
[Graphical view]
PfamiPF01754. zf-A20. 1 hit.
PF01428. zf-AN1. 1 hit.
[Graphical view]
SMARTiSM00259. ZnF_A20. 1 hit.
SM00154. ZnF_AN1. 1 hit.
[Graphical view]
PROSITEiPS51036. ZF_A20. 1 hit.
PS51039. ZF_AN1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H8U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDAGSERSK APSLPPRCPC GFWGSSKTMN LCSKCFADFQ KKQPDDDSAP
60 70 80 90 100
STSNSQSDLF SEETTSDNNN TSITTPTLSP SQQPLPTELN VTSPSKEECG
110 120 130 140 150
PCTDTAHVSL ITPTKRSCGT DSQSENEASP VKRPRLLENT ERSEETSRSK
160 170 180 190 200
QKSRRRCFQC QTKLELVQQE LGSCRCGYVF CMLHRLPEQH DCTFDHMGRG
210 220
REEAIMKMVK LDRKVGRSCQ RIGEGCS
Length:227
Mass (Da):25,184
Last modified:March 1, 2001 - v1
Checksum:i609F2B793F835E47
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120T → TA in CAI13989 (PubMed:14574404).Curated1
Sequence conflicti120T → TA in CAI42532 (PubMed:14574404).Curated1
Sequence conflicti120T → TA in CAI20983 (PubMed:14574404).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023284 mRNA. Translation: BAB14508.1.
AL589655, AL121574, AL133377 Genomic DNA. Translation: CAI13989.1.
AL133377, AL121574, AL589655 Genomic DNA. Translation: CAI42532.1.
AL121574, AL133377, AL589655 Genomic DNA. Translation: CAI20983.1.
AL589655, AL121574 Genomic DNA. Translation: CAI13991.1.
AL121574, AL589655 Genomic DNA. Translation: CAI20984.1.
BC031481 mRNA. Translation: AAH31481.1.
CCDSiCCDS4836.1.
RefSeqiNP_068762.1. NM_021943.2.
UniGeneiHs.36959.

Genome annotation databases

EnsembliENST00000287218; ENSP00000287218; ENSG00000156639.
GeneIDi60685.
KEGGihsa:60685.
UCSCiuc003onx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023284 mRNA. Translation: BAB14508.1.
AL589655, AL121574, AL133377 Genomic DNA. Translation: CAI13989.1.
AL133377, AL121574, AL589655 Genomic DNA. Translation: CAI42532.1.
AL121574, AL133377, AL589655 Genomic DNA. Translation: CAI20983.1.
AL589655, AL121574 Genomic DNA. Translation: CAI13991.1.
AL121574, AL589655 Genomic DNA. Translation: CAI20984.1.
BC031481 mRNA. Translation: AAH31481.1.
CCDSiCCDS4836.1.
RefSeqiNP_068762.1. NM_021943.2.
UniGeneiHs.36959.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X4WNMR-A147-200[»]
ProteinModelPortaliQ9H8U3.
SMRiQ9H8U3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121958. 3 interactors.
IntActiQ9H8U3. 3 interactors.
MINTiMINT-1395602.
STRINGi9606.ENSP00000287218.

PTM databases

iPTMnetiQ9H8U3.
PhosphoSitePlusiQ9H8U3.

Polymorphism and mutation databases

BioMutaiZFAND3.
DMDMi74733896.

Proteomic databases

EPDiQ9H8U3.
MaxQBiQ9H8U3.
PaxDbiQ9H8U3.
PeptideAtlasiQ9H8U3.
PRIDEiQ9H8U3.

Protocols and materials databases

DNASUi60685.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287218; ENSP00000287218; ENSG00000156639.
GeneIDi60685.
KEGGihsa:60685.
UCSCiuc003onx.4. human.

Organism-specific databases

CTDi60685.
DisGeNETi60685.
GeneCardsiZFAND3.
HGNCiHGNC:18019. ZFAND3.
HPAiHPA016755.
MIMi607455. gene.
neXtProtiNX_Q9H8U3.
OpenTargetsiENSG00000156639.
PharmGKBiPA38277.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3173. Eukaryota.
ENOG4111UWC. LUCA.
GeneTreeiENSGT00390000014679.
HOGENOMiHOG000007482.
HOVERGENiHBG083631.
InParanoidiQ9H8U3.
OMAiKNRRRCY.
OrthoDBiEOG091G0NSK.
PhylomeDBiQ9H8U3.
TreeFamiTF354281.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156639-MONOMER.

Miscellaneous databases

ChiTaRSiZFAND3. human.
EvolutionaryTraceiQ9H8U3.
GenomeRNAii60685.
PROiQ9H8U3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156639.
CleanExiHS_ZFAND3.
ExpressionAtlasiQ9H8U3. baseline and differential.
GenevisibleiQ9H8U3. HS.

Family and domain databases

Gene3Di4.10.1110.10. 1 hit.
InterProiIPR002653. Znf_A20.
IPR000058. Znf_AN1.
[Graphical view]
PfamiPF01754. zf-A20. 1 hit.
PF01428. zf-AN1. 1 hit.
[Graphical view]
SMARTiSM00259. ZnF_A20. 1 hit.
SM00154. ZnF_AN1. 1 hit.
[Graphical view]
PROSITEiPS51036. ZF_A20. 1 hit.
PS51039. ZF_AN1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZFAN3_HUMAN
AccessioniPrimary (citable) accession number: Q9H8U3
Secondary accession number(s): Q5SZZ0, Q5SZZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.