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Protein

AN1-type zinc finger protein 3

Gene

ZFAND3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 4433A20-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri154 – 20047AN1-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
AN1-type zinc finger protein 3
Alternative name(s):
Testis-expressed sequence 27
Gene namesi
Name:ZFAND3
Synonyms:TEX27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:18019. ZFAND3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38277.

Polymorphism and mutation databases

BioMutaiZFAND3.
DMDMi74733896.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227AN1-type zinc finger protein 3PRO_0000076370Add
BLAST

Proteomic databases

EPDiQ9H8U3.
MaxQBiQ9H8U3.
PaxDbiQ9H8U3.
PeptideAtlasiQ9H8U3.
PRIDEiQ9H8U3.

PTM databases

iPTMnetiQ9H8U3.
PhosphoSiteiQ9H8U3.

Expressioni

Gene expression databases

BgeeiQ9H8U3.
CleanExiHS_ZFAND3.
ExpressionAtlasiQ9H8U3. baseline and differential.
GenevisibleiQ9H8U3. HS.

Organism-specific databases

HPAiHPA016755.

Interactioni

Protein-protein interaction databases

BioGridi121958. 3 interactions.
IntActiQ9H8U3. 2 interactions.
MINTiMINT-1395602.
STRINGi9606.ENSP00000287218.

Structurei

Secondary structure

1
227
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi158 – 1603Combined sources
Helixi166 – 1727Combined sources
Beta strandi175 – 1773Combined sources
Turni182 – 1843Combined sources
Helixi188 – 1903Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X4WNMR-A147-200[»]
ProteinModelPortaliQ9H8U3.
SMRiQ9H8U3. Positions 150-200.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H8U3.

Family & Domainsi

Sequence similaritiesi

Contains 1 A20-type zinc finger.PROSITE-ProRule annotation
Contains 1 AN1-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 4433A20-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri154 – 20047AN1-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3173. Eukaryota.
ENOG4111UWC. LUCA.
GeneTreeiENSGT00390000014679.
HOGENOMiHOG000007482.
HOVERGENiHBG083631.
InParanoidiQ9H8U3.
OMAiKNRRRCY.
OrthoDBiEOG73JKWR.
PhylomeDBiQ9H8U3.
TreeFamiTF354281.

Family and domain databases

Gene3Di4.10.1110.10. 1 hit.
InterProiIPR002653. Znf_A20.
IPR000058. Znf_AN1.
[Graphical view]
PfamiPF01754. zf-A20. 1 hit.
PF01428. zf-AN1. 1 hit.
[Graphical view]
SMARTiSM00259. ZnF_A20. 1 hit.
SM00154. ZnF_AN1. 1 hit.
[Graphical view]
PROSITEiPS51036. ZF_A20. 1 hit.
PS51039. ZF_AN1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H8U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDAGSERSK APSLPPRCPC GFWGSSKTMN LCSKCFADFQ KKQPDDDSAP
60 70 80 90 100
STSNSQSDLF SEETTSDNNN TSITTPTLSP SQQPLPTELN VTSPSKEECG
110 120 130 140 150
PCTDTAHVSL ITPTKRSCGT DSQSENEASP VKRPRLLENT ERSEETSRSK
160 170 180 190 200
QKSRRRCFQC QTKLELVQQE LGSCRCGYVF CMLHRLPEQH DCTFDHMGRG
210 220
REEAIMKMVK LDRKVGRSCQ RIGEGCS
Length:227
Mass (Da):25,184
Last modified:March 1, 2001 - v1
Checksum:i609F2B793F835E47
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201T → TA in CAI13989 (PubMed:14574404).Curated
Sequence conflicti120 – 1201T → TA in CAI42532 (PubMed:14574404).Curated
Sequence conflicti120 – 1201T → TA in CAI20983 (PubMed:14574404).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023284 mRNA. Translation: BAB14508.1.
AL589655, AL121574, AL133377 Genomic DNA. Translation: CAI13989.1.
AL133377, AL121574, AL589655 Genomic DNA. Translation: CAI42532.1.
AL121574, AL133377, AL589655 Genomic DNA. Translation: CAI20983.1.
AL589655, AL121574 Genomic DNA. Translation: CAI13991.1.
AL121574, AL589655 Genomic DNA. Translation: CAI20984.1.
BC031481 mRNA. Translation: AAH31481.1.
CCDSiCCDS4836.1.
RefSeqiNP_068762.1. NM_021943.2.
UniGeneiHs.36959.

Genome annotation databases

EnsembliENST00000287218; ENSP00000287218; ENSG00000156639.
GeneIDi60685.
KEGGihsa:60685.
UCSCiuc003onx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023284 mRNA. Translation: BAB14508.1.
AL589655, AL121574, AL133377 Genomic DNA. Translation: CAI13989.1.
AL133377, AL121574, AL589655 Genomic DNA. Translation: CAI42532.1.
AL121574, AL133377, AL589655 Genomic DNA. Translation: CAI20983.1.
AL589655, AL121574 Genomic DNA. Translation: CAI13991.1.
AL121574, AL589655 Genomic DNA. Translation: CAI20984.1.
BC031481 mRNA. Translation: AAH31481.1.
CCDSiCCDS4836.1.
RefSeqiNP_068762.1. NM_021943.2.
UniGeneiHs.36959.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X4WNMR-A147-200[»]
ProteinModelPortaliQ9H8U3.
SMRiQ9H8U3. Positions 150-200.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121958. 3 interactions.
IntActiQ9H8U3. 2 interactions.
MINTiMINT-1395602.
STRINGi9606.ENSP00000287218.

PTM databases

iPTMnetiQ9H8U3.
PhosphoSiteiQ9H8U3.

Polymorphism and mutation databases

BioMutaiZFAND3.
DMDMi74733896.

Proteomic databases

EPDiQ9H8U3.
MaxQBiQ9H8U3.
PaxDbiQ9H8U3.
PeptideAtlasiQ9H8U3.
PRIDEiQ9H8U3.

Protocols and materials databases

DNASUi60685.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287218; ENSP00000287218; ENSG00000156639.
GeneIDi60685.
KEGGihsa:60685.
UCSCiuc003onx.4. human.

Organism-specific databases

CTDi60685.
GeneCardsiZFAND3.
HGNCiHGNC:18019. ZFAND3.
HPAiHPA016755.
MIMi607455. gene.
neXtProtiNX_Q9H8U3.
PharmGKBiPA38277.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3173. Eukaryota.
ENOG4111UWC. LUCA.
GeneTreeiENSGT00390000014679.
HOGENOMiHOG000007482.
HOVERGENiHBG083631.
InParanoidiQ9H8U3.
OMAiKNRRRCY.
OrthoDBiEOG73JKWR.
PhylomeDBiQ9H8U3.
TreeFamiTF354281.

Miscellaneous databases

ChiTaRSiZFAND3. human.
EvolutionaryTraceiQ9H8U3.
GenomeRNAii60685.
PROiQ9H8U3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H8U3.
CleanExiHS_ZFAND3.
ExpressionAtlasiQ9H8U3. baseline and differential.
GenevisibleiQ9H8U3. HS.

Family and domain databases

Gene3Di4.10.1110.10. 1 hit.
InterProiIPR002653. Znf_A20.
IPR000058. Znf_AN1.
[Graphical view]
PfamiPF01754. zf-A20. 1 hit.
PF01428. zf-AN1. 1 hit.
[Graphical view]
SMARTiSM00259. ZnF_A20. 1 hit.
SM00154. ZnF_AN1. 1 hit.
[Graphical view]
PROSITEiPS51036. ZF_A20. 1 hit.
PS51039. ZF_AN1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. "Solution structure of the ZF-AN1 domain from human hypothetical protein FLJ13222."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 147-200 IN COMPLEX WITH ZINC IONS.

Entry informationi

Entry nameiZFAN3_HUMAN
AccessioniPrimary (citable) accession number: Q9H8U3
Secondary accession number(s): Q5SZZ0, Q5SZZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.