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Q9H8T0

- AKTIP_HUMAN

UniProt

Q9H8T0 - AKTIP_HUMAN

Protein

AKT-interacting protein

Gene

AKTIP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.2 Publications

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. early endosome to late endosome transport Source: UniProtKB
    3. endosome organization Source: UniProtKB
    4. endosome to lysosome transport Source: UniProtKB
    5. lysosome organization Source: UniProtKB
    6. positive regulation of protein binding Source: MGI
    7. positive regulation of protein phosphorylation Source: MGI
    8. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis, Protein transport, Transport

    Enzyme and pathway databases

    SignaLinkiQ9H8T0.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AKT-interacting protein
    Alternative name(s):
    Ft1
    Fused toes protein homolog
    Gene namesi
    Name:AKTIP
    Synonyms:FTS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:16710. AKTIP.

    Subcellular locationi

    Cytoplasm 1 Publication. Cell membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. FHF complex Source: UniProtKB
    2. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi106 – 1072WF → AA: Impairs interaction with HOOK1, HOOK2 and HOOK3. 1 Publication

    Organism-specific databases

    PharmGKBiPA162376210.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292AKT-interacting proteinPRO_0000082609Add
    BLAST

    Proteomic databases

    MaxQBiQ9H8T0.
    PaxDbiQ9H8T0.
    PRIDEiQ9H8T0.

    PTM databases

    PhosphoSiteiQ9H8T0.

    Expressioni

    Gene expression databases

    BgeeiQ9H8T0.
    CleanExiHS_AKTIP.
    GenevestigatoriQ9H8T0.

    Organism-specific databases

    HPAiHPA041794.
    HPA046300.

    Interactioni

    Subunit structurei

    Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with HOOK1, HOOK2 and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex). Also interacts with AKT1.2 Publications

    Protein-protein interaction databases

    BioGridi122157. 28 interactions.
    IntActiQ9H8T0. 28 interactions.
    STRINGi9606.ENSP00000300245.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H8T0.
    SMRiQ9H8T0. Positions 78-223.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG285076.
    HOGENOMiHOG000033885.
    HOVERGENiHBG095637.
    InParanoidiQ9H8T0.
    OMAiSPWNPAV.
    OrthoDBiEOG7QG45C.
    PhylomeDBiQ9H8T0.
    TreeFamiTF314386.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H8T0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNPFWSMSTS SVRKRSEGEE KTLTGDVKTS PPRTAPKKQL PSIPKNALPI    50
    TKPTSPAPAA QSTNGTHASY GPFYLEYSLL AEFTLVVKQK LPGVYVQPSY 100
    RSALMWFGVI FIRHGLYQDG VFKFTVYIPD NYPDGDCPRL VFDIPVFHPL 150
    VDPTSGELDV KRAFAKWRRN HNHIWQVLMY ARRVFYKIDT ASPLNPEAAV 200
    LYEKDIQLFK SKVVDSVKVC TARLFDQPKI EDPYAISFSP WNPSVHDEAR 250
    EKMLTQKKPE EQHNKSVHVA GLSWVKPGSV QPFSKEEKTV AT 292
    Length:292
    Mass (Da):33,128
    Last modified:March 1, 2001 - v1
    Checksum:i3DD4E32980463324
    GO
    Isoform 2 (identifier: Q9H8T0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         256-256: Q → QK

    Show »
    Length:293
    Mass (Da):33,256
    Checksum:iCE781BABE3F9695C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti212 – 2121K → N in AAH95401. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei256 – 2561Q → QK in isoform 2. 2 PublicationsVSP_037631

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023320 mRNA. Translation: BAB14524.1.
    CR457308 mRNA. Translation: CAG33589.1.
    AK222743 mRNA. Translation: BAD96463.1.
    CH471092 Genomic DNA. Translation: EAW82805.1.
    BC001134 mRNA. Translation: AAH01134.1.
    BC095401 mRNA. Translation: AAH95401.1.
    CCDSiCCDS10749.1. [Q9H8T0-1]
    RefSeqiNP_001012398.1. NM_001012398.1. [Q9H8T0-1]
    NP_071921.1. NM_022476.2. [Q9H8T0-1]
    XP_005256151.1. XM_005256094.2. [Q9H8T0-2]
    XP_005256152.1. XM_005256095.2. [Q9H8T0-2]
    XP_005256153.1. XM_005256096.2. [Q9H8T0-2]
    XP_005256154.1. XM_005256097.2. [Q9H8T0-2]
    XP_005256155.1. XM_005256098.2. [Q9H8T0-2]
    UniGeneiHs.380897.

    Genome annotation databases

    EnsembliENST00000300245; ENSP00000300245; ENSG00000166971. [Q9H8T0-2]
    ENST00000394657; ENSP00000378152; ENSG00000166971. [Q9H8T0-1]
    ENST00000570004; ENSP00000455874; ENSG00000166971. [Q9H8T0-1]
    GeneIDi64400.
    KEGGihsa:64400.
    UCSCiuc002ehk.3. human. [Q9H8T0-1]
    uc002ehm.3. human. [Q9H8T0-2]

    Polymorphism databases

    DMDMi54035954.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023320 mRNA. Translation: BAB14524.1 .
    CR457308 mRNA. Translation: CAG33589.1 .
    AK222743 mRNA. Translation: BAD96463.1 .
    CH471092 Genomic DNA. Translation: EAW82805.1 .
    BC001134 mRNA. Translation: AAH01134.1 .
    BC095401 mRNA. Translation: AAH95401.1 .
    CCDSi CCDS10749.1. [Q9H8T0-1 ]
    RefSeqi NP_001012398.1. NM_001012398.1. [Q9H8T0-1 ]
    NP_071921.1. NM_022476.2. [Q9H8T0-1 ]
    XP_005256151.1. XM_005256094.2. [Q9H8T0-2 ]
    XP_005256152.1. XM_005256095.2. [Q9H8T0-2 ]
    XP_005256153.1. XM_005256096.2. [Q9H8T0-2 ]
    XP_005256154.1. XM_005256097.2. [Q9H8T0-2 ]
    XP_005256155.1. XM_005256098.2. [Q9H8T0-2 ]
    UniGenei Hs.380897.

    3D structure databases

    ProteinModelPortali Q9H8T0.
    SMRi Q9H8T0. Positions 78-223.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122157. 28 interactions.
    IntActi Q9H8T0. 28 interactions.
    STRINGi 9606.ENSP00000300245.

    PTM databases

    PhosphoSitei Q9H8T0.

    Polymorphism databases

    DMDMi 54035954.

    Proteomic databases

    MaxQBi Q9H8T0.
    PaxDbi Q9H8T0.
    PRIDEi Q9H8T0.

    Protocols and materials databases

    DNASUi 64400.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300245 ; ENSP00000300245 ; ENSG00000166971 . [Q9H8T0-2 ]
    ENST00000394657 ; ENSP00000378152 ; ENSG00000166971 . [Q9H8T0-1 ]
    ENST00000570004 ; ENSP00000455874 ; ENSG00000166971 . [Q9H8T0-1 ]
    GeneIDi 64400.
    KEGGi hsa:64400.
    UCSCi uc002ehk.3. human. [Q9H8T0-1 ]
    uc002ehm.3. human. [Q9H8T0-2 ]

    Organism-specific databases

    CTDi 64400.
    GeneCardsi GC16M053524.
    HGNCi HGNC:16710. AKTIP.
    HPAi HPA041794.
    HPA046300.
    MIMi 608483. gene.
    neXtProti NX_Q9H8T0.
    PharmGKBi PA162376210.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285076.
    HOGENOMi HOG000033885.
    HOVERGENi HBG095637.
    InParanoidi Q9H8T0.
    OMAi SPWNPAV.
    OrthoDBi EOG7QG45C.
    PhylomeDBi Q9H8T0.
    TreeFami TF314386.

    Enzyme and pathway databases

    SignaLinki Q9H8T0.

    Miscellaneous databases

    GeneWikii AKTIP.
    GenomeRNAii 64400.
    NextBioi 66346.
    PROi Q9H8T0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H8T0.
    CleanExi HS_AKTIP.
    Genevestigatori Q9H8T0.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Ovary.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Dermoid cancer.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Skin.
    6. "Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt."
      Remy I., Michnick S.W.
      Mol. Cell. Biol. 24:1493-1504(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH AKT1, SUBCELLULAR LOCATION.
    7. "An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex."
      Xu L., Sowa M.E., Chen J., Li X., Gygi S.P., Harper J.W.
      Mol. Biol. Cell 19:5059-5071(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE FHF COMPLEX, FUNCTION, ASSOCIATION WITH THE HOPS COMPLEX, MUTAGENESIS OF 106-TRP-PHE-107.

    Entry informationi

    Entry nameiAKTIP_HUMAN
    AccessioniPrimary (citable) accession number: Q9H8T0
    Secondary accession number(s): Q503B1, Q53H38
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3