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Protein

AKT-interacting protein

Gene

AKTIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.2 Publications

Caution

Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity.Curated

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • early endosome to late endosome transport Source: UniProtKB
  • endosome organization Source: UniProtKB
  • endosome to lysosome transport Source: UniProtKB
  • lysosome organization Source: UniProtKB
  • positive regulation of protein binding Source: MGI
  • positive regulation of protein phosphorylation Source: MGI
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processApoptosis, Protein transport, Transport

Enzyme and pathway databases

SignaLinkiQ9H8T0

Names & Taxonomyi

Protein namesi
Recommended name:
AKT-interacting protein
Alternative name(s):
Ft1
Fused toes protein homolog
Gene namesi
Name:AKTIP
Synonyms:FTS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000166971.16
HGNCiHGNC:16710 AKTIP
MIMi608483 gene
neXtProtiNX_Q9H8T0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi106 – 107WF → AA: Impairs interaction with HOOK1, HOOK2 and HOOK3. 1 Publication2

Organism-specific databases

DisGeNETi64400
OpenTargetsiENSG00000166971
PharmGKBiPA162376210

Polymorphism and mutation databases

BioMutaiAKTIP
DMDMi54035954

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000826091 – 292AKT-interacting proteinAdd BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H8T0
MaxQBiQ9H8T0
PaxDbiQ9H8T0
PeptideAtlasiQ9H8T0
PRIDEiQ9H8T0

PTM databases

iPTMnetiQ9H8T0
PhosphoSitePlusiQ9H8T0

Expressioni

Gene expression databases

BgeeiENSG00000166971
CleanExiHS_AKTIP
ExpressionAtlasiQ9H8T0 baseline and differential
GenevisibleiQ9H8T0 HS

Organism-specific databases

HPAiHPA041794
HPA046300

Interactioni

Subunit structurei

Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with HOOK1, HOOK2 and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex). Also interacts with AKT1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HOOK1Q9UJC38EBI-711399,EBI-746704

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122157, 40 interactors
CORUMiQ9H8T0
IntActiQ9H8T0, 34 interactors
STRINGi9606.ENSP00000378152

Structurei

3D structure databases

ProteinModelPortaliQ9H8T0
SMRiQ9H8T0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0429 Eukaryota
ENOG410ZQ9Z LUCA
GeneTreeiENSGT00390000010125
HOGENOMiHOG000033885
HOVERGENiHBG095637
InParanoidiQ9H8T0
OMAiPFWSMSA
PhylomeDBiQ9H8T0
TreeFamiTF314386

Family and domain databases

Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H8T0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPFWSMSTS SVRKRSEGEE KTLTGDVKTS PPRTAPKKQL PSIPKNALPI
60 70 80 90 100
TKPTSPAPAA QSTNGTHASY GPFYLEYSLL AEFTLVVKQK LPGVYVQPSY
110 120 130 140 150
RSALMWFGVI FIRHGLYQDG VFKFTVYIPD NYPDGDCPRL VFDIPVFHPL
160 170 180 190 200
VDPTSGELDV KRAFAKWRRN HNHIWQVLMY ARRVFYKIDT ASPLNPEAAV
210 220 230 240 250
LYEKDIQLFK SKVVDSVKVC TARLFDQPKI EDPYAISFSP WNPSVHDEAR
260 270 280 290
EKMLTQKKPE EQHNKSVHVA GLSWVKPGSV QPFSKEEKTV AT
Length:292
Mass (Da):33,128
Last modified:March 1, 2001 - v1
Checksum:i3DD4E32980463324
GO
Isoform 2 (identifier: Q9H8T0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-256: Q → QK

Show »
Length:293
Mass (Da):33,256
Checksum:iCE781BABE3F9695C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti212K → N in AAH95401 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037631256Q → QK in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023320 mRNA Translation: BAB14524.1
CR457308 mRNA Translation: CAG33589.1
AK222743 mRNA Translation: BAD96463.1
CH471092 Genomic DNA Translation: EAW82805.1
BC001134 mRNA Translation: AAH01134.1
BC095401 mRNA Translation: AAH95401.1
CCDSiCCDS10749.1 [Q9H8T0-1]
CCDS76866.1 [Q9H8T0-2]
RefSeqiNP_001012398.1, NM_001012398.2 [Q9H8T0-1]
NP_001295254.1, NM_001308325.1 [Q9H8T0-2]
NP_071921.1, NM_022476.3 [Q9H8T0-1]
XP_005256152.1, XM_005256095.4 [Q9H8T0-2]
XP_005256153.1, XM_005256096.4 [Q9H8T0-2]
XP_005256154.1, XM_005256097.4 [Q9H8T0-2]
XP_005256155.1, XM_005256098.4 [Q9H8T0-2]
XP_016879053.1, XM_017023564.1 [Q9H8T0-1]
XP_016879054.1, XM_017023565.1 [Q9H8T0-1]
XP_016879055.1, XM_017023566.1 [Q9H8T0-1]
UniGeneiHs.380897

Genome annotation databases

EnsembliENST00000300245; ENSP00000300245; ENSG00000166971 [Q9H8T0-2]
ENST00000394657; ENSP00000378152; ENSG00000166971 [Q9H8T0-1]
ENST00000570004; ENSP00000455874; ENSG00000166971 [Q9H8T0-1]
GeneIDi64400
KEGGihsa:64400
UCSCiuc002ehk.4 human [Q9H8T0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAKTIP_HUMAN
AccessioniPrimary (citable) accession number: Q9H8T0
Secondary accession number(s): Q503B1, Q53H38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health