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Protein

Cyclin N-terminal domain-containing protein 2

Gene

CNTD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ9H8S5

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin N-terminal domain-containing protein 2
Gene namesi
Name:CNTD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105219.8
HGNCiHGNC:25805 CNTD2
neXtProtiNX_Q9H8S5

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105219
PharmGKBiPA144596444

Polymorphism and mutation databases

BioMutaiCNTD2
DMDMi408360026

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002637041 – 307Cyclin N-terminal domain-containing protein 2Add BLAST307

Proteomic databases

EPDiQ9H8S5
PaxDbiQ9H8S5
PRIDEiQ9H8S5

PTM databases

iPTMnetiQ9H8S5
PhosphoSitePlusiQ9H8S5

Expressioni

Gene expression databases

BgeeiENSG00000105219
CleanExiHS_CNTD2
ExpressionAtlasiQ9H8S5 baseline and differential
GenevisibleiQ9H8S5 HS

Organism-specific databases

HPAiHPA045615

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000396755

Structurei

3D structure databases

ProteinModelPortaliQ9H8S5
SMRiQ9H8S5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 203Cyclin N-terminalAdd BLAST102

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00760000118939
HOGENOMiHOG000111848
InParanoidiQ9H8S5
OMAiIFAEVMV
OrthoDBiEOG091G15GL
PhylomeDBiQ9H8S5
TreeFamiTF342174

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H8S5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLVRGRDQGS GSRLGPIVRR WAPRPSPLQS LAASLDAEPS SAAVPDGFPA
60 70 80 90 100
GPTVSPRRLA RPPGLEEALS ALGLQGEREY AGDIFAEVMV CRVLPLRALP
110 120 130 140 150
RAVTPEMRAL VVDWLVQVHE YLGLAGDTLY LAVHLLDSYL SAGRVRLHRL
160 170 180 190 200
QLLGVACLFV ACKMEECVLP EPAFLCLLSA DSFSRAELLR AERRILSRLD
210 220 230 240 250
FRLHHPGPLL CLGLLAALAG SSPQVMLLAT YFLELSLLEA EAAGWEPGRR
260 270 280 290 300
AAAALSLAHR LLDGAGSRLQ PELYRCSLGG GSVWGHRSFR DLPSWSFLRS

RRMRDNY
Length:307
Mass (Da):33,574
Last modified:October 3, 2012 - v2
Checksum:i9A5E71ADCE0D63E0
GO
Isoform 2 (identifier: Q9H8S5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-119: Missing.
     172-185: PAFLCLLSADSFSR → ETEVRNLGPFQGRE
     186-307: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:155
Mass (Da):16,695
Checksum:i853888D55685C854
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04416590 – 119Missing in isoform 2. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_044166172 – 185PAFLC…DSFSR → ETEVRNLGPFQGRE in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_044167186 – 307Missing in isoform 2. 1 PublicationAdd BLAST122

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023327 mRNA Translation: BAB14529.1
AK301833 mRNA Translation: BAG63277.1
AC118344 Genomic DNA No translation available.
CCDSiCCDS12551.2 [Q9H8S5-1]
RefSeqiNP_079153.2, NM_024877.3 [Q9H8S5-1]
UniGeneiHs.631603

Genome annotation databases

EnsembliENST00000221818; ENSP00000221818; ENSG00000105219 [Q9H8S5-2]
ENST00000430325; ENSP00000396755; ENSG00000105219 [Q9H8S5-1]
GeneIDi79935
KEGGihsa:79935
UCSCiuc010xvi.2 human [Q9H8S5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCNTD2_HUMAN
AccessioniPrimary (citable) accession number: Q9H8S5
Secondary accession number(s): B4DX65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 3, 2012
Last modified: February 28, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM

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