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Protein

Zinc finger protein 395

Gene

ZNF395

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in papillomavirus genes transcription.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri280 – 305C2H2-typePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • enhancer sequence-specific DNA binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 395
Alternative name(s):
HD-regulating factor 2
Short name:
HDRF-2
Huntington disease gene regulatory region-binding protein 2
Short name:
HD gene regulatory region-binding protein 2
Short name:
HDBP-2
Papillomavirus regulatory factor 1
Short name:
PRF-1
Papillomavirus-binding factor
Gene namesi
Name:ZNF395
Synonyms:HDBP2, PBF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000186918.13
HGNCiHGNC:18737 ZNF395
MIMi609494 gene
neXtProtiNX_Q9H8N7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi109L → A: No change in subcellular location; when associated with A-113. 1 Publication1
Mutagenesisi113L → A: No change in subcellular location; when associated with A-109. 1 Publication1
Mutagenesisi169M → A: No shuttle from the nucleus to the cytoplasm; when associated with A-172. 1 Publication1
Mutagenesisi172M → A: No shuttle from the nucleus to the cytoplasm; when associated with A-169. 1 Publication1

Organism-specific databases

DisGeNETi55893
OpenTargetsiENSG00000186918
PharmGKBiPA134978145

Polymorphism and mutation databases

BioMutaiZNF395
DMDMi84028224

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475611 – 513Zinc finger protein 395Add BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248PhosphoserineCombined sources1
Modified residuei376PhosphoserineCombined sources1
Modified residuei449PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H8N7
MaxQBiQ9H8N7
PaxDbiQ9H8N7
PeptideAtlasiQ9H8N7
PRIDEiQ9H8N7

PTM databases

iPTMnetiQ9H8N7
PhosphoSitePlusiQ9H8N7

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

BgeeiENSG00000186918
CleanExiHS_ZNF395
ExpressionAtlasiQ9H8N7 baseline and differential
GenevisibleiQ9H8N7 HS

Organism-specific databases

HPAiHPA049382

Interactioni

Subunit structurei

Interacts with repression-mediating E2 binding site P2 of human papillomavirus type 8 (HPV8).

Protein-protein interaction databases

BioGridi120983, 6 interactors
IntActiQ9H8N7, 2 interactors
MINTiQ9H8N7
STRINGi9606.ENSP00000340494

Structurei

3D structure databases

ProteinModelPortaliQ9H8N7
SMRiQ9H8N7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi165 – 174Nuclear export signalSequence analysis10

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri280 – 305C2H2-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410II8D Eukaryota
ENOG4111TEU LUCA
GeneTreeiENSGT00400000022069
HOVERGENiHBG061238
InParanoidiQ9H8N7
OMAiCQEQPKE
OrthoDBiEOG091G08L7
PhylomeDBiQ9H8N7
TreeFamiTF326610

Family and domain databases

InterProiView protein in InterPro
IPR031940 DUF4772
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF15997 DUF4772, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H8N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVLSRRLG KRSLLGARVL GPSASEGPSA APPSEPLLEG AAPQPFTTSD
60 70 80 90 100
DTPCQEQPKE VLKAPSTSGL QQVAFQPGQK VYVWYGGQEC TGLVEQHSWM
110 120 130 140 150
EGQVTVWLLE QKLQVCCRVE EVWLAELQGP CPQAPPLEPG AQALAYRPVS
160 170 180 190 200
RNIDVPKRKS DAVEMDEMMA AMVLTSLSCS PVVQSPPGTE ANFSASRAAC
210 220 230 240 250
DPWKESGDIS DSGSSTTSGH WSGSSGVSTP SPPHPQASPK YLGDAFGSPQ
260 270 280 290 300
TDHGFETDPD PFLLDEPAPR KRKNSVKVMY KCLWPNCGKV LRSIVGIKRH
310 320 330 340 350
VKALHLGDTV DSDQFKREED FYYTEVQLKE ESAAAAAAAA AGTPVPGTPT
360 370 380 390 400
SEPAPTPSMT GLPLSALPPP LHKAQSSGPE HPGPESSLPS GALSKSAPGS
410 420 430 440 450
FWHIQADHAY QALPSFQIPV SPHIYTSVSW AAAPSAACSL SPVRSRSLSF
460 470 480 490 500
SEPQQPAPAM KSHLIVTSPP RAQSGARKAR GEAKKCRKVY GIEHRDQWCT
510
ACRWKKACQR FLD
Length:513
Mass (Da):54,939
Last modified:September 13, 2005 - v2
Checksum:i992990499E228EB8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140G → R in BAA96783 (PubMed:14625278).Curated1
Sequence conflicti140G → R in BAD29734 (PubMed:14625278).Curated1
Sequence conflicti464L → Q in BAB14571 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF263928 mRNA Translation: AAF73463.1
AB044750 mRNA Translation: BAA96783.1
AB044751 mRNA Translation: BAA96784.1
AB044752 mRNA Translation: BAA96785.1
AB057659 mRNA Translation: BAB39851.1
AB073627 mRNA Translation: BAD29734.1
AK002050 mRNA Translation: BAA92056.1
AK023418 mRNA Translation: BAB14571.1
AK098243 mRNA Translation: BAG53599.1
CH471080 Genomic DNA Translation: EAW63519.1
CH471080 Genomic DNA Translation: EAW63521.1
CH471080 Genomic DNA Translation: EAW63522.1
CH471080 Genomic DNA Translation: EAW63523.1
CH471080 Genomic DNA Translation: EAW63524.1
BC001237 mRNA Translation: AAH01237.1
CCDSiCCDS6067.1
RefSeqiNP_061130.1, NM_018660.2
UniGeneiHs.435535
Hs.695998

Genome annotation databases

EnsembliENST00000344423; ENSP00000340494; ENSG00000186918
ENST00000523095; ENSP00000428452; ENSG00000186918
ENST00000523202; ENSP00000429640; ENSG00000186918
GeneIDi55893
KEGGihsa:55893
UCSCiuc003xgq.4 human

Similar proteinsi

Entry informationi

Entry nameiZN395_HUMAN
AccessioniPrimary (citable) accession number: Q9H8N7
Secondary accession number(s): B3KUY7
, D3DST4, Q6F6H2, Q9BY72, Q9NPB2, Q9NS57, Q9NS58, Q9NS59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: March 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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