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Protein

Zinc finger protein 395

Gene

ZNF395

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in papillomavirus genes transcription.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri280 – 30526C2H2-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 395
Alternative name(s):
HD-regulating factor 2
Short name:
HDRF-2
Huntington disease gene regulatory region-binding protein 2
Short name:
HD gene regulatory region-binding protein 2
Short name:
HDBP-2
Papillomavirus regulatory factor 1
Short name:
PRF-1
Papillomavirus-binding factor
Gene namesi
Name:ZNF395
Synonyms:HDBP2, PBF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:18737. ZNF395.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi109 – 1091L → A: No change in subcellular location; when associated with A-113. 1 Publication
Mutagenesisi113 – 1131L → A: No change in subcellular location; when associated with A-109. 1 Publication
Mutagenesisi169 – 1691M → A: No shuttle from the nucleus to the cytoplasm; when associated with A-172. 1 Publication
Mutagenesisi172 – 1721M → A: No shuttle from the nucleus to the cytoplasm; when associated with A-169. 1 Publication

Organism-specific databases

PharmGKBiPA134978145.

Polymorphism and mutation databases

BioMutaiZNF395.
DMDMi84028224.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Zinc finger protein 395PRO_0000047561Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei248 – 2481PhosphoserineCombined sources
Modified residuei376 – 3761PhosphoserineCombined sources
Modified residuei449 – 4491PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H8N7.
MaxQBiQ9H8N7.
PaxDbiQ9H8N7.
PeptideAtlasiQ9H8N7.
PRIDEiQ9H8N7.

PTM databases

iPTMnetiQ9H8N7.
PhosphoSiteiQ9H8N7.

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

BgeeiENSG00000186918.
CleanExiHS_ZNF395.
ExpressionAtlasiQ9H8N7. baseline and differential.
GenevisibleiQ9H8N7. HS.

Organism-specific databases

HPAiHPA049382.

Interactioni

Subunit structurei

Interacts with repression-mediating E2 binding site P2 of human papillomavirus type 8 (HPV8).

Protein-protein interaction databases

BioGridi120983. 6 interactions.
IntActiQ9H8N7. 2 interactions.
MINTiMINT-7997332.
STRINGi9606.ENSP00000340494.

Structurei

3D structure databases

ProteinModelPortaliQ9H8N7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi165 – 17410Nuclear export signalSequence analysis

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri280 – 30526C2H2-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410II8D. Eukaryota.
ENOG4111TEU. LUCA.
GeneTreeiENSGT00400000022069.
HOVERGENiHBG061238.
InParanoidiQ9H8N7.
OMAiQKVYVWY.
OrthoDBiEOG091G08L7.
PhylomeDBiQ9H8N7.
TreeFamiTF326610.

Family and domain databases

InterProiIPR031940. DUF4772.
IPR007087. Znf_C2H2.
[Graphical view]
PfamiPF15997. DUF4772. 1 hit.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H8N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVLSRRLG KRSLLGARVL GPSASEGPSA APPSEPLLEG AAPQPFTTSD
60 70 80 90 100
DTPCQEQPKE VLKAPSTSGL QQVAFQPGQK VYVWYGGQEC TGLVEQHSWM
110 120 130 140 150
EGQVTVWLLE QKLQVCCRVE EVWLAELQGP CPQAPPLEPG AQALAYRPVS
160 170 180 190 200
RNIDVPKRKS DAVEMDEMMA AMVLTSLSCS PVVQSPPGTE ANFSASRAAC
210 220 230 240 250
DPWKESGDIS DSGSSTTSGH WSGSSGVSTP SPPHPQASPK YLGDAFGSPQ
260 270 280 290 300
TDHGFETDPD PFLLDEPAPR KRKNSVKVMY KCLWPNCGKV LRSIVGIKRH
310 320 330 340 350
VKALHLGDTV DSDQFKREED FYYTEVQLKE ESAAAAAAAA AGTPVPGTPT
360 370 380 390 400
SEPAPTPSMT GLPLSALPPP LHKAQSSGPE HPGPESSLPS GALSKSAPGS
410 420 430 440 450
FWHIQADHAY QALPSFQIPV SPHIYTSVSW AAAPSAACSL SPVRSRSLSF
460 470 480 490 500
SEPQQPAPAM KSHLIVTSPP RAQSGARKAR GEAKKCRKVY GIEHRDQWCT
510
ACRWKKACQR FLD
Length:513
Mass (Da):54,939
Last modified:September 13, 2005 - v2
Checksum:i992990499E228EB8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti140 – 1401G → R in BAA96783 (PubMed:14625278).Curated
Sequence conflicti140 – 1401G → R in BAD29734 (PubMed:14625278).Curated
Sequence conflicti464 – 4641L → Q in BAB14571 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF263928 mRNA. Translation: AAF73463.1.
AB044750 mRNA. Translation: BAA96783.1.
AB044751 mRNA. Translation: BAA96784.1.
AB044752 mRNA. Translation: BAA96785.1.
AB057659 mRNA. Translation: BAB39851.1.
AB073627 mRNA. Translation: BAD29734.1.
AK002050 mRNA. Translation: BAA92056.1.
AK023418 mRNA. Translation: BAB14571.1.
AK098243 mRNA. Translation: BAG53599.1.
CH471080 Genomic DNA. Translation: EAW63519.1.
CH471080 Genomic DNA. Translation: EAW63521.1.
CH471080 Genomic DNA. Translation: EAW63522.1.
CH471080 Genomic DNA. Translation: EAW63523.1.
CH471080 Genomic DNA. Translation: EAW63524.1.
BC001237 mRNA. Translation: AAH01237.1.
CCDSiCCDS6067.1.
RefSeqiNP_061130.1. NM_018660.2.
UniGeneiHs.435535.
Hs.695998.

Genome annotation databases

EnsembliENST00000344423; ENSP00000340494; ENSG00000186918.
ENST00000523095; ENSP00000428452; ENSG00000186918.
ENST00000523202; ENSP00000429640; ENSG00000186918.
GeneIDi55893.
KEGGihsa:55893.
UCSCiuc003xgq.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF263928 mRNA. Translation: AAF73463.1.
AB044750 mRNA. Translation: BAA96783.1.
AB044751 mRNA. Translation: BAA96784.1.
AB044752 mRNA. Translation: BAA96785.1.
AB057659 mRNA. Translation: BAB39851.1.
AB073627 mRNA. Translation: BAD29734.1.
AK002050 mRNA. Translation: BAA92056.1.
AK023418 mRNA. Translation: BAB14571.1.
AK098243 mRNA. Translation: BAG53599.1.
CH471080 Genomic DNA. Translation: EAW63519.1.
CH471080 Genomic DNA. Translation: EAW63521.1.
CH471080 Genomic DNA. Translation: EAW63522.1.
CH471080 Genomic DNA. Translation: EAW63523.1.
CH471080 Genomic DNA. Translation: EAW63524.1.
BC001237 mRNA. Translation: AAH01237.1.
CCDSiCCDS6067.1.
RefSeqiNP_061130.1. NM_018660.2.
UniGeneiHs.435535.
Hs.695998.

3D structure databases

ProteinModelPortaliQ9H8N7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120983. 6 interactions.
IntActiQ9H8N7. 2 interactions.
MINTiMINT-7997332.
STRINGi9606.ENSP00000340494.

PTM databases

iPTMnetiQ9H8N7.
PhosphoSiteiQ9H8N7.

Polymorphism and mutation databases

BioMutaiZNF395.
DMDMi84028224.

Proteomic databases

EPDiQ9H8N7.
MaxQBiQ9H8N7.
PaxDbiQ9H8N7.
PeptideAtlasiQ9H8N7.
PRIDEiQ9H8N7.

Protocols and materials databases

DNASUi55893.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344423; ENSP00000340494; ENSG00000186918.
ENST00000523095; ENSP00000428452; ENSG00000186918.
ENST00000523202; ENSP00000429640; ENSG00000186918.
GeneIDi55893.
KEGGihsa:55893.
UCSCiuc003xgq.4. human.

Organism-specific databases

CTDi55893.
GeneCardsiZNF395.
HGNCiHGNC:18737. ZNF395.
HPAiHPA049382.
MIMi609494. gene.
neXtProtiNX_Q9H8N7.
PharmGKBiPA134978145.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II8D. Eukaryota.
ENOG4111TEU. LUCA.
GeneTreeiENSGT00400000022069.
HOVERGENiHBG061238.
InParanoidiQ9H8N7.
OMAiQKVYVWY.
OrthoDBiEOG091G08L7.
PhylomeDBiQ9H8N7.
TreeFamiTF326610.

Miscellaneous databases

ChiTaRSiZNF395. human.
GenomeRNAii55893.
PROiQ9H8N7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186918.
CleanExiHS_ZNF395.
ExpressionAtlasiQ9H8N7. baseline and differential.
GenevisibleiQ9H8N7. HS.

Family and domain databases

InterProiIPR031940. DUF4772.
IPR007087. Znf_C2H2.
[Graphical view]
PfamiPF15997. DUF4772. 1 hit.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN395_HUMAN
AccessioniPrimary (citable) accession number: Q9H8N7
Secondary accession number(s): B3KUY7
, D3DST4, Q6F6H2, Q9BY72, Q9NPB2, Q9NS57, Q9NS58, Q9NS59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: September 7, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.