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Protein

Protein eva-1 homolog A

Gene

EVA1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Protein eva-1 homolog A
Alternative name(s):
Protein FAM176A
Transmembrane protein 166
Gene namesi
Name:EVA1A
Synonyms:FAM176A, TMEM166
ORF Names:SP24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25816. EVA1A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162387354.

Polymorphism and mutation databases

BioMutaiEVA1A.
DMDMi74733858.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 152152Protein eva-1 homolog APRO_0000278671Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei106 – 1061PhosphothreonineBy similarity
Modified residuei114 – 1141Phosphoserine; by FAM20C1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H8M9.
MaxQBiQ9H8M9.
PaxDbiQ9H8M9.
PeptideAtlasiQ9H8M9.
PRIDEiQ9H8M9.

PTM databases

iPTMnetiQ9H8M9.
PhosphoSiteiQ9H8M9.

Expressioni

Tissue specificityi

Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9H8M9.
CleanExiHS_FAM176A.
ExpressionAtlasiQ9H8M9. baseline and differential.
GenevisibleiQ9H8M9. HS.

Organism-specific databases

HPAiHPA008055.

Interactioni

Protein-protein interaction databases

BioGridi123910. 2 interactions.
IntActiQ9H8M9. 4 interactions.
MINTiMINT-1413218.
STRINGi9606.ENSP00000233712.

Structurei

3D structure databases

ProteinModelPortaliQ9H8M9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 6060Necessary for the localization and biological activityAdd
BLAST

Sequence similaritiesi

Belongs to the EVA1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZJN. Eukaryota.
ENOG410YJR4. LUCA.
GeneTreeiENSGT00840000129883.
HOGENOMiHOG000294093.
HOVERGENiHBG061487.
InParanoidiQ9H8M9.
OMAiCHTDCRQ.
OrthoDBiEOG7ZGX5P.
PhylomeDBiQ9H8M9.
TreeFamiTF352986.

Sequencei

Sequence statusi: Complete.

Q9H8M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPLSHSPE HVEMALLSNI LAAYSFVSEN PERAALYFVS GVCIGLVLTL
60 70 80 90 100
AALVIRISCH TDCRRRPGKK FLQDRESSSD SSDSEDGSED TVSDLSVRRH
110 120 130 140 150
RRFERTLNKN VFTSAEELER AQRLEERERI IREIWMNGQP EVPGTRSLNR

YY
Length:152
Mass (Da):17,470
Last modified:March 1, 2001 - v1
Checksum:i5ED1FD97D73E801A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371Y → C in AAG17981 (PubMed:15498874).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti150 – 1501R → H.
Corresponds to variant rs11126472 [ dbSNP | Ensembl ].
VAR_054077

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023453 mRNA. Translation: BAB14580.1.
AF177337 mRNA. Translation: AAG17981.1.
CR457314 mRNA. Translation: CAG33595.1.
AC007099 Genomic DNA. Translation: AAY14774.1.
CH471053 Genomic DNA. Translation: EAW99591.1.
CH471053 Genomic DNA. Translation: EAW99592.1.
CH471053 Genomic DNA. Translation: EAW99593.1.
CH471053 Genomic DNA. Translation: EAW99594.1.
BC016157 mRNA. Translation: AAH16157.1.
BC063016 mRNA. Translation: AAH63016.1.
CCDSiCCDS1959.1.
RefSeqiNP_001128504.1. NM_001135032.1.
NP_115557.1. NM_032181.2.
UniGeneiHs.302346.

Genome annotation databases

EnsembliENST00000233712; ENSP00000233712; ENSG00000115363.
ENST00000393913; ENSP00000377490; ENSG00000115363.
ENST00000410071; ENSP00000386930; ENSG00000115363.
ENST00000410113; ENSP00000386435; ENSG00000115363.
GeneIDi84141.
KEGGihsa:84141.
UCSCiuc002sni.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023453 mRNA. Translation: BAB14580.1.
AF177337 mRNA. Translation: AAG17981.1.
CR457314 mRNA. Translation: CAG33595.1.
AC007099 Genomic DNA. Translation: AAY14774.1.
CH471053 Genomic DNA. Translation: EAW99591.1.
CH471053 Genomic DNA. Translation: EAW99592.1.
CH471053 Genomic DNA. Translation: EAW99593.1.
CH471053 Genomic DNA. Translation: EAW99594.1.
BC016157 mRNA. Translation: AAH16157.1.
BC063016 mRNA. Translation: AAH63016.1.
CCDSiCCDS1959.1.
RefSeqiNP_001128504.1. NM_001135032.1.
NP_115557.1. NM_032181.2.
UniGeneiHs.302346.

3D structure databases

ProteinModelPortaliQ9H8M9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123910. 2 interactions.
IntActiQ9H8M9. 4 interactions.
MINTiMINT-1413218.
STRINGi9606.ENSP00000233712.

PTM databases

iPTMnetiQ9H8M9.
PhosphoSiteiQ9H8M9.

Polymorphism and mutation databases

BioMutaiEVA1A.
DMDMi74733858.

Proteomic databases

EPDiQ9H8M9.
MaxQBiQ9H8M9.
PaxDbiQ9H8M9.
PeptideAtlasiQ9H8M9.
PRIDEiQ9H8M9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233712; ENSP00000233712; ENSG00000115363.
ENST00000393913; ENSP00000377490; ENSG00000115363.
ENST00000410071; ENSP00000386930; ENSG00000115363.
ENST00000410113; ENSP00000386435; ENSG00000115363.
GeneIDi84141.
KEGGihsa:84141.
UCSCiuc002sni.3. human.

Organism-specific databases

CTDi84141.
GeneCardsiEVA1A.
HGNCiHGNC:25816. EVA1A.
HPAiHPA008055.
neXtProtiNX_Q9H8M9.
PharmGKBiPA162387354.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZJN. Eukaryota.
ENOG410YJR4. LUCA.
GeneTreeiENSGT00840000129883.
HOGENOMiHOG000294093.
HOVERGENiHBG061487.
InParanoidiQ9H8M9.
OMAiCHTDCRQ.
OrthoDBiEOG7ZGX5P.
PhylomeDBiQ9H8M9.
TreeFamiTF352986.

Miscellaneous databases

GenomeRNAii84141.
PROiQ9H8M9.

Gene expression databases

BgeeiQ9H8M9.
CleanExiHS_FAM176A.
ExpressionAtlasiQ9H8M9. baseline and differential.
GenevisibleiQ9H8M9. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary and Pancreas.
  7. "TMEM166, a novel transmembrane protein, regulates cell autophagy and apoptosis."
    Wang L., Yu C., Lu Y., He P., Guo J., Zhang C., Song Q., Ma D., Shi T., Chen Y.
    Apoptosis 12:1489-1502(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  8. "High-throughput functional screening for autophagy-related genes and identification of TM9SF1 as an autophagosome-inducing gene."
    He P., Peng Z., Luo Y., Wang L., Yu P., Deng W., An Y., Shi T., Ma D.
    Autophagy 5:52-60(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. Cited for: PHOSPHORYLATION AT SER-114.

Entry informationi

Entry nameiEVA1A_HUMAN
AccessioniPrimary (citable) accession number: Q9H8M9
Secondary accession number(s): D6W5J3, Q9HC41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.