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Q9H8M9 (EVA1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein eva-1 homolog A
Alternative name(s):
Protein FAM176A
Transmembrane protein 166
Gene names
Name:EVA1A
Synonyms:FAM176A, TMEM166
ORF Names:SP24
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length152 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis. Ref.7 Ref.8

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein Ref.7.

Tissue specificity

Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle. Ref.7

Sequence similarities

Belongs to the EVA1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 152152Protein eva-1 homolog A
PRO_0000278671

Regions

Transmembrane35 – 5521Helical; Potential
Region1 – 6060Necessary for the localization and biological activity

Amino acid modifications

Modified residue1061Phosphothreonine By similarity

Natural variations

Natural variant1501R → H.
Corresponds to variant rs11126472 [ dbSNP | Ensembl ].
VAR_054077

Experimental info

Sequence conflict371Y → C in AAG17981. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9H8M9 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 5ED1FD97D73E801A

FASTA15217,470
        10         20         30         40         50         60 
MRLPLSHSPE HVEMALLSNI LAAYSFVSEN PERAALYFVS GVCIGLVLTL AALVIRISCH 

        70         80         90        100        110        120 
TDCRRRPGKK FLQDRESSSD SSDSEDGSED TVSDLSVRRH RRFERTLNKN VFTSAEELER 

       130        140        150 
AQRLEERERI IREIWMNGQP EVPGTRSLNR YY 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[2]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary and Pancreas.
[7]"TMEM166, a novel transmembrane protein, regulates cell autophagy and apoptosis."
Wang L., Yu C., Lu Y., He P., Guo J., Zhang C., Song Q., Ma D., Shi T., Chen Y.
Apoptosis 12:1489-1502(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[8]"High-throughput functional screening for autophagy-related genes and identification of TM9SF1 as an autophagosome-inducing gene."
He P., Peng Z., Luo Y., Wang L., Yu P., Deng W., An Y., Shi T., Ma D.
Autophagy 5:52-60(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK023453 mRNA. Translation: BAB14580.1.
AF177337 mRNA. Translation: AAG17981.1.
CR457314 mRNA. Translation: CAG33595.1.
AC007099 Genomic DNA. Translation: AAY14774.1.
CH471053 Genomic DNA. Translation: EAW99591.1.
CH471053 Genomic DNA. Translation: EAW99592.1.
CH471053 Genomic DNA. Translation: EAW99593.1.
CH471053 Genomic DNA. Translation: EAW99594.1.
BC016157 mRNA. Translation: AAH16157.1.
BC063016 mRNA. Translation: AAH63016.1.
RefSeqNP_001128504.1. NM_001135032.1.
NP_115557.1. NM_032181.2.
UniGeneHs.302346.

3D structure databases

ProteinModelPortalQ9H8M9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123910. 3 interactions.
IntActQ9H8M9. 3 interactions.
MINTMINT-1413218.
STRING9606.ENSP00000233712.

PTM databases

PhosphoSiteQ9H8M9.

Polymorphism databases

DMDM74733858.

Proteomic databases

PaxDbQ9H8M9.
PRIDEQ9H8M9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000233712; ENSP00000233712; ENSG00000115363.
ENST00000393913; ENSP00000377490; ENSG00000115363.
ENST00000410071; ENSP00000386930; ENSG00000115363.
ENST00000410113; ENSP00000386435; ENSG00000115363.
GeneID84141.
KEGGhsa:84141.
UCSCuc002sni.2. human.

Organism-specific databases

CTD84141.
GeneCardsGC02M075697.
HGNCHGNC:25816. EVA1A.
HPAHPA008055.
neXtProtNX_Q9H8M9.
PharmGKBPA162387354.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44006.
HOGENOMHOG000294093.
HOVERGENHBG061487.
InParanoidQ9H8M9.
OMACHTDCRQ.
OrthoDBEOG7ZGX5P.
PhylomeDBQ9H8M9.
TreeFamTF352986.

Gene expression databases

ArrayExpressQ9H8M9.
BgeeQ9H8M9.
CleanExHS_FAM176A.
GenevestigatorQ9H8M9.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSFAM176A. human.
GenomeRNAi84141.
NextBio73452.
PROQ9H8M9.

Entry information

Entry nameEVA1A_HUMAN
AccessionPrimary (citable) accession number: Q9H8M9
Secondary accession number(s): D6W5J3, Q9HC41
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM