Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin carboxyl-terminal hydrolase MINDY-3

Gene

MINDY3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.1 Publication

Caution

Was named CARP for 'CARD domain-containing protein' by PubMed:12054670. However, no CARD domain is detected by any prediction tool.Curated

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51NucleophileBy similarity1
Active sitei287Proton acceptorBy similarity1

GO - Molecular functioni

  • cysteine-type carboxypeptidase activity Source: UniProtKB
  • Lys48-specific deubiquitinase activity Source: UniProtKB
  • thiol-dependent ubiquitinyl hydrolase activity Source: UniProtKB-EC

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processApoptosis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase MINDY-3 (EC:3.4.19.12)
Alternative name(s):
Dermal papilla-derived protein 5
Deubiquitinating enzyme MINDY-3
Protein CARP
Gene namesi
Name:MINDY3Imported
Synonyms:C10orf97, CARP, DERP5, FAM188A
ORF Names:MSTP126, My042
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148481.13
HGNCiHGNC:23578 MINDY3
MIMi611649 gene
neXtProtiNX_Q9H8M7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi80013
OpenTargetsiENSG00000148481
PharmGKBiPA165548562

Polymorphism and mutation databases

BioMutaiFAM188A
DMDMi74761533

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175601 – 445Ubiquitin carboxyl-terminal hydrolase MINDY-3Add BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei125PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H8M7
MaxQBiQ9H8M7
PaxDbiQ9H8M7
PeptideAtlasiQ9H8M7
PRIDEiQ9H8M7

PTM databases

iPTMnetiQ9H8M7
PhosphoSitePlusiQ9H8M7

Expressioni

Tissue specificityi

Widely expressed with high levels in heart, skeletal muscle, and kidney, and low levels in liver and brain (PubMed:12054670). Also expressed in lung (at protein level) (PubMed:21499297).2 Publications

Gene expression databases

BgeeiENSG00000148481
ExpressionAtlasiQ9H8M7 baseline and differential
GenevisibleiQ9H8M7 HS

Organism-specific databases

HPAiHPA038400
HPA038406

Interactioni

Subunit structurei

Interacts with COPS5.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123069, 31 interactors
IntActiQ9H8M7, 8 interactors
STRINGi9606.ENSP00000277632

Structurei

3D structure databases

ProteinModelPortaliQ9H8M7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2871 Eukaryota
ENOG410XSGV LUCA
GeneTreeiENSGT00530000063283
HOVERGENiHBG061682
InParanoidiQ9H8M7
OMAiPLIHSTY
OrthoDBiEOG091G0TF1
PhylomeDBiQ9H8M7
TreeFamiTF323996

Family and domain databases

InterProiView protein in InterPro
IPR025257 DUF4205
IPR011992 EF-hand-dom_pair
PfamiView protein in Pfam
PF13898 DUF4205, 1 hit
SMARTiView protein in SMART
SM01174 DUF4205, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H8M7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSELTKELME LVWGTKSSPG LSDTIFCRWT QGFVFSESEG SALEQFEGGP
60 70 80 90 100
CAVIAPVQAF LLKKLLFSSE KSSWRDCSEE EQKELLCHTL CDILESACCD
110 120 130 140 150
HSGSYCLVSW LRGKTTEETA SISGSPAESS CQVEHSSALA VEELGFERFH
160 170 180 190 200
ALIQKRSFRS LPELKDAVLD QYSMWGNKFG VLLFLYSVLL TKGIENIKNE
210 220 230 240 250
IEDASEPLID PVYGHGSQSL INLLLTGHAV SNVWDGDREC SGMKLLGIHE
260 270 280 290 300
QAAVGFLTLM EALRYCKVGS YLKSPKFPIW IVGSETHLTV FFAKDMALVA
310 320 330 340 350
PEAPSEQARR VFQTYDPEDN GFIPDSLLED VMKALDLVSD PEYINLMKNK
360 370 380 390 400
LDPEGLGIIL LGPFLQEFFP DQGSSGPESF TVYHYNGLKQ SNYNEKVMYV
410 420 430 440
EGTAVVMGFE DPMLQTDDTP IKRCLQTKWP YIELLWTTDR SPSLN
Length:445
Mass (Da):49,725
Last modified:March 1, 2001 - v1
Checksum:iF30B4A5E357AF52E
GO
Isoform 2 (identifier: Q9H8M7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-445: Missing.

Show »
Length:136
Mass (Da):14,942
Checksum:iFB29CAFB7F8C68AB
GO

Sequence cautioni

The sequence AAG43159 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH61585 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAQ13660 differs from that shown. Reason: Frameshift at position 111.Curated
The sequence CAI13817 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI13818 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI13819 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAW86233 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31Q → R in CAG33596 (Ref. 5) Curated1
Sequence conflicti96S → G in AAH20605 (PubMed:15489334).Curated1
Sequence conflicti111L → V in AAQ13660 (Ref. 6) Curated1
Sequence conflicti116T → A in CAG33596 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031039137 – 445Missing in isoform 2. 2 PublicationsAdd BLAST309

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014761 mRNA Translation: BAB87802.1
AK023459 mRNA Translation: BAB14582.1
AL833873 mRNA Translation: CAD38730.1
CR457315 mRNA Translation: CAG33596.1
AF176916 mRNA Translation: AAQ13660.1 Frameshift.
AL590439 Genomic DNA Translation: CAI13817.1 Sequence problems.
AL590439 Genomic DNA Translation: CAI13818.1 Sequence problems.
AL590439 Genomic DNA Translation: CAI13819.1 Sequence problems.
AL590439 Genomic DNA Translation: CAI13820.1
CH471072 Genomic DNA Translation: EAW86233.1 Sequence problems.
CH471072 Genomic DNA Translation: EAW86234.1
BC020605 mRNA Translation: AAH20605.1
BC061585 mRNA Translation: AAH61585.1 Sequence problems.
BC067799 mRNA Translation: AAH67799.1
AF063600 mRNA Translation: AAG43159.1 Different initiation.
CCDSiCCDS7110.1 [Q9H8M7-1]
PIRiJC7861
RefSeqiNP_001305259.1, NM_001318330.1
NP_079224.1, NM_024948.3 [Q9H8M7-1]
XP_005252657.1, XM_005252600.2
XP_005252659.1, XM_005252602.2
XP_011517996.1, XM_011519694.1
XP_016872162.1, XM_017016673.1
UniGeneiHs.158870

Genome annotation databases

EnsembliENST00000277632; ENSP00000277632; ENSG00000148481 [Q9H8M7-1]
GeneIDi80013
KEGGihsa:80013
UCSCiuc001iod.2 human [Q9H8M7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMINY3_HUMAN
AccessioniPrimary (citable) accession number: Q9H8M7
Secondary accession number(s): Q5SZ68
, Q5SZ69, Q5SZ70, Q6IA40, Q6P7P0, Q7Z2S1, Q8WUF1, Q9H3I4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health