Q9H8M7 (F188A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM188A

Alternative name(s):
Dermal papilla-derived protein 5
Protein CARP

Gene names

Name:	FAM188A
Synonyms:	C10orf97, CARP, DERP5
ORF Names:	MSTP126, My042

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May have pro-apoptotic function. Overexpression significantly inhibits cell proliferation in several tumor cell lines. Ref.1
Subcellular location	Nucleus Ref.1.
Tissue specificity	Highly expressed in heart, skeletal muscle, and kidney, with weak expression in liver and brain. Ref.1
Sequence similarities	Belongs to the FAM188 family.
Caution	Was named CARP for 'CARD domain-containing protein' by Ref.1. However, no CARD domain is detected by any prediction tool.
Sequence caution	The sequence AAG43159.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH61585.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAQ13660.1 differs from that shown. Reason: Frameshift at position 111. The sequence CAI13817.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI13818.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI13819.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence EAW86233.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nuclear membrane Inferred from direct assay. Source: HPA
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
COPS5	Q92905	3	EBI-724928,EBI-594661

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H8M7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H8M7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     137-445: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 445	445	Protein FAM188A		PRO_0000317560
Amino acid modifications
	Modified residue	125	1	Phosphoserine Ref.11
Natural variations
	Alternative sequence	137 – 445	309	Missing in isoform 2.		VSP_031039
Experimental info
	Sequence conflict	31	1	Q → R in CAG33596. Ref.5
	Sequence conflict	96	1	S → G in AAH20605. Ref.9
	Sequence conflict	111	1	L → V in AAQ13660. Ref.6
	Sequence conflict	116	1	T → A in CAG33596. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: F30B4A5E357AF52E	FASTA	445	49,725
	10 20 30 40 50 60 MSELTKELME LVWGTKSSPG LSDTIFCRWT QGFVFSESEG SALEQFEGGP CAVIAPVQAF 70 80 90 100 110 120 LLKKLLFSSE KSSWRDCSEE EQKELLCHTL CDILESACCD HSGSYCLVSW LRGKTTEETA 130 140 150 160 170 180 SISGSPAESS CQVEHSSALA VEELGFERFH ALIQKRSFRS LPELKDAVLD QYSMWGNKFG 190 200 210 220 230 240 VLLFLYSVLL TKGIENIKNE IEDASEPLID PVYGHGSQSL INLLLTGHAV SNVWDGDREC 250 260 270 280 290 300 SGMKLLGIHE QAAVGFLTLM EALRYCKVGS YLKSPKFPIW IVGSETHLTV FFAKDMALVA 310 320 330 340 350 360 PEAPSEQARR VFQTYDPEDN GFIPDSLLED VMKALDLVSD PEYINLMKNK LDPEGLGIIL 370 380 390 400 410 420 LGPFLQEFFP DQGSSGPESF TVYHYNGLKQ SNYNEKVMYV EGTAVVMGFE DPMLQTDDTP 430 440 IKRCLQTKWP YIELLWTTDR SPSLN
	Isoform 2 [UniParc]. Checksum: FB29CAFB7F8C68AB	FASTA	136	14,942
	10 20 30 40 50 60 MSELTKELME LVWGTKSSPG LSDTIFCRWT QGFVFSESEG SALEQFEGGP CAVIAPVQAF 70 80 90 100 110 120 LLKKLLFSSE KSSWRDCSEE EQKELLCHTL CDILESACCD HSGSYCLVSW LRGKTTEETA 130 SISGSPAESS CQVEHS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CARP is a novel caspase recruitment domain containing pro-apoptotic protein." Liu B., Liu Y., Chen J., Wei Z., Yu H., Zhen Y., Lu L., Hui R.T. Biochem. Biophys. Res. Commun. 293:1396-1404(2002) [PubMed: 12054670] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), POSSIBLE FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"Molecular cloning of a dermal papilla derived gene." Ikeda A., Yamashita M., Yoshimoto M. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]	"Homo sapiens normal aorta mRNA MST126." Liu B., Qin B.M., Sheng H., Zhao B., Liu Y.Q., Wang X.Y., Zhang Q., Song L., Liu B.H., Lu H., Xu H.S., Zheng W.Y., Gong J., Hui R.T. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Aorta.
[7]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain, Testis and Uterus.
[10]	Mao Y.M., Xie Y., Zheng Z.H. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 176-445. Tissue: Fetal brain.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB014761 mRNA. Translation: BAB87802.1. AK023459 mRNA. Translation: BAB14582.1. AL833873 mRNA. Translation: CAD38730.1. CR457315 mRNA. Translation: CAG33596.1. AF176916 mRNA. Translation: AAQ13660.1. Frameshift. AL590439 Genomic DNA. Translation: CAI13817.1. Sequence problems. AL590439 Genomic DNA. Translation: CAI13818.1. Sequence problems. AL590439 Genomic DNA. Translation: CAI13819.1. Sequence problems. AL590439 Genomic DNA. Translation: CAI13820.1. CH471072 Genomic DNA. Translation: EAW86233.1. Sequence problems. CH471072 Genomic DNA. Translation: EAW86234.1. BC020605 mRNA. Translation: AAH20605.1. BC061585 mRNA. Translation: AAH61585.1. Sequence problems. BC067799 mRNA. Translation: AAH67799.1. AF063600 mRNA. Translation: AAG43159.1. Different initiation.
IPI	IPI00549993. IPI00885206.
PIR	JC7861.
RefSeq	NP_079224.1. NM_024948.2.
UniGene	Hs.158870.
3D structure databases
ProteinModelPortal	Q9H8M7.
SMR	Q9H8M7. Positions 303-369.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H8M7. 2 interactions.
MINT	MINT-1412937.
STRING	Q9H8M7.
PTM databases
PhosphoSite	Q9H8M7.
Polymorphism databases
DMDM	74761533.
Proteomic databases
PRIDE	Q9H8M7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000277632; ENSP00000277632; ENSG00000148481.
GeneID	80013.
KEGG	hsa:80013.
UCSC	uc001iod.1. human.
Organism-specific databases
CTD	80013.
GeneCards	GC10M015820.
H-InvDB	HIX0008676.
HGNC	HGNC:23578. FAM188A.
HPA	HPA038400.
MIM	611649. gene.
neXtProt	NX_Q9H8M7.
PharmGKB	PA134866358. PA165548562.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08397.
GeneTree	ENSGT00530000063283.
HOVERGEN	HBG061682.
InParanoid	Q9H8M7.
OMA	PAQSSCQ.
OrthoDB	EOG4894MG.
PhylomeDB	Q9H8M7.
Gene expression databases
ArrayExpress	Q9H8M7.
Bgee	Q9H8M7.
Genevestigator	Q9H8M7.
Family and domain databases
InterPro	IPR011992. EF-hand-like_dom. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit.
ProtoNet	Search...
Other
NextBio	70114.
SOURCE	Search...

Entry information

Entry name

F188A_HUMAN

Accession

Primary (citable) accession number: Q9H8M7
Secondary accession number(s): Q5SZ68 , Q5SZ69, Q5SZ70, Q6IA40, Q6P7P0, Q7Z2S1, Q8WUF1, Q9H3I4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.