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Protein

Methyltransferase-like protein 7A

Gene

METTL7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable methyltransferase.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 7A (EC:2.1.1.-)
Alternative name(s):
Protein AAM-B
Gene namesi
Name:METTL7A
ORF Names:PRO0066, UNQ1902/PRO4348
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:24550. METTL7A.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • lipid particle Source: UniProtKB-SubCell
  • membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Lipid droplet, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394635.

Polymorphism and mutation databases

BioMutaiMETTL7A.
DMDMi74761529.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 244215Methyltransferase-like protein 7APRO_0000251921Add
BLAST

Proteomic databases

EPDiQ9H8H3.
MaxQBiQ9H8H3.
PaxDbiQ9H8H3.
PeptideAtlasiQ9H8H3.
PRIDEiQ9H8H3.

PTM databases

iPTMnetiQ9H8H3.
PhosphoSiteiQ9H8H3.

Expressioni

Gene expression databases

BgeeiQ9H8H3.
CleanExiHS_METTL7A.
ExpressionAtlasiQ9H8H3. baseline and differential.
GenevisibleiQ9H8H3. HS.

Organism-specific databases

HPAiHPA017434.

Interactioni

Subunit structurei

Self-associates.1 Publication

Protein-protein interaction databases

BioGridi117366. 6 interactions.
IntActiQ9H8H3. 1 interaction.
STRINGi9606.ENSP00000331787.

Structurei

3D structure databases

ProteinModelPortaliQ9H8H3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2828Targeting to lipid dropletsAdd
BLAST

Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IQG5. Eukaryota.
ENOG4111EZC. LUCA.
GeneTreeiENSGT00530000063658.
HOGENOMiHOG000236770.
HOVERGENiHBG054283.
InParanoidiQ9H8H3.
OMAiWHLLFDG.
OrthoDBiEOG73RBCN.
PhylomeDBiQ9H8H3.
TreeFamiTF331790.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H8H3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELTIFILRL AIYILTFPLY LLNFLGLWSW ICKKWFPYFL VRFTVIYNEQ
60 70 80 90 100
MASKKRELFS NLQEFAGPSG KLSLLEVGCG TGANFKFYPP GCRVTCIDPN
110 120 130 140 150
PNFEKFLIKS IAENRHLQFE RFVVAAGENM HQVADGSVDV VVCTLVLCSV
160 170 180 190 200
KNQERILREV CRVLRPGGAF YFMEHVAAEC STWNYFWQQV LDPAWHLLFD
210 220 230 240
GCNLTRESWK ALERASFSKL KLQHIQAPLS WELVRPHIYG YAVK
Length:244
Mass (Da):28,319
Last modified:March 1, 2001 - v1
Checksum:i6967783BAB2348BE
GO

Sequence cautioni

The sequence AAF20268.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391F → L in BAB14913 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti134 – 1341A → T.
Corresponds to variant rs28372674 [ dbSNP | Ensembl ].
VAR_050296

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ536233 mRNA. Translation: CAD60207.1.
AY358797 mRNA. Translation: AAQ89157.1.
AK023693 mRNA. Translation: BAB14643.1.
AK024409 mRNA. Translation: BAB14913.1.
BC004492 mRNA. Translation: AAH04492.1.
BC008180 mRNA. Translation: AAH08180.1.
AL050159 mRNA. Translation: CAB43300.1.
AF113007 mRNA. Translation: AAF20268.1. Different initiation.
CCDSiCCDS8804.1.
PIRiT08785.
RefSeqiNP_054752.3. NM_014033.3.
XP_006719395.1. XM_006719332.1.
UniGeneiHs.711113.
Hs.744021.

Genome annotation databases

EnsembliENST00000332160; ENSP00000331787; ENSG00000185432.
ENST00000547104; ENSP00000447542; ENSG00000185432.
ENST00000548553; ENSP00000448785; ENSG00000185432.
GeneIDi25840.
KEGGihsa:25840.
UCSCiuc001rxb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ536233 mRNA. Translation: CAD60207.1.
AY358797 mRNA. Translation: AAQ89157.1.
AK023693 mRNA. Translation: BAB14643.1.
AK024409 mRNA. Translation: BAB14913.1.
BC004492 mRNA. Translation: AAH04492.1.
BC008180 mRNA. Translation: AAH08180.1.
AL050159 mRNA. Translation: CAB43300.1.
AF113007 mRNA. Translation: AAF20268.1. Different initiation.
CCDSiCCDS8804.1.
PIRiT08785.
RefSeqiNP_054752.3. NM_014033.3.
XP_006719395.1. XM_006719332.1.
UniGeneiHs.711113.
Hs.744021.

3D structure databases

ProteinModelPortaliQ9H8H3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117366. 6 interactions.
IntActiQ9H8H3. 1 interaction.
STRINGi9606.ENSP00000331787.

PTM databases

iPTMnetiQ9H8H3.
PhosphoSiteiQ9H8H3.

Polymorphism and mutation databases

BioMutaiMETTL7A.
DMDMi74761529.

Proteomic databases

EPDiQ9H8H3.
MaxQBiQ9H8H3.
PaxDbiQ9H8H3.
PeptideAtlasiQ9H8H3.
PRIDEiQ9H8H3.

Protocols and materials databases

DNASUi25840.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332160; ENSP00000331787; ENSG00000185432.
ENST00000547104; ENSP00000447542; ENSG00000185432.
ENST00000548553; ENSP00000448785; ENSG00000185432.
GeneIDi25840.
KEGGihsa:25840.
UCSCiuc001rxb.3. human.

Organism-specific databases

CTDi25840.
GeneCardsiMETTL7A.
HGNCiHGNC:24550. METTL7A.
HPAiHPA017434.
neXtProtiNX_Q9H8H3.
PharmGKBiPA128394635.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQG5. Eukaryota.
ENOG4111EZC. LUCA.
GeneTreeiENSGT00530000063658.
HOGENOMiHOG000236770.
HOVERGENiHBG054283.
InParanoidiQ9H8H3.
OMAiWHLLFDG.
OrthoDBiEOG73RBCN.
PhylomeDBiQ9H8H3.
TreeFamiTF331790.

Miscellaneous databases

ChiTaRSiMETTL7A. human.
GenomeRNAii25840.
NextBioi47155.
PROiQ9H8H3.

Gene expression databases

BgeeiQ9H8H3.
CleanExiHS_METTL7A.
ExpressionAtlasiQ9H8H3. baseline and differential.
GenevisibleiQ9H8H3. HS.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression profiling of alternatively activated macrophages."
    Gratchev A., Kzhyhskowska J., Utikal J., Goerdt S.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Thyroid.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas and Placenta.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-244.
    Tissue: Uterus.
  6. "Functional prediction of the coding sequences of 14 new genes deduced by analysis of cDNA clones from human fetal liver."
    Zhang C., Yu Y., Zhang S., Ouyang S., Luo L., Wei H., Zhou G., Liu M., He F.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-244.
    Tissue: Fetal liver.
  7. "Identification of a novel N-terminal hydrophobic sequence that targets proteins to lipid droplets."
    Zehmer J.K., Bartz R., Liu P., Anderson R.G.W.
    J. Cell Sci. 121:1852-1860(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, SUBUNIT, REGION.
  8. "Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets."
    Zehmer J.K., Bartz R., Bisel B., Liu P., Seemann J., Anderson R.G.W.
    J. Cell Sci. 122:3694-3702(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMET7A_HUMAN
AccessioniPrimary (citable) accession number: Q9H8H3
Secondary accession number(s): Q9H7R3, Q9UHZ7, Q9Y422
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: March 16, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.