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Protein

Methyltransferase-like protein 7A

Gene

METTL7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable methyltransferase.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 7A (EC:2.1.1.-)
Alternative name(s):
Protein AAM-B
Gene namesi
Name:METTL7A
ORF Names:PRO0066, UNQ1902/PRO4348
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000185432.11
HGNCiHGNC:24550 METTL7A
neXtProtiNX_Q9H8H3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Lipid droplet, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi25840
OpenTargetsiENSG00000185432
PharmGKBiPA128394635

Polymorphism and mutation databases

BioMutaiMETTL7A
DMDMi74761529

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000025192130 – 244Methyltransferase-like protein 7AAdd BLAST215

Proteomic databases

EPDiQ9H8H3
MaxQBiQ9H8H3
PaxDbiQ9H8H3
PeptideAtlasiQ9H8H3
PRIDEiQ9H8H3

PTM databases

iPTMnetiQ9H8H3
PhosphoSitePlusiQ9H8H3
SwissPalmiQ9H8H3

Expressioni

Gene expression databases

BgeeiENSG00000185432
CleanExiHS_METTL7A
ExpressionAtlasiQ9H8H3 baseline and differential
GenevisibleiQ9H8H3 HS

Organism-specific databases

HPAiHPA017434

Interactioni

Subunit structurei

Self-associates.1 Publication

Protein-protein interaction databases

BioGridi117366, 6 interactors
IntActiQ9H8H3, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ9H8H3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28Targeting to lipid dropletsAdd BLAST28

Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IQG5 Eukaryota
ENOG4111EZC LUCA
GeneTreeiENSGT00530000063658
HOGENOMiHOG000236770
HOVERGENiHBG054283
InParanoidiQ9H8H3
OMAiVMYNEQM
OrthoDBiEOG091G0HKL
PhylomeDBiQ9H8H3
TreeFamiTF331790

Family and domain databases

InterProiView protein in InterPro
IPR013216 Methyltransf_11
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF08241 Methyltransf_11, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H8H3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELTIFILRL AIYILTFPLY LLNFLGLWSW ICKKWFPYFL VRFTVIYNEQ
60 70 80 90 100
MASKKRELFS NLQEFAGPSG KLSLLEVGCG TGANFKFYPP GCRVTCIDPN
110 120 130 140 150
PNFEKFLIKS IAENRHLQFE RFVVAAGENM HQVADGSVDV VVCTLVLCSV
160 170 180 190 200
KNQERILREV CRVLRPGGAF YFMEHVAAEC STWNYFWQQV LDPAWHLLFD
210 220 230 240
GCNLTRESWK ALERASFSKL KLQHIQAPLS WELVRPHIYG YAVK
Length:244
Mass (Da):28,319
Last modified:March 1, 2001 - v1
Checksum:i6967783BAB2348BE
GO

Sequence cautioni

The sequence AAF20268 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39F → L in BAB14913 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050296134A → T. Corresponds to variant dbSNP:rs28372674Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ536233 mRNA Translation: CAD60207.1
AY358797 mRNA Translation: AAQ89157.1
AK023693 mRNA Translation: BAB14643.1
AK024409 mRNA Translation: BAB14913.1
BC004492 mRNA Translation: AAH04492.1
BC008180 mRNA Translation: AAH08180.1
AL050159 mRNA Translation: CAB43300.1
AF113007 mRNA Translation: AAF20268.1 Different initiation.
CCDSiCCDS8804.1
PIRiT08785
RefSeqiNP_054752.3, NM_014033.3
XP_006719395.1, XM_006719332.1
UniGeneiHs.711113
Hs.744021

Genome annotation databases

EnsembliENST00000332160; ENSP00000331787; ENSG00000185432
ENST00000547104; ENSP00000447542; ENSG00000185432
ENST00000548553; ENSP00000448785; ENSG00000185432
GeneIDi25840
KEGGihsa:25840
UCSCiuc001rxb.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMET7A_HUMAN
AccessioniPrimary (citable) accession number: Q9H8H3
Secondary accession number(s): Q9H7R3, Q9UHZ7, Q9Y422
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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