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Protein

Nucleolar protein 11

Gene

NOL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b.1 Publication

Miscellaneous

Is the likely candidate for being the functional analog of yeast Utp8.1 Publication

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

  • maturation of SSU-rRNA Source: UniProtKB
  • positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter Source: UniProtKB
  • rRNA processing Source: Reactome
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator
Biological processRibosome biogenesis, rRNA processing, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 11
Gene namesi
Name:NOL11
ORF Names:L14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000130935.9.
HGNCiHGNC:24557. NOL11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi25926.
OpenTargetsiENSG00000130935.
PharmGKBiPA142671258.

Polymorphism and mutation databases

BioMutaiNOL11.
DMDMi73921238.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000969311 – 719Nucleolar protein 11Add BLAST719

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei346N6-methyllysineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ9H8H0.
MaxQBiQ9H8H0.
PaxDbiQ9H8H0.
PeptideAtlasiQ9H8H0.
PRIDEiQ9H8H0.

2D gel databases

SWISS-2DPAGEiQ9H8H0.

PTM databases

iPTMnetiQ9H8H0.
PhosphoSitePlusiQ9H8H0.
SwissPalmiQ9H8H0.

Expressioni

Gene expression databases

BgeeiENSG00000130935.
CleanExiHS_NOL11.
ExpressionAtlasiQ9H8H0. baseline and differential.
GenevisibleiQ9H8H0. HS.

Organism-specific databases

HPAiHPA022010.

Interactioni

Subunit structurei

Interacts with UTP4. Interacts with FBL/fibrillarin in a transcription-dependent manner (PubMed:22916032). May associate with the proposed t-UTP subcomplex of the SSU processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75.Curated1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UTP4Q969X65EBI-725885,EBI-2602591

Protein-protein interaction databases

BioGridi117426. 34 interactors.
IntActiQ9H8H0. 10 interactors.
MINTiMINT-1415753.
STRINGi9606.ENSP00000253247.

Structurei

3D structure databases

ProteinModelPortaliQ9H8H0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IESF. Eukaryota.
ENOG41118C1. LUCA.
GeneTreeiENSGT00390000009760.
HOGENOMiHOG000231042.
HOVERGENiHBG080063.
InParanoidiQ9H8H0.
OMAiWSDKRIF.
OrthoDBiEOG091G02IB.
PhylomeDBiQ9H8H0.
TreeFamiTF325877.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR012584. NUC205.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR036322. WD40_repeat_dom_sf.
PfamiView protein in Pfam
PF08168. NUC205. 1 hit.
SUPFAMiSSF50978. SSF50978. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H8H0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALEEEFTL SSVVLSAGPE GLLGVEQSDK TDQFLVTDSG RTVILYKVSD
60 70 80 90 100
QKPLGSWSVK QGQIITCPAV CNFQTGEYVV VHDNKVLRIW NNEDVNLDKV
110 120 130 140 150
FKATLSAEVY RILSVQGTEP LVLFKEGAVR GLEALLADPQ QKIETVISDE
160 170 180 190 200
EVIKWTKFFV VFRHPVLIFI TEKHGNYFAY VQMFNSRILT KYTLLLGQDE
210 220 230 240 250
NSVIKSFTAS VDRKFISLMS LSSDGCIYET LIPIRPADPE KNQSLVKSLL
260 270 280 290 300
LKAVVSGNAR NGVALTALDQ DHVAVLGSPL AASKECLSVW NIKFQTLQTS
310 320 330 340 350
KELPQGTSGQ LWYYGEHLFM LHGKSLTVIP YKCEVSSLAG ALGKLKHSQD
360 370 380 390 400
PGTHVVSHFV NWETPQGCGL GFQNSEQSRR ILRRRKIEVS LQPEVPPSKQ
410 420 430 440 450
LLSTIMKDSE KHIEVEVRKF LALKQTPDFH TVIGDTVTGL LERCKAEPSF
460 470 480 490 500
YPRNCLMQLI QTHVLSYSLC PDLMEIALKK KDVQLLQLCL QQFPDIPESV
510 520 530 540 550
TCACLKIFLS IGDDSLQETD VNMESVFDYS INSVHDEKME EQTEILQNGF
560 570 580 590 600
NPEEDKCNNC DQELNKKPQD ETKESTSCPV VQKRAALLNA ILHSAYSETF
610 620 630 640 650
LLPHLKDIPA QHITLFLKYL YFLYLKCSEN ATMTLPGIHP PTLNQIMDWI
660 670 680 690 700
CLLLDANFTV VVMMPEAKRL LINLYKLVKS QISVYSELNK IEVSFRELQK
710
LNQEKNNRGL YSIEVLELF
Length:719
Mass (Da):81,124
Last modified:March 1, 2001 - v1
Checksum:iB794F7A2635453DF
GO
Isoform 2 (identifier: Q9H8H0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-169: KWTKFFVVFRHPVLIF → NMEITLLTCKCLTHVS
     170-719: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:169
Mass (Da):18,599
Checksum:iDBAF194C4CDDE6B2
GO

Sequence cautioni

Q9H8H0: The sequence BAH13045 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
Q9H8H0: The sequence CAB53709 differs from that shown. Reason: Frameshift at positions 382 and 383.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051237115V → A1 PublicationCorresponds to variant dbSNP:rs2291284Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053283154 – 169KWTKF…PVLIF → NMEITLLTCKCLTHVS in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_053284170 – 719Missing in isoform 2. 1 PublicationAdd BLAST550

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598333 mRNA. Translation: AAT06744.1.
AK023702 mRNA. Translation: BAB14647.1.
AK299483 mRNA. Translation: BAH13045.1. Sequence problems.
AC006534 Genomic DNA. No translation available.
BC001726 mRNA. Translation: AAH01726.2.
BC064404 mRNA. Translation: AAH64404.1.
AL110271 mRNA. Translation: CAB53709.1. Frameshift.
CCDSiCCDS11671.1. [Q9H8H0-1]
PIRiT14789.
RefSeqiNP_001290201.1. NM_001303272.1.
NP_056277.2. NM_015462.4. [Q9H8H0-1]
UniGeneiHs.463936.

Genome annotation databases

EnsembliENST00000253247; ENSP00000253247; ENSG00000130935. [Q9H8H0-1]
ENST00000581375; ENSP00000463219; ENSG00000130935. [Q9H8H0-2]
GeneIDi25926.
KEGGihsa:25926.
UCSCiuc002jgd.2. human. [Q9H8H0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNOL11_HUMAN
AccessioniPrimary (citable) accession number: Q9H8H0
Secondary accession number(s): B7Z5V9, Q7L5S1, Q9UG18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot