Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleolar protein 11

Gene

NOL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b.1 Publication

Miscellaneous

Is the likely candidate for being the functional analog of yeast Utp8.1 Publication

GO - Molecular functioni

GO - Biological processi

  • maturation of SSU-rRNA Source: UniProtKB
  • positive regulation of transcription of nucleolar large rRNA by RNA polymerase I Source: UniProtKB
  • rRNA processing Source: Reactome
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator
Biological processRibosome biogenesis, rRNA processing, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 11
Gene namesi
Name:NOL11
ORF Names:L14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000130935.9
HGNCiHGNC:24557 NOL11
MIMi615366 gene
neXtProtiNX_Q9H8H0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi25926
OpenTargetsiENSG00000130935
PharmGKBiPA142671258

Polymorphism and mutation databases

BioMutaiNOL11
DMDMi73921238

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000969311 – 719Nucleolar protein 11Add BLAST719

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei346N6-methyllysineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ9H8H0
MaxQBiQ9H8H0
PaxDbiQ9H8H0
PeptideAtlasiQ9H8H0
PRIDEiQ9H8H0
ProteomicsDBi81208

2D gel databases

SWISS-2DPAGEiQ9H8H0

PTM databases

iPTMnetiQ9H8H0
PhosphoSitePlusiQ9H8H0
SwissPalmiQ9H8H0

Expressioni

Gene expression databases

BgeeiENSG00000130935
CleanExiHS_NOL11
ExpressionAtlasiQ9H8H0 baseline and differential
GenevisibleiQ9H8H0 HS

Organism-specific databases

HPAiHPA022010

Interactioni

Subunit structurei

Interacts with UTP4. Interacts with FBL/fibrillarin in a transcription-dependent manner (PubMed:22916032). May associate with the proposed t-UTP subcomplex of the SSU processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75.Curated1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UTP4Q969X65EBI-725885,EBI-2602591

Protein-protein interaction databases

BioGridi117426, 35 interactors
IntActiQ9H8H0, 10 interactors
MINTiQ9H8H0
STRINGi9606.ENSP00000253247

Structurei

3D structure databases

ProteinModelPortaliQ9H8H0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IESF Eukaryota
ENOG41118C1 LUCA
GeneTreeiENSGT00390000009760
HOGENOMiHOG000231042
HOVERGENiHBG080063
InParanoidiQ9H8H0
OMAiWSDKRIF
OrthoDBiEOG091G02IB
PhylomeDBiQ9H8H0
TreeFamiTF325877

Family and domain databases

InterProiView protein in InterPro
IPR012584 NUC205
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08168 NUC205, 1 hit
SUPFAMiSSF50978 SSF50978, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H8H0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALEEEFTL SSVVLSAGPE GLLGVEQSDK TDQFLVTDSG RTVILYKVSD
60 70 80 90 100
QKPLGSWSVK QGQIITCPAV CNFQTGEYVV VHDNKVLRIW NNEDVNLDKV
110 120 130 140 150
FKATLSAEVY RILSVQGTEP LVLFKEGAVR GLEALLADPQ QKIETVISDE
160 170 180 190 200
EVIKWTKFFV VFRHPVLIFI TEKHGNYFAY VQMFNSRILT KYTLLLGQDE
210 220 230 240 250
NSVIKSFTAS VDRKFISLMS LSSDGCIYET LIPIRPADPE KNQSLVKSLL
260 270 280 290 300
LKAVVSGNAR NGVALTALDQ DHVAVLGSPL AASKECLSVW NIKFQTLQTS
310 320 330 340 350
KELPQGTSGQ LWYYGEHLFM LHGKSLTVIP YKCEVSSLAG ALGKLKHSQD
360 370 380 390 400
PGTHVVSHFV NWETPQGCGL GFQNSEQSRR ILRRRKIEVS LQPEVPPSKQ
410 420 430 440 450
LLSTIMKDSE KHIEVEVRKF LALKQTPDFH TVIGDTVTGL LERCKAEPSF
460 470 480 490 500
YPRNCLMQLI QTHVLSYSLC PDLMEIALKK KDVQLLQLCL QQFPDIPESV
510 520 530 540 550
TCACLKIFLS IGDDSLQETD VNMESVFDYS INSVHDEKME EQTEILQNGF
560 570 580 590 600
NPEEDKCNNC DQELNKKPQD ETKESTSCPV VQKRAALLNA ILHSAYSETF
610 620 630 640 650
LLPHLKDIPA QHITLFLKYL YFLYLKCSEN ATMTLPGIHP PTLNQIMDWI
660 670 680 690 700
CLLLDANFTV VVMMPEAKRL LINLYKLVKS QISVYSELNK IEVSFRELQK
710
LNQEKNNRGL YSIEVLELF
Length:719
Mass (Da):81,124
Last modified:March 1, 2001 - v1
Checksum:iB794F7A2635453DF
GO
Isoform 2 (identifier: Q9H8H0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-169: KWTKFFVVFRHPVLIF → NMEITLLTCKCLTHVS
     170-719: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:169
Mass (Da):18,599
Checksum:iDBAF194C4CDDE6B2
GO

Sequence cautioni

The sequence BAH13045 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence CAB53709 differs from that shown. Reason: Frameshift at positions 382 and 383.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051237115V → A1 PublicationCorresponds to variant dbSNP:rs2291284Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053283154 – 169KWTKF…PVLIF → NMEITLLTCKCLTHVS in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_053284170 – 719Missing in isoform 2. 1 PublicationAdd BLAST550

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598333 mRNA Translation: AAT06744.1
AK023702 mRNA Translation: BAB14647.1
AK299483 mRNA Translation: BAH13045.1 Sequence problems.
AC006534 Genomic DNA No translation available.
BC001726 mRNA Translation: AAH01726.2
BC064404 mRNA Translation: AAH64404.1
AL110271 mRNA Translation: CAB53709.1 Frameshift.
CCDSiCCDS11671.1 [Q9H8H0-1]
PIRiT14789
RefSeqiNP_001290201.1, NM_001303272.1
NP_056277.2, NM_015462.4 [Q9H8H0-1]
UniGeneiHs.463936

Genome annotation databases

EnsembliENST00000253247; ENSP00000253247; ENSG00000130935 [Q9H8H0-1]
ENST00000581375; ENSP00000463219; ENSG00000130935 [Q9H8H0-2]
GeneIDi25926
KEGGihsa:25926
UCSCiuc002jgd.2 human [Q9H8H0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNOL11_HUMAN
AccessioniPrimary (citable) accession number: Q9H8H0
Secondary accession number(s): B7Z5V9, Q7L5S1, Q9UG18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health