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Q9H8H0 (NOL11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleolar protein 11
Gene names
Name:NOL11
ORF Names:L14
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length719 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Ref.8

Subunit structure

Forms a complex with CIRH1A, UTP15, WDR43 and WDR75; within this complex, directly interacts with CIRH1A. Interacts with FBL/fibrillarin in a transcription-dependent manner. Ref.8

Subcellular location

Nucleusnucleolus Ref.6 Ref.8.

Sequence caution

The sequence BAH13045.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

The sequence CAB53709.1 differs from that shown. Reason: Frameshift at positions 382 and 383.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H8H0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H8H0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     154-169: KWTKFFVVFRHPVLIF → NMEITLLTCKCLTHVS
     170-719: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 719719Nucleolar protein 11
PRO_0000096931

Natural variations

Alternative sequence154 – 16916KWTKF…PVLIF → NMEITLLTCKCLTHVS in isoform 2.
VSP_053283
Alternative sequence170 – 719550Missing in isoform 2.
VSP_053284
Natural variant1151V → A. Ref.5
Corresponds to variant rs2291284 [ dbSNP | Ensembl ].
VAR_051237

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: B794F7A2635453DF

FASTA71981,124
        10         20         30         40         50         60 
MAALEEEFTL SSVVLSAGPE GLLGVEQSDK TDQFLVTDSG RTVILYKVSD QKPLGSWSVK 

        70         80         90        100        110        120 
QGQIITCPAV CNFQTGEYVV VHDNKVLRIW NNEDVNLDKV FKATLSAEVY RILSVQGTEP 

       130        140        150        160        170        180 
LVLFKEGAVR GLEALLADPQ QKIETVISDE EVIKWTKFFV VFRHPVLIFI TEKHGNYFAY 

       190        200        210        220        230        240 
VQMFNSRILT KYTLLLGQDE NSVIKSFTAS VDRKFISLMS LSSDGCIYET LIPIRPADPE 

       250        260        270        280        290        300 
KNQSLVKSLL LKAVVSGNAR NGVALTALDQ DHVAVLGSPL AASKECLSVW NIKFQTLQTS 

       310        320        330        340        350        360 
KELPQGTSGQ LWYYGEHLFM LHGKSLTVIP YKCEVSSLAG ALGKLKHSQD PGTHVVSHFV 

       370        380        390        400        410        420 
NWETPQGCGL GFQNSEQSRR ILRRRKIEVS LQPEVPPSKQ LLSTIMKDSE KHIEVEVRKF 

       430        440        450        460        470        480 
LALKQTPDFH TVIGDTVTGL LERCKAEPSF YPRNCLMQLI QTHVLSYSLC PDLMEIALKK 

       490        500        510        520        530        540 
KDVQLLQLCL QQFPDIPESV TCACLKIFLS IGDDSLQETD VNMESVFDYS INSVHDEKME 

       550        560        570        580        590        600 
EQTEILQNGF NPEEDKCNNC DQELNKKPQD ETKESTSCPV VQKRAALLNA ILHSAYSETF 

       610        620        630        640        650        660 
LLPHLKDIPA QHITLFLKYL YFLYLKCSEN ATMTLPGIHP PTLNQIMDWI CLLLDANFTV 

       670        680        690        700        710 
VVMMPEAKRL LINLYKLVKS QISVYSELNK IEVSFRELQK LNQEKNNRGL YSIEVLELF 

« Hide

Isoform 2 [UniParc].

Checksum: DBAF194C4CDDE6B2
Show »

FASTA16918,599

References

« Hide 'large scale' references
[1]"Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer."
Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., Cerveny C., Law C.-L., Wahl A., Carter P.
Oncogene 23:7734-7745(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain and Placenta.
[3]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung and Uterus.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 101-719, VARIANT ALA-115.
Tissue: Uterus.
[6]"Functional proteomic analysis of human nucleolus."
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing."
Freed E.F., Prieto J.L., McCann K.L., McStay B., Baserga S.J.
PLoS Genet. 8:E1002892-E1002892(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FBL, IDENTIFICATION IN COMPLEX WITH CIRH1A; UTP15; WDR43 AND WDR75, SUBCELLULAR LOCATION, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY598333 mRNA. Translation: AAT06744.1.
AK023702 mRNA. Translation: BAB14647.1.
AK299483 mRNA. Translation: BAH13045.1. Sequence problems.
AC006534 Genomic DNA. No translation available.
BC001726 mRNA. Translation: AAH01726.2.
BC064404 mRNA. Translation: AAH64404.1.
AL110271 mRNA. Translation: CAB53709.1. Frameshift.
CCDSCCDS11671.1. [Q9H8H0-1]
PIRT14789.
RefSeqNP_056277.2. NM_015462.3. [Q9H8H0-1]
UniGeneHs.463936.

3D structure databases

ProteinModelPortalQ9H8H0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117426. 8 interactions.
IntActQ9H8H0. 2 interactions.
MINTMINT-1415753.
STRING9606.ENSP00000253247.

PTM databases

PhosphoSiteQ9H8H0.

Polymorphism databases

DMDM73921238.

2D gel databases

SWISS-2DPAGEQ9H8H0.

Proteomic databases

MaxQBQ9H8H0.
PaxDbQ9H8H0.
PRIDEQ9H8H0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000253247; ENSP00000253247; ENSG00000130935. [Q9H8H0-1]
ENST00000535137; ENSP00000443765; ENSG00000130935.
ENST00000581375; ENSP00000463219; ENSG00000130935. [Q9H8H0-2]
GeneID25926.
KEGGhsa:25926.
UCSCuc002jgd.1. human. [Q9H8H0-1]

Organism-specific databases

CTD25926.
GeneCardsGC17P065714.
HGNCHGNC:24557. NOL11.
HPAHPA022010.
MIM615366. gene.
neXtProtNX_Q9H8H0.
PharmGKBPA142671258.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG80969.
HOGENOMHOG000231042.
HOVERGENHBG080063.
InParanoidQ9H8H0.
OMAASVDRKF.
OrthoDBEOG761BT7.
PhylomeDBQ9H8H0.
TreeFamTF325877.

Gene expression databases

ArrayExpressQ9H8H0.
BgeeQ9H8H0.
CleanExHS_NOL11.
GenevestigatorQ9H8H0.

Family and domain databases

InterProIPR012584. NUC205.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF08168. NUC205. 1 hit.
[Graphical view]
SUPFAMSSF50978. SSF50978. 2 hits.
ProtoNetSearch...

Other

GenomeRNAi25926.
NextBio35479814.
PROQ9H8H0.
SOURCESearch...

Entry information

Entry nameNOL11_HUMAN
AccessionPrimary (citable) accession number: Q9H8H0
Secondary accession number(s): B7Z5V9, Q7L5S1, Q9UG18
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM