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Q9H8H0

- NOL11_HUMAN

UniProt

Q9H8H0 - NOL11_HUMAN

Protein

Nucleolar protein 11

Gene

NOL11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b.1 Publication

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. maturation of SSU-rRNA Source: UniProtKB
    2. positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    rRNA processing, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleolar protein 11
    Gene namesi
    Name:NOL11
    ORF Names:L14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:24557. NOL11.

    Subcellular locationi

    Nucleusnucleolus 2 Publications

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB
    2. t-UTP complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671258.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 719719Nucleolar protein 11PRO_0000096931Add
    BLAST

    Proteomic databases

    MaxQBiQ9H8H0.
    PaxDbiQ9H8H0.
    PRIDEiQ9H8H0.

    2D gel databases

    SWISS-2DPAGEQ9H8H0.

    PTM databases

    PhosphoSiteiQ9H8H0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H8H0.
    BgeeiQ9H8H0.
    CleanExiHS_NOL11.
    GenevestigatoriQ9H8H0.

    Organism-specific databases

    HPAiHPA022010.

    Interactioni

    Subunit structurei

    Forms a complex with CIRH1A, UTP15, WDR43 and WDR75; within this complex, directly interacts with CIRH1A. Interacts with FBL/fibrillarin in a transcription-dependent manner.1 Publication

    Protein-protein interaction databases

    BioGridi117426. 8 interactions.
    IntActiQ9H8H0. 2 interactions.
    MINTiMINT-1415753.
    STRINGi9606.ENSP00000253247.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H8H0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG80969.
    HOGENOMiHOG000231042.
    HOVERGENiHBG080063.
    InParanoidiQ9H8H0.
    OMAiASVDRKF.
    OrthoDBiEOG761BT7.
    PhylomeDBiQ9H8H0.
    TreeFamiTF325877.

    Family and domain databases

    InterProiIPR012584. NUC205.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF08168. NUC205. 1 hit.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 2 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H8H0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAALEEEFTL SSVVLSAGPE GLLGVEQSDK TDQFLVTDSG RTVILYKVSD    50
    QKPLGSWSVK QGQIITCPAV CNFQTGEYVV VHDNKVLRIW NNEDVNLDKV 100
    FKATLSAEVY RILSVQGTEP LVLFKEGAVR GLEALLADPQ QKIETVISDE 150
    EVIKWTKFFV VFRHPVLIFI TEKHGNYFAY VQMFNSRILT KYTLLLGQDE 200
    NSVIKSFTAS VDRKFISLMS LSSDGCIYET LIPIRPADPE KNQSLVKSLL 250
    LKAVVSGNAR NGVALTALDQ DHVAVLGSPL AASKECLSVW NIKFQTLQTS 300
    KELPQGTSGQ LWYYGEHLFM LHGKSLTVIP YKCEVSSLAG ALGKLKHSQD 350
    PGTHVVSHFV NWETPQGCGL GFQNSEQSRR ILRRRKIEVS LQPEVPPSKQ 400
    LLSTIMKDSE KHIEVEVRKF LALKQTPDFH TVIGDTVTGL LERCKAEPSF 450
    YPRNCLMQLI QTHVLSYSLC PDLMEIALKK KDVQLLQLCL QQFPDIPESV 500
    TCACLKIFLS IGDDSLQETD VNMESVFDYS INSVHDEKME EQTEILQNGF 550
    NPEEDKCNNC DQELNKKPQD ETKESTSCPV VQKRAALLNA ILHSAYSETF 600
    LLPHLKDIPA QHITLFLKYL YFLYLKCSEN ATMTLPGIHP PTLNQIMDWI 650
    CLLLDANFTV VVMMPEAKRL LINLYKLVKS QISVYSELNK IEVSFRELQK 700
    LNQEKNNRGL YSIEVLELF 719
    Length:719
    Mass (Da):81,124
    Last modified:March 1, 2001 - v1
    Checksum:iB794F7A2635453DF
    GO
    Isoform 2 (identifier: Q9H8H0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         154-169: KWTKFFVVFRHPVLIF → NMEITLLTCKCLTHVS
         170-719: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

    Show »
    Length:169
    Mass (Da):18,599
    Checksum:iDBAF194C4CDDE6B2
    GO

    Sequence cautioni

    The sequence CAB53709.1 differs from that shown. Reason: Frameshift at positions 382 and 383.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti115 – 1151V → A.1 Publication
    Corresponds to variant rs2291284 [ dbSNP | Ensembl ].
    VAR_051237

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei154 – 16916KWTKF…PVLIF → NMEITLLTCKCLTHVS in isoform 2. 1 PublicationVSP_053283Add
    BLAST
    Alternative sequencei170 – 719550Missing in isoform 2. 1 PublicationVSP_053284Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY598333 mRNA. Translation: AAT06744.1.
    AK023702 mRNA. Translation: BAB14647.1.
    AK299483 mRNA. Translation: BAH13045.1. Sequence problems.
    AC006534 Genomic DNA. No translation available.
    BC001726 mRNA. Translation: AAH01726.2.
    BC064404 mRNA. Translation: AAH64404.1.
    AL110271 mRNA. Translation: CAB53709.1. Frameshift.
    CCDSiCCDS11671.1. [Q9H8H0-1]
    PIRiT14789.
    RefSeqiNP_056277.2. NM_015462.3. [Q9H8H0-1]
    UniGeneiHs.463936.

    Genome annotation databases

    EnsembliENST00000253247; ENSP00000253247; ENSG00000130935. [Q9H8H0-1]
    ENST00000581375; ENSP00000463219; ENSG00000130935. [Q9H8H0-2]
    GeneIDi25926.
    KEGGihsa:25926.
    UCSCiuc002jgd.1. human. [Q9H8H0-1]

    Polymorphism databases

    DMDMi73921238.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY598333 mRNA. Translation: AAT06744.1 .
    AK023702 mRNA. Translation: BAB14647.1 .
    AK299483 mRNA. Translation: BAH13045.1 . Sequence problems.
    AC006534 Genomic DNA. No translation available.
    BC001726 mRNA. Translation: AAH01726.2 .
    BC064404 mRNA. Translation: AAH64404.1 .
    AL110271 mRNA. Translation: CAB53709.1 . Frameshift.
    CCDSi CCDS11671.1. [Q9H8H0-1 ]
    PIRi T14789.
    RefSeqi NP_056277.2. NM_015462.3. [Q9H8H0-1 ]
    UniGenei Hs.463936.

    3D structure databases

    ProteinModelPortali Q9H8H0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117426. 8 interactions.
    IntActi Q9H8H0. 2 interactions.
    MINTi MINT-1415753.
    STRINGi 9606.ENSP00000253247.

    PTM databases

    PhosphoSitei Q9H8H0.

    Polymorphism databases

    DMDMi 73921238.

    2D gel databases

    SWISS-2DPAGE Q9H8H0.

    Proteomic databases

    MaxQBi Q9H8H0.
    PaxDbi Q9H8H0.
    PRIDEi Q9H8H0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000253247 ; ENSP00000253247 ; ENSG00000130935 . [Q9H8H0-1 ]
    ENST00000581375 ; ENSP00000463219 ; ENSG00000130935 . [Q9H8H0-2 ]
    GeneIDi 25926.
    KEGGi hsa:25926.
    UCSCi uc002jgd.1. human. [Q9H8H0-1 ]

    Organism-specific databases

    CTDi 25926.
    GeneCardsi GC17P065714.
    HGNCi HGNC:24557. NOL11.
    HPAi HPA022010.
    MIMi 615366. gene.
    neXtProti NX_Q9H8H0.
    PharmGKBi PA142671258.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG80969.
    HOGENOMi HOG000231042.
    HOVERGENi HBG080063.
    InParanoidi Q9H8H0.
    OMAi ASVDRKF.
    OrthoDBi EOG761BT7.
    PhylomeDBi Q9H8H0.
    TreeFami TF325877.

    Miscellaneous databases

    GenomeRNAii 25926.
    NextBioi 35479814.
    PROi Q9H8H0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H8H0.
    Bgeei Q9H8H0.
    CleanExi HS_NOL11.
    Genevestigatori Q9H8H0.

    Family and domain databases

    InterProi IPR012584. NUC205.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF08168. NUC205. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer."
      Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., Cerveny C., Law C.-L., Wahl A., Carter P.
      Oncogene 23:7734-7745(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Placenta.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung and Uterus.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 101-719, VARIANT ALA-115.
      Tissue: Uterus.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing."
      Freed E.F., Prieto J.L., McCann K.L., McStay B., Baserga S.J.
      PLoS Genet. 8:E1002892-E1002892(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FBL, IDENTIFICATION IN COMPLEX WITH CIRH1A; UTP15; WDR43 AND WDR75, SUBCELLULAR LOCATION, FUNCTION.

    Entry informationi

    Entry nameiNOL11_HUMAN
    AccessioniPrimary (citable) accession number: Q9H8H0
    Secondary accession number(s): B7Z5V9, Q7L5S1, Q9UG18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3