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Q9H8H0

- NOL11_HUMAN

UniProt

Q9H8H0 - NOL11_HUMAN

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Protein
Nucleolar protein 11
Gene
NOL11, L14
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b.1 Publication

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. maturation of SSU-rRNA Source: UniProtKB
  2. positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

rRNA processing, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 11
Gene namesi
Name:NOL11
ORF Names:L14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:24557. NOL11.

Subcellular locationi

Nucleusnucleolus 2 Publications

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
  2. t-UTP complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671258.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 719719Nucleolar protein 11
PRO_0000096931Add
BLAST

Proteomic databases

MaxQBiQ9H8H0.
PaxDbiQ9H8H0.
PRIDEiQ9H8H0.

2D gel databases

SWISS-2DPAGEQ9H8H0.

PTM databases

PhosphoSiteiQ9H8H0.

Expressioni

Gene expression databases

ArrayExpressiQ9H8H0.
BgeeiQ9H8H0.
CleanExiHS_NOL11.
GenevestigatoriQ9H8H0.

Organism-specific databases

HPAiHPA022010.

Interactioni

Subunit structurei

Forms a complex with CIRH1A, UTP15, WDR43 and WDR75; within this complex, directly interacts with CIRH1A. Interacts with FBL/fibrillarin in a transcription-dependent manner.1 Publication

Protein-protein interaction databases

BioGridi117426. 8 interactions.
IntActiQ9H8H0. 2 interactions.
MINTiMINT-1415753.
STRINGi9606.ENSP00000253247.

Structurei

3D structure databases

ProteinModelPortaliQ9H8H0.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG80969.
HOGENOMiHOG000231042.
HOVERGENiHBG080063.
InParanoidiQ9H8H0.
OMAiASVDRKF.
OrthoDBiEOG761BT7.
PhylomeDBiQ9H8H0.
TreeFamiTF325877.

Family and domain databases

InterProiIPR012584. NUC205.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08168. NUC205. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H8H0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAALEEEFTL SSVVLSAGPE GLLGVEQSDK TDQFLVTDSG RTVILYKVSD    50
QKPLGSWSVK QGQIITCPAV CNFQTGEYVV VHDNKVLRIW NNEDVNLDKV 100
FKATLSAEVY RILSVQGTEP LVLFKEGAVR GLEALLADPQ QKIETVISDE 150
EVIKWTKFFV VFRHPVLIFI TEKHGNYFAY VQMFNSRILT KYTLLLGQDE 200
NSVIKSFTAS VDRKFISLMS LSSDGCIYET LIPIRPADPE KNQSLVKSLL 250
LKAVVSGNAR NGVALTALDQ DHVAVLGSPL AASKECLSVW NIKFQTLQTS 300
KELPQGTSGQ LWYYGEHLFM LHGKSLTVIP YKCEVSSLAG ALGKLKHSQD 350
PGTHVVSHFV NWETPQGCGL GFQNSEQSRR ILRRRKIEVS LQPEVPPSKQ 400
LLSTIMKDSE KHIEVEVRKF LALKQTPDFH TVIGDTVTGL LERCKAEPSF 450
YPRNCLMQLI QTHVLSYSLC PDLMEIALKK KDVQLLQLCL QQFPDIPESV 500
TCACLKIFLS IGDDSLQETD VNMESVFDYS INSVHDEKME EQTEILQNGF 550
NPEEDKCNNC DQELNKKPQD ETKESTSCPV VQKRAALLNA ILHSAYSETF 600
LLPHLKDIPA QHITLFLKYL YFLYLKCSEN ATMTLPGIHP PTLNQIMDWI 650
CLLLDANFTV VVMMPEAKRL LINLYKLVKS QISVYSELNK IEVSFRELQK 700
LNQEKNNRGL YSIEVLELF 719
Length:719
Mass (Da):81,124
Last modified:March 1, 2001 - v1
Checksum:iB794F7A2635453DF
GO
Isoform 2 (identifier: Q9H8H0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-169: KWTKFFVVFRHPVLIF → NMEITLLTCKCLTHVS
     170-719: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

Show »
Length:169
Mass (Da):18,599
Checksum:iDBAF194C4CDDE6B2
GO

Sequence cautioni

The sequence CAB53709.1 differs from that shown. Reason: Frameshift at positions 382 and 383.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti115 – 1151V → A.1 Publication
Corresponds to variant rs2291284 [ dbSNP | Ensembl ].
VAR_051237

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei154 – 16916KWTKF…PVLIF → NMEITLLTCKCLTHVS in isoform 2.
VSP_053283Add
BLAST
Alternative sequencei170 – 719550Missing in isoform 2.
VSP_053284Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY598333 mRNA. Translation: AAT06744.1.
AK023702 mRNA. Translation: BAB14647.1.
AK299483 mRNA. Translation: BAH13045.1. Sequence problems.
AC006534 Genomic DNA. No translation available.
BC001726 mRNA. Translation: AAH01726.2.
BC064404 mRNA. Translation: AAH64404.1.
AL110271 mRNA. Translation: CAB53709.1. Frameshift.
CCDSiCCDS11671.1. [Q9H8H0-1]
PIRiT14789.
RefSeqiNP_056277.2. NM_015462.3. [Q9H8H0-1]
UniGeneiHs.463936.

Genome annotation databases

EnsembliENST00000253247; ENSP00000253247; ENSG00000130935. [Q9H8H0-1]
ENST00000535137; ENSP00000443765; ENSG00000130935.
ENST00000581375; ENSP00000463219; ENSG00000130935. [Q9H8H0-2]
GeneIDi25926.
KEGGihsa:25926.
UCSCiuc002jgd.1. human. [Q9H8H0-1]

Polymorphism databases

DMDMi73921238.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY598333 mRNA. Translation: AAT06744.1 .
AK023702 mRNA. Translation: BAB14647.1 .
AK299483 mRNA. Translation: BAH13045.1 . Sequence problems.
AC006534 Genomic DNA. No translation available.
BC001726 mRNA. Translation: AAH01726.2 .
BC064404 mRNA. Translation: AAH64404.1 .
AL110271 mRNA. Translation: CAB53709.1 . Frameshift.
CCDSi CCDS11671.1. [Q9H8H0-1 ]
PIRi T14789.
RefSeqi NP_056277.2. NM_015462.3. [Q9H8H0-1 ]
UniGenei Hs.463936.

3D structure databases

ProteinModelPortali Q9H8H0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117426. 8 interactions.
IntActi Q9H8H0. 2 interactions.
MINTi MINT-1415753.
STRINGi 9606.ENSP00000253247.

PTM databases

PhosphoSitei Q9H8H0.

Polymorphism databases

DMDMi 73921238.

2D gel databases

SWISS-2DPAGE Q9H8H0.

Proteomic databases

MaxQBi Q9H8H0.
PaxDbi Q9H8H0.
PRIDEi Q9H8H0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000253247 ; ENSP00000253247 ; ENSG00000130935 . [Q9H8H0-1 ]
ENST00000535137 ; ENSP00000443765 ; ENSG00000130935 .
ENST00000581375 ; ENSP00000463219 ; ENSG00000130935 . [Q9H8H0-2 ]
GeneIDi 25926.
KEGGi hsa:25926.
UCSCi uc002jgd.1. human. [Q9H8H0-1 ]

Organism-specific databases

CTDi 25926.
GeneCardsi GC17P065714.
HGNCi HGNC:24557. NOL11.
HPAi HPA022010.
MIMi 615366. gene.
neXtProti NX_Q9H8H0.
PharmGKBi PA142671258.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG80969.
HOGENOMi HOG000231042.
HOVERGENi HBG080063.
InParanoidi Q9H8H0.
OMAi ASVDRKF.
OrthoDBi EOG761BT7.
PhylomeDBi Q9H8H0.
TreeFami TF325877.

Miscellaneous databases

GenomeRNAii 25926.
NextBioi 35479814.
PROi Q9H8H0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9H8H0.
Bgeei Q9H8H0.
CleanExi HS_NOL11.
Genevestigatori Q9H8H0.

Family and domain databases

InterProi IPR012584. NUC205.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF08168. NUC205. 1 hit.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer."
    Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., Cerveny C., Law C.-L., Wahl A., Carter P.
    Oncogene 23:7734-7745(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Placenta.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung and Uterus.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 101-719, VARIANT ALA-115.
    Tissue: Uterus.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing."
    Freed E.F., Prieto J.L., McCann K.L., McStay B., Baserga S.J.
    PLoS Genet. 8:E1002892-E1002892(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FBL, IDENTIFICATION IN COMPLEX WITH CIRH1A; UTP15; WDR43 AND WDR75, SUBCELLULAR LOCATION, FUNCTION.

Entry informationi

Entry nameiNOL11_HUMAN
AccessioniPrimary (citable) accession number: Q9H8H0
Secondary accession number(s): B7Z5V9, Q7L5S1, Q9UG18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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