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Protein

Zinc finger protein 430

Gene

ZNF430

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri205 – 227C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 430
Gene namesi
Name:ZNF430
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000118620.12.
HGNCiHGNC:20808. ZNF430.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi80264.
OpenTargetsiENSG00000118620.
PharmGKBiPA134987901.

Polymorphism and mutation databases

BioMutaiZNF430.
DMDMi296453068.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475781 – 570Zinc finger protein 430Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H8G1.
MaxQBiQ9H8G1.
PaxDbiQ9H8G1.
PeptideAtlasiQ9H8G1.
PRIDEiQ9H8G1.

PTM databases

iPTMnetiQ9H8G1.
PhosphoSitePlusiQ9H8G1.

Expressioni

Gene expression databases

BgeeiENSG00000118620.
CleanExiHS_ZNF430.
ExpressionAtlasiQ9H8G1. baseline and differential.
GenevisibleiQ9H8G1. HS.

Organism-specific databases

HPAiHPA059135.

Interactioni

Protein-protein interaction databases

BioGridi123206. 9 interactors.
STRINGi9606.ENSP00000261560.

Structurei

3D structure databases

ProteinModelPortaliQ9H8G1.
SMRiQ9H8G1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 107KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri205 – 227C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139354.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9H8G1.
KOiK09228.
OMAiGHEDLQL.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9H8G1.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 7 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.

Sequencei

Sequence statusi: Complete.

Q9H8G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENLKSGVYP LKEASGCPGA DRNLLVYSFY EKGPLTFRDV AIEFSLEEWQ
60 70 80 90 100
CLDTAQQDLY RKVMLENYRN LVFLAGIAVS KPDLITCLEQ GKEPWNMKRH
110 120 130 140 150
AMVDQPPVTY SHFAQDLWPE QGIKDSFQEV ILRRYGKCGH EDLQLRTGCK
160 170 180 190 200
SVDECNLHKE CYDELNQCLT TTQSEIFQYD KYVNVFYKFS NPNIQKIRHT
210 220 230 240 250
GKKPFKCKKC DKSFCMLLHL TQHKRIHIRE NSYQCEECGK VFNWFSTLTR
260 270 280 290 300
HRRIHTGEKP YKCEQCGKAF KQSSTLTTHK IIHTGEKPYR CEECGKTFNR
310 320 330 340 350
SSHLTTHKRI HTGEKPYRCE ECGRAFNRSS HLTTHKIIHT GEKPYKCEEC
360 370 380 390 400
GKAFNQSSTL TTHKIIHAGE KPYKCEECGK AFYRFSYLTK HKIIHTGEKF
410 420 430 440 450
YKCEECGKGF NWSSTLTKHK RIHTGEKPYK CEQCGKAFNE SSNLTAHKII
460 470 480 490 500
HTGEKPYKCE ECGKAFNRSP KLTAHKVIHS GEKPYKCEEC GKAFNQFSNL
510 520 530 540 550
TKHKITHIGD TSYKYLECDK AFSQSSTLTK HKVIHTGEKP YNCEEYGKAF
560 570
NQSSNLIEQS NSYWRETLQM
Length:570
Mass (Da):66,319
Last modified:May 18, 2010 - v3
Checksum:iF6A22E01714AB99E
GO

Sequence cautioni

The sequence BAB14656 differs from that shown. Reason: Frameshift at position 293.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150K → R in AAP30885 (Ref. 1) Curated1
Sequence conflicti150K → R in BAB14656 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY269787 mRNA. Translation: AAP30885.1.
AC012627 Genomic DNA. No translation available.
AK023721 mRNA. Translation: BAB14656.1. Frameshift.
CCDSiCCDS32978.1.
RefSeqiNP_079465.3. NM_025189.3.
UniGeneiHs.729202.

Genome annotation databases

EnsembliENST00000261560; ENSP00000261560; ENSG00000118620.
GeneIDi80264.
KEGGihsa:80264.
UCSCiuc002npj.4. human.

Similar proteinsi

Entry informationi

Entry nameiZN430_HUMAN
AccessioniPrimary (citable) accession number: Q9H8G1
Secondary accession number(s): Q86V70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: May 18, 2010
Last modified: September 27, 2017
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families