Q9H8G1 (ZN430_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 430

Gene names

Name:

ZNF430

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	570 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 12 C2H2-type zinc fingers. Contains 1 KRAB domain.
Sequence caution	The sequence BAB14656.1 differs from that shown. Reason: Frameshift at position 293.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 570	570	Zinc finger protein 430		PRO_0000047578
Regions
	Domain	35 – 107	73	KRAB
	Zinc finger	205 – 227	23	C2H2-type 1
	Zinc finger	233 – 255	23	C2H2-type 2
	Zinc finger	261 – 283	23	C2H2-type 3
	Zinc finger	289 – 311	23	C2H2-type 4
	Zinc finger	317 – 339	23	C2H2-type 5
	Zinc finger	345 – 367	23	C2H2-type 6
	Zinc finger	373 – 395	23	C2H2-type 7
	Zinc finger	401 – 423	23	C2H2-type 8
	Zinc finger	429 – 451	23	C2H2-type 9
	Zinc finger	457 – 479	23	C2H2-type 10
	Zinc finger	485 – 507	23	C2H2-type 11
	Zinc finger	513 – 535	23	C2H2-type 12; degenerate
Experimental info
	Sequence conflict	150	1	K → R in AAP30885. Ref.1
	Sequence conflict	150	1	K → R in BAB14656. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9H8G1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: F6A22E01714AB99E	FASTA	570	66,319
	10 20 30 40 50 60 MENLKSGVYP LKEASGCPGA DRNLLVYSFY EKGPLTFRDV AIEFSLEEWQ CLDTAQQDLY 70 80 90 100 110 120 RKVMLENYRN LVFLAGIAVS KPDLITCLEQ GKEPWNMKRH AMVDQPPVTY SHFAQDLWPE 130 140 150 160 170 180 QGIKDSFQEV ILRRYGKCGH EDLQLRTGCK SVDECNLHKE CYDELNQCLT TTQSEIFQYD 190 200 210 220 230 240 KYVNVFYKFS NPNIQKIRHT GKKPFKCKKC DKSFCMLLHL TQHKRIHIRE NSYQCEECGK 250 260 270 280 290 300 VFNWFSTLTR HRRIHTGEKP YKCEQCGKAF KQSSTLTTHK IIHTGEKPYR CEECGKTFNR 310 320 330 340 350 360 SSHLTTHKRI HTGEKPYRCE ECGRAFNRSS HLTTHKIIHT GEKPYKCEEC GKAFNQSSTL 370 380 390 400 410 420 TTHKIIHAGE KPYKCEECGK AFYRFSYLTK HKIIHTGEKF YKCEECGKGF NWSSTLTKHK 430 440 450 460 470 480 RIHTGEKPYK CEQCGKAFNE SSNLTAHKII HTGEKPYKCE ECGKAFNRSP KLTAHKVIHS 490 500 510 520 530 540 GEKPYKCEEC GKAFNQFSNL TKHKITHIGD TSYKYLECDK AFSQSSTLTK HKVIHTGEKP 550 560 570 YNCEEYGKAF NQSSNLIEQS NSYWRETLQM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homo sapiens mRNA similar to zinc finger protein 85." Bi A., Yu L. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-364. Tissue: Placenta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY269787 mRNA. Translation: AAP30885.1. AC012627 Genomic DNA. No translation available. AK023721 mRNA. Translation: BAB14656.1. Frameshift.
IPI	IPI00018748.
RefSeq	NP_079465.3. NM_025189.3.
UniGene	Hs.729202.
3D structure databases
ProteinModelPortal	Q9H8G1.
SMR	Q9H8G1. Positions 186-557.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000261560.
PTM databases
PhosphoSite	Q9H8G1.
Polymorphism databases
DMDM	296453068.
Proteomic databases
PaxDb	Q9H8G1.
PRIDE	Q9H8G1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000261560; ENSP00000261560; ENSG00000118620.
GeneID	80264.
KEGG	hsa:80264.
UCSC	uc002npj.3. human.
Organism-specific databases
CTD	80264.
GeneCards	GC19P021203.
HGNC	HGNC:20808. ZNF430.
neXtProt	NX_Q9H8G1.
PharmGKB	PA134987901.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q9H8G1.
KO	K09228.
OMA	PYNCEEY.
OrthoDB	EOG4CZBFG.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q9H8G1.
Bgee	Q9H8G1.
CleanEx	HS_ZNF430.
Genevestigator	Q9H8G1.
GermOnline	ENSG00000118620. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 13 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 12 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 11 hits. PS50157. ZINC_FINGER_C2H2_2. 12 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	80264.
NextBio	70725.

Entry information

Entry name

ZN430_HUMAN

Accession

Primary (citable) accession number: Q9H8G1
Secondary accession number(s): Q86V70

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 103 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.