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Q9H8G1 (ZN430_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 430
Gene names
Name:ZNF430
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 12 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence BAB14656.1 differs from that shown. Reason: Frameshift at position 293.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Zinc finger protein 430
PRO_0000047578

Regions

Domain35 – 10773KRAB
Zinc finger205 – 22723C2H2-type 1
Zinc finger233 – 25523C2H2-type 2
Zinc finger261 – 28323C2H2-type 3
Zinc finger289 – 31123C2H2-type 4
Zinc finger317 – 33923C2H2-type 5
Zinc finger345 – 36723C2H2-type 6
Zinc finger373 – 39523C2H2-type 7
Zinc finger401 – 42323C2H2-type 8
Zinc finger429 – 45123C2H2-type 9
Zinc finger457 – 47923C2H2-type 10
Zinc finger485 – 50723C2H2-type 11
Zinc finger513 – 53523C2H2-type 12; degenerate

Amino acid modifications

Modified residue11N-acetylmethionine Ref.4

Experimental info

Sequence conflict1501K → R in AAP30885. Ref.1
Sequence conflict1501K → R in BAB14656. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9H8G1 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: F6A22E01714AB99E

FASTA57066,319
        10         20         30         40         50         60 
MENLKSGVYP LKEASGCPGA DRNLLVYSFY EKGPLTFRDV AIEFSLEEWQ CLDTAQQDLY 

        70         80         90        100        110        120 
RKVMLENYRN LVFLAGIAVS KPDLITCLEQ GKEPWNMKRH AMVDQPPVTY SHFAQDLWPE 

       130        140        150        160        170        180 
QGIKDSFQEV ILRRYGKCGH EDLQLRTGCK SVDECNLHKE CYDELNQCLT TTQSEIFQYD 

       190        200        210        220        230        240 
KYVNVFYKFS NPNIQKIRHT GKKPFKCKKC DKSFCMLLHL TQHKRIHIRE NSYQCEECGK 

       250        260        270        280        290        300 
VFNWFSTLTR HRRIHTGEKP YKCEQCGKAF KQSSTLTTHK IIHTGEKPYR CEECGKTFNR 

       310        320        330        340        350        360 
SSHLTTHKRI HTGEKPYRCE ECGRAFNRSS HLTTHKIIHT GEKPYKCEEC GKAFNQSSTL 

       370        380        390        400        410        420 
TTHKIIHAGE KPYKCEECGK AFYRFSYLTK HKIIHTGEKF YKCEECGKGF NWSSTLTKHK 

       430        440        450        460        470        480 
RIHTGEKPYK CEQCGKAFNE SSNLTAHKII HTGEKPYKCE ECGKAFNRSP KLTAHKVIHS 

       490        500        510        520        530        540 
GEKPYKCEEC GKAFNQFSNL TKHKITHIGD TSYKYLECDK AFSQSSTLTK HKVIHTGEKP 

       550        560        570 
YNCEEYGKAF NQSSNLIEQS NSYWRETLQM 

« Hide

References

« Hide 'large scale' references
[1]"Homo sapiens mRNA similar to zinc finger protein 85."
Bi A., Yu L.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-364.
Tissue: Placenta.
[4]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY269787 mRNA. Translation: AAP30885.1.
AC012627 Genomic DNA. No translation available.
AK023721 mRNA. Translation: BAB14656.1. Frameshift.
RefSeqNP_079465.3. NM_025189.3.
UniGeneHs.729202.

3D structure databases

ProteinModelPortalQ9H8G1.
SMRQ9H8G1. Positions 29-84, 151-565.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123206. 1 interaction.
STRING9606.ENSP00000261560.

PTM databases

PhosphoSiteQ9H8G1.

Polymorphism databases

DMDM296453068.

Proteomic databases

PaxDbQ9H8G1.
PRIDEQ9H8G1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261560; ENSP00000261560; ENSG00000118620.
GeneID80264.
KEGGhsa:80264.
UCSCuc002npj.3. human.

Organism-specific databases

CTD80264.
GeneCardsGC19P021203.
HGNCHGNC:20808. ZNF430.
neXtProtNX_Q9H8G1.
PharmGKBPA134987901.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ9H8G1.
KOK09228.
OMASNSYWRE.
OrthoDBEOG7KSX7Q.
PhylomeDBQ9H8G1.
TreeFamTF342117.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9H8G1.
BgeeQ9H8G1.
CleanExHS_ZNF430.
GenevestigatorQ9H8G1.

Family and domain databases

Gene3D3.30.160.60. 13 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi80264.
NextBio70725.
PROQ9H8G1.

Entry information

Entry nameZN430_HUMAN
AccessionPrimary (citable) accession number: Q9H8G1
Secondary accession number(s): Q86V70
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM