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Q9H8G1

- ZN430_HUMAN

UniProt

Q9H8G1 - ZN430_HUMAN

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Protein

Zinc finger protein 430

Gene

ZNF430

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri205 – 22723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri233 – 25523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 47923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri485 – 50723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri513 – 53523C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. substantia nigra development Source: UniProt
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 430
Gene namesi
Name:ZNF430
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:20808. ZNF430.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134987901.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Zinc finger protein 430PRO_0000047578Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9H8G1.
PaxDbiQ9H8G1.
PRIDEiQ9H8G1.

PTM databases

PhosphoSiteiQ9H8G1.

Expressioni

Gene expression databases

BgeeiQ9H8G1.
CleanExiHS_ZNF430.
ExpressionAtlasiQ9H8G1. baseline and differential.
GenevestigatoriQ9H8G1.

Interactioni

Protein-protein interaction databases

BioGridi123206. 2 interactions.
STRINGi9606.ENSP00000261560.

Structurei

3D structure databases

ProteinModelPortaliQ9H8G1.
SMRiQ9H8G1. Positions 186-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 10773KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri205 – 22723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri233 – 25523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 47923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri485 – 50723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri513 – 53523C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00550000074383.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9H8G1.
KOiK09228.
OMAiSNSYWRE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9H8G1.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H8G1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENLKSGVYP LKEASGCPGA DRNLLVYSFY EKGPLTFRDV AIEFSLEEWQ
60 70 80 90 100
CLDTAQQDLY RKVMLENYRN LVFLAGIAVS KPDLITCLEQ GKEPWNMKRH
110 120 130 140 150
AMVDQPPVTY SHFAQDLWPE QGIKDSFQEV ILRRYGKCGH EDLQLRTGCK
160 170 180 190 200
SVDECNLHKE CYDELNQCLT TTQSEIFQYD KYVNVFYKFS NPNIQKIRHT
210 220 230 240 250
GKKPFKCKKC DKSFCMLLHL TQHKRIHIRE NSYQCEECGK VFNWFSTLTR
260 270 280 290 300
HRRIHTGEKP YKCEQCGKAF KQSSTLTTHK IIHTGEKPYR CEECGKTFNR
310 320 330 340 350
SSHLTTHKRI HTGEKPYRCE ECGRAFNRSS HLTTHKIIHT GEKPYKCEEC
360 370 380 390 400
GKAFNQSSTL TTHKIIHAGE KPYKCEECGK AFYRFSYLTK HKIIHTGEKF
410 420 430 440 450
YKCEECGKGF NWSSTLTKHK RIHTGEKPYK CEQCGKAFNE SSNLTAHKII
460 470 480 490 500
HTGEKPYKCE ECGKAFNRSP KLTAHKVIHS GEKPYKCEEC GKAFNQFSNL
510 520 530 540 550
TKHKITHIGD TSYKYLECDK AFSQSSTLTK HKVIHTGEKP YNCEEYGKAF
560 570
NQSSNLIEQS NSYWRETLQM
Length:570
Mass (Da):66,319
Last modified:May 18, 2010 - v3
Checksum:iF6A22E01714AB99E
GO

Sequence cautioni

The sequence BAB14656.1 differs from that shown. Reason: Frameshift at position 293. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti150 – 1501K → R in AAP30885. 1 PublicationCurated
Sequence conflicti150 – 1501K → R in BAB14656. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY269787 mRNA. Translation: AAP30885.1.
AC012627 Genomic DNA. No translation available.
AK023721 mRNA. Translation: BAB14656.1. Frameshift.
CCDSiCCDS32978.1.
RefSeqiNP_079465.3. NM_025189.3.
UniGeneiHs.729202.

Genome annotation databases

EnsembliENST00000261560; ENSP00000261560; ENSG00000118620.
GeneIDi80264.
KEGGihsa:80264.
UCSCiuc002npj.3. human.

Polymorphism databases

DMDMi296453068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY269787 mRNA. Translation: AAP30885.1 .
AC012627 Genomic DNA. No translation available.
AK023721 mRNA. Translation: BAB14656.1 . Frameshift.
CCDSi CCDS32978.1.
RefSeqi NP_079465.3. NM_025189.3.
UniGenei Hs.729202.

3D structure databases

ProteinModelPortali Q9H8G1.
SMRi Q9H8G1. Positions 186-557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123206. 2 interactions.
STRINGi 9606.ENSP00000261560.

PTM databases

PhosphoSitei Q9H8G1.

Polymorphism databases

DMDMi 296453068.

Proteomic databases

MaxQBi Q9H8G1.
PaxDbi Q9H8G1.
PRIDEi Q9H8G1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261560 ; ENSP00000261560 ; ENSG00000118620 .
GeneIDi 80264.
KEGGi hsa:80264.
UCSCi uc002npj.3. human.

Organism-specific databases

CTDi 80264.
GeneCardsi GC19P021203.
HGNCi HGNC:20808. ZNF430.
neXtProti NX_Q9H8G1.
PharmGKBi PA134987901.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00550000074383.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q9H8G1.
KOi K09228.
OMAi SNSYWRE.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q9H8G1.
TreeFami TF342117.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 80264.
NextBioi 70725.
PROi Q9H8G1.

Gene expression databases

Bgeei Q9H8G1.
CleanExi HS_ZNF430.
ExpressionAtlasi Q9H8G1. baseline and differential.
Genevestigatori Q9H8G1.

Family and domain databases

Gene3Di 3.30.160.60. 13 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens mRNA similar to zinc finger protein 85."
    Bi A., Yu L.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-364.
    Tissue: Placenta.
  4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN430_HUMAN
AccessioniPrimary (citable) accession number: Q9H8G1
Secondary accession number(s): Q86V70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3