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Q9H8G1

- ZN430_HUMAN

UniProt

Q9H8G1 - ZN430_HUMAN

Protein

Zinc finger protein 430

Gene

ZNF430

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri205 – 22723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri233 – 25523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri261 – 28323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri289 – 31123C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri317 – 33923C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri345 – 36723C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri373 – 39523C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri401 – 42323C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri429 – 45123C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri457 – 47923C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri485 – 50723C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri513 – 53523C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. substantia nigra development Source: UniProt
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 430
    Gene namesi
    Name:ZNF430
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:20808. ZNF430.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134987901.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570Zinc finger protein 430PRO_0000047578Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9H8G1.
    PaxDbiQ9H8G1.
    PRIDEiQ9H8G1.

    PTM databases

    PhosphoSiteiQ9H8G1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H8G1.
    BgeeiQ9H8G1.
    CleanExiHS_ZNF430.
    GenevestigatoriQ9H8G1.

    Interactioni

    Protein-protein interaction databases

    BioGridi123206. 1 interaction.
    STRINGi9606.ENSP00000261560.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H8G1.
    SMRiQ9H8G1. Positions 176-557.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 10773KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri205 – 22723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri233 – 25523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri261 – 28323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri289 – 31123C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri317 – 33923C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri345 – 36723C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri373 – 39523C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri401 – 42323C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri429 – 45123C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri457 – 47923C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri485 – 50723C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri513 – 53523C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ9H8G1.
    KOiK09228.
    OMAiSNSYWRE.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ9H8G1.
    TreeFamiTF342117.

    Family and domain databases

    Gene3Di3.30.160.60. 13 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 11 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H8G1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENLKSGVYP LKEASGCPGA DRNLLVYSFY EKGPLTFRDV AIEFSLEEWQ    50
    CLDTAQQDLY RKVMLENYRN LVFLAGIAVS KPDLITCLEQ GKEPWNMKRH 100
    AMVDQPPVTY SHFAQDLWPE QGIKDSFQEV ILRRYGKCGH EDLQLRTGCK 150
    SVDECNLHKE CYDELNQCLT TTQSEIFQYD KYVNVFYKFS NPNIQKIRHT 200
    GKKPFKCKKC DKSFCMLLHL TQHKRIHIRE NSYQCEECGK VFNWFSTLTR 250
    HRRIHTGEKP YKCEQCGKAF KQSSTLTTHK IIHTGEKPYR CEECGKTFNR 300
    SSHLTTHKRI HTGEKPYRCE ECGRAFNRSS HLTTHKIIHT GEKPYKCEEC 350
    GKAFNQSSTL TTHKIIHAGE KPYKCEECGK AFYRFSYLTK HKIIHTGEKF 400
    YKCEECGKGF NWSSTLTKHK RIHTGEKPYK CEQCGKAFNE SSNLTAHKII 450
    HTGEKPYKCE ECGKAFNRSP KLTAHKVIHS GEKPYKCEEC GKAFNQFSNL 500
    TKHKITHIGD TSYKYLECDK AFSQSSTLTK HKVIHTGEKP YNCEEYGKAF 550
    NQSSNLIEQS NSYWRETLQM 570
    Length:570
    Mass (Da):66,319
    Last modified:May 18, 2010 - v3
    Checksum:iF6A22E01714AB99E
    GO

    Sequence cautioni

    The sequence BAB14656.1 differs from that shown. Reason: Frameshift at position 293.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti150 – 1501K → R in AAP30885. 1 PublicationCurated
    Sequence conflicti150 – 1501K → R in BAB14656. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY269787 mRNA. Translation: AAP30885.1.
    AC012627 Genomic DNA. No translation available.
    AK023721 mRNA. Translation: BAB14656.1. Frameshift.
    CCDSiCCDS32978.1.
    RefSeqiNP_079465.3. NM_025189.3.
    UniGeneiHs.729202.

    Genome annotation databases

    EnsembliENST00000261560; ENSP00000261560; ENSG00000118620.
    GeneIDi80264.
    KEGGihsa:80264.
    UCSCiuc002npj.3. human.

    Polymorphism databases

    DMDMi296453068.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY269787 mRNA. Translation: AAP30885.1 .
    AC012627 Genomic DNA. No translation available.
    AK023721 mRNA. Translation: BAB14656.1 . Frameshift.
    CCDSi CCDS32978.1.
    RefSeqi NP_079465.3. NM_025189.3.
    UniGenei Hs.729202.

    3D structure databases

    ProteinModelPortali Q9H8G1.
    SMRi Q9H8G1. Positions 176-557.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123206. 1 interaction.
    STRINGi 9606.ENSP00000261560.

    PTM databases

    PhosphoSitei Q9H8G1.

    Polymorphism databases

    DMDMi 296453068.

    Proteomic databases

    MaxQBi Q9H8G1.
    PaxDbi Q9H8G1.
    PRIDEi Q9H8G1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261560 ; ENSP00000261560 ; ENSG00000118620 .
    GeneIDi 80264.
    KEGGi hsa:80264.
    UCSCi uc002npj.3. human.

    Organism-specific databases

    CTDi 80264.
    GeneCardsi GC19P021203.
    HGNCi HGNC:20808. ZNF430.
    neXtProti NX_Q9H8G1.
    PharmGKBi PA134987901.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q9H8G1.
    KOi K09228.
    OMAi SNSYWRE.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q9H8G1.
    TreeFami TF342117.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 80264.
    NextBioi 70725.
    PROi Q9H8G1.

    Gene expression databases

    ArrayExpressi Q9H8G1.
    Bgeei Q9H8G1.
    CleanExi HS_ZNF430.
    Genevestigatori Q9H8G1.

    Family and domain databases

    Gene3Di 3.30.160.60. 13 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 11 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homo sapiens mRNA similar to zinc finger protein 85."
      Bi A., Yu L.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-364.
      Tissue: Placenta.
    4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZN430_HUMAN
    AccessioniPrimary (citable) accession number: Q9H8G1
    Secondary accession number(s): Q86V70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 116 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3