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Q9H8E8

- CSR2B_HUMAN

UniProt

Q9H8E8 - CSR2B_HUMAN

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Protein

Cysteine-rich protein 2-binding protein

Gene

CSRP2BP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.1 Publication

GO - Molecular functioni

  1. histone acetyltransferase activity Source: MGI
  2. LIM domain binding Source: UniProtKB

GO - Biological processi

  1. chromatin organization Source: Reactome
  2. G2/M transition of mitotic cell cycle Source: Ensembl
  3. histone H3 acetylation Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_172610. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich protein 2-binding protein
Short name:
CSRP2-binding protein
Alternative name(s):
ADA2A-containing complex subunit 2
Short name:
ATAC2
CRP2-binding partner
Short name:
CRP2BP
Gene namesi
Name:CSRP2BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15904. CSRP2BP.

Subcellular locationi

Nucleus. Cytoplasm
Note: Mainly nuclear.

GO - Cellular componenti

  1. Ada2/Gcn5/Ada3 transcription activator complex Source: BHF-UCL
  2. cytoplasm Source: UniProtKB-KW
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26969.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 782782Cysteine-rich protein 2-binding proteinPRO_0000074603Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei231 – 2311N6-acetyllysineBy similarity
Modified residuei292 – 2921N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9H8E8.
PaxDbiQ9H8E8.
PRIDEiQ9H8E8.

PTM databases

PhosphoSiteiQ9H8E8.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, heart, lung, placenta, brain, liver, pancreas and kidney. High expression in skeletal muscle and heart. Lower expression in lung.

Gene expression databases

BgeeiQ9H8E8.
CleanExiHS_CSRP2BP.
ExpressionAtlasiQ9H8E8. baseline and differential.
GenevestigatoriQ9H8E8.

Organism-specific databases

HPAiCAB034224.

Interactioni

Subunit structurei

Interacts with the LIM 1 domain of CSRP2. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and WDR5.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MBIPQ9NS733EBI-750907,EBI-741953

Protein-protein interaction databases

BioGridi121485. 13 interactions.
IntActiQ9H8E8. 5 interactions.
MINTiMINT-1479938.
STRINGi9606.ENSP00000278816.

Structurei

3D structure databases

ProteinModelPortaliQ9H8E8.
SMRiQ9H8E8. Positions 672-758.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini638 – 782145N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG295186.
GeneTreeiENSGT00390000001146.
HOGENOMiHOG000230880.
HOVERGENiHBG051142.
InParanoidiQ9H8E8.
OMAiKEDICAF.
OrthoDBiEOG7M6D6R.
PhylomeDBiQ9H8E8.
TreeFamiTF324809.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H8E8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSSIHLSSL ISRHDDEATR TSTSEGLEEG EVEGETLLIV ESEDQASVDL
60 70 80 90 100
SHDQSGDSLN SDEGDVSWME EQLSYFCDKC QKWIPASQLR EQLSYLKGDN
110 120 130 140 150
FFRFTCSDCS ADGKEQYERL KLTWQQVVML AMYNLSLEGS GRQGYFRWKE
160 170 180 190 200
DICAFIEKHW TFLLGNRKKT STWWSTVAGC LSVGSPMYFR SGAQEFGEPG
210 220 230 240 250
WWKLVHNKPP TMKPEGEKLS ASTLKIKAAS KPTLDPIITV EGLRKRASRN
260 270 280 290 300
PVESAMELKE KRSRTQEAKD IRRAQKEAAG FLDRSTSSTP VKFISRGRRP
310 320 330 340 350
DVILEKGEVI DFSSLSSSDR TPLTSPSPSP SLDFSAPGTP ASHSATPSLL
360 370 380 390 400
SEADLIPDVM PPQALFHDDD EMEGDGVIDP GMEYVPPPAG SVASGPVVGV
410 420 430 440 450
RKKVRGPEQI KQEVESEEEK PDRMDIDSED TDSNTSLQTR AREKRKPQLE
460 470 480 490 500
KDTKPKEPRY TPVSIYEEKL LLKRLEACPG AVAMTPEARR LKRKLIVRQA
510 520 530 540 550
KRDRGLPLFD LDQVVNAALL LVDGIYGAKE GGISRLPAGQ ATYRTTCQDF
560 570 580 590 600
RILDRYQTSL PSRKGFRHQT TKFLYRLVGS EDMAVDQSIV SPYTSRILKP
610 620 630 640 650
YIRRDYETKP PKLQLLSQIR SHLHRSDPHW TPEPDAPLDY CYVRPNHIPT
660 670 680 690 700
INSMCQEFFW PGIDLSECLQ YPDFSVVVLY KKVIIAFGFM VPDVKYNEAY
710 720 730 740 750
ISFLFVHPEW RRAGIATFMI YHLIQTCMGK DVTLHVSASN PAMLLYQKFG
760 770 780
FKTEEYVLDF YDKYYPLEST ECKHAFFLRL RR
Length:782
Mass (Da):88,844
Last modified:October 5, 2010 - v3
Checksum:iE84FAEF06412EA77
GO
Isoform 2 (identifier: Q9H8E8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.

Note: May be due to an intron retention.

Show »
Length:654
Mass (Da):74,324
Checksum:i2EA7F2981E7D4195
GO

Sequence cautioni

The sequence CAB56651.2 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti535 – 5351R → G in BAB14669. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti214 – 2141P → L.
Corresponds to variant rs6081011 [ dbSNP | Ensembl ].
VAR_028034
Natural varianti400 – 4001V → G.2 Publications
Corresponds to variant rs1205193 [ dbSNP | Ensembl ].
VAR_028035
Natural varianti442 – 4421R → T.
Corresponds to variant rs2295182 [ dbSNP | Ensembl ].
VAR_020466
Natural varianti600 – 6001P → R.
Corresponds to variant rs11557577 [ dbSNP | Ensembl ].
VAR_033839
Natural varianti738 – 7381A → S.
Corresponds to variant rs6081027 [ dbSNP | Ensembl ].
VAR_048166

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 128128Missing in isoform 2. 2 PublicationsVSP_000070Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK023759 mRNA. Translation: BAB14669.1.
AL050321 Genomic DNA. Translation: CAB56651.2. Sequence problems.
AL050321 Genomic DNA. Translation: CAM28294.1.
CH471133 Genomic DNA. Translation: EAX10255.1.
BC007537 mRNA. Translation: AAH07537.1.
BC009174 mRNA. No translation available.
AF252257 mRNA. Translation: AAG10249.1.
CCDSiCCDS13133.1. [Q9H8E8-1]
RefSeqiNP_065397.3. NM_020536.4.
UniGeneiHs.488051.
Hs.728790.

Genome annotation databases

EnsembliENST00000435364; ENSP00000392318; ENSG00000149474. [Q9H8E8-1]
ENST00000489634; ENSP00000425909; ENSG00000149474. [Q9H8E8-2]
GeneIDi57325.
KEGGihsa:57325.
UCSCiuc002wqk.3. human. [Q9H8E8-1]

Polymorphism databases

DMDMi308153608.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK023759 mRNA. Translation: BAB14669.1 .
AL050321 Genomic DNA. Translation: CAB56651.2 . Sequence problems.
AL050321 Genomic DNA. Translation: CAM28294.1 .
CH471133 Genomic DNA. Translation: EAX10255.1 .
BC007537 mRNA. Translation: AAH07537.1 .
BC009174 mRNA. No translation available.
AF252257 mRNA. Translation: AAG10249.1 .
CCDSi CCDS13133.1. [Q9H8E8-1 ]
RefSeqi NP_065397.3. NM_020536.4.
UniGenei Hs.488051.
Hs.728790.

3D structure databases

ProteinModelPortali Q9H8E8.
SMRi Q9H8E8. Positions 672-758.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121485. 13 interactions.
IntActi Q9H8E8. 5 interactions.
MINTi MINT-1479938.
STRINGi 9606.ENSP00000278816.

PTM databases

PhosphoSitei Q9H8E8.

Polymorphism databases

DMDMi 308153608.

Proteomic databases

MaxQBi Q9H8E8.
PaxDbi Q9H8E8.
PRIDEi Q9H8E8.

Protocols and materials databases

DNASUi 57325.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000435364 ; ENSP00000392318 ; ENSG00000149474 . [Q9H8E8-1 ]
ENST00000489634 ; ENSP00000425909 ; ENSG00000149474 . [Q9H8E8-2 ]
GeneIDi 57325.
KEGGi hsa:57325.
UCSCi uc002wqk.3. human. [Q9H8E8-1 ]

Organism-specific databases

CTDi 57325.
GeneCardsi GC20P018066.
HGNCi HGNC:15904. CSRP2BP.
HPAi CAB034224.
neXtProti NX_Q9H8E8.
PharmGKBi PA26969.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG295186.
GeneTreei ENSGT00390000001146.
HOGENOMi HOG000230880.
HOVERGENi HBG051142.
InParanoidi Q9H8E8.
OMAi KEDICAF.
OrthoDBi EOG7M6D6R.
PhylomeDBi Q9H8E8.
TreeFami TF324809.

Enzyme and pathway databases

Reactomei REACT_172610. HATs acetylate histones.

Miscellaneous databases

GeneWikii CSRP2BP.
GenomeRNAii 57325.
NextBioi 63428.
PROi Q9H8E8.

Gene expression databases

Bgeei Q9H8E8.
CleanExi HS_CSRP2BP.
ExpressionAtlasi Q9H8E8. baseline and differential.
Genevestigatori Q9H8E8.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLY-400.
    Tissue: Placenta.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLY-400.
    Tissue: Eye and Placenta.
  5. "The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein."
    Weiskirchen R., Gressner A.M.
    Biochem. Biophys. Res. Commun. 274:655-663(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 546-782, INTERACTION WITH CSRP2.
    Tissue: Kidney.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "The double-histone-acetyltransferase complex ATAC is essential for mammalian development."
    Guelman S., Kozuka K., Mao Y., Pham V., Solloway M.J., Wang J., Wu J., Lill J.R., Zha J.
    Mol. Cell. Biol. 29:1176-1188(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN ATAC COMPLEX.
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-292, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCSR2B_HUMAN
AccessioniPrimary (citable) accession number: Q9H8E8
Secondary accession number(s): A2A2I5
, Q96GW6, Q96IH3, Q9HBF0, Q9UIY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3