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Protein

Cysteine-rich protein 2-binding protein

Gene

KAT14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.1 Publication

GO - Molecular functioni

  • histone acetyltransferase activity Source: MGI
  • LIM domain binding Source: UniProtKB

GO - Biological processi

  • G2/M transition of mitotic cell cycle Source: Ensembl
  • histone H3 acetylation Source: BHF-UCL

Enzyme and pathway databases

BRENDAi2.3.1.48. 2681.
ReactomeiR-HSA-3214847. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich protein 2-binding protein
Short name:
CSRP2-binding protein
Alternative name(s):
ADA2A-containing complex subunit 2
Short name:
ATAC2
CRP2-binding partner
Short name:
CRP2BP
Lysine acetyltransferase 14Imported
Gene namesi
Name:KAT14Imported
Synonyms:CSRP2BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15904. KAT14.

Subcellular locationi

GO - Cellular componenti

  • Ada2/Gcn5/Ada3 transcription activator complex Source: BHF-UCL
  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57325.
OpenTargetsiENSG00000149474.
PharmGKBiPA26969.

Polymorphism and mutation databases

BioMutaiCSRP2BP.
DMDMi308153608.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000746031 – 782Cysteine-rich protein 2-binding proteinAdd BLAST782

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineCombined sources1
Modified residuei231N6-acetyllysineBy similarity1
Modified residuei285PhosphoserineCombined sources1
Modified residuei292N6-acetyllysineCombined sources1
Modified residuei416PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H8E8.
MaxQBiQ9H8E8.
PaxDbiQ9H8E8.
PeptideAtlasiQ9H8E8.
PRIDEiQ9H8E8.

PTM databases

iPTMnetiQ9H8E8.
PhosphoSitePlusiQ9H8E8.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, heart, lung, placenta, brain, liver, pancreas and kidney. High expression in skeletal muscle and heart. Lower expression in lung.

Gene expression databases

BgeeiENSG00000149474.
CleanExiHS_CSRP2BP.
ExpressionAtlasiQ9H8E8. baseline and differential.
GenevisibleiQ9H8E8. HS.

Organism-specific databases

HPAiCAB034224.
HPA068443.

Interactioni

Subunit structurei

Interacts with the LIM 1 domain of CSRP2. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and WDR5.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • LIM domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121485. 36 interactors.
IntActiQ9H8E8. 12 interactors.
MINTiMINT-1479938.
STRINGi9606.ENSP00000278816.

Structurei

3D structure databases

ProteinModelPortaliQ9H8E8.
SMRiQ9H8E8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini638 – 782N-acetyltransferasePROSITE-ProRule annotationAdd BLAST145

Phylogenomic databases

eggNOGiENOG410IQJZ. Eukaryota.
ENOG410Y6C7. LUCA.
GeneTreeiENSGT00390000001146.
HOGENOMiHOG000230880.
HOVERGENiHBG051142.
InParanoidiQ9H8E8.
OMAiTWWSTVA.
OrthoDBiEOG091G0CJX.
PhylomeDBiQ9H8E8.
TreeFamiTF324809.

Family and domain databases

InterProiView protein in InterPro
IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
PfamiView protein in Pfam
PF13673. Acetyltransf_10. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiView protein in PROSITE
PS51186. GNAT. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H8E8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSSIHLSSL ISRHDDEATR TSTSEGLEEG EVEGETLLIV ESEDQASVDL
60 70 80 90 100
SHDQSGDSLN SDEGDVSWME EQLSYFCDKC QKWIPASQLR EQLSYLKGDN
110 120 130 140 150
FFRFTCSDCS ADGKEQYERL KLTWQQVVML AMYNLSLEGS GRQGYFRWKE
160 170 180 190 200
DICAFIEKHW TFLLGNRKKT STWWSTVAGC LSVGSPMYFR SGAQEFGEPG
210 220 230 240 250
WWKLVHNKPP TMKPEGEKLS ASTLKIKAAS KPTLDPIITV EGLRKRASRN
260 270 280 290 300
PVESAMELKE KRSRTQEAKD IRRAQKEAAG FLDRSTSSTP VKFISRGRRP
310 320 330 340 350
DVILEKGEVI DFSSLSSSDR TPLTSPSPSP SLDFSAPGTP ASHSATPSLL
360 370 380 390 400
SEADLIPDVM PPQALFHDDD EMEGDGVIDP GMEYVPPPAG SVASGPVVGV
410 420 430 440 450
RKKVRGPEQI KQEVESEEEK PDRMDIDSED TDSNTSLQTR AREKRKPQLE
460 470 480 490 500
KDTKPKEPRY TPVSIYEEKL LLKRLEACPG AVAMTPEARR LKRKLIVRQA
510 520 530 540 550
KRDRGLPLFD LDQVVNAALL LVDGIYGAKE GGISRLPAGQ ATYRTTCQDF
560 570 580 590 600
RILDRYQTSL PSRKGFRHQT TKFLYRLVGS EDMAVDQSIV SPYTSRILKP
610 620 630 640 650
YIRRDYETKP PKLQLLSQIR SHLHRSDPHW TPEPDAPLDY CYVRPNHIPT
660 670 680 690 700
INSMCQEFFW PGIDLSECLQ YPDFSVVVLY KKVIIAFGFM VPDVKYNEAY
710 720 730 740 750
ISFLFVHPEW RRAGIATFMI YHLIQTCMGK DVTLHVSASN PAMLLYQKFG
760 770 780
FKTEEYVLDF YDKYYPLEST ECKHAFFLRL RR
Length:782
Mass (Da):88,844
Last modified:October 5, 2010 - v3
Checksum:iE84FAEF06412EA77
GO
Isoform 2 (identifier: Q9H8E8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.

Note: May be due to an intron retention.
Show »
Length:654
Mass (Da):74,324
Checksum:i2EA7F2981E7D4195
GO

Sequence cautioni

The sequence CAB56651 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti535R → G in BAB14669 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028034214P → L. Corresponds to variant dbSNP:rs6081011Ensembl.1
Natural variantiVAR_028035400V → G2 PublicationsCorresponds to variant dbSNP:rs1205193Ensembl.1
Natural variantiVAR_020466442R → T. Corresponds to variant dbSNP:rs2295182Ensembl.1
Natural variantiVAR_033839600P → R. Corresponds to variant dbSNP:rs11557577Ensembl.1
Natural variantiVAR_048166738A → S. Corresponds to variant dbSNP:rs6081027Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0000701 – 128Missing in isoform 2. 2 PublicationsAdd BLAST128

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023759 mRNA. Translation: BAB14669.1.
AL050321 Genomic DNA. Translation: CAB56651.2. Sequence problems.
AL050321 Genomic DNA. Translation: CAM28294.1.
CH471133 Genomic DNA. Translation: EAX10255.1.
BC007537 mRNA. Translation: AAH07537.1.
BC009174 mRNA. No translation available.
AF252257 mRNA. Translation: AAG10249.1.
CCDSiCCDS13133.1. [Q9H8E8-1]
RefSeqiNP_065397.3. NM_020536.4.
UniGeneiHs.488051.
Hs.728790.

Genome annotation databases

EnsembliENST00000435364; ENSP00000392318; ENSG00000149474. [Q9H8E8-1]
ENST00000489634; ENSP00000425909; ENSG00000149474. [Q9H8E8-2]
GeneIDi57325.
KEGGihsa:57325.
UCSCiuc002wqk.3. human. [Q9H8E8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCSR2B_HUMAN
AccessioniPrimary (citable) accession number: Q9H8E8
Secondary accession number(s): A2A2I5
, Q96GW6, Q96IH3, Q9HBF0, Q9UIY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 5, 2010
Last modified: August 30, 2017
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations